{"id":"https://openalex.org/W2707742039","doi":"https://doi.org/10.1109/tcst.2018.2815551","title":"Semiadaptive Infusion Control of Medications With Excitatory Dose-Dependent Effects","display_name":"Semiadaptive Infusion Control of Medications With Excitatory Dose-Dependent Effects","publication_year":2018,"publication_date":"2018-04-13","ids":{"openalex":"https://openalex.org/W2707742039","doi":"https://doi.org/10.1109/tcst.2018.2815551","mag":"2707742039"},"language":"en","primary_location":{"id":"doi:10.1109/tcst.2018.2815551","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2018.2815551","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.13016/m2xk31","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072743312","display_name":"Junxi Zhu","orcid":"https://orcid.org/0000-0001-5058-5738"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junxi Zhu","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":"https://orcid.org/0000-0001-5058-5738","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100717111","display_name":"Xin Jin","orcid":"https://orcid.org/0000-0002-5582-3907"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Jin","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-5582-3907","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080459058","display_name":"Ramin Bighamian","orcid":"https://orcid.org/0000-0002-2660-0851"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramin Bighamian","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085338347","display_name":"Chang\u2010Sei Kim","orcid":"https://orcid.org/0000-0003-4532-2006"},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang-Sei Kim","raw_affiliation_strings":["School of Mechanical Engineering, Chonnam National University, Gwangju, South Korea"],"raw_orcid":"https://orcid.org/0000-0003-4532-2006","affiliations":[{"raw_affiliation_string":"School of Mechanical Engineering, Chonnam National University, Gwangju, South Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064309896","display_name":"Steven T. Shipley","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven T. Shipley","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057276590","display_name":"Jin\u2010Oh Hahn","orcid":"https://orcid.org/0000-0001-5429-2836"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Oh Hahn","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":"https://orcid.org/0000-0001-5429-2836","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072743312"],"corresponding_institution_ids":["https://openalex.org/I66946132"],"apc_list":null,"apc_paid":null,"fwci":1.2009,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.77479366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"27","issue":"4","first_page":"1735","last_page":"1743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.7720127105712891},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5253210067749023},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.5087924599647522},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42341217398643494},{"id":"https://openalex.org/keywords/frequency-response","display_name":"Frequency response","score":0.4193035364151001},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3051072061061859},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.2351214587688446},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1456848680973053},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13141906261444092},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.13091006875038147},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1272147297859192},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11741682887077332}],"concepts":[{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7720127105712891},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5253210067749023},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.5087924599647522},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42341217398643494},{"id":"https://openalex.org/C8590192","wikidata":"https://www.wikidata.org/wiki/Q1054694","display_name":"Frequency response","level":2,"score":0.4193035364151001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3051072061061859},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2351214587688446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1456848680973053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13141906261444092},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.13091006875038147},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1272147297859192},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11741682887077332},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/tcst.2018.2815551","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2018.2815551","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"},{"id":"pmh:oai:drum.lib.umd.edu:1903/19415","is_oa":false,"landing_page_url":"http://hdl.handle.net/1903/19415","pdf_url":null,"source":{"id":"https://openalex.org/S4306402644","display_name":"Digital Repository at the University of Maryland (University of Maryland College Park)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"doi:10.13016/m2xk31","is_oa":true,"landing_page_url":"https://doi.org/10.13016/m2xk31","pdf_url":null,"source":{"id":"https://openalex.org/S4306402644","display_name":"Digital Repository at the University of Maryland (University of Maryland College Park)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.13016/m2xk31","is_oa":true,"landing_page_url":"https://doi.org/10.13016/m2xk31","pdf_url":null,"source":{"id":"https://openalex.org/S4306402644","display_name":"Digital Repository at the University of Maryland (University of Maryland College Park)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"awards":[{"id":"https://openalex.org/G5413616413","display_name":null,"funder_award_id":"N000141512018","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G6894515429","display_name":null,"funder_award_id":"N000141410591","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W74630330","https://openalex.org/W1487127700","https://openalex.org/W1509868643","https://openalex.org/W1966065377","https://openalex.org/W1980876624","https://openalex.org/W1981819050","https://openalex.org/W1993385337","https://openalex.org/W1996446238","https://openalex.org/W1999357988","https://openalex.org/W2039948489","https://openalex.org/W2044321898","https://openalex.org/W2102392294","https://openalex.org/W2105336635","https://openalex.org/W2107038257","https://openalex.org/W2114325189","https://openalex.org/W2137164841","https://openalex.org/W2139951413","https://openalex.org/W2159171548","https://openalex.org/W2160846111","https://openalex.org/W2165597735","https://openalex.org/W2410376912","https://openalex.org/W2555777152","https://openalex.org/W2591734604","https://openalex.org/W2742164534","https://openalex.org/W2752733073","https://openalex.org/W2754930286","https://openalex.org/W4230381201"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"This":[0],"brief":[1],"presents":[2],"a":[3,39,57,83,95,107,112,164,201],"closed-loop":[4,21,69],"control":[5,22,64,71,126],"approach":[6,65,127,155],"to":[7,67,98,106,115,120,131,137,163],"infusion":[8,70],"of":[9,23,31,72,86,90,145,152,159,204],"medications":[10,25],"that":[11,27,179,191],"exhibit":[12],"excitatory":[13,34,73,122],"dose-dependent":[14],"effects.":[15],"A":[16],"unique":[17],"challenge":[18,41],"associated":[19],"with":[20],"such":[24],"is":[26,36],"the":[28,32,44,47,68,80,87,91,104,117,133,138,150,153,180,187,192,198],"upper":[29,88],"limit":[30,89],"medication-induced":[33,92],"response":[35,93,119,162,199],"unknown,":[37],"presenting":[38],"severe":[40],"in":[42,46,200],"estimating":[43],"parameters":[45],"traditional":[48],"dose-response":[49,59,77,101,140,182],"model.":[50],"To":[51],"address":[52],"this":[53],"challenge,":[54],"we":[55],"proposed":[56,154],"new":[58,76,139,181],"model":[60,78,141,183],"and":[61,111,174,190],"semiadaptive":[62],"(SA)":[63],"applicable":[66],"medications.":[74],"The":[75,124],"eliminates":[79],"need":[81],"for":[82],"priori":[84],"knowledge":[85],"via":[94,142],"novel":[96],"parameterization":[97],"capture":[99],"local":[100],"relationship":[102],"from":[103],"baseline":[105],"target":[108],"set":[109],"point":[110],"nonlinear":[113],"function":[114],"convert":[116],"depressive":[118],"an":[121,157],"response.":[123],"SA":[125,193],"makes":[128],"it":[129],"possible":[130],"apply":[132],"well-established":[134],"MRAC":[135],"technique":[136],"selective":[143],"adaptation":[144],"high-sensitivity":[146],"parameters.":[147],"We":[148],"examined":[149],"efficacy":[151],"using":[156,171],"example":[158],"heart":[160],"rate":[161],"vasoactive":[165],"medication":[166],"norepinephrine.":[167],"System":[168],"identification":[169],"analysis":[170],"experimental":[172,188],"data":[173],"in-silico":[175],"controller":[176,194],"testing":[177],"suggested":[178],"could":[184,195],"faithfully":[185],"reproduce":[186],"data,":[189],"effectively":[196],"regulate":[197],"wide":[202],"range":[203],"simulated":[205],"subjects.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}