{"id":"https://openalex.org/W2918010644","doi":"https://doi.org/10.1109/tcsi.2019.2895652","title":"High-DR CMOS Fluorescence Biosensor With Extended Counting ADC and Noise Cancellation","display_name":"High-DR CMOS Fluorescence Biosensor With Extended Counting ADC and Noise Cancellation","publication_year":2019,"publication_date":"2019-02-21","ids":{"openalex":"https://openalex.org/W2918010644","doi":"https://doi.org/10.1109/tcsi.2019.2895652","mag":"2918010644"},"language":"en","primary_location":{"id":"doi:10.1109/tcsi.2019.2895652","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcsi.2019.2895652","pdf_url":null,"source":{"id":"https://openalex.org/S116977442","display_name":"IEEE Transactions on Circuits and Systems I Regular Papers","issn_l":"1549-8328","issn":["1549-8328","1558-0806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Circuits and Systems I: Regular Papers","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053327556","display_name":"Mehdi Noormohammadi Khiarak","orcid":"https://orcid.org/0000-0002-1773-3257"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mehdi Noormohammadi Khiarak","raw_affiliation_strings":["Smart Biomedical Microsystems Lab, Universit\u00e9 Laval, Quebec, QC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1773-3257","affiliations":[{"raw_affiliation_string":"Smart Biomedical Microsystems Lab, Universit\u00e9 Laval, Quebec, QC, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032472238","display_name":"Sylvain Martel","orcid":"https://orcid.org/0000-0003-4234-9959"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvain Martel","raw_affiliation_strings":["NanoRobotics Laboratory, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoRobotics Laboratory, Montreal, QC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017328884","display_name":"Yves De Koninck","orcid":"https://orcid.org/0000-0002-5779-9330"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yves De Koninck","raw_affiliation_strings":["CERVO Brain Research Center, Universit\u00e9 Laval, Quebec, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CERVO Brain Research Center, Universit\u00e9 Laval, Quebec, QC, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018071134","display_name":"Benoit Gosselin","orcid":"https://orcid.org/0000-0003-1473-3451"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benoit Gosselin","raw_affiliation_strings":["Smart Biomedical Microsystems Lab, Universit\u00e9 Laval, Quebec, QC, Canada"],"raw_orcid":"https://orcid.org/0000-0003-1473-3451","affiliations":[{"raw_affiliation_string":"Smart Biomedical Microsystems Lab, Universit\u00e9 Laval, Quebec, QC, Canada","institution_ids":["https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4011,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81432338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"66","issue":"6","first_page":"2077","last_page":"2087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11992","display_name":"CCD and CMOS Imaging Sensors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11992","display_name":"CCD and CMOS Imaging Sensors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cmos","display_name":"CMOS","score":0.693301796913147},{"id":"https://openalex.org/keywords/dynamic-range","display_name":"Dynamic range","score":0.6659148335456848},{"id":"https://openalex.org/keywords/correlated-double-sampling","display_name":"Correlated double sampling","score":0.654589056968689},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.5724214315414429},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.5312352776527405},{"id":"https://openalex.org/keywords/wide-dynamic-range","display_name":"Wide dynamic range","score":0.48594462871551514},{"id":"https://openalex.org/keywords/photodiode","display_name":"Photodiode","score":0.43548229336738586},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36866581439971924},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35477420687675476},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3258420526981354},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.28368160128593445},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2257699966430664},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10591185092926025},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.1052977442741394}],"concepts":[{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.693301796913147},{"id":"https://openalex.org/C87133666","wikidata":"https://www.wikidata.org/wiki/Q1161699","display_name":"Dynamic range","level":2,"score":0.6659148335456848},{"id":"https://openalex.org/C118277053","wikidata":"https://www.wikidata.org/wiki/Q5172837","display_name":"Correlated double sampling","level":4,"score":0.654589056968689},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.5724214315414429},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.5312352776527405},{"id":"https://openalex.org/C2776179129","wikidata":"https://www.wikidata.org/wiki/Q7998640","display_name":"Wide dynamic range","level":2,"score":0.48594462871551514},{"id":"https://openalex.org/C751236","wikidata":"https://www.wikidata.org/wiki/Q175943","display_name":"Photodiode","level":2,"score":0.43548229336738586},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36866581439971924},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35477420687675476},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3258420526981354},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.28368160128593445},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2257699966430664},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10591185092926025},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1052977442741394},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C194257627","wikidata":"https://www.wikidata.org/wiki/Q211554","display_name":"Amplifier","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcsi.2019.2895652","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcsi.2019.2895652","pdf_url":null,"source":{"id":"https://openalex.org/S116977442","display_name":"IEEE Transactions on Circuits and Systems I Regular Papers","issn_l":"1549-8328","issn":["1549-8328","1558-0806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Circuits and Systems I: Regular Papers","raw_type":"journal-article"},{"id":"pmh:oai:publications.polymtl.ca:52843","is_oa":false,"landing_page_url":"https://publications.polymtl.ca/52843/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article de revue"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8500000238418579,"display_name":"Affordable and clean energy"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W571960815","https://openalex.org/W1875506666","https://openalex.org/W1977514547","https://openalex.org/W1996332175","https://openalex.org/W2011883734","https://openalex.org/W2026303472","https://openalex.org/W2060267700","https://openalex.org/W2064716621","https://openalex.org/W2077374589","https://openalex.org/W2080433909","https://openalex.org/W2102102476","https://openalex.org/W2118842680","https://openalex.org/W2141499558","https://openalex.org/W2171332611","https://openalex.org/W2293446808","https://openalex.org/W2294462607","https://openalex.org/W2466228052","https://openalex.org/W2482857251","https://openalex.org/W2616708953","https://openalex.org/W2738867549","https://openalex.org/W2742766012","https://openalex.org/W2766485669","https://openalex.org/W2793670796","https://openalex.org/W2804346262","https://openalex.org/W2808870314","https://openalex.org/W2908377202","https://openalex.org/W6752806527"],"related_works":["https://openalex.org/W2053377655","https://openalex.org/W2158002277","https://openalex.org/W2065223761","https://openalex.org/W2025249826","https://openalex.org/W2109112228","https://openalex.org/W2586835351","https://openalex.org/W2143589838","https://openalex.org/W2105254225","https://openalex.org/W2883278278","https://openalex.org/W1986905381"],"abstract_inverted_index":{"Accurately":[0],"resolving":[1],"small":[2],"fluorescence":[3,97],"power":[4,166],"variations":[5],"in":[6,168,181,190],"presence":[7],"of":[8,61,136,146,155,207,214,221,233],"noise":[9,53,101,108,116],"and":[10,26,95,175,179,217,248],"high-background":[11],"tissue":[12],"autofluorescence":[13],"from":[14,117,198],"deep":[15],"brain":[16],"structures":[17],"with":[18,44,52],"a":[19,33,40,45,72,86,121,132,141,150,159,191,199,205,210,218,242,245,249],"fiber":[20,246],"photometry":[21],"system":[22,173],"requires":[23],"highly":[24],"linear":[25],"sensitive":[27],"photo":[28],"detectors.":[29],"This":[30],"paper":[31],"presents":[32],"high-dynamic":[34],"range":[35,94],"(DR)":[36],"CMOS":[37,193],"biosensor":[38,130,187,235],"fusing":[39],"low-noise":[41],"photosensing":[42],"front-end":[43],"high-precision":[46,96],"extended":[47],"counting":[48],"analog-to-digital":[49],"converter":[50],"(ADC)":[51],"cancellation":[54,109],"to":[55,140,161,171,176],"detect":[56],"florescence":[57],"neural":[58],"signal":[59,119],"fluctuations":[60],"very":[62,151],"low":[63,152,163],"incident":[64],"power.":[65],"The":[66,99,184],"7":[67],"MSBs":[68],"are":[69],"resolved":[70],"by":[71,85,105],"first":[73],"order":[74],"continuous-time":[75],"resettable":[76],"\u03a3\u0394":[77],"ADC,":[78],"whereas":[79],"the":[80,114,118,129,182,230,234],"residue":[81],"voltage":[82,202],"is":[83,102,112,158,188],"quantized":[84],"10-bit":[87],"single":[88],"slope":[89],"ADC":[90],"for":[91],"enabling":[92],"wide-dynamic":[93],"sensing.":[98],"reset":[100,115],"canceled":[103],"out":[104],"an":[106,237],"embedded":[107],"scheme":[110],"which":[111,157],"subtracting":[113],"using":[120,236],"correlated":[122],"double":[123],"sampling":[124,144],"scheme.":[125],"Unlike":[126],"other":[127],"solutions,":[128],"has":[131],"short":[133],"conversion":[134],"time":[135],"306.5":[137],"\u03bcs":[138],"compared":[139],"typical":[142],"fluoresence":[143],"period":[145],"10":[147],"ms,":[148],"providing":[149],"duty":[153],"cyle":[154],"3%,":[156],"key":[160],"achieve":[162],"excitation":[164],"source":[165],"consumption":[167],"this":[169],"application":[170],"extend":[172],"autonomy,":[174],"avoid":[177],"photobleaching":[178],"phototoxicity":[180],"tissue.":[183],"proposed":[185],"optoelectronic":[186],"implemented":[189],"0.18-\u03bcm":[192],"technology,":[194],"consuming":[195],"93":[196],"\u03bcW":[197],"3.3-V":[200],"supply":[201],"while":[203],"achieving":[204],"DR":[206],"104":[208],"dB,":[209],"minimum":[211],"detectable":[212],"current":[213],"1.3":[215],"pArms,":[216],"chip":[219],"area":[220],"0.475":[222],"mm":[223],"<sup":[224],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[225],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[226],".":[227],"We":[228],"present":[229],"measured":[231],"performance":[232],"optical":[238],"experimental":[239],"setup":[240],"including":[241],"LED":[243],"driver,":[244],"optic,":[247],"test":[250],"board.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}