{"id":"https://openalex.org/W4402450477","doi":"https://doi.org/10.1109/tci.2024.3458411","title":"Zero-Shot Image Denoising for High-Resolution Electron Microscopy","display_name":"Zero-Shot Image Denoising for High-Resolution Electron Microscopy","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4402450477","doi":"https://doi.org/10.1109/tci.2024.3458411"},"language":"en","primary_location":{"id":"doi:10.1109/tci.2024.3458411","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tci.2024.3458411","pdf_url":null,"source":{"id":"https://openalex.org/S4210233665","display_name":"IEEE Transactions on Computational Imaging","issn_l":"2333-9403","issn":["2333-9403","2573-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086474293","display_name":"Xuanyu Tian","orcid":"https://orcid.org/0009-0009-6724-373X"},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuanyu Tian","raw_affiliation_strings":["School of Information Science and Technology, ShanghaiTech University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061234276","display_name":"Zhuoya Dong","orcid":null},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoya Dong","raw_affiliation_strings":["School of Physical Science and Technology, ShanghaiTech University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Physical Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046594795","display_name":"Xiyue Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiyue Lin","raw_affiliation_strings":["School of Information Science and Technology, ShanghaiTech University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yue Gao","orcid":"https://orcid.org/0000-0002-4971-590X"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Gao","raw_affiliation_strings":["BNRist, THUIBCS, KLISS, BLBCI, School of Software, Tsinghua University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"BNRist, THUIBCS, KLISS, BLBCI, School of Software, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004774673","display_name":"Hongjiang Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjiang Wei","raw_affiliation_strings":["School of Biomedical Engineering and Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109720326","display_name":"Yanhang Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhang Ma","raw_affiliation_strings":["School of Physical Science and Technology, ShanghaiTech University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Physical Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101500646","display_name":"Jingyi Yu","orcid":"https://orcid.org/0000-0001-9198-6853"},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Yu","raw_affiliation_strings":["School of Information Science and Technology, ShanghaiTech University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yuyao Zhang","orcid":"https://orcid.org/0000-0001-6706-4867"},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyao Zhang","raw_affiliation_strings":["School of Information Science and Technology, ShanghaiTech University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5086474293"],"corresponding_institution_ids":["https://openalex.org/I30809798"],"apc_list":null,"apc_paid":null,"fwci":3.1087,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.92390057,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"1462","last_page":"1475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9803000092506409,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9803000092506409,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12039","display_name":"Electron and X-Ray Spectroscopy Techniques","score":0.9693999886512756,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9638000130653381,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5549441576004028},{"id":"https://openalex.org/keywords/noise-reduction","display_name":"Noise reduction","score":0.5349553823471069},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.5132567882537842},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5118729472160339},{"id":"https://openalex.org/keywords/shot-noise","display_name":"Shot noise","score":0.49095919728279114},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.467803031206131},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.4603680372238159},{"id":"https://openalex.org/keywords/resolution","display_name":"Resolution (logic)","score":0.45908963680267334},{"id":"https://openalex.org/keywords/image-denoising","display_name":"Image denoising","score":0.4454854726791382},{"id":"https://openalex.org/keywords/shot","display_name":"Shot (pellet)","score":0.42423540353775024},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.421004980802536},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4133400321006775},{"id":"https://openalex.org/keywords/zero","display_name":"Zero (linguistics)","score":0.411957323551178},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36837995052337646},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.3582453727722168},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.29067814350128174}],"concepts":[{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5549441576004028},{"id":"https://openalex.org/C163294075","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Noise reduction","level":2,"score":0.5349553823471069},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.5132567882537842},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5118729472160339},{"id":"https://openalex.org/C72659945","wikidata":"https://www.wikidata.org/wiki/Q1503574","display_name":"Shot noise","level":3,"score":0.49095919728279114},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.467803031206131},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.4603680372238159},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.45908963680267334},{"id":"https://openalex.org/C2983327147","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Image denoising","level":3,"score":0.4454854726791382},{"id":"https://openalex.org/C2778344882","wikidata":"https://www.wikidata.org/wiki/Q278938","display_name":"Shot (pellet)","level":2,"score":0.42423540353775024},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.421004980802536},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4133400321006775},{"id":"https://openalex.org/C2780813799","wikidata":"https://www.wikidata.org/wiki/Q3274237","display_name":"Zero (linguistics)","level":2,"score":0.411957323551178},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36837995052337646},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3582453727722168},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29067814350128174},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tci.2024.3458411","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tci.2024.3458411","pdf_url":null,"source":{"id":"https://openalex.org/S4210233665","display_name":"IEEE Transactions on Computational Imaging","issn_l":"2333-9403","issn":["2333-9403","2573-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Imaging","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3703025150","display_name":null,"funder_award_id":"62071299","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G878503462","display_name":null,"funder_award_id":"22222108","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1958968158","https://openalex.org/W1966854554","https://openalex.org/W2014910451","https://openalex.org/W2020221684","https://openalex.org/W2056370875","https://openalex.org/W2087348835","https://openalex.org/W2097073572","https://openalex.org/W2099244020","https://openalex.org/W2133665775","https://openalex.org/W2136566546","https://openalex.org/W2157057971","https://openalex.org/W2167439109","https://openalex.org/W2208532855","https://openalex.org/W2476548250","https://openalex.org/W2508457857","https://openalex.org/W2743063281","https://openalex.org/W2764207251","https://openalex.org/W2794984043","https://openalex.org/W2902857081","https://openalex.org/W2953231542","https://openalex.org/W2964125708","https://openalex.org/W2986057551","https://openalex.org/W2997508111","https://openalex.org/W2999278172","https://openalex.org/W3034902810","https://openalex.org/W3035542568","https://openalex.org/W3084979415","https://openalex.org/W3093834713","https://openalex.org/W3093943387","https://openalex.org/W3097262261","https://openalex.org/W3107426509","https://openalex.org/W3134276259","https://openalex.org/W3174829522","https://openalex.org/W3183780241","https://openalex.org/W4214843102","https://openalex.org/W4225672218","https://openalex.org/W4282935701","https://openalex.org/W4296195149","https://openalex.org/W4307715697","https://openalex.org/W4312526003","https://openalex.org/W4312575110","https://openalex.org/W4312812783","https://openalex.org/W4385376291","https://openalex.org/W4386076517","https://openalex.org/W4390872913","https://openalex.org/W6631190155","https://openalex.org/W6749271710","https://openalex.org/W6759001153","https://openalex.org/W6762734363","https://openalex.org/W6784847106"],"related_works":["https://openalex.org/W2895947835","https://openalex.org/W2087258800","https://openalex.org/W2810018092","https://openalex.org/W2387428419","https://openalex.org/W4401571043","https://openalex.org/W2098237619","https://openalex.org/W1974034585","https://openalex.org/W2353444452","https://openalex.org/W2001438600","https://openalex.org/W2499707420"],"abstract_inverted_index":{"High-resolution":[0],"electron":[1],"microscopy":[2],"(HREM)":[3],"imaging":[4,220],"technique":[5],"is":[6,71,105],"a":[7,13,42,56,80,173],"powerful":[8],"tool":[9],"for":[10,49,119,152,212],"directly":[11],"visualizing":[12],"broad":[14],"range":[15],"of":[16,101,160,182,207,216],"materials":[17],"in":[18,24,90,184,218],"real-space.":[19],"However,":[20],"it":[21],"faces":[22],"challenges":[23],"denoising":[25,47,170,190,200],"due":[26],"to":[27,73,129],"ultra-low":[28],"signal-to-noise":[29],"ratio":[30],"(SNR)":[31],"and":[32,121,163,187,197],"scarce":[33],"data":[34,88],"availability.":[35],"In":[36],"this":[37],"work,":[38],"we":[39,54,137],"propose":[40,55],"Noise2SR,":[41],"zero-shot":[43,91],"self-supervised":[44,60],"learning":[45],"(ZS-SSL)":[46],"framework":[48],"HREM.":[50],"Within":[51],"our":[52],"framework,":[53],"super-resolution":[57],"(SR)":[58],"based":[59],"training":[61,112,161],"strategy,":[62],"incorporating":[63],"the":[64,95,114,122,127,134,139,153,157,180,214],"Random":[65,69],"Sub-sampler":[66,70],"module.":[67],"The":[68,110,205],"designed":[72],"generate":[74],"approximate":[75],"infinite":[76],"noisy":[77,82,99,175],"pairs":[78],"from":[79],"single":[81,174],"image,":[83],"serving":[84],"as":[85],"an":[86],"effective":[87],"augmentation":[89],"denoising.":[92],"Noise2SR":[93,166,183,208],"trains":[94],"network":[96,115,128],"with":[97,202],"paired":[98],"images":[100,217],"different":[102],"resolutions,":[103],"which":[104],"conducted":[106],"via":[107],"SR":[108],"strategy.":[109],"SR-based":[111],"facilitates":[113],"adopting":[116,145],"more":[117],"pixels":[118],"supervision,":[120],"random":[123],"sub-sampling":[124],"helps":[125],"compel":[126],"learn":[130],"continuous":[131],"signals":[132],"enhancing":[133],"robustness.":[135],"Meanwhile,":[136],"mitigate":[138],"uncertainty":[140],"caused":[141],"by":[142,144],"random-sampling":[143],"minimum":[146],"mean":[147],"squared":[148],"error":[149],"(MMSE)":[150],"estimation":[151],"denoised":[154],"results.":[155],"With":[156],"distinctive":[158],"integration":[159],"strategy":[162],"proposed":[164],"designs,":[165],"can":[167],"achieve":[168],"superior":[169],"performance":[171,181,201],"using":[172],"HREM":[176,189],"image.":[177],"We":[178],"evaluate":[179],"both":[185],"simulated":[186],"real":[188],"tasks.":[191],"It":[192],"outperforms":[193],"state-of-the-art":[194],"ZS-SSL":[195],"methods":[196],"achieves":[198],"comparable":[199],"supervised":[203],"methods.":[204],"success":[206],"suggests":[209],"its":[210],"potential":[211],"improving":[213],"SNR":[215],"material":[219],"domains.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}