{"id":"https://openalex.org/W2994990015","doi":"https://doi.org/10.1109/tci.2020.3039951","title":"Effect of Pixelation on the Parameter Estimation of Single Molecule Trajectories","display_name":"Effect of Pixelation on the Parameter Estimation of Single Molecule Trajectories","publication_year":2020,"publication_date":"2020-11-23","ids":{"openalex":"https://openalex.org/W2994990015","doi":"https://doi.org/10.1109/tci.2020.3039951","mag":"2994990015","pmid":"https://pubmed.ncbi.nlm.nih.gov/33604418"},"language":"en","primary_location":{"id":"doi:10.1109/tci.2020.3039951","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tci.2020.3039951","pdf_url":"https://ieeexplore.ieee.org/ielx7/6745852/9318600/09266576.pdf","source":{"id":"https://openalex.org/S4210233665","display_name":"IEEE Transactions on Computational Imaging","issn_l":"2333-9403","issn":["2333-9403","2573-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/6745852/9318600/09266576.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Milad R. Vahid","orcid":"https://orcid.org/0000-0002-1785-0234"},"institutions":[{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Milad R. Vahid","raw_affiliation_strings":["Department of Biomedical Data ScienceStanford UniversityStanfordCA94305USA","Department of Biomedical EngineeringTexas A&M UniversityCollege StationTX77843USA"],"raw_orcid":"https://orcid.org/0000-0002-1785-0234","affiliations":[{"raw_affiliation_string":"Department of Biomedical Data ScienceStanford UniversityStanfordCA94305USA","institution_ids":["https://openalex.org/I54459138"]},{"raw_affiliation_string":"Department of Biomedical EngineeringTexas A&M UniversityCollege StationTX77843USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bernard Hanzon","orcid":null},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Bernard Hanzon","raw_affiliation_strings":["Department of MathematicsUniversity College CorkT12YX86CorkIreland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of MathematicsUniversity College CorkT12YX86CorkIreland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"last","author":{"id":null,"display_name":"Raimund J. Ober","orcid":null},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raimund J. Ober","raw_affiliation_strings":["Centre for Cancer ImmunologyFaculty of Medicine, University of SouthamptonSouthamptonSO16 6YDU.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer ImmunologyFaculty of Medicine, University of SouthamptonSouthamptonSO16 6YDU.K","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4519,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.76602692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"7","issue":null,"first_page":"98","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9059000015258789,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9059000015258789,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.5748000144958496},{"id":"https://openalex.org/keywords/photon","display_name":"Photon","score":0.5745000243186951},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.5519000291824341},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5478000044822693},{"id":"https://openalex.org/keywords/kalman-filter","display_name":"Kalman filter","score":0.5388000011444092},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.47870001196861267},{"id":"https://openalex.org/keywords/stochastic-process","display_name":"Stochastic process","score":0.4242999851703644},{"id":"https://openalex.org/keywords/detector","display_name":"Detector","score":0.41929998993873596},{"id":"https://openalex.org/keywords/microscope","display_name":"Microscope","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.5748000144958496},{"id":"https://openalex.org/C159317903","wikidata":"https://www.wikidata.org/wiki/Q3198","display_name":"Photon","level":2,"score":0.5745000243186951},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.5519000291824341},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5478000044822693},{"id":"https://openalex.org/C157286648","wikidata":"https://www.wikidata.org/wiki/Q846780","display_name":"Kalman filter","level":2,"score":0.5388000011444092},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4828000068664551},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.47870001196861267},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.45190000534057617},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.4242999851703644},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.41929998993873596},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.41350001096725464},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.4090000092983246},{"id":"https://openalex.org/C29406490","wikidata":"https://www.wikidata.org/wiki/Q1420659","display_name":"Fisher information","level":2,"score":0.39980000257492065},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.384799987077713},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.37560001015663147},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.3695000112056732},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.35929998755455017},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.3560999929904938},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3515999913215637},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.3215999901294708},{"id":"https://openalex.org/C32230216","wikidata":"https://www.wikidata.org/wiki/Q7882499","display_name":"Uncertainty quantification","level":2,"score":0.32109999656677246},{"id":"https://openalex.org/C149441793","wikidata":"https://www.wikidata.org/wiki/Q200726","display_name":"Probability distribution","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C51955184","wikidata":"https://www.wikidata.org/wiki/Q1545585","display_name":"Stochastic differential equation","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C38111792","wikidata":"https://www.wikidata.org/wiki/Q15712714","display_name":"Biomolecular structure","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.25600001215934753}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/tci.2020.3039951","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tci.2020.3039951","pdf_url":"https://ieeexplore.ieee.org/ielx7/6745852/9318600/09266576.pdf","source":{"id":"https://openalex.org/S4210233665","display_name":"IEEE Transactions on Computational Imaging","issn_l":"2333-9403","issn":["2333-9403","2573-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Imaging","raw_type":"journal-article"},{"id":"pmid:33604418","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33604418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational imaging","raw_type":null},{"id":"pmh:oai:arXiv.org:1912.07182","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1912.07182","pdf_url":"https://arxiv.org/pdf/1912.07182","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:eprints.soton.ac.uk:445440","is_oa":true,"landing_page_url":"http://doi.org/10.1109/TCI.2020.3039951>).","pdf_url":"https://eprints.soton.ac.uk/445440/1/Two_column_manuscript_1_.pdf","source":{"id":"https://openalex.org/S4306401020","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:7879562","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7879562","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Comput Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/tci.2020.3039951","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tci.2020.3039951","pdf_url":"https://ieeexplore.ieee.org/ielx7/6745852/9318600/09266576.pdf","source":{"id":"https://openalex.org/S4210233665","display_name":"IEEE Transactions on Computational Imaging","issn_l":"2333-9403","issn":["2333-9403","2573-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1378606300","display_name":null,"funder_award_id":"R01 GM085575","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G339059223","display_name":null,"funder_award_id":"Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4593551239","display_name":null,"funder_award_id":"206411/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994990015.pdf","grobid_xml":"https://content.openalex.org/works/W2994990015.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1483307070","https://openalex.org/W1566017489","https://openalex.org/W1586180564","https://openalex.org/W1982021999","https://openalex.org/W1999727451","https://openalex.org/W2000217017","https://openalex.org/W2003967703","https://openalex.org/W2010522529","https://openalex.org/W2023922762","https://openalex.org/W2026652831","https://openalex.org/W2030396921","https://openalex.org/W2032894380","https://openalex.org/W2037475521","https://openalex.org/W2042256028","https://openalex.org/W2049537646","https://openalex.org/W2054821964","https://openalex.org/W2061040818","https://openalex.org/W2066997160","https://openalex.org/W2067733907","https://openalex.org/W2099858077","https://openalex.org/W2131949800","https://openalex.org/W2135438092","https://openalex.org/W2147688960","https://openalex.org/W2171820152","https://openalex.org/W2171854187","https://openalex.org/W2267351104","https://openalex.org/W2315265924","https://openalex.org/W2381448841","https://openalex.org/W2417956311","https://openalex.org/W2465598250","https://openalex.org/W2586980209","https://openalex.org/W2602586002","https://openalex.org/W2725992404","https://openalex.org/W2886734336","https://openalex.org/W2953191499","https://openalex.org/W4240788980","https://openalex.org/W4241214195","https://openalex.org/W6735076024"],"related_works":[],"abstract_inverted_index":{"The":[0,172,196],"advent":[1],"of":[2,18,24,45,62,76,81,83,104,119,125,142,145,154,190,205],"single":[3,105,126],"molecule":[4,106,127,156],"microscopy":[5,57],"has":[6],"revolutionized":[7],"biological":[8],"investigations":[9],"by":[10],"providing":[11],"a":[12,111,133,146,185],"powerful":[13],"tool":[14],"for":[15,167,210],"the":[16,43,54,60,63,78,84,89,94,97,102,117,122,138,143,152,155,163,178,181,188,220],"study":[17],"intercellular":[19],"and":[20],"intracellular":[21],"trafficking":[22],"processes":[23],"protein":[25],"molecules":[26],"which":[27,93,211],"was":[28],"not":[29],"available":[30],"before":[31],"through":[32,177],"conventional":[33],"microscopy.":[34],"In":[35,129],"practice,":[36],"pixelated":[37,109],"detectors":[38],"are":[39,175],"used":[40],"to":[41,136,218],"acquire":[42],"images":[44,58],"fluorescently":[46],"labeled":[47],"objects":[48],"moving":[49],"in":[50,66,92,157,184],"cellular":[51],"environments.":[52],"Then,":[53],"acquired":[55],"fluorescence":[56],"contain":[59],"numbers":[61],"photons":[64,95],"detected":[65],"each":[67],"pixel,":[68],"during":[69],"an":[70],"exposure":[71],"time":[72],"interval.":[73],"Moreover,":[74],"instead":[75],"having":[77],"exact":[79],"locations":[80],"detection":[82],"photons,":[85],"we":[86,115,131,212],"only":[87],"know":[88],"pixel":[90],"areas":[91],"impact":[96],"detector.":[98],"These":[99],"challenges":[100],"make":[101],"analysis":[103],"trajectories,":[107],"from":[108],"images,":[110],"complex":[112],"problem.":[113,171],"Here,":[114],"investigate":[116],"effect":[118],"pixelation":[120],"on":[121,214],"parameter":[123,169],"estimation":[124,170],"trajectories.":[128],"particular,":[130],"develop":[132],"stochastic":[134,147],"framework":[135,198],"calculate":[137,162],"maximum":[139],"likelihood":[140],"estimates":[141],"parameters":[144],"differential":[148],"equation":[149],"that":[150,180],"describes":[151],"motion":[153],"living":[158],"cells.":[159],"We":[160],"also":[161],"Fisher":[164],"information":[165],"matrix":[166],"this":[168],"analytical":[173,197],"results":[174],"complicated":[176],"fact":[179],"observation":[182],"process":[183],"microscope":[186],"prohibits":[187],"use":[189],"standard":[191],"Kalman":[192],"filter":[193],"type":[194],"approaches.":[195],"presented":[199],"here":[200],"is":[201],"illustrated":[202],"with":[203],"examples":[204],"low":[206],"photon":[207],"count":[208],"scenarios":[209],"rely":[213],"Monte":[215],"Carlo":[216],"methods":[217],"compute":[219],"associated":[221],"probability":[222],"distributions.":[223]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2019-12-26T00:00:00"}