{"id":"https://openalex.org/W7128474614","doi":"https://doi.org/10.1109/tcbbio.2026.3663364","title":"AGEP_TWAS: A Deep Learning-Based Framework for Predicting Gene Expression Levels in Tissues","display_name":"AGEP_TWAS: A Deep Learning-Based Framework for Predicting Gene Expression Levels in Tissues","publication_year":2026,"publication_date":"2026-02-10","ids":{"openalex":"https://openalex.org/W7128474614","doi":"https://doi.org/10.1109/tcbbio.2026.3663364","pmid":"https://pubmed.ncbi.nlm.nih.gov/41666075"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2026.3663364","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2026.3663364","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125554086","display_name":"Sizhe Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sizhe Wang","raw_affiliation_strings":["College of Information Engineering, Northwest A and F University, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Northwest A and F University, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhichao Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhichao Zhou","raw_affiliation_strings":["College of Information Engineering, Northwest A and F University, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Northwest A and F University, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125584215","display_name":"Chen Li","orcid":null},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chen Li","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1847-754X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029286413","display_name":"YUDONG CAI","orcid":null},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yudong Cai","raw_affiliation_strings":["College of Animal Science and Technology, Northwest A&F University, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Northwest A&F University, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiong Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiong Wang","raw_affiliation_strings":["College of Animal Science and Technology, Northwest A&F University, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Northwest A&F University, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064049071","display_name":"Zhuangbiao Zhang","orcid":"https://orcid.org/0000-0002-9540-7852"},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuangbiao Zhang","raw_affiliation_strings":["College of Animal Science and Technology, Northwest A&F University, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Northwest A&F University, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428061","display_name":"Ran Li","orcid":"https://orcid.org/0000-0001-8567-3527"},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Li","raw_affiliation_strings":["College of Animal Science and Technology, Northwest A&F University, Yangling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Northwest A&F University, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012682609","display_name":"Zhannur Niyazbekova","orcid":"https://orcid.org/0000-0002-8556-0212"},"institutions":[{"id":"https://openalex.org/I4210128817","display_name":"Kazakh National Agrarian Research University","ror":"https://ror.org/033cvvt68","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210128817"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Zhannur Niyazbekova","raw_affiliation_strings":["Reference Center for Safety and Quality of Agricultural Products, Kazakh National Agrarian Research University, Almaty, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reference Center for Safety and Quality of Agricultural Products, Kazakh National Agrarian Research University, Almaty, Kazakhstan","institution_ids":["https://openalex.org/I4210128817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125526421","display_name":"Yu Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210128817","display_name":"Kazakh National Agrarian Research University","ror":"https://ror.org/033cvvt68","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210128817"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Yu Jiang","raw_affiliation_strings":["Reference Center for Safety and Quality of Agricultural Products, Kazakh National Agrarian Research University, Almaty, Kazakhstan"],"raw_orcid":"https://orcid.org/0000-0003-4821-3585","affiliations":[{"raw_affiliation_string":"Reference Center for Safety and Quality of Agricultural Products, Kazakh National Agrarian Research University, Almaty, Kazakhstan","institution_ids":["https://openalex.org/I4210128817"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5125525138","display_name":"Quanzhong Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quanzhong Liu","raw_affiliation_strings":["College of Information Engineering, Northwest A and F University, Yangling, China"],"raw_orcid":"https://orcid.org/0000-0002-6217-6285","affiliations":[{"raw_affiliation_string":"College of Information Engineering, Northwest A and F University, Yangling, China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16053583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"2","first_page":"853","last_page":"862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.36489999294281006,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.36489999294281006,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.20090000331401825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pruning","display_name":"Pruning","score":0.6370999813079834},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6304000020027161},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.5884000062942505},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5623999834060669},{"id":"https://openalex.org/keywords/gene-prediction","display_name":"Gene prediction","score":0.5297999978065491},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.4447000026702881},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.4406000077724457},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4185999929904938},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.38429999351501465}],"concepts":[{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.6370999813079834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6304000020027161},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6248999834060669},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5884000062942505},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5623999834060669},{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.5297999978065491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5022000074386597},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4447000026702881},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.4406000077724457},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4383000135421753},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4185999929904938},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4113999903202057},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39160001277923584},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.38420000672340393},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37229999899864197},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.3659999966621399},{"id":"https://openalex.org/C167085575","wikidata":"https://www.wikidata.org/wiki/Q6803654","display_name":"Mean squared prediction error","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.3422999978065491},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.33149999380111694},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31630000472068787},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.31029999256134033},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2944999933242798},{"id":"https://openalex.org/C55078378","wikidata":"https://www.wikidata.org/wiki/Q1136628","display_name":"Pearson product-moment correlation coefficient","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C164085508","wikidata":"https://www.wikidata.org/wiki/Q4811327","display_name":"Matthews correlation coefficient","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.257999986410141},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2026.3663364","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2026.3663364","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41666075","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41666075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G715904284","display_name":"\u4e09\u7ef4\u57fa\u56e0\u7ec4\u8c03\u63a7\u5c42\u9762\u7684\u764c\u75c7\u81f4\u75c5\u901a\u8def\u6316\u6398\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61972322","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Accurate":[0],"prediction":[1,39,154,228],"of":[2,10,18,37,90,105,118,132,140,188,215,223,268],"gene":[3,43,80,152,239],"expression":[4,81,130,153,186,204,240],"levels":[5,82,131,187,241],"across":[6,120,242],"different":[7,121,243],"tissues":[8,244],"is":[9,49,125],"great":[11],"significance":[12],"in":[13,20,26,44,72,84,93,135,245,262,277],"understanding":[14],"the":[15,35,73,87,115,129,136,185,201,234,265],"functional":[16],"roles":[17],"genes":[19,57,107,134,179,190,274],"various":[21],"biological":[22],"processes":[23],"and":[24,51,83,165,217],"assisting":[25],"transcriptome-wide":[27],"association":[28],"studies":[29],"(TWAS).":[30],"Traditional":[31],"methods":[32],"rely":[33],"on":[34,200,258],"construction":[36],"a":[38,45,102,151,158,170,181,210,218],"model":[40],"for":[41,149],"each":[42],"specific":[46,103],"tissue,":[47],"which":[48],"time-consuming":[50],"inefficient":[52],"when":[53,231],"dealing":[54],"with":[55,270,283],"numerous":[56],"or":[58],"tissues.":[59],"In":[60,138],"addition,":[61],"current":[62],"approaches":[63,92],"do":[64],"not":[65],"consider":[66],"missing":[67],"single":[68],"nucleotide":[69],"polymorphisms":[70],"(SNPs)":[71],"training":[74],"population.":[75],"These":[76],"SNPs":[77],"significantly":[78],"affect":[79],"turn":[85],"limit":[86],"predictive":[88,250],"capability":[89],"these":[91],"new":[94],"samples.":[95],"Recent":[96],"research":[97],"indicates":[98],"that":[99,112,156,191,207],"by":[100],"identifying":[101],"group":[104],"core":[106],"(known":[108],"as":[109],"landmark":[110,178],"genes)":[111],"accurately":[113],"reflect":[114],"cellular":[116],"states":[117],"samples":[119],"experimental":[122],"conditions,":[123],"it":[124],"possible":[126],"to":[127,183,194,233,237,253,280],"predict":[128,184,195],"other":[133,189],"genome.":[137],"light":[139],"this,":[141],"we":[142],"propose":[143],"AGEP_TWAS":[144,176,208,247],"(Adaptive":[145],"Gene":[146],"Expression":[147],"Predictor":[148],"TWAS),":[150],"method":[155],"utilizes":[157],"dense":[159],"connection":[160],"network,":[161],"adaptive":[162],"activation":[163],"functions,":[164],"parameter":[166],"pruning":[167],"strategies":[168],"within":[169,180],"nonlinear":[171],"feature":[172],"extraction":[173],"computational":[174],"framework.":[175],"leverages":[177],"tissue":[182],"are":[192],"challenging":[193],"using":[196],"traditional":[197],"methods.":[198,255],"Results":[199],"human":[202],"GEO":[203],"dataset":[205,236],"demonstrate":[206],"achieved":[209],"mean":[211],"squared":[212],"error":[213],"(MSE)":[214],"0.1821":[216],"Pearson":[219],"correlation":[220],"coefficient":[221],"(PCC)":[222],"0.9004,":[224],"outperforming":[225],"existing":[226,254],"state-of-the-art":[227],"models.":[229],"Additionally,":[230],"applied":[232],"CattleGTEx":[235],"infer":[238],"cattle,":[246],"exhibited":[248],"superior":[249],"performance":[251],"compared":[252],"A":[256],"TWAS":[257],"milk":[259,284],"production":[260,285],"traits":[261],"cattle":[263],"highlights":[264],"practical":[266],"utility":[267],"AGEP_TWAS,":[269],"six":[271],"identified":[272],"significant":[273],"already":[275],"reported":[276],"scientific":[278],"literature":[279],"be":[281],"associated":[282],"traits.":[286]},"counts_by_year":[],"updated_date":"2026-04-04T06:10:10.580331","created_date":"2026-02-11T00:00:00"}