{"id":"https://openalex.org/W4415445372","doi":"https://doi.org/10.1109/tcbbio.2025.3624040","title":"scMID: A Deep Multi-Omics Integration Framework for Comprehensive Single-Cell Data Analysis","display_name":"scMID: A Deep Multi-Omics Integration Framework for Comprehensive Single-Cell Data Analysis","publication_year":2025,"publication_date":"2025-10-22","ids":{"openalex":"https://openalex.org/W4415445372","doi":"https://doi.org/10.1109/tcbbio.2025.3624040","pmid":"https://pubmed.ncbi.nlm.nih.gov/41124064"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3624040","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3624040","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086050506","display_name":"Qiu Xiao","orcid":"https://orcid.org/0000-0002-4726-7154"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu Xiao","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-4726-7154","affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456144","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0001-7544-6611"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114859464","display_name":"Wanwan Shi","orcid":"https://orcid.org/0000-0003-4730-4610"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanwan Shi","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-4730-4610","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336197","display_name":"Li Wang","orcid":"https://orcid.org/0000-0003-2165-0080"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103233436","display_name":"Ying Zuo","orcid":"https://orcid.org/0000-0003-2739-3863"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zuo","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100702161","display_name":"Fei Guo","orcid":"https://orcid.org/0000-0001-8346-0798"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Guo","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-8346-0798","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026469278","display_name":"Jiawei Luo","orcid":"https://orcid.org/0000-0003-2385-8272"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Luo","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-2385-8272","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23033785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"6","first_page":"3375","last_page":"3385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.6583999991416931},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6061999797821045},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4779999852180481},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.44110000133514404},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.41850000619888306},{"id":"https://openalex.org/keywords/downstream","display_name":"Downstream (manufacturing)","score":0.40700000524520874},{"id":"https://openalex.org/keywords/dropout","display_name":"Dropout (neural networks)","score":0.39629998803138733},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.3921999931335449}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6898999810218811},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.6583999991416931},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6061999797821045},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.49540001153945923},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4779999852180481},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.44110000133514404},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43700000643730164},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.41850000619888306},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.40700000524520874},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39649999141693115},{"id":"https://openalex.org/C2776145597","wikidata":"https://www.wikidata.org/wiki/Q25339462","display_name":"Dropout (neural networks)","level":2,"score":0.39629998803138733},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.3921999931335449},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C19527686","wikidata":"https://www.wikidata.org/wiki/Q1665453","display_name":"System integration","level":2,"score":0.2777999937534332},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3624040","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3624040","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41124064","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41124064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1107513399","display_name":null,"funder_award_id":"2023M731059","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G3262265625","display_name":null,"funder_award_id":"2024JJ5272","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G4956348030","display_name":null,"funder_award_id":"62372165","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W2025828346","https://openalex.org/W2051658465","https://openalex.org/W2086504823","https://openalex.org/W2118258530","https://openalex.org/W2120205807","https://openalex.org/W2302476265","https://openalex.org/W2308998873","https://openalex.org/W2468232576","https://openalex.org/W2473258837","https://openalex.org/W2551194178","https://openalex.org/W2808845633","https://openalex.org/W2884197618","https://openalex.org/W2889236955","https://openalex.org/W2923748945","https://openalex.org/W2949237386","https://openalex.org/W2949755237","https://openalex.org/W2951890476","https://openalex.org/W2979911343","https://openalex.org/W3012788672","https://openalex.org/W3023456235","https://openalex.org/W3027051073","https://openalex.org/W3102434595","https://openalex.org/W3119521568","https://openalex.org/W3129725981","https://openalex.org/W3134897856","https://openalex.org/W3164692211","https://openalex.org/W3164736847","https://openalex.org/W3203404644","https://openalex.org/W3215916291","https://openalex.org/W4214854288","https://openalex.org/W4225727976","https://openalex.org/W4229366049","https://openalex.org/W4235169531","https://openalex.org/W4311232381","https://openalex.org/W4312182122","https://openalex.org/W4322766901","https://openalex.org/W4378212544","https://openalex.org/W4379521442","https://openalex.org/W4382631424","https://openalex.org/W4388500682","https://openalex.org/W4392168151","https://openalex.org/W4392934845","https://openalex.org/W4393306818","https://openalex.org/W4396954023","https://openalex.org/W4401093660","https://openalex.org/W4401165138","https://openalex.org/W4402912319","https://openalex.org/W4404399964","https://openalex.org/W4406234938","https://openalex.org/W4406632986","https://openalex.org/W4411054984","https://openalex.org/W4411799204"],"related_works":[],"abstract_inverted_index":{"Biological":[0],"research":[1],"on":[2,31,136],"single":[3],"cells":[4],"has":[5,76],"witnessed":[6],"remarkable":[7],"progress":[8],"in":[9,19,67,123,217],"recent":[10],"years,":[11],"with":[12,192],"downstream":[13,218],"analyses":[14],"playing":[15],"a":[16,96,182,231],"crucial":[17],"role":[18],"uncovering":[20],"cellular":[21,50,101],"functions":[22],"and":[23,60,91,115,141,163,229],"mechanisms.":[24],"Traditional":[25],"single-cell":[26,36,72,125,137,215],"analyses,":[27,219],"which":[28],"predominantly":[29],"rely":[30],"single-omics":[32],"data":[33,139,161],"such":[34],"as":[35],"RNA":[37],"sequencing,":[38],"are":[39,62],"inherently":[40],"limited.":[41],"These":[42],"methods":[43,106,228],"can":[44],"only":[45],"capture":[46],"one":[47],"aspect":[48],"of":[49,71,84,100,117,154,202,214,224],"information,":[51],"overlooking":[52],"the":[53,82,109,113,152,165,170,175,199,212,222],"complex":[54,237],"interplay":[55],"between":[56],"different":[57],"molecular":[58,86],"layers,":[59],"thus":[61],"prone":[63],"to":[64,111,189],"introducing":[65],"biases":[66],"results.":[68],"The":[69],"advent":[70],"multi-omics":[73,118,138,155],"sequencing":[74],"technologies":[75,94],"revolutionized":[77],"this":[78,128],"landscape.":[79],"By":[80],"enabling":[81],"integration":[83,105,140],"diverse":[85],"profiles,":[87],"including":[88],"transcriptomics,":[89],"epigenomics,":[90],"proteomics,":[92],"these":[93],"offer":[95],"more":[97],"holistic":[98],"view":[99],"functions.":[102],"However,":[103],"existing":[104],"often":[107],"lack":[108],"ability":[110],"handle":[112],"complexity":[114],"heterogeneity":[116],"data,":[119,156],"limiting":[120],"their":[121],"application":[122],"in-depth":[124],"studies.":[126],"In":[127],"study,":[129],"we":[130],"propose":[131],"an":[132],"analysis":[133],"method":[134],"based":[135],"dropout":[142,177],"pattern":[143],"(scMID).":[144],"Specifically,":[145],"scMID":[146,180,209],"utilizes":[147],"omics-independent":[148],"deep":[149],"autoencoders":[150],"for":[151,160,184,235],"alignment":[153],"employs":[157],"GCN":[158],"algorithm":[159],"integration,":[162],"calculates":[164],"gene":[166,171,186],"importance":[167],"by":[168],"combining":[169],"similarity":[172],"obtained":[173],"from":[174],"binarized":[176],"pattern.":[178],"Meanwhile,":[179],"proposes":[181],"dual-strategy":[183],"feature":[185,226],"screening,":[187],"aiming":[188],"identify":[190],"genes":[191],"high":[193],"biological":[194,238],"significance":[195],"that":[196,208],"best":[197],"match":[198],"structural":[200],"characteristics":[201],"reference":[203],"data.":[204],"Experimental":[205],"results":[206],"demonstrate":[207],"significantly":[210],"improves":[211],"accuracy":[213],"clustering":[216],"breaking":[220],"through":[221],"limitations":[223],"traditional":[225],"selection":[227],"providing":[230],"superior":[232],"analytical":[233],"framework":[234],"decoding":[236],"information.":[239]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-24T00:00:00"}
