{"id":"https://openalex.org/W4413917061","doi":"https://doi.org/10.1109/tcbbio.2025.3605719","title":"Integrating Graph Convolutional Networks for Missing Gene Expression Imputation","display_name":"Integrating Graph Convolutional Networks for Missing Gene Expression Imputation","publication_year":2025,"publication_date":"2025-09-02","ids":{"openalex":"https://openalex.org/W4413917061","doi":"https://doi.org/10.1109/tcbbio.2025.3605719","pmid":"https://pubmed.ncbi.nlm.nih.gov/40892650"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3605719","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3605719","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100386226","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0003-1792-0121"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":true,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]},{"raw_affiliation_string":"School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100580164","display_name":"Hongjin Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I200845125","display_name":"Nanjing University of Information Science and Technology","ror":"https://ror.org/02y0rxk19","country_code":"CN","type":"education","lineage":["https://openalex.org/I200845125"]},{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Jin Yu","raw_affiliation_strings":["Computer Science and Technology, Nanjing University of Information Science and Technology, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Computer Science and Technology, Nanjing University of Information Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199","https://openalex.org/I200845125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101916749","display_name":"Zihao Yan","orcid":"https://orcid.org/0000-0002-8131-4663"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zi-Hao Yan","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tong Pan","orcid":"https://orcid.org/0009-0003-6676-5727"},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tong Pan","raw_affiliation_strings":["Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia"],"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yiwen Zhang","orcid":"https://orcid.org/0000-0001-9570-4147"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Yiwen Zhang","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]},{"raw_affiliation_string":"School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047530483","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0002-5331-3655"},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":["Department of Computer Science, Yangzhou University, Yangzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Yangzhou University, Yangzhou, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371500","display_name":"Shanshan Li","orcid":"https://orcid.org/0000-0002-9021-8470"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shanshan Li","raw_affiliation_strings":["School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia"],"affiliations":[{"raw_affiliation_string":"School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604759","display_name":"Yuming Guo","orcid":"https://orcid.org/0000-0002-1766-6592"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yuming Guo","raw_affiliation_strings":["School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia"],"affiliations":[{"raw_affiliation_string":"School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709797","display_name":"Jiangning Song","orcid":"https://orcid.org/0000-0001-8031-9086"},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jiangning Song","raw_affiliation_strings":["Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia"],"affiliations":[{"raw_affiliation_string":"Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008960436","display_name":"Dong\u2010Jun Yu","orcid":"https://orcid.org/0000-0002-6786-8053"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-Jun Yu","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5100386226"],"corresponding_institution_ids":["https://openalex.org/I36399199","https://openalex.org/I56590836"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20026689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"6","first_page":"2955","last_page":"2963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9176999926567078,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.7241989374160767},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.5228943228721619},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5043243169784546},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4784248471260071},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.20551735162734985},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.15359997749328613}],"concepts":[{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.7241989374160767},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.5228943228721619},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5043243169784546},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4784248471260071},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.20551735162734985},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.15359997749328613}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3605719","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3605719","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40892650","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40892650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1702080893","display_name":null,"funder_award_id":"62372234","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7719334545","display_name":null,"funder_award_id":"62072243","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320320971","display_name":"Monash University","ror":"https://ror.org/02bfwt286"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1602702667","https://openalex.org/W2471536144","https://openalex.org/W2533012945","https://openalex.org/W2605624585","https://openalex.org/W2753908609","https://openalex.org/W2809368942","https://openalex.org/W2897249806","https://openalex.org/W2899224111","https://openalex.org/W2915848182","https://openalex.org/W2923300855","https://openalex.org/W2948469692","https://openalex.org/W2949177718","https://openalex.org/W2949535577","https://openalex.org/W2952383043","https://openalex.org/W2955754489","https://openalex.org/W2965985232","https://openalex.org/W2969948459","https://openalex.org/W2972445800","https://openalex.org/W2972983657","https://openalex.org/W3021920958","https://openalex.org/W3022836409","https://openalex.org/W3036371598","https://openalex.org/W3086157479","https://openalex.org/W3087138957","https://openalex.org/W3112563877","https://openalex.org/W3116500759","https://openalex.org/W3118728054","https://openalex.org/W3122762933","https://openalex.org/W3125011419","https://openalex.org/W3125488134","https://openalex.org/W3161226217","https://openalex.org/W3163684167","https://openalex.org/W3167327839","https://openalex.org/W3182503854","https://openalex.org/W3190759848","https://openalex.org/W3196495189","https://openalex.org/W3198511950","https://openalex.org/W3205339884","https://openalex.org/W3208940117","https://openalex.org/W3210002151","https://openalex.org/W4213458181","https://openalex.org/W4280533477","https://openalex.org/W4283790499","https://openalex.org/W4403516090","https://openalex.org/W4405666966"],"related_works":["https://openalex.org/W2181530120","https://openalex.org/W4211215373","https://openalex.org/W2024529227","https://openalex.org/W2055961818","https://openalex.org/W2903115227","https://openalex.org/W1574575415","https://openalex.org/W3144172081","https://openalex.org/W3179858851","https://openalex.org/W2081476516","https://openalex.org/W2581984549"],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1,97],"sequencing":[2],"(scRNA-seq)":[3],"techniques":[4],"are":[5,78],"emerging":[6],"to":[7,58,89,111,122],"revolutionize":[8],"modern":[9],"biomedical":[10],"sciences":[11],"by":[12,126],"providing":[13],"a":[14,86,107,119],"detailed":[15],"landscape":[16],"of":[17,76,94,144],"individual":[18],"cells.":[19],"However,":[20],"these":[21],"methods":[22],"often":[23],"lack":[24],"crucial":[25],"spatial":[26,33,45,52,74,92,101,113],"localization":[27],"information.":[28,46],"To":[29],"address":[30],"this":[31,68,138],"gap,":[32],"transcriptomic":[34,53],"technologies":[35,54],"have":[36],"developed,":[37],"enabling":[38],"gene":[39,49,124,145],"expression":[40,125,146],"profiling":[41],"while":[42],"mapping":[43],"cells":[44,64],"Yet,":[47],"the":[48,73,91,95,128,133],"throughput":[50],"in":[51,65],"makes":[55],"it":[56],"challenging":[57],"characterize":[59],"whole-transcriptome-level":[60],"data":[61,115,131],"for":[62,71],"single":[63],"space.":[66],"In":[67],"context,":[69],"approaches":[70],"predicting":[72],"distribution":[75,93],"genes":[77],"still":[79],"under":[80],"development.":[81],"Here,":[82],"we":[83],"present":[84],"GCNgene,":[85],"novel":[87],"method":[88],"predict":[90],"undetected":[96],"transcripts,":[98],"through":[99],"integrating":[100],"and":[102,116],"scRNA-seq":[103],"datasets.":[104],"GCNgene":[105],"leverages":[106],"graph":[108],"convolutional":[109],"network":[110],"embed":[112],"transcriptomics":[114],"then":[117],"applies":[118],"learned":[120,139],"rule":[121],"reconstruct":[123],"combining":[127],"reference":[129],"single-cell":[130],"with":[132],"calculated":[134],"cell-type":[135],"proportions.":[136],"Ultimately,":[137],"paradigm":[140],"enables":[141],"accurate":[142],"predictions":[143],"levels.":[147]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}