{"id":"https://openalex.org/W4411688791","doi":"https://doi.org/10.1109/tcbbio.2025.3583565","title":"Deep Ring-Wise Block Network for Joint Association Analysis and Alzheimer\u2019s Disease Diagnosis With Interpretability","display_name":"Deep Ring-Wise Block Network for Joint Association Analysis and Alzheimer\u2019s Disease Diagnosis With Interpretability","publication_year":2025,"publication_date":"2025-06-26","ids":{"openalex":"https://openalex.org/W4411688791","doi":"https://doi.org/10.1109/tcbbio.2025.3583565","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811284"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3583565","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3583565","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100416056","display_name":"Meiling Wang","orcid":"https://orcid.org/0000-0001-6569-2798"},"institutions":[{"id":"https://openalex.org/I41198531","display_name":"Nanjing University of Posts and Telecommunications","ror":"https://ror.org/043bpky34","country_code":"CN","type":"education","lineage":["https://openalex.org/I41198531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meiling Wang","raw_affiliation_strings":["School of Computer Science, Nanjing University of Posts and Telecommunications, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Shao","orcid":"https://orcid.org/0000-0003-1476-2068"},"institutions":[{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Shao","raw_affiliation_strings":["College of Artificial Intelligence, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing, China","College of Artificial Intelligence, Nanjing University of Aeronautics and Astronautics, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing, China","institution_ids":["https://openalex.org/I9842412"]},{"raw_affiliation_string":"College of Artificial Intelligence, Nanjing University of Aeronautics and Astronautics, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing, China","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018821033","display_name":"Daoqiang Zhang","orcid":"https://orcid.org/0000-0002-5658-7643"},"institutions":[{"id":"https://openalex.org/I9842412","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794","country_code":"CN","type":"education","lineage":["https://openalex.org/I9842412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daoqiang Zhang","raw_affiliation_strings":["College of Artificial Intelligence, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing, China","College of Artificial Intelligence, Nanjing University of Aeronautics and Astronautics, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing, China","institution_ids":["https://openalex.org/I9842412"]},{"raw_affiliation_string":"College of Artificial Intelligence, Nanjing University of Aeronautics and Astronautics, Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing, China","institution_ids":["https://openalex.org/I9842412"]}]},{"author_position":"last","author":{"id":null,"display_name":"Qingshan Liu","orcid":"https://orcid.org/0000-0002-5512-6984"},"institutions":[{"id":"https://openalex.org/I41198531","display_name":"Nanjing University of Posts and Telecommunications","ror":"https://ror.org/043bpky34","country_code":"CN","type":"education","lineage":["https://openalex.org/I41198531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingshan Liu","raw_affiliation_strings":["School of Computer Science, Nanjing University of Posts and Telecommunications, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Nanjing University of Posts and Telecommunications, Nanjing, China","institution_ids":["https://openalex.org/I41198531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100416056"],"corresponding_institution_ids":["https://openalex.org/I41198531"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19096774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"5","first_page":"2129","last_page":"2142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9613000154495239,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9613000154495239,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.9011567234992981},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.610643744468689},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.4915817677974701},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4748568534851074},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.44740912318229675},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.44624584913253784},{"id":"https://openalex.org/keywords/ring","display_name":"Ring (chemistry)","score":0.44228243827819824},{"id":"https://openalex.org/keywords/joint-disease","display_name":"Joint disease","score":0.42347851395606995},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3415467143058777},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.29092973470687866},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2743867039680481},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.25090545415878296},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19294339418411255},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09549450874328613},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.0921124815940857},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.07751867175102234},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"Alternative medicine","score":0.055259495973587036}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.9011567234992981},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.610643744468689},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.4915817677974701},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4748568534851074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44740912318229675},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.44624584913253784},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.44228243827819824},{"id":"https://openalex.org/C3017807761","wikidata":"https://www.wikidata.org/wiki/Q708176","display_name":"Joint disease","level":4,"score":0.42347851395606995},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3415467143058777},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29092973470687866},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2743867039680481},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25090545415878296},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19294339418411255},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09549450874328613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0921124815940857},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.07751867175102234},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.055259495973587036},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3583565","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3583565","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811284","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1649070833","display_name":null,"funder_award_id":"2024A1515011925","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G3734283955","display_name":null,"funder_award_id":"NJ2024029","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G3771418834","display_name":null,"funder_award_id":"62106104","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7869937607","display_name":null,"funder_award_id":"62136004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8386303559","display_name":null,"funder_award_id":"62276130","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8781492514","display_name":null,"funder_award_id":"62572254","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W3971279","https://openalex.org/W281036081","https://openalex.org/W1525222323","https://openalex.org/W1600471557","https://openalex.org/W1966366847","https://openalex.org/W1979587499","https://openalex.org/W1989217296","https://openalex.org/W2003851329","https://openalex.org/W2004053049","https://openalex.org/W2005821483","https://openalex.org/W2038899746","https://openalex.org/W2058046532","https://openalex.org/W2105351532","https://openalex.org/W2120572720","https://openalex.org/W2121101037","https://openalex.org/W2122320288","https://openalex.org/W2130017876","https://openalex.org/W2166348468","https://openalex.org/W2167792187","https://openalex.org/W2302574298","https://openalex.org/W2418179447","https://openalex.org/W2436594444","https://openalex.org/W2607528709","https://openalex.org/W2735438349","https://openalex.org/W2786073924","https://openalex.org/W2790446188","https://openalex.org/W2912452970","https://openalex.org/W2978016176","https://openalex.org/W2982638646","https://openalex.org/W2991909137","https://openalex.org/W3002127012","https://openalex.org/W3033715510","https://openalex.org/W3134970000","https://openalex.org/W3176666329","https://openalex.org/W4210819299","https://openalex.org/W4312258136","https://openalex.org/W4387717683","https://openalex.org/W4392405394","https://openalex.org/W4394627530","https://openalex.org/W4403071515","https://openalex.org/W4408148068"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W4312407344","https://openalex.org/W2894289927"],"abstract_inverted_index":{"In":[0],"the":[1,16,39,83,86,107,119,130,139,147,153,163],"brain":[2,59,115,148],"imaging":[3,101,149,182],"genomic":[4,102,150],"tasks,":[5],"it":[6],"is":[7,92,126],"challenging":[8],"to":[9,99],"provide":[10],"accurate":[11],"prior":[12],"knowledge":[13],"for":[14,55,109,128],"estimating":[15],"association":[17,56,87,111],"between":[18],"quantitative":[19],"traits":[20],"(QTs)":[21],"extracted":[22],"from":[23,152],"neuroimaging":[24],"and":[25,58,79,113,173,193],"genetic":[26,186],"markers":[27],"like":[28],"single-nucleotide":[29],"polymorphisms":[30],"(SNPs).":[31],"The":[32,136,159],"hidden":[33,68],"structural":[34,69],"patterns":[35],"in":[36],"data":[37,84,151],"limit":[38],"discovery":[40],"of":[41,138,177],"disease-related":[42],"biomarkers.":[43],"To":[44],"this":[45],"end,":[46],"we":[47,63,105],"present":[48],"a":[49,66,90],"deep":[50],"ring-wise":[51,72,132],"block":[52,73,78],"network":[53],"(RB-Net)":[54],"analysis":[57],"disease":[60,116,191],"diagnosis.":[61,117],"Specifically,":[62],"first":[64],"construct":[65],"new":[67],"pattern,":[70,74],"namely,":[71],"that":[75,162],"satisfies":[76],"both":[77],"ring":[80],"properties":[81],"within":[82],"before":[85],"analysis.":[88],"Subsequently,":[89],"RB-Net":[91],"developed":[93],"via":[94],"using":[95],"an":[96],"auto-encoder":[97],"(AE)":[98],"represent":[100],"data.":[103],"Furthermore,":[104],"design":[106],"approach":[108,165],"joint":[110],"learning":[112],"automated":[114],"Additionally,":[118],"optimization":[120],"scheme":[121],"based":[122],"on":[123,146],"alternating":[124],"update":[125],"presented":[127],"solve":[129],"built":[131],"block-perception":[133],"layer":[134],"model.":[135],"performance":[137],"designed":[140],"method":[141],"has":[142],"been":[143],"experimentally":[144],"assessed":[145],"Alzheimer's":[154],"Disease":[155],"Neuroimaging":[156],"Initiative":[157],"(ADNI).":[158],"results":[160],"validate":[161],"proposed":[164],"outperforms":[166],"some":[167],"competing":[168],"approaches,":[169],"establishes":[170],"strong":[171],"associations,":[172],"identifies":[174],"crucial":[175],"regions":[176],"interest":[178],"(ROIs)":[179],"across":[180],"different":[181],"phenotypes":[183],"associated":[184],"with":[185],"risk":[187],"biomarkers,":[188],"thereby":[189],"guiding":[190],"interpretation":[192],"diagnosis":[194],"prediction.":[195]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}