{"id":"https://openalex.org/W4411600138","doi":"https://doi.org/10.1109/tcbbio.2025.3582572","title":"FSKansformer: An ncRNA-Protein Interaction Prediction Model Based on Feature Salience and Kansformer","display_name":"FSKansformer: An ncRNA-Protein Interaction Prediction Model Based on Feature Salience and Kansformer","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4411600138","doi":"https://doi.org/10.1109/tcbbio.2025.3582572","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811248"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3582572","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3582572","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101907040","display_name":"Yun Zhou","orcid":"https://orcid.org/0000-0002-2306-8986"},"institutions":[{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Zhou","raw_affiliation_strings":["Key Laboratory of Artificial Intelligence and Personalized Learning in Education of Henan Province, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Artificial Intelligence and Personalized Learning in Education of Henan Province, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111354658","display_name":"Haoyu Cui","orcid":"https://orcid.org/0009-0006-5745-0792"},"institutions":[{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyu Cui","raw_affiliation_strings":["College of Computer and Information Engineering, Henan Normal University, Xinxiang, China"],"affiliations":[{"raw_affiliation_string":"College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003983454","display_name":"Wenbo Cai","orcid":"https://orcid.org/0000-0002-6448-4900"},"institutions":[{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Cai","raw_affiliation_strings":["College of Computer and Information Engineering, Henan Normal University, Xinxiang, China"],"affiliations":[{"raw_affiliation_string":"College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032176468","display_name":"Dong Liu","orcid":"https://orcid.org/0000-0003-4346-9565"},"institutions":[{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Liu","raw_affiliation_strings":["College of Computer and Information Engineering, Henan Normal University, Xinxiang, China"],"affiliations":[{"raw_affiliation_string":"College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392023","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-6024-0589"},"institutions":[{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Key Laboratory of Artificial Intelligence and Personalized Learning in Education of Henan Province, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Artificial Intelligence and Personalized Learning in Education of Henan Province, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101907040"],"corresponding_institution_ids":["https://openalex.org/I75955062"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13390625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"5","first_page":"2082","last_page":"2092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9584000110626221,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.906499981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salience","display_name":"Salience (neuroscience)","score":0.7601584196090698},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.524077832698822},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4033215045928955},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3917456269264221},{"id":"https://openalex.org/keywords/linguistics","display_name":"Linguistics","score":0.05574801564216614}],"concepts":[{"id":"https://openalex.org/C108154423","wikidata":"https://www.wikidata.org/wiki/Q1469792","display_name":"Salience (neuroscience)","level":2,"score":0.7601584196090698},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.524077832698822},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4033215045928955},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3917456269264221},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.05574801564216614},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3582572","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3582572","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811248","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/13","display_name":"Climate action"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W286749509","https://openalex.org/W2005120335","https://openalex.org/W2009133700","https://openalex.org/W2019982711","https://openalex.org/W2028529745","https://openalex.org/W2052938279","https://openalex.org/W2104195344","https://openalex.org/W2119501676","https://openalex.org/W2119988314","https://openalex.org/W2147667050","https://openalex.org/W2326124692","https://openalex.org/W2744846399","https://openalex.org/W2920083709","https://openalex.org/W2971428843","https://openalex.org/W3121647224","https://openalex.org/W3127862818","https://openalex.org/W3129725165","https://openalex.org/W3144812654","https://openalex.org/W3153976197","https://openalex.org/W3158985355","https://openalex.org/W3160412534","https://openalex.org/W3200563416","https://openalex.org/W4200344092","https://openalex.org/W4205617467","https://openalex.org/W4206660090","https://openalex.org/W4220690626","https://openalex.org/W4225917625","https://openalex.org/W4292180525","https://openalex.org/W4293243592","https://openalex.org/W4300861904","https://openalex.org/W4308955971","https://openalex.org/W4312946813","https://openalex.org/W4316038422","https://openalex.org/W4319593646","https://openalex.org/W4367721763","https://openalex.org/W4375954779","https://openalex.org/W4378673947","https://openalex.org/W4380792423","https://openalex.org/W4389373162","https://openalex.org/W4396680512","https://openalex.org/W4396732012","https://openalex.org/W4402987787","https://openalex.org/W4403295588","https://openalex.org/W4404388739","https://openalex.org/W4404636525","https://openalex.org/W4409656140","https://openalex.org/W4412507037"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"The":[0],"interaction":[1],"between":[2],"non-coding":[3],"RNA":[4],"(ncRNA)":[5],"and":[6,17,49,82,105,127],"protein":[7],"(ncRPI)":[8],"plays":[9],"a":[10,24,35,64,72,116],"crucial":[11],"role":[12],"in":[13,70,114],"many":[14],"physiological":[15],"activities":[16],"disease":[18],"progression.":[19],"To":[20,59],"identify":[21],"ncRPIs":[22],"on":[23,31,168],"large":[25],"scale":[26],"by":[27,99],"computational":[28,40],"methods":[29,41],"based":[30],"deep":[32],"learning":[33],"is":[34,76,119],"common":[36],"practice.":[37],"However,":[38],"existing":[39],"face":[42],"challenges":[43],"such":[44],"as":[45],"low":[46],"feature":[47,57,73,87,96,104],"expression":[48],"redundant":[50],"suppression":[51],"capability":[52],"when":[53],"processing":[54],"high":[55],"dimensional":[56],"data.":[58],"this":[60],"end,":[61],"we":[62,108],"propose":[63,109],"new":[65],"prediction":[66,158],"model,":[67],"called":[68],"FSKansformer,":[69],"which":[71,115],"salience":[74],"module":[75],"introduced":[77],"to":[78,91,121,132,154],"highlight":[79],"useful":[80],"information":[81,97],"suppress":[83],"noise":[84],"of":[85,95,102],"multi-view":[86],"matrices.":[88],"In":[89],"order":[90],"reduce":[92],"the":[93,139,147,156],"loss":[94],"caused":[98],"serial":[100],"extraction":[101,112],"global":[103,123],"local":[106,134],"feature,":[107],"an":[110],"parallel":[111],"framework":[113],"improved":[117],"Kansformer":[118],"designed":[120],"extract":[122,133],"high-dimensional":[124,135,142],"features,":[125],"BiLSTM":[126],"LSTM":[128],"techniques":[129],"are":[130,144],"used":[131],"features":[136,143],"simultaneously.":[137],"Finally,":[138],"fused":[140],"global-local":[141],"input":[145],"into":[146],"three-layer":[148],"KAN":[149],"network":[150],"for":[151],"dimensionality":[152],"reduction":[153],"generate":[155],"final":[157],"score.":[159],"Experiment":[160],"results":[161],"show":[162],"that":[163],"FSKansformer":[164],"achieves":[165],"state-of-the-art":[166],"performance":[167],"five":[169],"benchmark":[170],"datasets":[171],"compared":[172],"with":[173],"other":[174],"models.":[175]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}