{"id":"https://openalex.org/W4410394873","doi":"https://doi.org/10.1109/tcbbio.2025.3570519","title":"Study on Robustness of Denoising and Clusterization Algorithms for the Computation of Microbiome Data","display_name":"Study on Robustness of Denoising and Clusterization Algorithms for the Computation of Microbiome Data","publication_year":2025,"publication_date":"2025-05-15","ids":{"openalex":"https://openalex.org/W4410394873","doi":"https://doi.org/10.1109/tcbbio.2025.3570519","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811344"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3570519","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3570519","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014339791","display_name":"Alejandro Rodr\u00edguez\u2013S\u00e1nchez","orcid":"https://orcid.org/0000-0001-6647-4944"},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Alejandro Rodriguez-Sanchez","raw_affiliation_strings":["Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054476230","display_name":"J. Gonz\u00e1lez\u2010L\u00f3pez","orcid":"https://orcid.org/0000-0003-0457-5453"},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus Gonzalez-Lopez","raw_affiliation_strings":["Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007463179","display_name":"Alejandro Gonz\u00e1lez\u2010Mart\u00ednez","orcid":"https://orcid.org/0000-0002-4438-6430"},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Gonzalez-Martinez","raw_affiliation_strings":["Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014339791"],"corresponding_institution_ids":["https://openalex.org/I173304897"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1161333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"4","first_page":"1752","last_page":"1765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9811000227928162,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7423491477966309},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.7196488380432129},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5831001996994019},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.5595728158950806},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4450390934944153},{"id":"https://openalex.org/keywords/noise-reduction","display_name":"Noise reduction","score":0.4365394711494446},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36682626605033875},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1575608253479004},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10756906867027283}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7423491477966309},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.7196488380432129},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5831001996994019},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5595728158950806},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4450390934944153},{"id":"https://openalex.org/C163294075","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Noise reduction","level":2,"score":0.4365394711494446},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36682626605033875},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1575608253479004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10756906867027283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3570519","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3570519","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811344","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W573199863","https://openalex.org/W1569930069","https://openalex.org/W1990746682","https://openalex.org/W1992257986","https://openalex.org/W2073925485","https://openalex.org/W2079520182","https://openalex.org/W2086865963","https://openalex.org/W2103412200","https://openalex.org/W2105368763","https://openalex.org/W2106882534","https://openalex.org/W2108718991","https://openalex.org/W2114859967","https://openalex.org/W2121055398","https://openalex.org/W2124351063","https://openalex.org/W2124608356","https://openalex.org/W2127036970","https://openalex.org/W2127322768","https://openalex.org/W2132598047","https://openalex.org/W2150914285","https://openalex.org/W2163236435","https://openalex.org/W2396605020","https://openalex.org/W2401404581","https://openalex.org/W2430390055","https://openalex.org/W2513506562","https://openalex.org/W2538509698","https://openalex.org/W2592367925","https://openalex.org/W2593591803","https://openalex.org/W2596926044","https://openalex.org/W2750791471","https://openalex.org/W2769542288","https://openalex.org/W2787925891","https://openalex.org/W2897415494","https://openalex.org/W2917802047","https://openalex.org/W2923611692","https://openalex.org/W2951971263","https://openalex.org/W2982530970","https://openalex.org/W2989723692","https://openalex.org/W2999369378","https://openalex.org/W3094521503","https://openalex.org/W3110829178","https://openalex.org/W3128355020","https://openalex.org/W3137029520","https://openalex.org/W3144995900","https://openalex.org/W3157021351","https://openalex.org/W3181823224","https://openalex.org/W3186247356","https://openalex.org/W3209521497","https://openalex.org/W4210320416","https://openalex.org/W4212974503","https://openalex.org/W4213427769","https://openalex.org/W4220785839","https://openalex.org/W4226441453","https://openalex.org/W4251751280","https://openalex.org/W4280600426","https://openalex.org/W4289855726","https://openalex.org/W4308451206","https://openalex.org/W4361269501","https://openalex.org/W4366422398","https://openalex.org/W4380264664","https://openalex.org/W4381469619","https://openalex.org/W4383263109","https://openalex.org/W4385754662","https://openalex.org/W4385952084","https://openalex.org/W4389097402","https://openalex.org/W4390948630","https://openalex.org/W4391042185","https://openalex.org/W4391099216","https://openalex.org/W4391177952","https://openalex.org/W4391482417","https://openalex.org/W4391514688","https://openalex.org/W4391751365","https://openalex.org/W4391819566","https://openalex.org/W4391970273","https://openalex.org/W6679304060","https://openalex.org/W6729038451","https://openalex.org/W6760729129"],"related_works":["https://openalex.org/W2051487156","https://openalex.org/W2604155846","https://openalex.org/W2073681303","https://openalex.org/W4231884825","https://openalex.org/W4390658901","https://openalex.org/W3121185202","https://openalex.org/W4393043634","https://openalex.org/W4206185765","https://openalex.org/W2900546243","https://openalex.org/W3035180550"],"abstract_inverted_index":{"One":[0],"crucial":[1],"factor":[2],"for":[3,55,102,142,179,186,192],"dissimilarity":[4],"of":[5,22,30,41,58,60,79,93,104,117,123,128,133,154,168,183],"microbiome":[6,43,187],"studies":[7],"is":[8],"the":[9,18,28,37,42,56,77,105,124,161,165,171,180],"choice":[10],"between":[11],"denoising":[12,62,69,149],"or":[13,20],"clusterization":[14,64,73],"algorithms,":[15,115],"respectively.":[16],"Moreover,":[17],"robustness,":[19],"stability":[21],"these":[23],"algorithms":[24,106,143,150],"with":[25,112],"respect":[26,113],"to":[27,114],"number":[29,116],"sequences":[31,118],"computed,":[32,119],"and":[33,63,72,76,120,135,138,144,148,163],"its":[34],"effect":[35,67,78],"on":[36],"calculated":[38],"ecological":[39,84],"metrics":[40,137],"studied,":[44],"are":[45,177],"currently":[46],"unknown.":[47],"In":[48],"this":[49,197],"study,":[50],"mock":[51],"communities":[52],"were":[53,86,157],"used":[54],"investigation":[57],"robustness":[59,92],"several":[61],"algorithms.":[65],"The":[66,89,174],"that":[68],"error":[70],"models":[71],"similarity":[74,167],"thresholds,":[75],"rare":[80,129],"biosphere":[81,130],"removal":[82],"from":[83],"analyses,":[85],"also":[87],"assessed.":[88],"results":[90,175],"showed":[91,110,151],"\u03b1-diversity":[94,134],"metrics,":[95],"while":[96],"\u03b2-diversity":[97,136],"was":[98],"clearly":[99],"affected":[100,131],"differentially":[101],"each":[103],"tested.":[107,146],"Taxonomic":[108],"accuracy":[109,140],"differences":[111],"taxonomic":[121,139,166],"closeness":[122],"community":[125,172],"studied.":[126,173],"Removal":[127],"values":[132],"differently":[141],"datasets":[145],"Clusterization":[147],"different":[152],"degrees":[153],"stability,":[155],"which":[156],"influenced":[158],"greatly":[159],"by":[160],"dataset,":[162],"possibly":[164],"microorganisms":[169],"in":[170,196],"obtained":[176],"important":[178],"future":[181],"configuration":[182],"universal":[184],"standards":[185],"exploration":[188],"as":[189,191],"well":[190],"current":[193],"methodological":[194],"applications":[195],"field.":[198]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}