{"id":"https://openalex.org/W4409883154","doi":"https://doi.org/10.1109/tcbbio.2025.3565151","title":"Screening and Predicting Multi-Omics T-ALL Core Genes Based on PU Learning","display_name":"Screening and Predicting Multi-Omics T-ALL Core Genes Based on PU Learning","publication_year":2025,"publication_date":"2025-04-28","ids":{"openalex":"https://openalex.org/W4409883154","doi":"https://doi.org/10.1109/tcbbio.2025.3565151","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811299"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3565151","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3565151","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tao Zhang","orcid":"https://orcid.org/0000-0002-2241-7830"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China"],"raw_orcid":"https://orcid.org/0000-0002-2241-7830","affiliations":[{"raw_affiliation_string":"College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]},{"raw_affiliation_string":"College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062695688","display_name":"Baoqi Huang","orcid":"https://orcid.org/0000-0003-4027-1756"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoqi Huang","raw_affiliation_strings":["College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China"],"raw_orcid":"https://orcid.org/0000-0003-4027-1756","affiliations":[{"raw_affiliation_string":"College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]},{"raw_affiliation_string":"College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028310649","display_name":"Bing Jia","orcid":"https://orcid.org/0000-0003-3294-6303"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Jia","raw_affiliation_strings":["College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China"],"raw_orcid":"https://orcid.org/0000-0003-3294-6303","affiliations":[{"raw_affiliation_string":"College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]},{"raw_affiliation_string":"College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107865961","display_name":"Fei Hao","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Hao","raw_affiliation_strings":["School of Life Sciences and the State Key Laboratory of Reproductive Regulation &amp; Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and the State Key Laboratory of Reproductive Regulation &amp; Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083235166","display_name":"Dongjun Liu","orcid":"https://orcid.org/0000-0002-3201-0559"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongjun Liu","raw_affiliation_strings":["School of Life Sciences and the State Key Laboratory of Reproductive Regulation &amp; Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and the State Key Laboratory of Reproductive Regulation &amp; Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065503233","display_name":"Haodong Cen","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haodong Cen","raw_affiliation_strings":["College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science, Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]},{"raw_affiliation_string":"College of Computer Science and the Inner Mongolia A. R. Key Laboratory of Wireless Networking and Mobile Computing, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2722730"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07029234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"4","first_page":"1653","last_page":"1661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.945900022983551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5618546605110168},{"id":"https://openalex.org/keywords/core","display_name":"Core (optical fiber)","score":0.5113536715507507},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4695228934288025},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.42459768056869507},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35791462659835815},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.29598453640937805},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20487737655639648}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5618546605110168},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.5113536715507507},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4695228934288025},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.42459768056869507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35791462659835815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29598453640937805},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20487737655639648},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3565151","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3565151","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811299","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3727306880","display_name":null,"funder_award_id":"42161070","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4426016032","display_name":null,"funder_award_id":"62262046","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W2019845433","https://openalex.org/W2050871273","https://openalex.org/W2068773963","https://openalex.org/W2077735774","https://openalex.org/W2103017472","https://openalex.org/W2112697101","https://openalex.org/W2123958887","https://openalex.org/W2126560506","https://openalex.org/W2143426320","https://openalex.org/W2498191157","https://openalex.org/W2511322806","https://openalex.org/W2537679995","https://openalex.org/W2559588208","https://openalex.org/W2749830411","https://openalex.org/W2808815573","https://openalex.org/W2886654930","https://openalex.org/W2991833105","https://openalex.org/W3025046345","https://openalex.org/W3036867764","https://openalex.org/W3120656404","https://openalex.org/W3128323382","https://openalex.org/W3159395723","https://openalex.org/W3184359261","https://openalex.org/W4224225221","https://openalex.org/W4225146487","https://openalex.org/W4288421627","https://openalex.org/W4317761995","https://openalex.org/W4361283935","https://openalex.org/W4383504285","https://openalex.org/W4402003053","https://openalex.org/W6753795921","https://openalex.org/W6777987991"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"T-cell":[0],"acute":[1],"lymphoblastic":[2],"leukemia":[3],"(T-ALL)":[4],"is":[5,57,71,176],"a":[6,60,81,111,126],"malignant":[7],"neoplastic":[8],"disease.":[9],"Accurate":[10],"identification":[11],"of":[12,20,41,156,160],"core":[13,138,144,183,187],"genes":[14,47,55,139,145,188],"helps":[15],"to":[16,91,102,118,148,163,178,192],"explore":[17],"the":[18,33,87,93,104,120,134,143,165,173,190,200],"pathogenesis":[19],"T-ALL":[21,42,67,105,181,196],"and":[22,37,137,150,158,185],"develop":[23],"relevant":[24,161],"targeted":[25],"drugs.":[26],"In":[27],"this":[28,124],"paper,":[29],"we":[30],"first":[31],"screened":[32],"RNA-seq,":[34],"CTCF":[35],"ChIP-seq":[36],"DNA":[38],"methylation":[39],"datasets":[40],"for":[43],"intersecting":[44],"differentially":[45],"expressed":[46],"(DEGs)":[48],"using":[49],"bioinformatics":[50],"software.":[51],"As":[52],"such,":[53],"candidate":[54,107,135],"screening":[56],"transformed":[58],"into":[59],"semi-supervised":[61],"classification":[62,121],"problem":[63],"given":[64],"all":[65,186],"known":[66],"related":[68,106,182],"genes.":[69],"It":[70],"clear":[72],"that":[73,172],"there":[74],"are":[75],"no":[76],"labelled":[77,83],"negative":[78],"samples":[79,85],"but":[80],"few":[82],"positive":[84],"in":[86,109,195,199],"dataset,":[88],"motivating":[89],"us":[90],"employ":[92],"PU":[94],"bagging":[95],"method":[96,175],"based":[97],"on":[98],"Positive-unlabeled":[99],"(PU)":[100],"learning":[101],"discover":[103],"genes,":[108,136,184],"which":[110],"multi-layer":[112],"perceptron":[113],"(MLP)":[114],"classifier":[115],"was":[116,131],"employed":[117],"accomplish":[119],"task.":[122],"On":[123],"ground,":[125],"protein-protein":[127],"interaction":[128],"(PPI)":[129],"network":[130],"built":[132],"with":[133],"were":[140,146],"screened.":[141],"Finally,":[142],"subjected":[147],"GO":[149],"KEGG":[151],"functional":[152],"enrichment":[153],"analysis,":[154],"search":[155],"CTD":[157],"review":[159],"literature":[162],"validate":[164],"proposed":[166,174],"method.":[167],"The":[168],"validation":[169],"results":[170],"showed":[171],"able":[177],"effectively":[179],"predict":[180],"have":[189],"potential":[191],"become":[193],"candidates":[194],"biomarker":[197],"studies":[198],"future.":[201]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
