{"id":"https://openalex.org/W4409019477","doi":"https://doi.org/10.1109/tcbbio.2025.3556409","title":"MDAGCN: Predicting Mutation-Drug Associations Through Signed Graph Convolutional Networks via Graph Sampling","display_name":"MDAGCN: Predicting Mutation-Drug Associations Through Signed Graph Convolutional Networks via Graph Sampling","publication_year":2025,"publication_date":"2025-03-31","ids":{"openalex":"https://openalex.org/W4409019477","doi":"https://doi.org/10.1109/tcbbio.2025.3556409","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811304"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3556409","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3556409","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100724913","display_name":"Xiaosong Wang","orcid":"https://orcid.org/0000-0002-9733-2030"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaosong Wang","raw_affiliation_strings":["School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134","https://openalex.org/I143868143"]},{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755097","display_name":"Xiaodi Li","orcid":"https://orcid.org/0000-0001-5124-7159"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodi Li","raw_affiliation_strings":["School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134","https://openalex.org/I143868143"]},{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001963009","display_name":"Ying Xiang","orcid":"https://orcid.org/0009-0004-8560-271X"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Xiang","raw_affiliation_strings":["School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134","https://openalex.org/I143868143"]},{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070321507","display_name":"Tao Xu","orcid":"https://orcid.org/0000-0001-9023-5134"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Xu","raw_affiliation_strings":["School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134","https://openalex.org/I143868143"]},{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044447237","display_name":"Zhenyu Yue","orcid":"https://orcid.org/0000-0002-9370-2540"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Yue","raw_affiliation_strings":["School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134","https://openalex.org/I143868143"]},{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020360433","display_name":"Lichuan Gu","orcid":"https://orcid.org/0000-0002-3768-8203"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]},{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lichuan Gu","raw_affiliation_strings":["School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134","https://openalex.org/I143868143"]},{"raw_affiliation_string":"School of Information and Artificial Intelligence, Anhui Provincial Engineering Research Center for Beidou Precision Agriculture Information, Anhui Provincial Engineering Research Center for Agricultural Information Perception and Intelligent Computing, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100724913"],"corresponding_institution_ids":["https://openalex.org/I140221134","https://openalex.org/I143868143"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07253687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"4","first_page":"1428","last_page":"1440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5963459014892578},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.515531063079834},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.28200846910476685}],"concepts":[{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5963459014892578},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.515531063079834},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.28200846910476685}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3556409","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3556409","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811304","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G175642438","display_name":null,"funder_award_id":"2308085QF202","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"},{"id":"https://openalex.org/G2543759693","display_name":null,"funder_award_id":"62472005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3003946067","display_name":null,"funder_award_id":"32472007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4568847643","display_name":null,"funder_award_id":"2023YFD1802200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6253636927","display_name":null,"funder_award_id":"62102004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7066316259","display_name":null,"funder_award_id":"2308085MF217","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W967848597","https://openalex.org/W1966716734","https://openalex.org/W2043338013","https://openalex.org/W2095659509","https://openalex.org/W2126773860","https://openalex.org/W2194609483","https://openalex.org/W2583911935","https://openalex.org/W2614443510","https://openalex.org/W2621662488","https://openalex.org/W2622576506","https://openalex.org/W2624407581","https://openalex.org/W2767891136","https://openalex.org/W2807463161","https://openalex.org/W2885091354","https://openalex.org/W2887092413","https://openalex.org/W2911535432","https://openalex.org/W2938012438","https://openalex.org/W2947626248","https://openalex.org/W2949492942","https://openalex.org/W2951071083","https://openalex.org/W2953576895","https://openalex.org/W2973140148","https://openalex.org/W2997638284","https://openalex.org/W3005505802","https://openalex.org/W3006386963","https://openalex.org/W3009850650","https://openalex.org/W3010217868","https://openalex.org/W3033050543","https://openalex.org/W3037489518","https://openalex.org/W3039075121","https://openalex.org/W3089843526","https://openalex.org/W3107609030","https://openalex.org/W3116278528","https://openalex.org/W3130891725","https://openalex.org/W3143789190","https://openalex.org/W3150675149","https://openalex.org/W3158396170","https://openalex.org/W3160381762","https://openalex.org/W3187046408","https://openalex.org/W3206417123","https://openalex.org/W3216642120","https://openalex.org/W4200432712","https://openalex.org/W4205247356","https://openalex.org/W4213355816","https://openalex.org/W4226333008","https://openalex.org/W4281650778","https://openalex.org/W4283745047","https://openalex.org/W4390563851","https://openalex.org/W4391402357","https://openalex.org/W4392111029","https://openalex.org/W4393938964","https://openalex.org/W4394014430","https://openalex.org/W6726873649","https://openalex.org/W6738964360","https://openalex.org/W6748799445","https://openalex.org/W6748848838","https://openalex.org/W6748856961","https://openalex.org/W6754030515"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"The":[0],"surge":[1],"in":[2,14,63,107],"accessible":[3],"high-throughput":[4],"molecular":[5],"data":[6,94],"presents":[7],"computational":[8],"challenges":[9],"for":[10,39,120],"the":[11,19,56,68,84,89,114,141,145,148],"precision":[12],"medicine":[13],"cancer.":[15,64],"Genetic":[16],"mutations":[17],"have":[18],"potential":[20,142],"to":[21,28,54,135,143,153],"act":[22],"as":[23],"reliable":[24],"biomarkers":[25],"indicating":[26],"responses":[27],"targeted":[29],"drugs.":[30],"Accurate":[31],"prediction":[32],"of":[33,72,116,156],"mutation-drug":[34,57,97,151],"associations":[35,58,152],"is":[36,125],"critically":[37],"important":[38],"drug":[40,157],"development":[41],"and":[42,70,80,92,159],"cancer":[43,136],"treatment.":[44],"We":[45],"propose":[46],"a":[47,78,126],"novel":[48,150],"graph":[49,82,117],"convolutional":[50],"network":[51],"method,":[52],"MDAGCN,":[53],"predict":[55],"with":[59,96],"specific":[60],"types":[61],"(sensitive/resistant)":[62],"To":[65],"enhance":[66],"both":[67],"efficiency":[69],"accuracy":[71],"training,":[73],"we":[74,112],"begin":[75],"by":[76],"constructing":[77],"feature":[79,93],"topological":[81],"using":[83],"k-Nearest":[85],"Neighbors":[86],"algorithm,":[87],"incorporating":[88],"structural":[90],"relationship":[91],"associated":[95],"interactions.":[98],"Experimental":[99],"results":[100],"show":[101,113],"that":[102,130],"MDAGCN":[103,124],"outperforms":[104],"state-of-the-art":[105],"methods":[106],"different":[108],"experimental":[109],"settings.":[110],"Moreover,":[111],"effectiveness":[115],"sampling":[118],"technique":[119],"training":[121],"signed":[122],"graphs.":[123],"comprehensive":[127],"end-to-end":[128],"framework":[129,139],"could":[131],"be":[132],"broadly":[133],"applicable":[134],"pharmacogenomics.":[137],"This":[138],"has":[140],"facilitate":[144],"mapping":[146],"from":[147],"discovering":[149],"in-depth":[154],"analysis":[155],"sensitivity":[158],"resistance.":[160]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
