{"id":"https://openalex.org/W4408145717","doi":"https://doi.org/10.1109/tcbbio.2025.3547952","title":"ACP-ESM2: Enhancing Anticancer Peptide Prediction With Pre-Trained Protein Language Models","display_name":"ACP-ESM2: Enhancing Anticancer Peptide Prediction With Pre-Trained Protein Language Models","publication_year":2025,"publication_date":"2025-03-04","ids":{"openalex":"https://openalex.org/W4408145717","doi":"https://doi.org/10.1109/tcbbio.2025.3547952","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811365"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3547952","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3547952","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026006632","display_name":"Shun Gao","orcid":"https://orcid.org/0000-0001-5608-2269"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Gao","raw_affiliation_strings":["School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Xia","orcid":null},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Xia","raw_affiliation_strings":["School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101559550","display_name":"Xingfeng Li","orcid":"https://orcid.org/0000-0002-8958-0341"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingfeng Li","raw_affiliation_strings":["School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":"https://orcid.org/0000-0002-8958-0341","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061028143","display_name":"Feifei Cui","orcid":"https://orcid.org/0000-0001-7055-3813"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifei Cui","raw_affiliation_strings":["School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":"https://orcid.org/0000-0001-7055-3813","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101829682","display_name":"Qingchen Zhang","orcid":"https://orcid.org/0000-0001-5525-687X"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingchen Zhang","raw_affiliation_strings":["School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":"https://orcid.org/0000-0001-5525-687X","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Quan Zou","orcid":"https://orcid.org/0000-0001-6406-1142"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Zou","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, USA","Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0001-6406-1142","affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, USA","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":null,"display_name":"Zilong Zhang","orcid":"https://orcid.org/0009-0007-4710-9870"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zilong Zhang","raw_affiliation_strings":["School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":"https://orcid.org/0009-0007-4710-9870","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3811,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.94521288,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"22","issue":"3","first_page":"1041","last_page":"1051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.5024001598358154},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45878392457962036},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3731365203857422},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2521361708641052},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22151082754135132},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15347862243652344}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5024001598358154},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45878392457962036},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3731365203857422},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2521361708641052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22151082754135132},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15347862243652344}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3547952","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3547952","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811365","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2800956338","display_name":null,"funder_award_id":"62101100","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8875385470","display_name":null,"funder_award_id":"62262015","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1931581539","https://openalex.org/W2016043834","https://openalex.org/W2095705004","https://openalex.org/W2099153308","https://openalex.org/W2102492119","https://openalex.org/W2136007332","https://openalex.org/W2170747616","https://openalex.org/W2175270296","https://openalex.org/W2529838505","https://openalex.org/W2598922467","https://openalex.org/W2626017178","https://openalex.org/W2739999456","https://openalex.org/W2786672974","https://openalex.org/W2899423466","https://openalex.org/W2937145808","https://openalex.org/W2945375732","https://openalex.org/W3048086963","https://openalex.org/W3092054443","https://openalex.org/W3110828293","https://openalex.org/W3129096424","https://openalex.org/W3130604207","https://openalex.org/W3136101359","https://openalex.org/W3139265997","https://openalex.org/W3176873949","https://openalex.org/W4225983992","https://openalex.org/W4281480754","https://openalex.org/W4282961683","https://openalex.org/W4289525677","https://openalex.org/W4312827846","https://openalex.org/W4313278994","https://openalex.org/W4317886222","https://openalex.org/W4327550249","https://openalex.org/W4378782822","https://openalex.org/W4382789906","https://openalex.org/W4385245566","https://openalex.org/W4390629592","https://openalex.org/W4390955747","https://openalex.org/W4390971042","https://openalex.org/W4391288425","https://openalex.org/W4391618534","https://openalex.org/W4391671392","https://openalex.org/W4393237361","https://openalex.org/W4399153512","https://openalex.org/W4400000389","https://openalex.org/W4401171136","https://openalex.org/W4403015851","https://openalex.org/W4403409634","https://openalex.org/W4403782367","https://openalex.org/W6674330103","https://openalex.org/W6675533928","https://openalex.org/W6748816842","https://openalex.org/W6755310813","https://openalex.org/W7056935005"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Anticancer":[0],"peptide":[1],"(ACP)":[2],"are":[3,44],"short":[4],"peptides":[5],"with":[6,98,135],"anti-cancer":[7],"properties":[8],"that":[9,103,122],"have":[10,53],"generated":[11],"increasing":[12],"attention":[13],"in":[14,63,143],"recent":[15],"years":[16],"due":[17],"to":[18,28],"their":[19,26],"low":[20],"toxicity,":[21],"minimal":[22],"side":[23],"effects,":[24],"and":[25,31,46,141,147,171],"ability":[27],"precisely":[29],"target":[30],"kill":[32],"cancer":[33],"cells.":[34],"Traditionally,":[35],"identifying":[36],"ACP":[37,116],"has":[38],"relied":[39],"on":[40,78,131,151],"experimental":[41,119],"methods,":[42],"which":[43,87],"time-consuming":[45],"labor-intensive.":[47],"While":[48],"deep":[49,74],"learning-based":[50],"prediction":[51],"methods":[52],"made":[54],"significant":[55,125],"progress,":[56],"there":[57],"is":[58],"still":[59],"room":[60],"for":[61,115,174],"improvement":[62],"achieving":[64],"optimal":[65],"performance.":[66],"In":[67],"this":[68],"study,":[69],"we":[70],"present":[71],"ACP-ESM2,":[72],"a":[73,111],"learning":[75],"framework":[76],"based":[77],"the":[79,132,152],"Evolutionary":[80],"Scale":[81],"Modeling":[82],"2":[83],"(ESM2)":[84],"pre-trained":[85],"model,":[86],"captures":[88],"rich":[89],"evolutionary":[90],"information":[91],"from":[92],"protein":[93],"sequences.":[94],"By":[95],"combining":[96],"ESM2":[97],"convolutional":[99],"neural":[100],"network":[101],"(CNN)":[102],"excels":[104],"at":[105],"detecting":[106],"local":[107],"patterns,":[108],"ACP-ESM2":[109,123,155,167],"offers":[110],"highly":[112],"accurate":[113],"tool":[114,173],"prediction.":[117],"The":[118],"results":[120],"indicate":[121],"shows":[124],"improvements":[126],"over":[127],"best-existing":[128],"recognition":[129],"techniques":[130],"Test1":[133],"set,":[134,154],"enhancements":[136],"of":[137,159],"2.3%,":[138],"7.2%,":[139],"12.6%,":[140],"5%":[142],"ACC,":[144],"SN,":[145],"SP,":[146],"MCC,":[148],"respectively.":[149],"Notably,":[150],"Test2":[153],"achieves":[156],"an":[157,169],"accuracy":[158],"97.6%,":[160],"showcasing":[161],"its":[162],"exceptional":[163],"robustness.":[164],"This":[165],"establishes":[166],"as":[168],"efficient":[170],"precise":[172],"predicting":[175],"anticancer":[176],"peptides.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
