{"id":"https://openalex.org/W4408047895","doi":"https://doi.org/10.1109/tcbbio.2025.3546729","title":"UMMAN: Unsupervised Multi-Graph Merge Adversarial Network for Disease Prediction Based on Intestinal Flora","display_name":"UMMAN: Unsupervised Multi-Graph Merge Adversarial Network for Disease Prediction Based on Intestinal Flora","publication_year":2025,"publication_date":"2025-02-28","ids":{"openalex":"https://openalex.org/W4408047895","doi":"https://doi.org/10.1109/tcbbio.2025.3546729","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811355"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3546729","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3546729","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007737151","display_name":"Dingkun Liu","orcid":"https://orcid.org/0000-0002-1262-8458"},"institutions":[{"id":"https://openalex.org/I4210157617","display_name":"Huazhong University of Science and Technology Hospital","ror":"https://ror.org/05f9vfg11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210157617"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dingkun Liu","raw_affiliation_strings":["Huazhong University of Science and Technology, Wuhan, China","University of Huazhong University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"University of Huazhong University of Science and Technology, China","institution_ids":["https://openalex.org/I4210157617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075998044","display_name":"Hongjie Zhou","orcid":"https://orcid.org/0000-0002-7156-188X"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjie Zhou","raw_affiliation_strings":["Harbin Institute of Technology, Weihai, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Weihai, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114202925","display_name":"Yilu Qu","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilu Qu","raw_affiliation_strings":["Harbin Institute of Technology, Weihai, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Weihai, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029868730","display_name":"Huimei Zhang","orcid":"https://orcid.org/0000-0002-5508-696X"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimei Zhang","raw_affiliation_strings":["Harbin Institute of Technology, Weihai, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Weihai, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103562421","display_name":"Yongdong Xu","orcid":"https://orcid.org/0000-0003-2349-5643"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongdong Xu","raw_affiliation_strings":["Harbin Institute of Technology, Weihai, China","University of Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Weihai, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"University of Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007737151"],"corresponding_institution_ids":["https://openalex.org/I4210157617","https://openalex.org/I47720641"],"apc_list":null,"apc_paid":null,"fwci":1.7129,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.81821958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"22","issue":"3","first_page":"1023","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9830999970436096,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merge","display_name":"Merge (version control)","score":0.7300395965576172},{"id":"https://openalex.org/keywords/adversarial-system","display_name":"Adversarial system","score":0.6439397931098938},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5333905816078186},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4358506500720978},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.419063925743103},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.2393541932106018},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.0759660005569458}],"concepts":[{"id":"https://openalex.org/C197129107","wikidata":"https://www.wikidata.org/wiki/Q1921621","display_name":"Merge (version control)","level":2,"score":0.7300395965576172},{"id":"https://openalex.org/C37736160","wikidata":"https://www.wikidata.org/wiki/Q1801315","display_name":"Adversarial system","level":2,"score":0.6439397931098938},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5333905816078186},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4358506500720978},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.419063925743103},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2393541932106018},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.0759660005569458}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3546729","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3546729","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811355","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.8799999952316284,"display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1498436455","https://openalex.org/W1964027278","https://openalex.org/W1967821667","https://openalex.org/W1974577714","https://openalex.org/W2004549986","https://openalex.org/W2023615726","https://openalex.org/W2071841602","https://openalex.org/W2073332363","https://openalex.org/W2088833470","https://openalex.org/W2092696502","https://openalex.org/W2097875133","https://openalex.org/W2125826054","https://openalex.org/W2126446070","https://openalex.org/W2156145269","https://openalex.org/W2473355215","https://openalex.org/W2952564192","https://openalex.org/W2953583829","https://openalex.org/W2964015378","https://openalex.org/W3003756647","https://openalex.org/W3028383715","https://openalex.org/W3033050543","https://openalex.org/W3122818329","https://openalex.org/W3130891725","https://openalex.org/W3135687130","https://openalex.org/W3164117062","https://openalex.org/W3172837682","https://openalex.org/W3187582009","https://openalex.org/W4221116063","https://openalex.org/W4224981545","https://openalex.org/W4385245566","https://openalex.org/W4389317742","https://openalex.org/W4390874273","https://openalex.org/W4390938618","https://openalex.org/W4396623723","https://openalex.org/W4400762160","https://openalex.org/W4401201076","https://openalex.org/W4401730694","https://openalex.org/W4403028081","https://openalex.org/W4408047895","https://openalex.org/W6684191040","https://openalex.org/W6726873649","https://openalex.org/W6738964360","https://openalex.org/W6758205271","https://openalex.org/W6871262642"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2502115930","https://openalex.org/W2482350142","https://openalex.org/W4246396837","https://openalex.org/W3126451824","https://openalex.org/W1561927205","https://openalex.org/W3191453585","https://openalex.org/W4297672492"],"abstract_inverted_index":{"The":[0],"abundance":[1,48],"of":[2,28,101,131,166,213],"intestinal":[3,132],"flora":[4,133],"is":[5,120],"closely":[6,190],"related":[7],"to":[8,67,79,123,161,182],"human":[9],"diseases,":[10],"but":[11],"diseases":[12],"are":[13],"not":[14],"caused":[15],"by":[16,148],"a":[17,41,87,172],"single":[18],"gut":[19,38,73,205],"microbe.":[20],"Instead,":[21],"they":[22],"result":[23],"from":[24,50,75,196],"the":[25,69,99,104,113,121,129,138,146,150,154,163,167,185,192,197,209],"complex":[26],"interplay":[27],"numerous":[29],"microbial":[30],"entities.":[31],"This":[32],"intricate":[33],"and":[34,115,144,178,194,211],"implicit":[35,116],"connection":[36],"among":[37,72],"microbes":[39,74],"poses":[40],"significant":[42],"challenge":[43],"for":[44],"disease":[45,134],"prediction":[46],"using":[47,140],"information":[49],"OTU":[51,204],"data.":[52],"Recently,":[53],"several":[54],"methods":[55,65],"have":[56],"shown":[57],"potential":[58],"in":[59,103],"predicting":[60],"corresponding":[61],"diseases.":[62],"However,":[63],"these":[64],"fail":[66],"learn":[68,112],"inner":[70],"association":[71],"different":[76],"hosts,":[77],"leading":[78],"unsatisfactory":[80],"performance.":[81],"In":[82],"this":[83],"paper,":[84],"we":[85,170],"propose":[86],"novel":[88],"architecture,":[89],"Unsupervised":[90],"Multi-graph":[91],"Merge":[92],"Adversarial":[93],"Network":[94],"(UMMAN).":[95],"UMMAN":[96],"can":[97],"obtain":[98],"embeddings":[100],"nodes":[102],"Multi-Graph":[105],"with":[106,128,191],"an":[107],"unsupervised":[108],"scenario,":[109],"which":[110],"helps":[111],"multiplex":[114],"association.":[117],"Our":[118],"method":[119],"first":[122],"combine":[124],"Graph":[125],"Neural":[126],"Networks":[127],"task":[130],"prediction.":[135],"We":[136,152],"construct":[137],"Original-Graph":[139,193],"multiple":[141],"relation":[142],"types":[143],"generate":[145],"Shuffled-Graph":[147],"disrupting":[149],"nodes.":[151],"introduce":[153],"Node":[155],"Feature":[156],"Global":[157],"Integration":[158],"(NFGI)":[159],"module":[160],"represent":[162],"global":[164],"features":[165],"graph.":[168],"Furthermore,":[169],"design":[171],"joint":[173],"loss":[174,177,181],"comprising":[175],"adversarial":[176],"hybrid":[179],"attention":[180],"ensure":[183],"that":[184],"real":[186],"graph":[187],"embedding":[188],"aligns":[189],"diverges":[195],"Shuffled-Graph.":[198],"Comprehensive":[199],"experiments":[200],"on":[201],"five":[202],"benchmark":[203],"microbiome":[206],"datasets":[207],"demonstrate":[208],"effectiveness":[210],"stability":[212],"our":[214],"method.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-02-25T08:12:03.925757","created_date":"2025-10-10T00:00:00"}
