{"id":"https://openalex.org/W4407938717","doi":"https://doi.org/10.1109/tcbbio.2025.3543643","title":"Predicting miRNA-Disease Associations via Meta-Path Embedding","display_name":"Predicting miRNA-Disease Associations via Meta-Path Embedding","publication_year":2025,"publication_date":"2025-02-25","ids":{"openalex":"https://openalex.org/W4407938717","doi":"https://doi.org/10.1109/tcbbio.2025.3543643","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811389"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2025.3543643","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3543643","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101952789","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0002-0946-5694"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Wang","raw_affiliation_strings":["The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016858165","display_name":"Xun Huang","orcid":"https://orcid.org/0000-0001-8785-4292"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Huang","raw_affiliation_strings":["The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100659708","display_name":"Xueming Liu","orcid":"https://orcid.org/0000-0002-8951-7238"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueming Liu","raw_affiliation_strings":["The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-8951-7238","affiliations":[{"raw_affiliation_string":"The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101952789"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":null,"apc_paid":null,"fwci":2.4223,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.87606609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"911","last_page":"922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meta-analysis","display_name":"Meta-analysis","score":0.6419933438301086},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6330434083938599},{"id":"https://openalex.org/keywords/path","display_name":"Path (computing)","score":0.550502359867096},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5158335566520691},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.4552704989910126},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4196591079235077},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.411739706993103},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.40812379121780396},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3393658697605133},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24301013350486755},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22675654292106628},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21762415766716003},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14840394258499146},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.14264625310897827},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06089448928833008}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6419933438301086},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6330434083938599},{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.550502359867096},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5158335566520691},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.4552704989910126},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4196591079235077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.411739706993103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40812379121780396},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3393658697605133},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24301013350486755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22675654292106628},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21762415766716003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14840394258499146},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.14264625310897827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06089448928833008}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2025.3543643","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2025.3543643","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811389","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G212651269","display_name":null,"funder_award_id":"T2422010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7167264676","display_name":null,"funder_award_id":"62172170","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W2000946983","https://openalex.org/W2002995168","https://openalex.org/W2022732522","https://openalex.org/W2042571564","https://openalex.org/W2059382687","https://openalex.org/W2086809547","https://openalex.org/W2090891622","https://openalex.org/W2099435530","https://openalex.org/W2122287487","https://openalex.org/W2126619650","https://openalex.org/W2128768066","https://openalex.org/W2129158737","https://openalex.org/W2132694427","https://openalex.org/W2138041394","https://openalex.org/W2142937131","https://openalex.org/W2145361279","https://openalex.org/W2146292498","https://openalex.org/W2154851992","https://openalex.org/W2158135353","https://openalex.org/W2328176404","https://openalex.org/W2393319904","https://openalex.org/W2511620854","https://openalex.org/W2542498494","https://openalex.org/W2584926544","https://openalex.org/W2592189645","https://openalex.org/W2601934706","https://openalex.org/W2609468276","https://openalex.org/W2736584458","https://openalex.org/W2743104969","https://openalex.org/W2765372324","https://openalex.org/W2765950793","https://openalex.org/W2809363952","https://openalex.org/W2888358121","https://openalex.org/W2917245118","https://openalex.org/W2985146206","https://openalex.org/W2999336918","https://openalex.org/W3017317719","https://openalex.org/W3155999360","https://openalex.org/W4293476626","https://openalex.org/W4294376371","https://openalex.org/W4295241431","https://openalex.org/W4297183296","https://openalex.org/W4386305887","https://openalex.org/W4389076297","https://openalex.org/W4394735448"],"related_works":["https://openalex.org/W2081900870","https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2050308539","https://openalex.org/W3151405604","https://openalex.org/W3134325150","https://openalex.org/W2037549926","https://openalex.org/W4406877153","https://openalex.org/W4241694095"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"play":[2],"a":[3,37,51,155],"critical":[4],"role":[5],"in":[6],"various":[7],"biological":[8],"processes,":[9],"making":[10],"the":[11,58,112,127],"accurate":[12],"identification":[13],"of":[14,54,72,78,89,111,132],"miRNA-disease":[15,55,64,162],"associations":[16,27],"essential":[17],"for":[18,24,160],"understanding":[19],"human":[20],"diseases.":[21,94],"Existing":[22],"methods":[23],"predicting":[25,161],"these":[26],"often":[28],"lack":[29],"interpretability.":[30],"In":[31],"this":[32],"study,":[33],"we":[34],"introduce":[35],"MNEMDA,":[36],"novel":[38],"computational":[39],"method":[40],"that":[41],"leverages":[42],"meta-path-based":[43],"network":[44,53],"embedding":[45],"(metapath2vec)":[46],"to":[47,150],"extract":[48],"features":[49],"from":[50],"heterogeneous":[52],"interactions.":[56],"Using":[57],"XGBoost":[59],"classifier,":[60],"MNEMDA":[61,135,147],"predicts":[62],"potential":[63],"associations.":[65,163],"Our":[66],"approach":[67],"achieves":[68],"an":[69,75,85],"overall":[70,76],"AUC":[71,87],"0.959":[73],"and":[74,101,109,129,157],"AUPR":[77],"0.952,":[79],"outperforming":[80],"several":[81],"state-of-the-art":[82],"models":[83],"with":[84,107],"average":[86],"score":[88],"0.958":[90],"across":[91],"15":[92],"common":[93],"Case":[95],"studies":[96],"on":[97,139],"renal":[98],"cell":[99],"carcinoma":[100],"breast":[102],"neoplasms":[103],"confirm":[104],"MNEMDA's":[105],"efficacy,":[106],"93%":[108],"97%":[110],"top":[113],"30":[114],"predicted":[115],"miRNAs,":[116],"respectively,":[117],"validated":[118],"by":[119],"recent":[120],"experimental":[121],"reports.":[122],"Survival":[123],"analysis":[124],"also":[125],"verifies":[126],"effectiveness":[128],"practical":[130],"value":[131],"MNEMDA.":[133],"Additionally,":[134],"maintains":[136],"excellent":[137],"performance":[138],"other":[140],"datasets,":[141],"demonstrating":[142],"its":[143],"generalization":[144],"ability.":[145],"Moreover,":[146],"shows":[148],"insensitivity":[149],"input":[151],"data":[152],"noise,":[153],"providing":[154],"robust":[156],"interpretable":[158],"tool":[159]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}
