{"id":"https://openalex.org/W4406047179","doi":"https://doi.org/10.1109/tcbbio.2024.3509982","title":"A Review of RNA Structure Prediction: Exploring the Potential of Computational Approaches","display_name":"A Review of RNA Structure Prediction: Exploring the Potential of Computational Approaches","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4406047179","doi":"https://doi.org/10.1109/tcbbio.2024.3509982","pmid":"https://pubmed.ncbi.nlm.nih.gov/40811237"},"language":"en","primary_location":{"id":"doi:10.1109/tcbbio.2024.3509982","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2024.3509982","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025326475","display_name":"Anushree Tripathi","orcid":"https://orcid.org/0000-0002-5202-339X"},"institutions":[{"id":"https://openalex.org/I11793825","display_name":"National Institute of Technology Patna","ror":"https://ror.org/056wyhh33","country_code":"IN","type":"education","lineage":["https://openalex.org/I11793825","https://openalex.org/I4210152752"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anushree Tripathi","raw_affiliation_strings":["Department of Computer Science and Engineering, National Institute of Technology Patna, Patna, Bihar, India","Department of Computer Science and Engineering, National Institute of Technology Patna, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, National Institute of Technology Patna, Patna, Bihar, India","institution_ids":["https://openalex.org/I11793825"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, National Institute of Technology Patna, India","institution_ids":["https://openalex.org/I11793825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046559581","display_name":"Richa Dhanuka","orcid":"https://orcid.org/0000-0002-5280-2641"},"institutions":[{"id":"https://openalex.org/I3133096102","display_name":"Regenesys Business School","ror":"https://ror.org/005bfja03","country_code":"ZA","type":"education","lineage":["https://openalex.org/I3133096102"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Richa Dhanuka","raw_affiliation_strings":["Regenesys Business School, Sandton, South Africa","Regenesys Business School, India"],"affiliations":[{"raw_affiliation_string":"Regenesys Business School, Sandton, South Africa","institution_ids":["https://openalex.org/I3133096102"]},{"raw_affiliation_string":"Regenesys Business School, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035277232","display_name":"Jyoti Prakash Singh","orcid":"https://orcid.org/0000-0002-3742-7484"},"institutions":[{"id":"https://openalex.org/I11793825","display_name":"National Institute of Technology Patna","ror":"https://ror.org/056wyhh33","country_code":"IN","type":"education","lineage":["https://openalex.org/I11793825","https://openalex.org/I4210152752"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jyoti Prakash Singh","raw_affiliation_strings":["Department of Computer Science and Engineering, National Institute of Technology Patna, Patna, Bihar, India","Department of Computer Science and Engineering, National Institute of Technology Patna, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, National Institute of Technology Patna, Patna, Bihar, India","institution_ids":["https://openalex.org/I11793825"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, National Institute of Technology Patna, India","institution_ids":["https://openalex.org/I11793825"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025326475"],"corresponding_institution_ids":["https://openalex.org/I11793825"],"apc_list":null,"apc_paid":null,"fwci":0.8073,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68052258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"22","issue":"1","first_page":"180","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.7305424213409424},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6517701148986816},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.592764675617218},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.5182049870491028},{"id":"https://openalex.org/keywords/nucleic-acid-structure","display_name":"Nucleic acid structure","score":0.5116653442382812},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37297433614730835},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.346233606338501},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3242795169353485},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3208645284175873},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2987246513366699},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13119906187057495}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7305424213409424},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6517701148986816},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.592764675617218},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.5182049870491028},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.5116653442382812},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37297433614730835},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.346233606338501},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3242795169353485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3208645284175873},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2987246513366699},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13119906187057495}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbbio.2024.3509982","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbbio.2024.3509982","pdf_url":null,"source":{"id":"https://openalex.org/S5407042751","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"2998-4165","issn":["2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40811237","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40811237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1415011740","https://openalex.org/W1543796220","https://openalex.org/W1559047570","https://openalex.org/W1585306636","https://openalex.org/W1822105579","https://openalex.org/W1944024379","https://openalex.org/W1966857768","https://openalex.org/W1998618859","https://openalex.org/W2004945910","https://openalex.org/W2009818318","https://openalex.org/W2018216725","https://openalex.org/W2025763720","https://openalex.org/W2049283139","https://openalex.org/W2054697783","https://openalex.org/W2069779808","https://openalex.org/W2098571862","https://openalex.org/W2102017611","https://openalex.org/W2103230738","https://openalex.org/W2153140501","https://openalex.org/W2171753092","https://openalex.org/W2283077449","https://openalex.org/W2335480701","https://openalex.org/W2463369936","https://openalex.org/W2556500313","https://openalex.org/W2762224301","https://openalex.org/W2899282864","https://openalex.org/W2902683473","https://openalex.org/W2902978435","https://openalex.org/W2910435270","https://openalex.org/W2932634309","https://openalex.org/W2945901478","https://openalex.org/W2990528340","https://openalex.org/W3000595341","https://openalex.org/W3005909538","https://openalex.org/W3021883475","https://openalex.org/W3047090055","https://openalex.org/W3084513853","https://openalex.org/W3094645514","https://openalex.org/W3126773939","https://openalex.org/W3132975991","https://openalex.org/W3177828909","https://openalex.org/W3182011789","https://openalex.org/W3207591281","https://openalex.org/W3212533323","https://openalex.org/W3213615006","https://openalex.org/W4200607868","https://openalex.org/W4205118596","https://openalex.org/W4210378368","https://openalex.org/W4220877148","https://openalex.org/W4225376695","https://openalex.org/W4226341325","https://openalex.org/W4226497342","https://openalex.org/W4238219065","https://openalex.org/W4280509920","https://openalex.org/W4283832815","https://openalex.org/W4295747628","https://openalex.org/W4300861274","https://openalex.org/W4300861280","https://openalex.org/W4302362590","https://openalex.org/W4309781259","https://openalex.org/W4310568385","https://openalex.org/W4313454382","https://openalex.org/W4313585046","https://openalex.org/W4313837385","https://openalex.org/W4315436171","https://openalex.org/W4316468754","https://openalex.org/W4317813207","https://openalex.org/W4319316212","https://openalex.org/W4321484068","https://openalex.org/W4321496101","https://openalex.org/W4361002046","https://openalex.org/W4362737339","https://openalex.org/W4367312401","https://openalex.org/W4384664255","https://openalex.org/W4385068123","https://openalex.org/W4386208722","https://openalex.org/W4386804219","https://openalex.org/W4387893024","https://openalex.org/W4387931208","https://openalex.org/W4390971893","https://openalex.org/W4399510571","https://openalex.org/W6771520483","https://openalex.org/W6839309144"],"related_works":["https://openalex.org/W1472344963","https://openalex.org/W3093937951","https://openalex.org/W2554722417","https://openalex.org/W2581348958","https://openalex.org/W2264054990","https://openalex.org/W2581888268","https://openalex.org/W2902683473","https://openalex.org/W1989561030","https://openalex.org/W2088051090","https://openalex.org/W2010378972"],"abstract_inverted_index":{"RNA":[0,16,51,57,77,90,141],"plays":[1,28],"a":[2,29],"crucial":[3],"role":[4,31],"in":[5,32,56],"regulating":[6],"gene":[7],"expression,":[8],"thereby":[9],"ensuring":[10],"the":[11,33,45,54,118,127,131],"maintenance":[12],"of":[13,35,50,133],"genetic":[14],"integrity.":[15],"can":[17,144],"fold":[18],"into":[19,140],"various":[20],"structures":[21,49,78,142],"based":[22],"on":[23],"alternative":[24],"intra-molecular":[25],"base-pairings":[26],"and":[27,40,47,98,114],"critical":[30],"production":[34],"functional":[36],"proteins.":[37],"Many":[38],"experimental":[39],"computational":[41,67,99,102],"techniques":[42],"have":[43,61,72],"revealed":[44],"secondary":[46],"tertiary":[48],"molecules.":[52],"With":[53],"increase":[55],"data,":[58],"structure":[59,91],"predictions":[60],"evolved":[62],"from":[63],"conventional":[64],"to":[65,75,79,123,136,148],"advanced":[66],"methods.":[68,116],"Various":[69],"bioinformatics":[70],"methods":[71,135],"been":[73],"developed":[74],"predict":[76],"understand":[80],"underlying":[81],"molecular":[82],"mechanisms.":[83],"This":[84],"review":[85,129],"summarizes":[86],"multiple":[87],"methodologies":[88],"for":[89,154],"prediction,":[92],"encompassing":[93],"biophysical":[94],"techniques,":[95,126],"probing":[96],"methods,":[97],"approaches.":[100],"These":[101],"approaches":[103],"include":[104],"free":[105],"energy":[106],"minimization,":[107],"comparative":[108],"sequence":[109],"analysis,":[110],"deep":[111,124],"learning":[112,125],"algorithms,":[113],"hybrid":[115],"Since":[117],"current":[119],"era":[120],"is":[121],"dedicated":[122],"present":[128],"highlights":[130],"significance":[132],"these":[134],"provide":[137],"better":[138],"insights":[139],"that":[143],"be":[145],"further":[146],"explored":[147],"discover":[149],"novel":[150],"therapeutic":[151],"drug":[152],"targets":[153],"diseases.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}