{"id":"https://openalex.org/W4399665769","doi":"https://doi.org/10.1109/tcbb.2024.3414498","title":"SIG: Graph-Based Cancer Subtype Stratification With Gene Mutation Structural Information","display_name":"SIG: Graph-Based Cancer Subtype Stratification With Gene Mutation Structural Information","publication_year":2024,"publication_date":"2024-06-14","ids":{"openalex":"https://openalex.org/W4399665769","doi":"https://doi.org/10.1109/tcbb.2024.3414498","pmid":"https://pubmed.ncbi.nlm.nih.gov/38875076"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2024.3414498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2024.3414498","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102788659","display_name":"Chengcheng Zhang","orcid":"https://orcid.org/0009-0009-7642-0996"},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengcheng Zhang","raw_affiliation_strings":["School of Artificial Intelligence and Computer Science and Jiangsu Key Laboratory of Media Design and Software Technology and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","School of Artificial Intelligence and Computer Science & Jiangsu Key Laboratory of Media Design and Software Technology & Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China"],"raw_orcid":"https://orcid.org/0009-0009-7642-0996","affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence and Computer Science and Jiangsu Key Laboratory of Media Design and Software Technology and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]},{"raw_affiliation_string":"School of Artificial Intelligence and Computer Science & Jiangsu Key Laboratory of Media Design and Software Technology & Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318161","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-3135-0447"},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["School of Artificial Intelligence and Computer Science and Jiangsu Key Laboratory of Media Design and Software Technology and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","School of Artificial Intelligence and Computer Science & Jiangsu Key Laboratory of Media Design and Software Technology & Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-3135-0447","affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence and Computer Science and Jiangsu Key Laboratory of Media Design and Software Technology and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]},{"raw_affiliation_string":"School of Artificial Intelligence and Computer Science & Jiangsu Key Laboratory of Media Design and Software Technology & Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041733488","display_name":"Ming Deng","orcid":"https://orcid.org/0000-0003-4916-4877"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Deng","raw_affiliation_strings":["Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0003-4916-4877","affiliations":[{"raw_affiliation_string":"Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210120234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068828491","display_name":"Yizhang Jiang","orcid":"https://orcid.org/0000-0002-4558-9803"},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhang Jiang","raw_affiliation_strings":["School of Artificial Intelligence and Computer Science and Jiangsu Key Laboratory of Media Design and Software Technology and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","School of Artificial Intelligence and Computer Science & Jiangsu Key Laboratory of Media Design and Software Technology, Jiangnan University, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-4558-9803","affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence and Computer Science and Jiangsu Key Laboratory of Media Design and Software Technology and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education, Jiangnan University, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]},{"raw_affiliation_string":"School of Artificial Intelligence and Computer Science & Jiangsu Key Laboratory of Media Design and Software Technology, Jiangnan University, Jiangsu, China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041280931","display_name":"Xiaohui Cui","orcid":"https://orcid.org/0000-0001-6079-009X"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Cui","raw_affiliation_strings":["School of Cyber Science and Engineering, Wuhan University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0001-6079-009X","affiliations":[{"raw_affiliation_string":"School of Cyber Science and Engineering, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100400329","display_name":"Ping Chen","orcid":"https://orcid.org/0000-0003-3789-7686"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Chen","raw_affiliation_strings":["Department of Engineering, University of Massachusetts Boston, Boston, MA, USA","Department of Engineering, University of Massachusetts Boston, USA"],"raw_orcid":"https://orcid.org/0000-0003-3789-7686","affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Massachusetts Boston, Boston, MA, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Engineering, University of Massachusetts Boston, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I33434090"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3196,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54623141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"21","issue":"6","first_page":"1752","last_page":"1764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.9836999773979187,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7073456645011902},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5802876949310303},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5599544644355774},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48946893215179443},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.42872127890586853},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40242260694503784},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3312399387359619},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11598971486091614}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7073456645011902},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5802876949310303},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5599544644355774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48946893215179443},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42872127890586853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40242260694503784},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3312399387359619},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11598971486091614}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2024.3414498","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2024.3414498","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38875076","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38875076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7861401651","display_name":null,"funder_award_id":"2022YFF1101100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1519425500","https://openalex.org/W1548779692","https://openalex.org/W1987219048","https://openalex.org/W2038122249","https://openalex.org/W2062567955","https://openalex.org/W2097308346","https://openalex.org/W2100438487","https://openalex.org/W2120043163","https://openalex.org/W2121906867","https://openalex.org/W2125118217","https://openalex.org/W2128728535","https://openalex.org/W2167686991","https://openalex.org/W2299795119","https://openalex.org/W2411950200","https://openalex.org/W2442835468","https://openalex.org/W2569086487","https://openalex.org/W2624021832","https://openalex.org/W2741504978","https://openalex.org/W2808223587","https://openalex.org/W2940627982","https://openalex.org/W2964015378","https://openalex.org/W3044641639","https://openalex.org/W3080130308","https://openalex.org/W3083006614","https://openalex.org/W3107431276","https://openalex.org/W3109711993","https://openalex.org/W3126192485","https://openalex.org/W3191003990","https://openalex.org/W4212816649","https://openalex.org/W4226076641","https://openalex.org/W4230962320","https://openalex.org/W4233762729","https://openalex.org/W4244030505","https://openalex.org/W4285236097","https://openalex.org/W4285820659","https://openalex.org/W4298289240","https://openalex.org/W4309848592","https://openalex.org/W4312581984","https://openalex.org/W4385954349","https://openalex.org/W4386432228","https://openalex.org/W6637568146","https://openalex.org/W6726873649","https://openalex.org/W6810856614"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4298130764","https://openalex.org/W2804364458","https://openalex.org/W2132641928","https://openalex.org/W4310225030","https://openalex.org/W2090259340","https://openalex.org/W2086525401","https://openalex.org/W2987420353","https://openalex.org/W1491897707","https://openalex.org/W2034625591"],"abstract_inverted_index":{"Somatic":[0],"tumors":[1],"have":[2],"a":[3,20,74,91,111,140],"high-dimensional,":[4],"sparse,":[5],"and":[6,67,109,149,167,196],"small":[7],"sample":[8],"size":[9],"nature,":[10],"making":[11],"cancer":[12,26,64,78,87,154],"subtype":[13,65,70,79],"stratification":[14],"based":[15],"on":[16,30,194],"somatic":[17,159],"genomic":[18],"data":[19],"challenge.":[21],"Current":[22],"methods":[23],"for":[24,77],"improving":[25],"clustering":[27,80,183,192],"performance":[28,184],"focus":[29],"dimension":[31],"reduction,":[32],"integrating":[33],"multi-omics":[34],"data,":[35],"or":[36],"generating":[37],"realistic":[38],"samples,":[39],"yet":[40],"ignore":[41],"the":[42,48,102,127,146,158,163],"associations":[43,55,97,133],"between":[44,98,118],"mutated":[45,99,120,136],"genes":[46,100,121,137],"within":[47,84,101],"patient-gene":[49],"matrix.":[50],"We":[51,72,129,156],"refer":[52],"to":[53,113,123,138,153,170,186],"these":[54,132],"as":[56,189],"gene":[57,147,165],"mutation":[58],"structural":[59,141],"information,":[60],"which":[61,144],"implicitly":[62],"includes":[63],"information":[66,142],"can":[68],"enhance":[69],"clustering.":[71,155],"introduce":[73],"novel":[75],"method":[76,180],"called":[81],"SIG(Structural":[82],"Information":[83],"Graph).":[85],"As":[86],"is":[88],"driven":[89],"by":[90,107,191],"combination":[92],"of":[93],"genes,":[94],"we":[95],"establish":[96],"same":[103],"patient":[104],"sample,":[105],"pair":[106],"pair,":[108],"use":[110],"graph":[112],"represent":[114],"them.":[115],"An":[116],"association":[117],"two":[119],"corresponds":[122],"an":[124],"edge":[125],"in":[126,175],"graph.":[128],"then":[130],"merge":[131],"among":[134],"all":[135],"obtain":[139],"graph,":[143],"enriches":[145],"network":[148,166,177],"improves":[150],"its":[151],"relevance":[152],"integrate":[157],"tumor":[160],"genome":[161],"with":[162,173],"enriched":[164],"propagate":[168],"it":[169],"cluster":[171],"patients":[172],"mutations":[174],"similar":[176],"regions.":[178],"Our":[179],"achieves":[181],"superior":[182],"compared":[185],"SOTA":[187],"methods,":[188],"demonstrated":[190],"experiments":[193],"ovarian":[195],"LUAD":[197],"datasets.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-08-10T07:06:39.071514","created_date":"2025-10-10T00:00:00"}