{"id":"https://openalex.org/W4394939108","doi":"https://doi.org/10.1109/tcbb.2024.3385796","title":"A Network Enhancement Method to Identify Spurious Drug-Drug Interactions","display_name":"A Network Enhancement Method to Identify Spurious Drug-Drug Interactions","publication_year":2024,"publication_date":"2024-04-18","ids":{"openalex":"https://openalex.org/W4394939108","doi":"https://doi.org/10.1109/tcbb.2024.3385796","pmid":"https://pubmed.ncbi.nlm.nih.gov/38635380"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2024.3385796","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2024.3385796","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054184997","display_name":"Huan Wang","orcid":"https://orcid.org/0000-0002-3162-2350"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Wang","raw_affiliation_strings":["Key Laboratory of Smart Farming for Agricultural Animals, Engineering Research Center of Intelligent Technology for Agriculture, Ministry of Education, Hubei Engineering Technology Research Center of Agricultural Big Data, and College of Informatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-3162-2350","affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Engineering Research Center of Intelligent Technology for Agriculture, Ministry of Education, Hubei Engineering Technology Research Center of Agricultural Big Data, and College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ziwen Cui","orcid":"https://orcid.org/0000-0002-2210-3110"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziwen Cui","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-2210-3110","affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104283623","display_name":"Yinguang Yang","orcid":"https://orcid.org/0009-0005-2704-3806"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinguang Yang","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":"https://orcid.org/0009-0005-2704-3806","affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065479977","display_name":"B. Wang","orcid":"https://orcid.org/0009-0006-4005-9500"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baijing Wang","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":"https://orcid.org/0009-0006-4005-9500","affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114832713","display_name":"Lida Zhu","orcid":"https://orcid.org/0000-0001-8789-0058"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lida Zhu","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0001-8789-0058","affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100448121","display_name":"Wen Zhang","orcid":"https://orcid.org/0000-0001-5221-2628"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Zhang","raw_affiliation_strings":["Key Laboratory of Smart Farming for Agricultural Animals, Engineering Research Center of Intelligent Technology for Agriculture, Ministry of Education, Hubei Engineering Technology Research Center of Agricultural Big Data, and College of Informatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0001-5221-2628","affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Engineering Research Center of Intelligent Technology for Agriculture, Ministry of Education, Hubei Engineering Technology Research Center of Agricultural Big Data, and College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":null,"apc_paid":null,"fwci":2.594,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.90401972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"21","issue":"5","first_page":"1335","last_page":"1347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9240999817848206,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9235000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.8762738704681396},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7646968960762024},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4560546576976776},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3084286153316498},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28584229946136475},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.14890843629837036}],"concepts":[{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.8762738704681396},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7646968960762024},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4560546576976776},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3084286153316498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28584229946136475},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.14890843629837036}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2024.3385796","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2024.3385796","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38635380","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38635380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1578932543","https://openalex.org/W2046584449","https://openalex.org/W2123060905","https://openalex.org/W2467779447","https://openalex.org/W2473876819","https://openalex.org/W2746995956","https://openalex.org/W2750707006","https://openalex.org/W2755012395","https://openalex.org/W2767891136","https://openalex.org/W2937963363","https://openalex.org/W2946438679","https://openalex.org/W2952343887","https://openalex.org/W2952522777","https://openalex.org/W2965993245","https://openalex.org/W2974658886","https://openalex.org/W2999886378","https://openalex.org/W3004960822","https://openalex.org/W3008216748","https://openalex.org/W3017228204","https://openalex.org/W3024894285","https://openalex.org/W3035011799","https://openalex.org/W3088680691","https://openalex.org/W3094497296","https://openalex.org/W3094946818","https://openalex.org/W3156650687","https://openalex.org/W3160363665","https://openalex.org/W3195617298","https://openalex.org/W3198755792","https://openalex.org/W4200227922","https://openalex.org/W4200565005","https://openalex.org/W4205463297","https://openalex.org/W4292425860","https://openalex.org/W4296044817","https://openalex.org/W4307093167","https://openalex.org/W4309842604","https://openalex.org/W4313405519","https://openalex.org/W4379967792","https://openalex.org/W4380204660","https://openalex.org/W4380551520","https://openalex.org/W4384696429","https://openalex.org/W4385636941","https://openalex.org/W6748856961","https://openalex.org/W6773867245","https://openalex.org/W6845955646"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3113091479","https://openalex.org/W2162899405","https://openalex.org/W941090075","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2075065631","https://openalex.org/W2519167559"],"abstract_inverted_index":{"As":[0],"medical":[1],"safety":[2],"and":[3,66,87,111,137],"drug":[4,59,123],"regulation":[5],"gain":[6],"heightened":[7],"attention,":[8],"the":[9,45,63,68,95,105,108,112,127,139],"detection":[10],"of":[11,70,97,141],"spurious":[12,89,142,151,163],"drug-drug":[13],"interactions":[14],"(DDI)":[15],"has":[16,32],"become":[17],"key":[18,103],"in":[19,44,161],"healthcare.":[20],"Although":[21],"current":[22],"research":[23],"using":[24],"graph":[25],"neural":[26],"networks":[27],"(GNNs)":[28],"to":[29,39,85,133],"predict":[30],"DDI":[31,43,47,98,143],"shown":[33],"impressive":[34],"results,":[35],"it":[36],"often":[37],"fails":[38],"account":[40],"for":[41,93],"false":[42,55],"constructed":[46],"networks.":[48,99],"Such":[49],"inaccuracies":[50],"caused":[51],"by":[52],"data":[53],"errors,":[54],"alarms,":[56],"or":[57],"incorrect":[58],"details":[60],"can":[61],"skew":[62],"network's":[64],"structure":[65],"hinder":[67],"accuracy":[69,96],"GNN-based":[71],"predictions.":[72],"To":[73],"tackle":[74],"this":[75],"challenge,":[76],"we":[77],"propose":[78],"ANSM,":[79],"a":[80],"network-enhancement":[81],"method":[82],"specifically":[83],"designed":[84],"identify":[86],"attenuate":[88],"links":[90],"between":[91],"drugs":[92],"ensuring":[94],"ANSM":[100,157],"integrates":[101],"three":[102],"components:":[104],"feature":[106,116,135],"extractor,":[107],"network":[109,128,131],"optimizer,":[110],"discriminative":[113,146],"classifier.":[114],"The":[115,145],"extractor":[117],"captures":[118],"local":[119],"structural":[120],"features":[121],"from":[122],"node":[124],"pairs,":[125],"while":[126],"optimizer":[129],"leverages":[130],"information":[132],"improve":[134],"extraction":[136],"reduce":[138],"impact":[140],"links.":[144,152],"classifier":[147],"then":[148],"identifies":[149],"potential":[150],"Experimental":[153],"results":[154],"demonstrate":[155],"that":[156],"outperforms":[158],"state-of-the-art":[159],"methods":[160],"identifying":[162],"DDI.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}