{"id":"https://openalex.org/W4379985215","doi":"https://doi.org/10.1109/tcbb.2023.3284505","title":"Predicting Disease-Associated N7\u2013Methylguanosine (m<sup>7</sup>G) Sites via Random Walk on Heterogeneous Network","display_name":"Predicting Disease-Associated N7\u2013Methylguanosine (m<sup>7</sup>G) Sites via Random Walk on Heterogeneous Network","publication_year":2023,"publication_date":"2023-06-09","ids":{"openalex":"https://openalex.org/W4379985215","doi":"https://doi.org/10.1109/tcbb.2023.3284505","pmid":"https://pubmed.ncbi.nlm.nih.gov/37294648"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2023.3284505","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2023.3284505","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059183788","display_name":"Huang Yi-ran","orcid":"https://orcid.org/0000-0001-6289-8766"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiran Huang","raw_affiliation_strings":["School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","Guangxi Universities Key Laboratory of Parallel and Distributed Computing and Guangxi Key Laboratory of Multimedia Communications and Network Technology, Guangxi University, Nanning, China"],"affiliations":[{"raw_affiliation_string":"School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi Universities Key Laboratory of Parallel and Distributed Computing and Guangxi Key Laboratory of Multimedia Communications and Network Technology, Guangxi University, Nanning, China","institution_ids":["https://openalex.org/I150807315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106484714","display_name":"Zhihong Wu","orcid":"https://orcid.org/0009-0009-2272-9912"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihong Wu","raw_affiliation_strings":["School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China"],"affiliations":[{"raw_affiliation_string":"School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041285376","display_name":"Wei Lan","orcid":"https://orcid.org/0000-0001-5839-7504"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lan","raw_affiliation_strings":["School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","Guangxi Universities Key Laboratory of Parallel and Distributed Computing and Guangxi Key Laboratory of Multimedia Communications and Network Technology, Guangxi University, Nanning, China","Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China"],"affiliations":[{"raw_affiliation_string":"School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi Universities Key Laboratory of Parallel and Distributed Computing and Guangxi Key Laboratory of Multimedia Communications and Network Technology, Guangxi University, Nanning, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101747550","display_name":"Cheng Zhong","orcid":"https://orcid.org/0000-0002-5560-2151"},"institutions":[{"id":"https://openalex.org/I150807315","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167","country_code":"CN","type":"education","lineage":["https://openalex.org/I150807315"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Zhong","raw_affiliation_strings":["School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","Guangxi Universities Key Laboratory of Parallel and Distributed Computing and Guangxi Key Laboratory of Multimedia Communications and Network Technology, Guangxi University, Nanning, China"],"affiliations":[{"raw_affiliation_string":"School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Yiran Huang is with the School of Computer, Electronics and Information, Guangxi University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I150807315"]},{"raw_affiliation_string":"Guangxi Universities Key Laboratory of Parallel and Distributed Computing and Guangxi Key Laboratory of Multimedia Communications and Network Technology, Guangxi University, Nanning, China","institution_ids":["https://openalex.org/I150807315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059183788"],"corresponding_institution_ids":["https://openalex.org/I150807315"],"apc_list":null,"apc_paid":null,"fwci":2.0061,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.86441892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"5","first_page":"3173","last_page":"3181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.6147692203521729},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6047048568725586},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.33903560042381287},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17894074320793152},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.15926361083984375},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.0786348283290863}],"concepts":[{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.6147692203521729},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6047048568725586},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33903560042381287},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17894074320793152},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15926361083984375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0786348283290863},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006151","descriptor_name":"Guanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2023.3284505","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2023.3284505","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37294648","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37294648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.550000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1655953585","display_name":null,"funder_award_id":"61961004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2005522715","display_name":null,"funder_award_id":"Natural Science Foundation of Guangxi","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7614210686","display_name":null,"funder_award_id":"2020GXNSFAA159074","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8262811428","display_name":null,"funder_award_id":"61862006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1597704210","https://openalex.org/W1906138272","https://openalex.org/W2035618305","https://openalex.org/W2038122249","https://openalex.org/W2070779203","https://openalex.org/W2071723661","https://openalex.org/W2077528068","https://openalex.org/W2082565035","https://openalex.org/W2100443476","https://openalex.org/W2105079791","https://openalex.org/W2118557731","https://openalex.org/W2119412782","https://openalex.org/W2122732537","https://openalex.org/W2128049108","https://openalex.org/W2129769331","https://openalex.org/W2136945519","https://openalex.org/W2148499186","https://openalex.org/W2154654747","https://openalex.org/W2180304330","https://openalex.org/W2346950316","https://openalex.org/W2625581340","https://openalex.org/W2737592062","https://openalex.org/W2768466792","https://openalex.org/W2913060526","https://openalex.org/W2938096234","https://openalex.org/W2971063457","https://openalex.org/W2971130449","https://openalex.org/W2996505894","https://openalex.org/W3010754381","https://openalex.org/W3025364826","https://openalex.org/W3044861841","https://openalex.org/W3096693229","https://openalex.org/W3129154869","https://openalex.org/W3135418749","https://openalex.org/W3138476244","https://openalex.org/W3188557385","https://openalex.org/W3196991641","https://openalex.org/W4200236626","https://openalex.org/W4280644103","https://openalex.org/W4288058395","https://openalex.org/W4293512880","https://openalex.org/W6838576935"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2935759653","https://openalex.org/W3105167352","https://openalex.org/W54078636","https://openalex.org/W2954470139","https://openalex.org/W1501425562","https://openalex.org/W2902782467","https://openalex.org/W3084825885","https://openalex.org/W2298861036","https://openalex.org/W2271181815"],"abstract_inverted_index":{"Recent":[0],"studies":[1,31],"revealed":[2],"that":[3,168],"the":[4,54,57,74,77,102,111,126,131,161,177,185],"modification":[5],"of":[6,56,66,76,105,134,187],"N7-methylguanosine":[7],"(m<sup>7</sup>G)":[8],"has":[9],"associations":[10,94,114,129,159],"with":[11,110,130,152],"many":[12],"human":[13],"diseases.":[14,48],"Effectively":[15],"identifying":[16],"disease-associated":[17,38,78],"m<sup>7</sup>G":[18,39,45,67,79,106,117,135],"methylation":[19],"sites":[20,40,46],"would":[21],"provide":[22],"crucial":[23],"clues":[24],"for":[25],"disease":[26,109,121,138],"diagnosis":[27],"and":[28,47,69,108,120,137],"treatment.":[29],"Previous":[30],"have":[32,51],"developed":[33],"computational":[34,87],"methods":[35],"to":[36,91,115,139,155,176],"predict":[37,92],"based":[41],"on":[42,53,62,160],"similarities":[43],"among":[44],"However,":[49],"few":[50],"focused":[52],"influence":[55],"known":[58,112,127],"m<sup>7</sup>G-disease":[59,93,113,128,142,158,192],"association":[60],"information":[61,104],"calculating":[63],"similarity":[64,119,133],"measures":[65],"site":[68,107,118,136],"disease,":[70],"which":[71],"potentially":[72],"promotes":[73],"identification":[75],"sites.":[80],"In":[81],"this":[82],"work,":[83],"we":[84],"propose":[85],"\u0430":[86],"method":[88,170],"called":[89],"m<sup>7</sup>GDP-RW":[90,99,124,146,188],"by":[95],"random":[96,150],"walk":[97,151],"algorithm.":[98],"first":[100],"incorporates":[101],"feature":[103],"compute":[116],"similarity.":[122],"Then":[123],"combines":[125],"computed":[132],"construct":[140],"a":[141,148],"heterogeneous":[143,162],"network.":[144,163],"Finally,":[145],"utilizes":[147],"two-pass":[149],"restart":[153],"algorithm":[154],"find":[156],"novel":[157],"The":[164,180],"experimental":[165],"results":[166],"show":[167],"our":[169],"achieves":[171],"higher":[172],"prediction":[173],"accuracy":[174],"compared":[175],"existing":[178],"methods.":[179],"study":[181],"case":[182],"also":[183],"demonstrates":[184],"effectiveness":[186],"in":[189],"discovering":[190],"potential":[191],"associations.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2023-06-10T00:00:00"}