{"id":"https://openalex.org/W4304758198","doi":"https://doi.org/10.1109/tcbb.2022.3213914","title":"Assessment of Prediction Uncertainty Quantification Methods in Systems Biology","display_name":"Assessment of Prediction Uncertainty Quantification Methods in Systems Biology","publication_year":2022,"publication_date":"2022-10-12","ids":{"openalex":"https://openalex.org/W4304758198","doi":"https://doi.org/10.1109/tcbb.2022.3213914","pmid":"https://pubmed.ncbi.nlm.nih.gov/36223355"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2022.3213914","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3213914","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/4359833/09917308.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/8857/4359833/09917308.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032919554","display_name":"Alejandro F. Villaverde","orcid":"https://orcid.org/0000-0001-7401-7380"},"institutions":[{"id":"https://openalex.org/I2802755756","display_name":"Centro de Supercomputaci\u00f3n de Galicia","ror":"https://ror.org/02z51cq88","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2802755756"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro F. Villaverde","raw_affiliation_strings":["CITMAga, Santiago de Compostela, Galicia, Spain","CITMAga, 15782 Santiago de Compostela, Galicia, Spain","Department of Systems and Control Engineering, Universidade de Vigo, Vigo, Galicia, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7401-7380","affiliations":[{"raw_affiliation_string":"CITMAga, Santiago de Compostela, Galicia, Spain","institution_ids":["https://openalex.org/I2802755756"]},{"raw_affiliation_string":"CITMAga, 15782 Santiago de Compostela, Galicia, Spain","institution_ids":["https://openalex.org/I2802755756"]},{"raw_affiliation_string":"Department of Systems and Control Engineering, Universidade de Vigo, Vigo, Galicia, Spain","institution_ids":["https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025694782","display_name":"Elba Raim\u00fandez","orcid":"https://orcid.org/0000-0002-2790-6668"},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elba Raim\u00fandez","raw_affiliation_strings":["Universität Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universität Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063254041","display_name":"Jan Hasenauer","orcid":"https://orcid.org/0000-0002-4935-3312"},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2802755756","display_name":"Centro de Supercomputaci\u00f3n de Galicia","ror":"https://ror.org/02z51cq88","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2802755756"]}],"countries":["DE","ES"],"is_corresponding":false,"raw_author_name":"Jan Hasenauer","raw_affiliation_strings":["Universität Bonn, Bonn, Germany","CITMAga, 15782 Santiago de Compostela, Galicia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universität Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"CITMAga, 15782 Santiago de Compostela, Galicia, Spain","institution_ids":["https://openalex.org/I2802755756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090264675","display_name":"Julio R. Banga","orcid":"https://orcid.org/0000-0002-4245-0320"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210098595","display_name":"Misi\u00f3n Biol\u00f3gica de Galicia","ror":"https://ror.org/00tpn9z48","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210098595"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio R. Banga","raw_affiliation_strings":["Computational Biology Lab, Biological Mission of Galicia (Spanish National Research Council, MBG-CSIC), Pontevedra, Galicia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4245-0320","affiliations":[{"raw_affiliation_string":"Computational Biology Lab, Biological Mission of Galicia (Spanish National Research Council, MBG-CSIC), Pontevedra, Galicia, Spain","institution_ids":["https://openalex.org/I4210098595","https://openalex.org/I134820265"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3511,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.93809593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"20","issue":"3","first_page":"1725","last_page":"1736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8826000094413757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8826000094413757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8626000285148621,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7649999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.9025126695632935},{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"Uncertainty quantification","score":0.650979220867157},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6166786551475525},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5420549511909485},{"id":"https://openalex.org/keywords/strengths-and-weaknesses","display_name":"Strengths and weaknesses","score":0.5172151327133179},{"id":"https://openalex.org/keywords/experimental-data","display_name":"Experimental data","score":0.45972320437431335},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.4570704698562622},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.42638060450553894},{"id":"https://openalex.org/keywords/uncertainty-analysis","display_name":"Uncertainty analysis","score":0.424514502286911},{"id":"https://openalex.org/keywords/sensitivity-analysis","display_name":"Sensitivity analysis","score":0.4141903817653656},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.32335609197616577},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3227623701095581},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.29888471961021423},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.29058516025543213},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25751611590385437},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.16905885934829712},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.09221023321151733},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07537880539894104}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.9025126695632935},{"id":"https://openalex.org/C32230216","wikidata":"https://www.wikidata.org/wiki/Q7882499","display_name":"Uncertainty quantification","level":2,"score":0.650979220867157},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6166786551475525},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5420549511909485},{"id":"https://openalex.org/C63882131","wikidata":"https://www.wikidata.org/wiki/Q17122954","display_name":"Strengths and weaknesses","level":2,"score":0.5172151327133179},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.45972320437431335},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.4570704698562622},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.42638060450553894},{"id":"https://openalex.org/C177803969","wikidata":"https://www.wikidata.org/wiki/Q29205","display_name":"Uncertainty analysis","level":2,"score":0.424514502286911},{"id":"https://openalex.org/C176147448","wikidata":"https://www.wikidata.org/wiki/Q1889114","display_name":"Sensitivity analysis","level":3,"score":0.4141903817653656},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.32335609197616577},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3227623701095581},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.29888471961021423},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.29058516025543213},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25751611590385437},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.16905885934829712},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.09221023321151733},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07537880539894104},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1109/tcbb.2022.3213914","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3213914","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/4359833/09917308.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36223355","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36223355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null},{"id":"pmh:oai:push-zb.helmholtz-munich.de:67498","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=67498","pdf_url":"https://push-zb.helmholtz-munich.de/deliver.php?id=35800","source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM Trans. Comput. Biol. Bioinform. 20, 1725-1736 (2022)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/286357","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/286357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:67498","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67498","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM Trans. Comput. Biol. Bioinform., DOI: 10.1109/TCBB.2022.3213914 (2022)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.investigo.biblioteca.uvigo.es:11093/4170","is_oa":true,"landing_page_url":"http://hdl.handle.net/11093/4170","pdf_url":null,"source":{"id":"https://openalex.org/S4377196408","display_name":"Investigo Institutional repository of UVigo (Universidade de Vigo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I6289922","host_organization_name":"Universidade de Vigo","host_organization_lineage":["https://openalex.org/I6289922"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1109/tcbb.2022.3213914","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3213914","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/4359833/09917308.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G1091473466","display_name":null,"funder_award_id":"ED431F 2021/003","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G1521016025","display_name":"EXC 2047: Hausdorff Center for Mathematics (HCM)","funder_award_id":"390685813","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1771795543","display_name":null,"funder_award_id":"PID2020-117271RB-C22","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G2114305129","display_name":null,"funder_award_id":"MCIN/AEI/ 10.13039","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2262748287","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G2601397997","display_name":null,"funder_award_id":"10.13039/501100011033","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G300979063","display_name":null,"funder_award_id":"10.13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3412273058","display_name":null,"funder_award_id":"AEI/ 10.13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3480869486","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3681454997","display_name":null,"funder_award_id":"13039/501100011033","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4042783231","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4120009395","display_name":null,"funder_award_id":"RYC-2019-027537-I","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G425668148","display_name":null,"funder_award_id":".13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G4462967385","display_name":null,"funder_award_id":"ED431F","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G4549622993","display_name":null,"funder_award_id":"EXC 2151","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4718490797","display_name":null,"funder_award_id":"MCIN/AEI/ 10.13039/501100011033","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G5080475149","display_name":null,"funder_award_id":"10.13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5127146920","display_name":null,"funder_award_id":"EXC-2047/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5601183438","display_name":null,"funder_award_id":"EXC 2151","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5683662034","display_name":"TRR 333: Braunes und beiges Fett  Organinteraktionen, Signalwege und Energiehaushalt (BATenergy)","funder_award_id":"450149205","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6218905885","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G6238101420","display_name":null,"funder_award_id":"686282","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7149750178","display_name":null,"funder_award_id":"MCIN/AEI/ 10.13039/501100011033","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7266728691","display_name":null,"funder_award_id":"13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G7515004340","display_name":"Generation of the CanPath prototype - a platform for predictive cancer pathway modeling","funder_award_id":"686282","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8796401741","display_name":"EXC 2151: ImmunoSensation2  the immune sensory system","funder_award_id":"390873048","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8909017353","display_name":null,"funder_award_id":"MCIN/AEI/ 10.13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320326655","display_name":"Xunta de Galicia","ror":"https://ror.org/0181xnw06"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4304758198.pdf","grobid_xml":"https://content.openalex.org/works/W4304758198.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1975383652","https://openalex.org/W2020228681","https://openalex.org/W2023106695","https://openalex.org/W2041215343","https://openalex.org/W2064446502","https://openalex.org/W2104772878","https://openalex.org/W2105437542","https://openalex.org/W2109320913","https://openalex.org/W2110517028","https://openalex.org/W2117057692","https://openalex.org/W2126817055","https://openalex.org/W2131230954","https://openalex.org/W2159482231","https://openalex.org/W2179083909","https://openalex.org/W2259909839","https://openalex.org/W2310232479","https://openalex.org/W2336517807","https://openalex.org/W2416901147","https://openalex.org/W2524449277","https://openalex.org/W2728562028","https://openalex.org/W2782661788","https://openalex.org/W2808342221","https://openalex.org/W2905097210","https://openalex.org/W2952056515","https://openalex.org/W2964036097","https://openalex.org/W2998087029","https://openalex.org/W3016545960","https://openalex.org/W3126293391","https://openalex.org/W3139456908","https://openalex.org/W3142344196","https://openalex.org/W3204234525"],"related_works":["https://openalex.org/W2116089868","https://openalex.org/W4249135812","https://openalex.org/W93577605","https://openalex.org/W1991803138","https://openalex.org/W2033170585","https://openalex.org/W1983007452","https://openalex.org/W4387046439","https://openalex.org/W3128892391","https://openalex.org/W2115703496","https://openalex.org/W2124353633"],"abstract_inverted_index":{"Biological":[0],"processes":[1],"are":[2,15,56],"often":[3],"modelled":[4],"using":[5],"ordinary":[6],"differential":[7],"equations.":[8],"The":[9,27],"unknown":[10],"parameters":[11],"of":[12,21,35,58,75,83,111,122],"these":[13,45],"models":[14],"estimated":[16],"by":[17],"optimizing":[18],"the":[19,51,72,112,128,143],"fit":[20],"model":[22,61,76],"simulation":[23],"and":[24,94,133,151],"experimental":[25],"data.":[26],"resulting":[28,52],"parameter":[29,46],"estimates":[30],"inevitably":[31],"possess":[32],"some":[33],"degree":[34],"uncertainty.":[36],"In":[37],"practical":[38],"applications":[39],"it":[40,153],"is":[41,68],"important":[42],"to":[43,71,118],"quantify":[44],"uncertainties":[47,57,66],"as":[48,50],"well":[49],"prediction":[53,65],"uncertainty,":[54],"which":[55],"potentially":[59],"time-dependent":[60],"characteristics.":[62],"Unfortunately,":[63],"estimating":[64],"accurately":[67],"nontrivial,":[69],"due":[70],"nonlinear":[73],"dependence":[74],"characteristics":[77],"on":[78],"parameters.":[79],"While":[80],"a":[81,148],"number":[82],"numerical":[84],"approaches":[85],"have":[86,96],"been":[87,98],"proposed":[88],"for":[89,115,141,147],"this":[90,104],"task,":[91],"their":[92,131,134],"strengths":[93],"weaknesses":[95],"not":[97],"systematically":[99],"assessed":[100],"yet.":[101],"To":[102],"fill":[103],"knowledge":[105],"gap,":[106],"we":[107],"apply":[108],"four":[109,119],"state":[110],"art":[113],"methods":[114],"uncertainty":[116],"quantification":[117],"case":[120],"studies":[121],"different":[123],"computational":[124],"complexities.":[125],"This":[126],"reveals":[127],"trade-offs":[129],"between":[130],"applicability":[132],"statistical":[135],"interpretability.":[136],"Our":[137],"results":[138],"provide":[139],"guidelines":[140],"choosing":[142],"most":[144],"appropriate":[145],"technique":[146],"given":[149],"problem":[150],"applying":[152],"successfully.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-07-03T08:13:44.112507","created_date":"2025-10-10T00:00:00"}