{"id":"https://openalex.org/W4281259900","doi":"https://doi.org/10.1109/tcbb.2022.3176456","title":"MuCoMiD: A <b>Mu</b>ltitask Graph <b>Co</b>nvolutional Learning Framework for <b>mi</b>RNA-<b>D</b>isease Association Prediction","display_name":"MuCoMiD: A <b>Mu</b>ltitask Graph <b>Co</b>nvolutional Learning Framework for <b>mi</b>RNA-<b>D</b>isease Association Prediction","publication_year":2022,"publication_date":"2022-05-20","ids":{"openalex":"https://openalex.org/W4281259900","doi":"https://doi.org/10.1109/tcbb.2022.3176456","pmid":"https://pubmed.ncbi.nlm.nih.gov/35594217"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2022.3176456","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3176456","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019546782","display_name":"Thi Ngan Dong","orcid":"https://orcid.org/0000-0002-3240-9068"},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]},{"id":"https://openalex.org/I4210136150","display_name":"L3S Research Center","ror":"https://ror.org/039t4wk02","country_code":"DE","type":"facility","lineage":["https://openalex.org/I114112103","https://openalex.org/I4210136150","https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ngan Dong","raw_affiliation_strings":["L3S Research Center, Leibniz University of Hannover, Hannover, Germany","L3S Research Center, Leibniz Universitat Hannover, 26555 Hannover, Lower Saxony, Germany, 30167"],"raw_orcid":"https://orcid.org/0000-0002-3240-9068","affiliations":[{"raw_affiliation_string":"L3S Research Center, Leibniz University of Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I4210136150"]},{"raw_affiliation_string":"L3S Research Center, Leibniz Universitat Hannover, 26555 Hannover, Lower Saxony, Germany, 30167","institution_ids":["https://openalex.org/I4210136150","https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054570560","display_name":"Stefanie M\u00fccke","orcid":"https://orcid.org/0000-0001-9890-4523"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanie M\u00fccke","raw_affiliation_strings":["TRAIN Omics, Translational Alliance in Lower Saxony, Hannover, Germany","TRAIN Omics, Translational Alliance in Lower Saxony, Hannover, Lower Saxony, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9890-4523","affiliations":[{"raw_affiliation_string":"TRAIN Omics, Translational Alliance in Lower Saxony, Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"TRAIN Omics, Translational Alliance in Lower Saxony, Hannover, Lower Saxony, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027689420","display_name":"Megha Khosla","orcid":"https://orcid.org/0000-0002-0319-3181"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Megha Khosla","raw_affiliation_strings":["Delft University of Technology (TU Delft), Delft, CD, Netherlands","Intelligent Systems, Delft University of Technology, 2860 Delft, Zuid-Holland, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-0319-3181","affiliations":[{"raw_affiliation_string":"Delft University of Technology (TU Delft), Delft, CD, Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Intelligent Systems, Delft University of Technology, 2860 Delft, Zuid-Holland, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.252,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78667719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"19","issue":"6","first_page":"3081","last_page":"3092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/overfitting","display_name":"Overfitting","score":0.8999086618423462},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7004621624946594},{"id":"https://openalex.org/keywords/multi-task-learning","display_name":"Multi-task learning","score":0.6984712481498718},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.63619464635849},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.556451141834259},{"id":"https://openalex.org/keywords/scarcity","display_name":"Scarcity","score":0.5530569553375244},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5203747153282166},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4565649926662445},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43276673555374146},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.1735934615135193},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14296388626098633},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.10030370950698853},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.0940452516078949},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.0926513671875}],"concepts":[{"id":"https://openalex.org/C22019652","wikidata":"https://www.wikidata.org/wiki/Q331309","display_name":"Overfitting","level":3,"score":0.8999086618423462},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7004621624946594},{"id":"https://openalex.org/C28006648","wikidata":"https://www.wikidata.org/wiki/Q6934509","display_name":"Multi-task learning","level":3,"score":0.6984712481498718},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.63619464635849},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.556451141834259},{"id":"https://openalex.org/C109747225","wikidata":"https://www.wikidata.org/wiki/Q815758","display_name":"Scarcity","level":2,"score":0.5530569553375244},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5203747153282166},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4565649926662445},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43276673555374146},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.1735934615135193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14296388626098633},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.10030370950698853},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0940452516078949},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.0926513671875},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C175444787","wikidata":"https://www.wikidata.org/wiki/Q39072","display_name":"Microeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tcbb.2022.3176456","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3176456","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35594217","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35594217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null},{"id":"pmh:oai:tudelft.nl:uuid:5a372c27-1f91-4321-a1f0-b560f0b6dcf1","is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:5a372c27-1f91-4321-a1f0-b560f0b6dcf1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G367552324","display_name":"Internationales Leibniz Zukunftslabor K\u00fcnstliche Intelligenz","funder_award_id":"01DD20003","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G5480750190","display_name":null,"funder_award_id":"11-76251-99-3/19","funder_id":"https://openalex.org/F4320326493","funder_display_name":"Nieders\u00e4chsisches Ministerium f\u00fcr Wissenschaft und Kultur"},{"id":"https://openalex.org/G8606806560","display_name":null,"funder_award_id":"76251-99","funder_id":"https://openalex.org/F4320326493","funder_display_name":"Nieders\u00e4chsisches Ministerium f\u00fcr Wissenschaft und Kultur"}],"funders":[{"id":"https://openalex.org/F4320320882","display_name":"Volkswagen Foundation","ror":"https://ror.org/03bsmfz84"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320326493","display_name":"Nieders\u00e4chsisches Ministerium f\u00fcr Wissenschaft und Kultur","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1601459316","https://openalex.org/W1979268646","https://openalex.org/W1990061381","https://openalex.org/W2017426710","https://openalex.org/W2017570593","https://openalex.org/W2032395102","https://openalex.org/W2053039860","https://openalex.org/W2055506356","https://openalex.org/W2096173332","https://openalex.org/W2097869179","https://openalex.org/W2115441328","https://openalex.org/W2129158737","https://openalex.org/W2141222510","https://openalex.org/W2142937131","https://openalex.org/W2158135353","https://openalex.org/W2159092541","https://openalex.org/W2165437648","https://openalex.org/W2170952313","https://openalex.org/W2572986783","https://openalex.org/W2802314916","https://openalex.org/W2808496637","https://openalex.org/W2895841321","https://openalex.org/W2898799689","https://openalex.org/W2903959374","https://openalex.org/W2936144882","https://openalex.org/W2952799694","https://openalex.org/W2964015378","https://openalex.org/W2972551688","https://openalex.org/W2972771793","https://openalex.org/W2979556676","https://openalex.org/W2995337846","https://openalex.org/W3000082418","https://openalex.org/W3017317719","https://openalex.org/W3021920177","https://openalex.org/W3093863546","https://openalex.org/W3117987410","https://openalex.org/W3128158319","https://openalex.org/W3146565636","https://openalex.org/W3157330827","https://openalex.org/W3165614405","https://openalex.org/W3214353330","https://openalex.org/W4233698560","https://openalex.org/W4246271082","https://openalex.org/W6726873649"],"related_works":["https://openalex.org/W4362597605","https://openalex.org/W1574414179","https://openalex.org/W4297676672","https://openalex.org/W3009056573","https://openalex.org/W2922073769","https://openalex.org/W4281702477","https://openalex.org/W2490526372","https://openalex.org/W4376166922","https://openalex.org/W4378510483","https://openalex.org/W3099765033"],"abstract_inverted_index":{"Growing":[0],"evidence":[1],"from":[2,81,117,226],"recent":[3,45],"studies":[4],"implies":[5],"that":[6,57],"microRNAs":[7],"or":[8],"miRNAs":[9,24],"could":[10],"serve":[11],"as":[12,107,173,175,210,212],"biomarkers":[13],"in":[14,44,50,140,213,253],"various":[15],"complex":[16],"human":[17],"diseases.":[18],"Since":[19],"wet-lab":[20],"experiments":[21,167],"for":[22,36,268],"detecting":[23],"associated":[25],"with":[26,74,206],"a":[27,97,141,146,251],"disease":[28,138,259],"are":[29],"expensive":[30],"and":[31,84,126,137,149,183,235,270],"time-consuming,":[32],"machine":[33,53],"learning":[34,54,224],"techniques":[35],"miRNA-disease":[37],"association":[38],"prediction":[39],"have":[40],"attracted":[41],"much":[42],"attention":[43],"years.":[46],"A":[47],"big":[48],"challenge":[49],"building":[51],"reliable":[52],"models":[55,197],"is":[56,145,231,250],"of":[58,92,161,216,223,245],"data":[59,85],"scarcity.":[60],"In":[61],"particular,":[62],"existing":[63,93],"approaches":[64],"trained":[65],"on":[66,168,176,198],"the":[67,90,158,169,214,254],"available":[68],"small":[69],"datasets,":[70],"even":[71],"when":[72],"combined":[73],"precalculated":[75],"handcrafted":[76,238],"input":[77,228],"features,":[78],"often":[79],"suffer":[80],"bad":[82],"generalization":[83,159],"leakage":[86],"problems.":[87],"We":[88,264],"overcome":[89],"limitations":[91],"works":[94],"by":[95],"proposing":[96],"novel":[98,147],"multitask":[99,142],"graph":[100],"convolution-based":[101],"approach,":[102],"which":[103,144,241],"we":[104,164],"refer":[105],"to":[106,220,233],"MuCoMiD.":[108],"MuCoMiD":[109,186,230],"allows":[110],"automatic":[111],"feature":[112],"extraction":[113],"while":[114],"incorporating":[115],"knowledge":[116],"five":[118],"heterogeneous":[119],"biological":[120],"information":[121,256],"sources":[122,257],"(associations":[123],"between":[124,131],"miRNAs/diseases":[125],"protein-coding":[127,132],"genes":[128],"(PCGs),":[129],"interactions":[130],"genes,":[133],"miRNA":[134],"family":[135],"information,":[136,229],"ontology)":[139],"setting":[143],"perspective":[148],"has":[150],"not":[151],"been":[152],"studied":[153],"before.":[154],"To":[155],"effectively":[156],"test":[157],"capability":[160,222],"our":[162,177,266],"model,":[163],"conduct":[165],"large-scale":[166],"standard":[170],"benchmark":[171],"datasets":[172],"well":[174,211],"proposed":[178],"large":[179,200],"independent":[180,201],"testing":[181,202],"sets":[182],"case":[184],"studies.":[185],"obtains":[187],"significantly":[188],"higher":[189],"Average":[190],"Precision":[191],"(AP)":[192],"scores":[193],"than":[194,237],"all":[195],"benchmarked":[196],"three":[199],"sets,":[203],"especially":[204],"those":[205],"many":[207],"new":[208],"miRNAs,":[209],"detection":[215],"false":[217],"positives.":[218],"Thanks":[219],"its":[221],"directly":[225],"raw":[227],"easier":[232],"maintain":[234],"update":[236],"feature-based":[239],"methods,":[240],"would":[242],"require":[243],"recomputation":[244],"features":[246],"every":[247],"time":[248],"there":[249],"change":[252],"original":[255],"(e.g.,":[258],"ontology,":[260],"miRNA/disease-PCG":[261],"associations,":[262],"etc.).":[263],"share":[265],"code":[267],"reproducibility":[269],"future":[271],"research":[272],"at":[273],"https://git.l3s.uni-hannover.de/dong/cmtt.":[274]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2022-05-23T00:00:00"}