{"id":"https://openalex.org/W4280607022","doi":"https://doi.org/10.1109/tcbb.2022.3173969","title":"Robust KALMAN Filter State Estimation for Gene Regulatory Networks","display_name":"Robust KALMAN Filter State Estimation for Gene Regulatory Networks","publication_year":2022,"publication_date":"2022-05-10","ids":{"openalex":"https://openalex.org/W4280607022","doi":"https://doi.org/10.1109/tcbb.2022.3173969","pmid":"https://pubmed.ncbi.nlm.nih.gov/35536813"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2022.3173969","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3173969","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017227182","display_name":"Amir Hossein Abolmasoumi","orcid":"https://orcid.org/0000-0001-9739-1340"},"institutions":[{"id":"https://openalex.org/I35510649","display_name":"Arak University","ror":"https://ror.org/00ngrq502","country_code":"IR","type":"education","lineage":["https://openalex.org/I35510649"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["IR","US"],"is_corresponding":true,"raw_author_name":"Amir H. Abolmasoumi","raw_affiliation_strings":["Department of Electrical Engineering, Faculty of Engineering, Arak University, Arak, Iran","Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Falls Church, VA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9739-1340","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Faculty of Engineering, Arak University, Arak, Iran","institution_ids":["https://openalex.org/I35510649"]},{"raw_affiliation_string":"Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Falls Church, VA, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090977106","display_name":"Mohammad Mohammadian","orcid":null},"institutions":[{"id":"https://openalex.org/I4210157180","display_name":"Arak University of Technology","ror":"https://ror.org/053wftt74","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210157180"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Mohammadian","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Arak University of Technology, Arak, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Arak University of Technology, Arak, Iran","institution_ids":["https://openalex.org/I4210157180"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073678278","display_name":"Lamine Mili","orcid":"https://orcid.org/0000-0001-6134-3945"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lamine Mili","raw_affiliation_strings":["Bradley Department of Electrical and Computer Engineering, Northern Virginia Center, Virginia Polytechnic Institute and State University, Falls Church, VA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6134-3945","affiliations":[{"raw_affiliation_string":"Bradley Department of Electrical and Computer Engineering, Northern Virginia Center, Virginia Polytechnic Institute and State University, Falls Church, VA, USA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017227182"],"corresponding_institution_ids":["https://openalex.org/I35510649","https://openalex.org/I859038795"],"apc_list":null,"apc_paid":null,"fwci":0.8493,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71088103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"20","issue":"2","first_page":"1395","last_page":"1405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.7365993857383728},{"id":"https://openalex.org/keywords/kalman-filter","display_name":"Kalman filter","score":0.6777650117874146},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4876059591770172},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.487179696559906},{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.4443839192390442},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4294912815093994},{"id":"https://openalex.org/keywords/extended-kalman-filter","display_name":"Extended Kalman filter","score":0.42499685287475586},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3872496485710144},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.3732326626777649},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2878778874874115},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.256719708442688},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09554183483123779}],"concepts":[{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.7365993857383728},{"id":"https://openalex.org/C157286648","wikidata":"https://www.wikidata.org/wiki/Q846780","display_name":"Kalman filter","level":2,"score":0.6777650117874146},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4876059591770172},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.487179696559906},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.4443839192390442},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4294912815093994},{"id":"https://openalex.org/C206833254","wikidata":"https://www.wikidata.org/wiki/Q5421817","display_name":"Extended Kalman filter","level":3,"score":0.42499685287475586},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3872496485710144},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3732326626777649},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2878778874874115},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.256719708442688},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09554183483123779},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2022.3173969","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3173969","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35536813","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35536813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W640119782","https://openalex.org/W1509039949","https://openalex.org/W1587024196","https://openalex.org/W1645305843","https://openalex.org/W1749494163","https://openalex.org/W1804494423","https://openalex.org/W1822076674","https://openalex.org/W1885340657","https://openalex.org/W1967180093","https://openalex.org/W1979852947","https://openalex.org/W1984916226","https://openalex.org/W1988973871","https://openalex.org/W1999271758","https://openalex.org/W2001114241","https://openalex.org/W2002684146","https://openalex.org/W2004466539","https://openalex.org/W2013171578","https://openalex.org/W2013873232","https://openalex.org/W2023348596","https://openalex.org/W2032909213","https://openalex.org/W2043432167","https://openalex.org/W2046538693","https://openalex.org/W2048430744","https://openalex.org/W2054091988","https://openalex.org/W2061233009","https://openalex.org/W2065881180","https://openalex.org/W2067568029","https://openalex.org/W2068302187","https://openalex.org/W2072035745","https://openalex.org/W2081837126","https://openalex.org/W2083402998","https://openalex.org/W2094224141","https://openalex.org/W2101792624","https://openalex.org/W2109455849","https://openalex.org/W2109944603","https://openalex.org/W2112140459","https://openalex.org/W2119883478","https://openalex.org/W2121652333","https://openalex.org/W2123487311","https://openalex.org/W2127989808","https://openalex.org/W2133897017","https://openalex.org/W2138262972","https://openalex.org/W2139997707","https://openalex.org/W2145137020","https://openalex.org/W2145417574","https://openalex.org/W2152517317","https://openalex.org/W2157886837","https://openalex.org/W2160145365","https://openalex.org/W2163152452","https://openalex.org/W2166787100","https://openalex.org/W2168745297","https://openalex.org/W2324632057","https://openalex.org/W2375099263","https://openalex.org/W2413971139","https://openalex.org/W2527751063","https://openalex.org/W2551758879","https://openalex.org/W2588781374","https://openalex.org/W2800676474","https://openalex.org/W2886298435","https://openalex.org/W2943020437","https://openalex.org/W2964141730","https://openalex.org/W3009274367","https://openalex.org/W4211059059","https://openalex.org/W4213251304"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2089114113","https://openalex.org/W2389555968","https://openalex.org/W2352634297","https://openalex.org/W80107739","https://openalex.org/W2020144404","https://openalex.org/W2385286892","https://openalex.org/W2350927655","https://openalex.org/W2162299404","https://openalex.org/W2103062922"],"abstract_inverted_index":{"This":[0],"paper":[1],"proposes":[2],"a":[3,55,108,164],"revised":[4],"version":[5,166],"of":[6,21,29,32,43,57,137,167],"the":[7,18,27,38,41,44,48,85,94,119,123,130,134,138,150,153,159,168,170,179,189,198],"robust":[8,109],"generalized":[9],"maximum":[10],"likelihood":[11],"(GM)-type":[12],"unscented":[13],"KALMAN":[14],"filter":[15,142],"(GM-UKF)":[16],"for":[17,184,197],"state":[19],"estimation":[20],"gene":[22],"regulatory":[23],"networks":[24],"(GRNs)":[25],"in":[26,63,84,121,126,200],"presence":[28],"different":[30],"types":[31,187],"deviations":[33],"from":[34],"assumptions.":[35],"As":[36],"known,":[37],"parameters":[39],"and":[40,60,65,100,133,163],"power":[42],"assumed":[45],"noises":[46],"within":[47],"GRN":[49],"model":[50,86],"may":[51,70,81,90],"change":[52],"abruptly":[53],"as":[54,129],"result":[56],"jump":[58],"behavior":[59,132],"bursting":[61],"process":[62],"transcription":[64],"translation":[66],"phases.":[67],"Moreover,":[68],"there":[69],"be":[71,91],"outlying":[72],"samples":[73],"among":[74],"genomic":[75],"measurement":[76],"data.":[77],"Some":[78],"other":[79,182],"outliers":[80,89],"also":[82],"occur":[83],"dynamics.":[87],"The":[88,140,174],"misinterpreted":[92],"by":[93],"filtering":[95],"method":[96],"if":[97],"not":[98],"detected":[99],"downweighted.":[101],"To":[102],"deal":[103],"with":[104],"all":[105,185],"such":[106,128],"deviations,":[107],"GM-UKF":[110,180],"is":[111,143,195],"designed":[112],"that":[113,178],"includes":[114],"some":[115],"modifications":[116],"to":[117,145],"address":[118],"challenges":[120],"calculating":[122],"projection":[124],"statistics":[125],"GRNs":[127],"nonlinear":[131],"natural":[135],"distance":[136],"states.":[139],"proposed":[141],"compared":[144],"four":[146],"Bayesian":[147],"filters,":[148],"i.e.,":[149],"conventional":[151],"UKF,":[152],"H":[154,190],"<inline-formula><tex-math":[155,191],"notation=\"LaTeX\">$_{\\infty":[156,192],"}$</tex-math></inline-formula>":[157,193],"-UKF,":[158],"downweighting":[160],"UKF":[161],"(DW-UKF),":[162],"modified":[165],"GM-UKF,":[169],"so-called":[171],"maximum-likelihood":[172],"UKF(M-UKF).":[173],"outcome":[175],"results":[176],"demonstrate":[177],"outperforms":[181],"methods":[183],"outlier":[186],"while":[188],"-UKF":[194],"appropriate":[196],"changes":[199],"noise":[201],"powers.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}