{"id":"https://openalex.org/W4205124816","doi":"https://doi.org/10.1109/tcbb.2022.3141697","title":"Computational Methods for the Analysis and Prediction of EGFR-Mutated Lung Cancer Drug Resistance: Recent Advances in Drug Design, Challenges and Future Prospects","display_name":"Computational Methods for the Analysis and Prediction of EGFR-Mutated Lung Cancer Drug Resistance: Recent Advances in Drug Design, Challenges and Future Prospects","publication_year":2022,"publication_date":"2022-01-10","ids":{"openalex":"https://openalex.org/W4205124816","doi":"https://doi.org/10.1109/tcbb.2022.3141697","pmid":"https://pubmed.ncbi.nlm.nih.gov/35007197"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2022.3141697","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3141697","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Computational_Methods_for_the_Analysis_and_Prediction_of_EGFR-Mutated_Lung_Cancer_Drug_Resistance_Recent_Advances_in_Drug_Design_Challenges_and_Future_Prospects/26827777","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050513983","display_name":"Rizwan Qureshi","orcid":"https://orcid.org/0000-0002-0039-982X"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I201384688","display_name":"National University of Computer and Emerging Sciences","ror":"https://ror.org/003eyb898","country_code":"PK","type":"education","lineage":["https://openalex.org/I201384688"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","PK","QA","US"],"is_corresponding":true,"raw_author_name":"Rizwan Qureshi","raw_affiliation_strings":["Department of Electrical Engineering, City University of Hong Kong, Hong Kong","College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","institution_ids":["https://openalex.org/I201384688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042683997","display_name":"Bin Zou","orcid":"https://orcid.org/0000-0002-6861-4493"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I201384688","display_name":"National University of Computer and Emerging Sciences","ror":"https://ror.org/003eyb898","country_code":"PK","type":"education","lineage":["https://openalex.org/I201384688"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","PK","QA","US"],"is_corresponding":false,"raw_author_name":"Bin Zou","raw_affiliation_strings":["Department of Electrical Engineering, City University of Hong Kong, Hong Kong","Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","institution_ids":["https://openalex.org/I201384688"]},{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073854686","display_name":"Tanvir Alam","orcid":"https://orcid.org/0000-0001-7033-3693"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I201384688","display_name":"National University of Computer and Emerging Sciences","ror":"https://ror.org/003eyb898","country_code":"PK","type":"education","lineage":["https://openalex.org/I201384688"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","PK","QA","US"],"is_corresponding":false,"raw_author_name":"Tanvir Alam","raw_affiliation_strings":["College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,"],"affiliations":[{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","institution_ids":["https://openalex.org/I201384688"]},{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006220393","display_name":"Jia Wu","orcid":"https://orcid.org/0000-0001-8392-8338"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I201384688","display_name":"National University of Computer and Emerging Sciences","ror":"https://ror.org/003eyb898","country_code":"PK","type":"education","lineage":["https://openalex.org/I201384688"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","PK","QA","US"],"is_corresponding":false,"raw_author_name":"Jia Wu","raw_affiliation_strings":["Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA","National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,"],"affiliations":[{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","institution_ids":["https://openalex.org/I201384688"]},{"raw_affiliation_string":"the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100743993","display_name":"Victor Lee","orcid":"https://orcid.org/0000-0002-6283-978X"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I201384688","display_name":"National University of Computer and Emerging Sciences","ror":"https://ror.org/003eyb898","country_code":"PK","type":"education","lineage":["https://openalex.org/I201384688"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","PK","QA","US"],"is_corresponding":false,"raw_author_name":"Victor H. F. Lee","raw_affiliation_strings":["Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","institution_ids":["https://openalex.org/I201384688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100644375","display_name":"Hong Yan","orcid":"https://orcid.org/0000-0001-9661-3095"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I201384688","display_name":"National University of Computer and Emerging Sciences","ror":"https://ror.org/003eyb898","country_code":"PK","type":"education","lineage":["https://openalex.org/I201384688"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","PK","QA","US"],"is_corresponding":false,"raw_author_name":"Hong Yan","raw_affiliation_strings":["Department of Electrical Engineering, City University of Hong Kong, Hong Kong","Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Department of Electrical Engineer-ing, City University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong, Hong Kong, and with the Fast School of Comput-ing,","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"National University of Computer and Emerging Sciences, Karachi 75160, Pakistan,","institution_ids":["https://openalex.org/I201384688"]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"the College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5050513983"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I168719708","https://openalex.org/I201384688","https://openalex.org/I4210144839","https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":8.673,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.98519477,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"238","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.807391881942749},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.7022988200187683},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.6934325695037842},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6381856799125671},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5590751767158508},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.5415471196174622},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.49563300609588623},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.48997798562049866},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.43887749314308167},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.4356006979942322},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.43147119879722595},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41728121042251587},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.400982528924942},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3949812650680542},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3418193459510803},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2988949418067932},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.25337502360343933},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16462105512619019},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0849280059337616},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08460533618927002}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.807391881942749},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7022988200187683},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6934325695037842},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6381856799125671},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5590751767158508},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.5415471196174622},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.49563300609588623},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.48997798562049866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43887749314308167},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4356006979942322},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.43147119879722595},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41728121042251587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.400982528924942},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3949812650680542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3418193459510803},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2988949418067932},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25337502360343933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16462105512619019},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0849280059337616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08460533618927002},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tcbb.2022.3141697","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2022.3141697","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35007197","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35007197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null},{"id":"pmh:oai:figshare.com:article/26827777","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Computational_Methods_for_the_Analysis_and_Prediction_of_EGFR-Mutated_Lung_Cancer_Drug_Resistance_Recent_Advances_in_Drug_Design_Challenges_and_Future_Prospects/26827777","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:hub.hku.hk:10722/347906","is_oa":true,"landing_page_url":"https://hub.hku.hk/handle/10722/347906","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/26827777","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Computational_Methods_for_the_Analysis_and_Prediction_of_EGFR-Mutated_Lung_Cancer_Drug_Resistance_Recent_Advances_in_Drug_Design_Challenges_and_Future_Prospects/26827777","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"awards":[{"id":"https://openalex.org/G1859322275","display_name":null,"funder_award_id":"InnoHK","funder_id":"https://openalex.org/F4320321920","funder_display_name":"Innovation and Technology Commission"},{"id":"https://openalex.org/G2642563814","display_name":null,"funder_award_id":"CIMDA","funder_id":"https://openalex.org/F4320321920","funder_display_name":"Innovation and Technology Commission"},{"id":"https://openalex.org/G5330193577","display_name":null,"funder_award_id":"11204821","funder_id":"https://openalex.org/F4320309893","funder_display_name":"City University of Hong Kong"},{"id":"https://openalex.org/G5544219327","display_name":null,"funder_award_id":"9610034","funder_id":"https://openalex.org/F4320309893","funder_display_name":"City University of Hong Kong"}],"funders":[{"id":"https://openalex.org/F4320309893","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23"},{"id":"https://openalex.org/F4320321920","display_name":"Innovation and Technology Commission","ror":"https://ror.org/04vf9tr09"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":171,"referenced_works":["https://openalex.org/W99169666","https://openalex.org/W129942927","https://openalex.org/W1520194282","https://openalex.org/W1523002040","https://openalex.org/W1526983978","https://openalex.org/W1546552389","https://openalex.org/W1549357029","https://openalex.org/W1549816642","https://openalex.org/W1563795667","https://openalex.org/W1834835434","https://openalex.org/W1929984647","https://openalex.org/W1966803171","https://openalex.org/W1967394241","https://openalex.org/W1968324646","https://openalex.org/W1971848312","https://openalex.org/W1973494171","https://openalex.org/W1977185509","https://openalex.org/W1981078630","https://openalex.org/W1982660347","https://openalex.org/W1988782368","https://openalex.org/W1989228404","https://openalex.org/W1991098690","https://openalex.org/W1993169666","https://openalex.org/W1997291694","https://openalex.org/W1999491936","https://openalex.org/W2000231857","https://openalex.org/W2000572824","https://openalex.org/W2004226562","https://openalex.org/W2005312471","https://openalex.org/W2005474992","https://openalex.org/W2012800796","https://openalex.org/W2014849405","https://openalex.org/W2016710415","https://openalex.org/W2018594213","https://openalex.org/W2022948223","https://openalex.org/W2027109368","https://openalex.org/W2028593825","https://openalex.org/W2031973565","https://openalex.org/W2033231433","https://openalex.org/W2038682861","https://openalex.org/W2040299716","https://openalex.org/W2043398720","https://openalex.org/W2044722516","https://openalex.org/W2046799991","https://openalex.org/W2054141820","https://openalex.org/W2070595900","https://openalex.org/W2071040849","https://openalex.org/W2073758233","https://openalex.org/W2078290150","https://openalex.org/W2078933151","https://openalex.org/W2080601747","https://openalex.org/W2082586732","https://openalex.org/W2084817237","https://openalex.org/W2089872551","https://openalex.org/W2090198980","https://openalex.org/W2093858501","https://openalex.org/W2095124748","https://openalex.org/W2097099115","https://openalex.org/W2101786389","https://openalex.org/W2102273931","https://openalex.org/W2102316672","https://openalex.org/W2102365935","https://openalex.org/W2104167441","https://openalex.org/W2108068107","https://openalex.org/W2109773217","https://openalex.org/W2110655770","https://openalex.org/W2110782084","https://openalex.org/W2111072639","https://openalex.org/W2111662961","https://openalex.org/W2112937261","https://openalex.org/W2114933215","https://openalex.org/W2115733720","https://openalex.org/W2118233996","https://openalex.org/W2127760066","https://openalex.org/W2129258733","https://openalex.org/W2132870547","https://openalex.org/W2134574317","https://openalex.org/W2135192471","https://openalex.org/W2137297899","https://openalex.org/W2139119404","https://openalex.org/W2139236349","https://openalex.org/W2142544064","https://openalex.org/W2147925490","https://openalex.org/W2147988069","https://openalex.org/W2149441684","https://openalex.org/W2151357092","https://openalex.org/W2154969724","https://openalex.org/W2157077639","https://openalex.org/W2159013299","https://openalex.org/W2161821474","https://openalex.org/W2165698076","https://openalex.org/W2167341806","https://openalex.org/W2168841596","https://openalex.org/W2171313739","https://openalex.org/W2179425537","https://openalex.org/W2180898434","https://openalex.org/W2187181884","https://openalex.org/W2281688700","https://openalex.org/W2298324804","https://openalex.org/W2311607323","https://openalex.org/W2424454289","https://openalex.org/W2424876691","https://openalex.org/W2464765867","https://openalex.org/W2479380037","https://openalex.org/W2510475640","https://openalex.org/W2510837837","https://openalex.org/W2554688226","https://openalex.org/W2595082024","https://openalex.org/W2610682595","https://openalex.org/W2624385633","https://openalex.org/W2657631929","https://openalex.org/W2722321450","https://openalex.org/W2736835377","https://openalex.org/W2767891136","https://openalex.org/W2770828094","https://openalex.org/W2775708988","https://openalex.org/W2782635154","https://openalex.org/W2784341656","https://openalex.org/W2792066564","https://openalex.org/W2794284562","https://openalex.org/W2794354720","https://openalex.org/W2798613236","https://openalex.org/W2799800440","https://openalex.org/W2808399951","https://openalex.org/W2887711510","https://openalex.org/W2899136361","https://openalex.org/W2906132609","https://openalex.org/W2907384932","https://openalex.org/W2910380368","https://openalex.org/W2921547696","https://openalex.org/W2941644628","https://openalex.org/W2942945599","https://openalex.org/W2945490964","https://openalex.org/W2950104637","https://openalex.org/W2952540014","https://openalex.org/W2953085814","https://openalex.org/W2955594811","https://openalex.org/W2976516489","https://openalex.org/W2992231995","https://openalex.org/W2995320383","https://openalex.org/W3001408868","https://openalex.org/W3003192283","https://openalex.org/W3006091015","https://openalex.org/W3007942792","https://openalex.org/W3008353588","https://openalex.org/W3009608204","https://openalex.org/W3022867981","https://openalex.org/W3027977667","https://openalex.org/W3035604179","https://openalex.org/W3037018542","https://openalex.org/W3078555423","https://openalex.org/W3089488726","https://openalex.org/W3094880241","https://openalex.org/W3099535402","https://openalex.org/W3106417893","https://openalex.org/W3106536628","https://openalex.org/W3115476987","https://openalex.org/W3128646645","https://openalex.org/W3177828909","https://openalex.org/W3199928453","https://openalex.org/W4237417303","https://openalex.org/W4251922469","https://openalex.org/W4313527262","https://openalex.org/W4321000873","https://openalex.org/W6633802082","https://openalex.org/W6717697761","https://openalex.org/W6734460052","https://openalex.org/W6739901393","https://openalex.org/W6758779491","https://openalex.org/W7073782271","https://openalex.org/W7075630220"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W4399651953","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4403376686","https://openalex.org/W4298001029"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,7,20,243],"is":[2,22],"a":[3,12,43,99,215],"major":[4],"cause":[5],"of":[6,26,34,69,80,91,102,118,133,188,228],"deaths":[8],"worldwide,":[9],"and":[10,114,123,151,164,185,190,202,233,238],"has":[11,38],"very":[13],"low":[14],"survival":[15,122],"rate.":[16],"Non-small":[17],"cell":[18],"lung":[19,27,55,242],"(NSCLC)":[21],"the":[23,46,66,77,83,89,115,121,131,186,199,235],"largest":[24],"subset":[25],"cancers,":[28],"which":[29],"accounts":[30],"for":[31,105,217,223],"about":[32],"85%":[33],"all":[35],"cases.":[36],"It":[37],"been":[39],"well":[40],"established":[41],"that":[42],"mutation":[44],"in":[45,137,173,198,241],"epidermal":[47],"growth":[48],"factor":[49],"receptor":[50],"(EGFR)":[51],"can":[52],"lead":[53],"to":[54,64,88,205,219],"cancer.":[56],"EGFR":[57,112,135],"Tyrosine":[58],"Kinase":[59],"Inhibitors":[60],"(TKIs)":[61],"are":[62,126,168,192],"developed":[63],"target":[65],"kinase":[67],"domain":[68],"EGFR.":[70],"These":[71],"TKIs":[72],"produce":[73],"promising":[74],"results":[75],"at":[76],"initial":[78],"stage":[79],"therapy,":[81],"but":[82],"efficacy":[84],"becomes":[85],"limited":[86],"due":[87],"development":[90],"drug":[92,107,138,155,159,162,231,236],"resistance.":[93],"In":[94],"this":[95,210],"paper,":[96],"we":[97,129],"provide":[98],"comprehensive":[100],"overview":[101],"computational":[103,221],"methods,":[104],"understanding":[106,234],"resistance":[108,139,156,239],"mechanisms.":[109],"The":[110],"important":[111,134],"mutants":[113],"different":[116],"generations":[117],"EGFR-TKIs,":[119],"with":[120],"response":[124,160,237],"rates":[125],"discussed.":[127,170],"Next,":[128],"evaluate":[130],"role":[132],"parameters":[136],"mechanism,":[140],"including":[141],"structural":[142],"dynamics,":[143],"hydrogen":[144],"bonds,":[145],"stability,":[146],"dimerization,":[147],"binding":[148],"free":[149],"energies,":[150],"signaling":[152],"pathways.":[153],"Personalized":[154],"prediction":[157],"models,":[158,181],"curve,":[161],"synergy,":[163],"other":[165],"data-driven":[166],"methods":[167],"also":[169,193],"Recent":[171],"advancements":[172],"deep":[174,179],"learning;":[175],"such":[176],"as":[177,214],"AlphaFold2,":[178],"generative":[180],"big":[182],"data":[183],"analytics,":[184],"applications":[187],"statistics":[189],"permutation":[191],"highlighted.":[194],"We":[195,208],"explore":[196],"limitations":[197],"current":[200],"methodologies,":[201],"discuss":[203],"strategies":[204],"overcome":[206],"them.":[207],"believe":[209],"review":[211],"will":[212],"serve":[213],"reference":[216],"researchers;":[218],"apply":[220],"techniques":[222],"precision":[224],"medicine,":[225],"analyzing":[226],"structures":[227],"protein-drug":[229],"complexes,":[230],"discovery,":[232],"mechanisms":[240],"patients.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":4}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2022-01-26T00:00:00"}