{"id":"https://openalex.org/W3196572827","doi":"https://doi.org/10.1109/tcbb.2021.3110850","title":"EnTSSR: A Weighted Ensemble Learning Method to Impute Single-Cell RNA Sequencing Data","display_name":"EnTSSR: A Weighted Ensemble Learning Method to Impute Single-Cell RNA Sequencing Data","publication_year":2021,"publication_date":"2021-09-08","ids":{"openalex":"https://openalex.org/W3196572827","doi":"https://doi.org/10.1109/tcbb.2021.3110850","mag":"3196572827","pmid":"https://pubmed.ncbi.nlm.nih.gov/34495837"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2021.3110850","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2021.3110850","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080310406","display_name":"Fan L\u00fc","orcid":"https://orcid.org/0000-0002-4932-3850"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210104064","display_name":"Shenzhen Academy of Robotics","ror":"https://ror.org/01h027j09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210104064"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fan Lu","raw_affiliation_strings":["Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China","institution_ids":["https://openalex.org/I4210104064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110458065","display_name":"Yilong Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210104064","display_name":"Shenzhen Academy of Robotics","ror":"https://ror.org/01h027j09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210104064"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilong Lin","raw_affiliation_strings":["Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China","institution_ids":["https://openalex.org/I4210104064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034747883","display_name":"Chongbin Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210104064","display_name":"Shenzhen Academy of Robotics","ror":"https://ror.org/01h027j09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210104064"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongbin Yuan","raw_affiliation_strings":["Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China","institution_ids":["https://openalex.org/I4210104064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447043","display_name":"Xiao-Fei Zhang","orcid":"https://orcid.org/0000-0002-5052-9725"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Fei Zhang","raw_affiliation_strings":["School of Mathematics and Statistics & Hubei Key Laboratory of Mathematical Sciences, Central China Normal University, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-5052-9725","affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics & Hubei Key Laboratory of Mathematical Sciences, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030129372","display_name":"Le Ou-Yang","orcid":"https://orcid.org/0000-0003-4007-4568"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210104064","display_name":"Shenzhen Academy of Robotics","ror":"https://ror.org/01h027j09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210104064"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Ou-Yang","raw_affiliation_strings":["Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0003-4007-4568","affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China","institution_ids":["https://openalex.org/I4210104064"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080310406"],"corresponding_institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210104064"],"apc_list":null,"apc_paid":null,"fwci":0.4881,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62314324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"18","issue":"6","first_page":"2781","last_page":"2787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.7988853454589844},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6919888257980347},{"id":"https://openalex.org/keywords/dropout","display_name":"Dropout (neural networks)","score":0.6745891571044922},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6418797969818115},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6253992319107056},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5956864356994629},{"id":"https://openalex.org/keywords/ensemble-learning","display_name":"Ensemble learning","score":0.49356210231781006},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.48006996512413025},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.47903600335121155},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4676453769207001},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.43165063858032227}],"concepts":[{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.7988853454589844},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6919888257980347},{"id":"https://openalex.org/C2776145597","wikidata":"https://www.wikidata.org/wiki/Q25339462","display_name":"Dropout (neural networks)","level":2,"score":0.6745891571044922},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6418797969818115},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6253992319107056},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5956864356994629},{"id":"https://openalex.org/C45942800","wikidata":"https://www.wikidata.org/wiki/Q245652","display_name":"Ensemble learning","level":2,"score":0.49356210231781006},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48006996512413025},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.47903600335121155},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4676453769207001},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.43165063858032227}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2021.3110850","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2021.3110850","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34495837","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34495837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1957408769","display_name":null,"funder_award_id":"62173235","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2587881520","display_name":null,"funder_award_id":"11871237","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4256946538","display_name":null,"funder_award_id":"JCYJ20170817095210760","funder_id":"https://openalex.org/F4320329791","funder_display_name":"Shenzhen Fundamental Research Program"},{"id":"https://openalex.org/G4434048650","display_name":null,"funder_award_id":"61602309","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G500467270","display_name":null,"funder_award_id":"CCNU18TS026","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G549144630","display_name":null,"funder_award_id":"2019A1515011384","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G6771178980","display_name":null,"funder_award_id":"2018CFB521","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G8657404496","display_name":null,"funder_award_id":"11871026","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320329791","display_name":"Shenzhen Fundamental Research Program","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1979283544","https://openalex.org/W2023887100","https://openalex.org/W2033072655","https://openalex.org/W2051658465","https://openalex.org/W2062451863","https://openalex.org/W2069089843","https://openalex.org/W2114104545","https://openalex.org/W2118017182","https://openalex.org/W2128049108","https://openalex.org/W2135029798","https://openalex.org/W2149573463","https://openalex.org/W2373831850","https://openalex.org/W2461230718","https://openalex.org/W2511896561","https://openalex.org/W2523620612","https://openalex.org/W2528543174","https://openalex.org/W2598326928","https://openalex.org/W2601723752","https://openalex.org/W2740711073","https://openalex.org/W2751468300","https://openalex.org/W2792693509","https://openalex.org/W2805619986","https://openalex.org/W2813324578","https://openalex.org/W2888615663","https://openalex.org/W2900510132","https://openalex.org/W2927507212","https://openalex.org/W2945823867","https://openalex.org/W2949148097","https://openalex.org/W2950104637","https://openalex.org/W2951217100","https://openalex.org/W2951381561","https://openalex.org/W2980495984","https://openalex.org/W3007573310","https://openalex.org/W3008081001","https://openalex.org/W3009560560","https://openalex.org/W3080162757","https://openalex.org/W6680012447","https://openalex.org/W6754636705"],"related_works":["https://openalex.org/W2181530120","https://openalex.org/W4211215373","https://openalex.org/W2024529227","https://openalex.org/W1574575415","https://openalex.org/W3144172081","https://openalex.org/W3179858851","https://openalex.org/W3028371478","https://openalex.org/W2081476516","https://openalex.org/W2581984549","https://openalex.org/W3123177881"],"abstract_inverted_index":{"The":[0],"advancements":[1],"of":[2,21,36,119,158,175],"single-cell":[3],"RNA":[4],"sequencing":[5],"(scRNA-seq)":[6],"technologies":[7],"have":[8,53],"provided":[9],"us":[10],"unprecedented":[11],"opportunities":[12],"to":[13,25,56,87,130,154],"characterize":[14],"cellular":[15],"states":[16],"and":[17,111,147],"investigate":[18],"the":[19,46,71,106,116,132,156,171],"mechanisms":[20],"complex":[22],"diseases.":[23],"Due":[24],"technical":[26],"issues":[27],"such":[28],"as":[29],"dropout":[30,58,89],"events,":[31],"scRNA-seq":[32,61,92,176],"data":[33],"contains":[34],"excess":[35],"false":[37],"zero":[38],"counts,":[39],"which":[40,69],"has":[41],"a":[42,79,96,126],"substantial":[43],"impact":[44],"on":[45,68,115],"downstream":[47],"analyses.":[48],"Although":[49],"several":[50],"computational":[51],"approaches":[52],"been":[54],"proposed":[55,160],"impute":[57,88],"events":[59,90],"in":[60,91],"data,":[62],"there":[63],"is":[64,70],"no":[65],"strong":[66],"consensus":[67,107],"best":[72],"approach.":[73],"In":[74],"this":[75],"study,":[76],"we":[77,124],"propose":[78],"novel":[80],"weighted":[81,127],"ensemble":[82,128],"learning":[83],"method,":[84],"named":[85],"EnTSSR,":[86],"data.":[93,177],"By":[94],"using":[95],"multi-view":[97],"two-side":[98],"sparse":[99],"self-representation":[100],"framework,":[101],"our":[102,159,166],"model":[103],"can":[104,168],"exploit":[105],"similarities":[108],"between":[109,112],"genes":[110],"cells":[113],"based":[114],"imputed":[117],"results":[118,163],"various":[120,136],"imputation":[121,137],"methods.":[122],"Moreover,":[123],"introduce":[125],"strategy":[129],"leverage":[131],"information":[133],"captured":[134],"by":[135],"methods":[138],"effectively.":[139],"Down-sampling":[140],"experiments,":[141],"clustering":[142],"analysis,":[143],"differential":[144],"expression":[145,173],"analysis":[146],"cell":[148],"trajectory":[149],"inference":[150],"are":[151],"carried":[152],"out":[153],"evaluate":[155],"performance":[157],"model.":[161],"Experiment":[162],"demonstrate":[164],"that":[165],"EnTSSR":[167],"effectively":[169],"recover":[170],"true":[172],"pattern":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
