{"id":"https://openalex.org/W3172821627","doi":"https://doi.org/10.1109/tcbb.2021.3090586","title":"Clustering of Cancer Attributed Networks by Dynamically and Jointly Factorizing Multi-Layer Graphs","display_name":"Clustering of Cancer Attributed Networks by Dynamically and Jointly Factorizing Multi-Layer Graphs","publication_year":2021,"publication_date":"2021-06-18","ids":{"openalex":"https://openalex.org/W3172821627","doi":"https://doi.org/10.1109/tcbb.2021.3090586","mag":"3172821627","pmid":"https://pubmed.ncbi.nlm.nih.gov/34143738"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2021.3090586","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2021.3090586","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101570010","display_name":"Zhi-Hao Huang","orcid":"https://orcid.org/0000-0002-5398-0706"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihao Huang","raw_affiliation_strings":["School of Computer Science and Technology, Xidian University, Xi&#x2019;an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xidian University, Xi&#x2019;an, Shaanxi, China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101704856","display_name":"Yan Wang","orcid":"https://orcid.org/0009-0001-4810-6731"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["School of Computer Science and Technology, Xidian University, Xi&#x2019;an, Shaanxi, China","Department of Library, Xidian University, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xidian University, Xi&#x2019;an, Shaanxi, China","institution_ids":["https://openalex.org/I149594827"]},{"raw_affiliation_string":"Department of Library, Xidian University, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029088205","display_name":"Xiaoke Ma","orcid":"https://orcid.org/0000-0002-5604-7137"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoke Ma","raw_affiliation_strings":["School of Computer Science and Technology, Xidian University, Xi&#x2019;an, Shaanxi, China","State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-5604-7137","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xidian University, Xi&#x2019;an, Shaanxi, China","institution_ids":["https://openalex.org/I149594827"]},{"raw_affiliation_string":"State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7916,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.85502267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"5","first_page":"2737","last_page":"2748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7360201478004456},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6544182300567627},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.615247905254364},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.5697572827339172},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5369104743003845},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.4795417785644531},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.4335940480232239},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.41937437653541565},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38752463459968567},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3380609154701233},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14498043060302734},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.125173419713974},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.08694794774055481}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7360201478004456},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6544182300567627},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.615247905254364},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.5697572827339172},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5369104743003845},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4795417785644531},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.4335940480232239},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.41937437653541565},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38752463459968567},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3380609154701233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14498043060302734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.125173419713974},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.08694794774055481},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2021.3090586","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2021.3090586","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34143738","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34143738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4230207668","display_name":"\u57fa\u4e8e\u591a\u5c42\u5f02\u8d28\u7f51\u7edc\u7684\u764c\u75c7\u7532\u57fa\u5316\u56fe\u6a21\u5f0f\u6316\u6398\u7b97\u6cd5\u7814\u7a76","funder_award_id":"61772394","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4954413281","display_name":null,"funder_award_id":"2021ZDLGY02-02","funder_id":"https://openalex.org/F4320336350","funder_display_name":"Key Research and Development Projects of Shaanxi Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336350","display_name":"Key Research and Development Projects of Shaanxi Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1614298861","https://openalex.org/W1887892324","https://openalex.org/W1902027874","https://openalex.org/W1966327575","https://openalex.org/W1984358873","https://openalex.org/W1987520879","https://openalex.org/W1995996823","https://openalex.org/W2089458547","https://openalex.org/W2103017472","https://openalex.org/W2107060225","https://openalex.org/W2120043163","https://openalex.org/W2125118217","https://openalex.org/W2125342106","https://openalex.org/W2127518316","https://openalex.org/W2134711219","https://openalex.org/W2141012957","https://openalex.org/W2143197507","https://openalex.org/W2154851992","https://openalex.org/W2154947819","https://openalex.org/W2160892471","https://openalex.org/W2162142896","https://openalex.org/W2163327652","https://openalex.org/W2163893850","https://openalex.org/W2166676212","https://openalex.org/W2167686991","https://openalex.org/W2411855254","https://openalex.org/W2581499940","https://openalex.org/W2616561032","https://openalex.org/W2741363425","https://openalex.org/W2788730644","https://openalex.org/W2799579300","https://openalex.org/W2802815569","https://openalex.org/W2889646458","https://openalex.org/W2913305430","https://openalex.org/W2917430324","https://openalex.org/W2962756421","https://openalex.org/W2971091813","https://openalex.org/W2995026154","https://openalex.org/W3014807564","https://openalex.org/W3033392434","https://openalex.org/W3087749555","https://openalex.org/W3104097132","https://openalex.org/W3140715906","https://openalex.org/W4239048948","https://openalex.org/W6604108467","https://openalex.org/W6636510571","https://openalex.org/W6678885109","https://openalex.org/W6680012447","https://openalex.org/W6684578312"],"related_works":["https://openalex.org/W2997512100","https://openalex.org/W2331043530","https://openalex.org/W2961085424","https://openalex.org/W2393933887","https://openalex.org/W4306674287","https://openalex.org/W2374725260","https://openalex.org/W1607315280","https://openalex.org/W2767490506","https://openalex.org/W4384401175","https://openalex.org/W2070019828"],"abstract_inverted_index":{"The":[0,129],"accumulated":[1],"omic":[2,96,218],"data":[3,97],"provides":[4],"an":[5,57],"opportunity":[6],"to":[7,27,55,64,174],"exploit":[8],"the":[9,31,40,51,69,76,86,92,105,113,121,132,144,150,156,163,176,207,210,214],"mechanisms":[10],"of":[11,39,42,46,79,83,95,100,115,139,165,178,209,217],"cancers":[12],"and":[13,44,59,71,117,136,146,162,198],"poses":[14],"a":[15,109,171],"challenge":[16],"for":[17,112,213],"their":[18],"integrative":[19,93,215],"analysis.":[20],"Although":[21],"extensive":[22],"efforts":[23],"have":[24],"been":[25],"devoted":[26],"address":[28],"this":[29,49,154],"issue,":[30],"current":[32],"algorithms":[33],"result":[34],"in":[35,85,126,180],"undesirable":[36],"performance":[37,201],"because":[38],"complexity":[41],"patterns":[43],"heterogeneity":[45],"data.":[47,73,219],"In":[48,153],"study,":[50],"ultimate":[52],"goal":[53],"is":[54,159,167,192],"propose":[56],"effective":[58],"efficient":[60],"algorithm":[61],"(called":[62],"NMF-DEC)":[63],"identify":[65],"clusters":[66],"by":[67,141],"integrating":[68],"interactome":[70],"transcriptome":[72],"By":[74],"treating":[75],"expression":[77],"profiles":[78],"genes":[80,116],"as":[81],"attributes":[82,114,135,166],"vertices":[84],"gene":[87],"interaction":[88,147,157],"networks,":[89,205],"we":[90,107],"transform":[91],"analysis":[94,216],"into":[98,120],"clustering":[99],"attributed":[101,181,204],"networks.":[102,128,182],"To":[103],"circumvent":[104],"heterogeneity,":[106],"construct":[108],"similarity":[110,145],"network":[111,158],"cast":[118],"it":[119],"common":[122],"module":[123],"detection":[124],"problem":[125],"multi-layer":[127],"NMF-DEC":[130,191],"explores":[131],"relation":[133],"between":[134],"topological":[137],"structure":[138,177],"networks":[140,148],"jointly":[142],"factorizing":[143],"with":[149,188],"same":[151],"basis.":[152],"optimization,":[155],"dynamically":[160,168],"updated":[161],"information":[164],"incorporated,":[169],"providing":[170],"better":[172,200],"strategy":[173],"characterize":[175],"modules":[179],"Extensive":[183],"experiments":[184],"indicate":[185],"that":[186],"compared":[187],"state-of-the-art":[189],"baselines,":[190],"more":[193],"accurate":[194],"on":[195,202],"social":[196],"network,":[197],"show":[199],"cancer":[203],"implying":[206],"superiority":[208],"proposed":[211],"methods":[212]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
