{"id":"https://openalex.org/W3133798944","doi":"https://doi.org/10.1109/tcbb.2021.3065054","title":"Robust Principal Component Analysis Based On Hypergraph Regularization for Sample Clustering and Co-Characteristic Gene Selection","display_name":"Robust Principal Component Analysis Based On Hypergraph Regularization for Sample Clustering and Co-Characteristic Gene Selection","publication_year":2021,"publication_date":"2021-03-10","ids":{"openalex":"https://openalex.org/W3133798944","doi":"https://doi.org/10.1109/tcbb.2021.3065054","mag":"3133798944","pmid":"https://pubmed.ncbi.nlm.nih.gov/33690124"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2021.3065054","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2021.3065054","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026569643","display_name":"Ying-Lian Gao","orcid":"https://orcid.org/0000-0003-0483-5622"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying-Lian Gao","raw_affiliation_strings":["Qufu Normal University Library, Qufu Normal University, Rizhao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qufu Normal University Library, Qufu Normal University, Rizhao, Shandong, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101906637","display_name":"Ming-Juan Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Juan Wu","raw_affiliation_strings":["School of Computer Science, Qufu Normal University, Rizhao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Qufu Normal University, Rizhao, Shandong, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073144090","display_name":"Jin\u2010Xing Liu","orcid":"https://orcid.org/0000-0001-6104-2149"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Xing Liu","raw_affiliation_strings":["School of Computer Science, Qufu Normal University, Rizhao, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0001-6104-2149","affiliations":[{"raw_affiliation_string":"School of Computer Science, Qufu Normal University, Rizhao, Shandong, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Hou Zheng","raw_affiliation_strings":["School of Computer Science, Qufu Normal University, Rizhao, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0002-2695-1926","affiliations":[{"raw_affiliation_string":"School of Computer Science, Qufu Normal University, Rizhao, Shandong, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100347490","display_name":"Juan Wang","orcid":"https://orcid.org/0000-0003-3934-0435"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Wang","raw_affiliation_strings":["School of Computer Science, Qufu Normal University, Rizhao, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0003-3934-0435","affiliations":[{"raw_affiliation_string":"School of Computer Science, Qufu Normal University, Rizhao, Shandong, China","institution_ids":["https://openalex.org/I202126657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5026569643"],"corresponding_institution_ids":["https://openalex.org/I202126657"],"apc_list":null,"apc_paid":null,"fwci":0.244,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51704268,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"4","first_page":"2420","last_page":"2430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10057","display_name":"Face and Expression Recognition","score":0.9768999814987183,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9763000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.754004955291748},{"id":"https://openalex.org/keywords/hypergraph","display_name":"Hypergraph","score":0.7302939891815186},{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.7178225517272949},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6217504143714905},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5928915143013},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5928685069084167},{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.5782379508018494},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5614029169082642},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5348203778266907},{"id":"https://openalex.org/keywords/robust-principal-component-analysis","display_name":"Robust principal component analysis","score":0.4835224151611328},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45027464628219604},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.44576138257980347},{"id":"https://openalex.org/keywords/sparse-pca","display_name":"Sparse PCA","score":0.43456345796585083},{"id":"https://openalex.org/keywords/clustering-high-dimensional-data","display_name":"Clustering high-dimensional data","score":0.42128559947013855},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.35578322410583496},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11626127362251282},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1061486005783081}],"concepts":[{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.754004955291748},{"id":"https://openalex.org/C2781221856","wikidata":"https://www.wikidata.org/wiki/Q840247","display_name":"Hypergraph","level":2,"score":0.7302939891815186},{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.7178225517272949},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6217504143714905},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5928915143013},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5928685069084167},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.5782379508018494},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5614029169082642},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5348203778266907},{"id":"https://openalex.org/C2777749129","wikidata":"https://www.wikidata.org/wiki/Q17148469","display_name":"Robust principal component analysis","level":3,"score":0.4835224151611328},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45027464628219604},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.44576138257980347},{"id":"https://openalex.org/C24252448","wikidata":"https://www.wikidata.org/wiki/Q7573786","display_name":"Sparse PCA","level":3,"score":0.43456345796585083},{"id":"https://openalex.org/C184509293","wikidata":"https://www.wikidata.org/wiki/Q5136711","display_name":"Clustering high-dimensional data","level":3,"score":0.42128559947013855},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.35578322410583496},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11626127362251282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1061486005783081},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2021.3065054","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2021.3065054","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33690124","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33690124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6399999856948853}],"awards":[{"id":"https://openalex.org/G5609717784","display_name":null,"funder_award_id":"61872220","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5860415692","display_name":null,"funder_award_id":"61572284","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1479960756","https://openalex.org/W1900280998","https://openalex.org/W1972908405","https://openalex.org/W1989722080","https://openalex.org/W1994761691","https://openalex.org/W1997571574","https://openalex.org/W2002469984","https://openalex.org/W2036064915","https://openalex.org/W2043329902","https://openalex.org/W2049145125","https://openalex.org/W2057298934","https://openalex.org/W2071773243","https://openalex.org/W2097308346","https://openalex.org/W2105136962","https://openalex.org/W2106210113","https://openalex.org/W2128728535","https://openalex.org/W2131838954","https://openalex.org/W2147339185","https://openalex.org/W2154205964","https://openalex.org/W2157824687","https://openalex.org/W2168793364","https://openalex.org/W2317901060","https://openalex.org/W2507470109","https://openalex.org/W2518398099","https://openalex.org/W2566835380","https://openalex.org/W2586242296","https://openalex.org/W2599383895","https://openalex.org/W2768310818","https://openalex.org/W2782463043","https://openalex.org/W2916771055","https://openalex.org/W2963720294","https://openalex.org/W2963960715","https://openalex.org/W2973418100","https://openalex.org/W2976511826","https://openalex.org/W3038100514","https://openalex.org/W3105202832"],"related_works":["https://openalex.org/W3037121946","https://openalex.org/W2991135868","https://openalex.org/W4387454008","https://openalex.org/W2302215559","https://openalex.org/W2463344124","https://openalex.org/W107071865","https://openalex.org/W2145962650","https://openalex.org/W4283792950","https://openalex.org/W2962768932","https://openalex.org/W2951443864"],"abstract_inverted_index":{"Extracting":[0],"genes":[1],"involved":[2],"in":[3,27,120],"cancer":[4,13],"lesions":[5],"from":[6],"gene":[7],"expression":[8],"data":[9,101,122,134,142],"is":[10,36,86,108],"critical":[11],"for":[12,41],"research":[14],"and":[15,56,99,125,147],"drug":[16],"development.":[17],"The":[18],"method":[19,40,127],"of":[20,30,47,58,97,131,149],"feature":[21],"selection":[22],"has":[23],"attracted":[24],"much":[25],"attention":[26],"the":[28,54,59,62,66,95,105,112,121,129,132,145,150],"field":[29],"bioinformatics.":[31],"Principal":[32,79],"Component":[33,80],"Analysis":[34,81],"(PCA)":[35],"a":[37,74],"widely":[38],"used":[39],"learning":[42],"low-dimensional":[43],"representation.":[44],"Some":[45],"variants":[46],"PCA":[48],"have":[49],"been":[50],"proposed":[51,151],"to":[52,93,110],"improve":[53],"robustness":[55],"sparsity":[57],"algorithm.":[60],"However,":[61],"existing":[63],"methods":[64],"ignore":[65],"high-order":[67],"relationships":[68],"between":[69],"data.":[70,116],"In":[71,88],"this":[72,126],"paper,":[73],"new":[75],"model":[76],"named":[77],"Robust":[78],"via":[82],"Hypergraph":[83],"Regularization":[84],"(HRPCA)":[85],"proposed.":[87],"detail,":[89],"HRPCA":[90],"utilizes":[91],"L2,1-norm":[92],"reduce":[94],"effect":[96],"outliers":[98],"make":[100],"sufficiently":[102],"row-sparse.":[103],"And":[104],"hypergraph":[106],"regularization":[107],"introduced":[109],"consider":[111],"complex":[113],"relationship":[114,135],"among":[115],"Important":[117],"information":[118],"hidden":[119],"are":[123],"mined,":[124],"ensures":[128],"accuracy":[130],"resulting":[133],"information.":[136],"Extensive":[137],"experiments":[138],"on":[139],"multi-view":[140],"biological":[141],"demonstrate":[143],"that":[144],"feasible":[146],"effective":[148],"approach.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}