{"id":"https://openalex.org/W3080164248","doi":"https://doi.org/10.1109/tcbb.2020.3019042","title":"Deep Reinforcement Learning-Based Progressive Sequence Saliency Discovery Network for Mitosis Detection In Time-Lapse Phase-Contrast Microscopy Images","display_name":"Deep Reinforcement Learning-Based Progressive Sequence Saliency Discovery Network for Mitosis Detection In Time-Lapse Phase-Contrast Microscopy Images","publication_year":2020,"publication_date":"2020-08-25","ids":{"openalex":"https://openalex.org/W3080164248","doi":"https://doi.org/10.1109/tcbb.2020.3019042","mag":"3080164248","pmid":"https://pubmed.ncbi.nlm.nih.gov/32841120"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2020.3019042","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.3019042","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033713097","display_name":"Yuting Su","orcid":"https://orcid.org/0000-0001-5165-204X"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Ting Su","raw_affiliation_strings":["School of Electrical and Information Engineering, Tianjin University, Tianjin, China"],"raw_orcid":"https://orcid.org/0000-0001-5165-204X","affiliations":[{"raw_affiliation_string":"School of Electrical and Information Engineering, Tianjin University, Tianjin, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102027566","display_name":"Yao Lu","orcid":"https://orcid.org/0000-0002-5074-891X"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Lu","raw_affiliation_strings":["School of Electrical and Information Engineering, Tianjin University, Tianjin, China"],"raw_orcid":"https://orcid.org/0000-0002-5074-891X","affiliations":[{"raw_affiliation_string":"School of Electrical and Information Engineering, Tianjin University, Tianjin, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360830","display_name":"Mei Chen","orcid":"https://orcid.org/0000-0001-6809-147X"},"institutions":[{"id":"https://openalex.org/I1290206253","display_name":"Microsoft (United States)","ror":"https://ror.org/00d0nc645","country_code":"US","type":"company","lineage":["https://openalex.org/I1290206253"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Chen","raw_affiliation_strings":["Microsoft Company, Redmond, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microsoft Company, Redmond, WA, USA","institution_ids":["https://openalex.org/I1290206253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081485810","display_name":"An-An Liu","orcid":"https://orcid.org/0000-0001-5755-9145"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"An-An Liu","raw_affiliation_strings":["School of Electrical and Information Engineering, Tianjin University, Tianjin, China"],"raw_orcid":"https://orcid.org/0000-0001-5755-9145","affiliations":[{"raw_affiliation_string":"School of Electrical and Information Engineering, Tianjin University, Tianjin, China","institution_ids":["https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9562,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.8120756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"19","issue":"2","first_page":"854","last_page":"865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11605","display_name":"Visual Attention and Saliency Detection","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6732504367828369},{"id":"https://openalex.org/keywords/mitosis","display_name":"Mitosis","score":0.6429378986358643},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6133173108100891},{"id":"https://openalex.org/keywords/salient","display_name":"Salient","score":0.6058500409126282},{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"Reinforcement learning","score":0.5233594179153442},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4825584292411804},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.43907174468040466},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3408902883529663},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0891486406326294}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6732504367828369},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6429378986358643},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6133173108100891},{"id":"https://openalex.org/C2780719617","wikidata":"https://www.wikidata.org/wiki/Q1030752","display_name":"Salient","level":2,"score":0.6058500409126282},{"id":"https://openalex.org/C97541855","wikidata":"https://www.wikidata.org/wiki/Q830687","display_name":"Reinforcement learning","level":2,"score":0.5233594179153442},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4825584292411804},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.43907174468040466},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3408902883529663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0891486406326294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008858","descriptor_name":"Microscopy, Phase-Contrast","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008858","descriptor_name":"Microscopy, Phase-Contrast","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008858","descriptor_name":"Microscopy, Phase-Contrast","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2020.3019042","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.3019042","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32841120","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32841120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.7699999809265137,"display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G2050428177","display_name":"\u591a\u6a21\u8026\u5408\u7684\u5f00\u653e\u96c6\u89c6\u9891\u81ea\u52a8\u89e3\u6790\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61772359","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3141489049","display_name":null,"funder_award_id":"A2005","funder_id":"https://openalex.org/F4320322927","funder_display_name":"Zhejiang University"},{"id":"https://openalex.org/G956964051","display_name":null,"funder_award_id":"A2012","funder_id":"https://openalex.org/F4320322927","funder_display_name":"Zhejiang University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1644641054","https://openalex.org/W1792334496","https://openalex.org/W1947481528","https://openalex.org/W1978985990","https://openalex.org/W1983364832","https://openalex.org/W2011604289","https://openalex.org/W2019607023","https://openalex.org/W2030105367","https://openalex.org/W2066729341","https://openalex.org/W2076337359","https://openalex.org/W2082943297","https://openalex.org/W2101187282","https://openalex.org/W2109187183","https://openalex.org/W2119717200","https://openalex.org/W2126516766","https://openalex.org/W2128871431","https://openalex.org/W2132031490","https://openalex.org/W2148266328","https://openalex.org/W2168462175","https://openalex.org/W2506522517","https://openalex.org/W2526958461","https://openalex.org/W2560920277","https://openalex.org/W2591514928","https://openalex.org/W2602468037","https://openalex.org/W2732711189","https://openalex.org/W2751195109","https://openalex.org/W2752740243","https://openalex.org/W2790265491","https://openalex.org/W2901300079","https://openalex.org/W2906196094","https://openalex.org/W2910669864","https://openalex.org/W2947611729","https://openalex.org/W2953384591","https://openalex.org/W2958500321","https://openalex.org/W2969643617","https://openalex.org/W2976811275","https://openalex.org/W2979910668","https://openalex.org/W6638106647","https://openalex.org/W6679078458","https://openalex.org/W6713134421","https://openalex.org/W6730513390"],"related_works":["https://openalex.org/W2329500892","https://openalex.org/W28991112","https://openalex.org/W2370726991","https://openalex.org/W2369710579","https://openalex.org/W2545348020","https://openalex.org/W4306904969","https://openalex.org/W4327728159","https://openalex.org/W2912751582","https://openalex.org/W1990856605","https://openalex.org/W2138720691"],"abstract_inverted_index":{"Mitosis":[0],"detection":[1,42,211,225],"plays":[2],"an":[3],"important":[4],"role":[5],"in":[6,19,43,58,93,106],"the":[7,51,59,66,74,87,94,104,107,125,129,137,164,168,175,178,186,200,209,214,218,222,234,236],"analysis":[8],"of":[9,76,90,116,140,151,167,177],"cell":[10,55,131],"status":[11],"and":[12,14,23,96,154,247],"behavior":[13],"is":[15,172,199],"therefore":[16],"widely":[17],"utilized":[18],"many":[20],"biological":[21],"research":[22],"medical":[24],"applications.":[25],"In":[26,213],"this":[27,198],"article,":[28],"we":[29,216],"propose":[30],"a":[31,80,149],"deep":[32,99,205],"reinforcement":[33,100,206],"learning-based":[34],"progressive":[35],"sequence":[36,133,150,161],"saliency":[37,120,169],"discovery":[38,75,110,121,170],"network":[39,166],"(PSSD)for":[40],"mitosis":[41,67,70,144,179,193,210,224,245],"time-lapse":[44],"phase":[45],"contrast":[46],"microscopy":[47],"images.":[48],"By":[49],"discovering":[50],"salient":[52,77,91,108,126,141,152,187],"frames":[53,78,92,127,153,188],"when":[54],"state":[56],"changes":[57],"sequence,":[60,95],"PSSD":[61,182],"can":[62,183,239],"more":[63],"effectively":[64],"model":[65],"process":[68],"for":[69,159,192,243],"detection.":[71,194],"We":[72],"formulate":[73],"as":[79],"Markov":[81],"Decision":[82],"Process":[83],"(MDP)that":[84],"progressively":[85,135],"adjusts":[86],"selection":[88,138],"positions":[89,139],"further":[97],"leverage":[98],"learning":[101,207],"to":[102,203,208],"learn":[103],"policy":[105,165],"frame":[109],"process.":[111],"The":[112],"proposed":[113,219,237],"method":[114,220,238],"consists":[115],"two":[117],"parts:":[118],"1)the":[119],"module":[122,146,171],"that":[123,147,189,231],"selects":[124],"from":[128],"input":[130],"image":[132],"by":[134],"adjusting":[136],"frames;":[142],"2)the":[143],"identification":[145,180,246],"takes":[148],"performs":[155],"temporal":[156,248],"information":[157],"fusion":[158],"mitotic":[160],"classification.":[162],"Since":[163],"trained":[173],"under":[174],"guidance":[176],"module,":[181],"comprehensively":[184],"explore":[185],"are":[190],"beneficial":[191],"To":[195],"our":[196],"knowledge,":[197],"first":[201],"work":[202],"implement":[204],"problem.":[212],"experiment,":[215],"evaluate":[217],"on":[221,250],"largest":[223],"dataset,":[226],"C2C12-16.":[227,251],"Experiment":[228],"results":[229],"show":[230],"compared":[232],"with":[233],"state-of-the-arts,":[235],"achieve":[240],"significant":[241],"improvement":[242],"both":[244],"localization":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}
