{"id":"https://openalex.org/W3049581539","doi":"https://doi.org/10.1109/tcbb.2020.3016781","title":"Deciphering Key Genes and miRNAs Associated With Hepatocellular Carcinoma via Network-Based Approach","display_name":"Deciphering Key Genes and miRNAs Associated With Hepatocellular Carcinoma via Network-Based Approach","publication_year":2020,"publication_date":"2020-08-14","ids":{"openalex":"https://openalex.org/W3049581539","doi":"https://doi.org/10.1109/tcbb.2020.3016781","mag":"3049581539","pmid":"https://pubmed.ncbi.nlm.nih.gov/32795971"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2020.3016781","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.3016781","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001747787","display_name":"Sachin Bhatt","orcid":"https://orcid.org/0000-0002-2505-6049"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sachin Bhatt","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019926785","display_name":"Prithvi Singh","orcid":"https://orcid.org/0000-0002-2562-0914"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prithvi Singh","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101940440","display_name":"Archana Sharma","orcid":"https://orcid.org/0000-0002-5555-3652"},"institutions":[{"id":"https://openalex.org/I4210153536","display_name":"National Institute of Plant Genome Research","ror":"https://ror.org/04zw11527","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210153536"]},{"id":"https://openalex.org/I3141573830","display_name":"Department of Biotechnology","ror":"https://ror.org/03tjsyq23","country_code":"IN","type":"funder","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Archana Sharma","raw_affiliation_strings":["National Institute of Plant Genome Research, New Delhi, India","Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"National Institute of Plant Genome Research, New Delhi, India","institution_ids":["https://openalex.org/I4210153536"]},{"raw_affiliation_string":"Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India","institution_ids":["https://openalex.org/I59475050","https://openalex.org/I3141573830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037371119","display_name":"Arpita Rai","orcid":"https://orcid.org/0000-0001-9078-0642"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arpita Rai","raw_affiliation_strings":["Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039919375","display_name":"Ravins Dohare","orcid":"https://orcid.org/0000-0002-0602-3719"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravins Dohare","raw_affiliation_strings":["Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080984621","display_name":"Shweta Sankhwar","orcid":"https://orcid.org/0000-0003-0743-6854"},"institutions":[{"id":"https://openalex.org/I143247161","display_name":"Babasaheb Bhimrao Ambedkar University","ror":"https://ror.org/04x7ccp17","country_code":"IN","type":"education","lineage":["https://openalex.org/I143247161"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shweta Sankhwar","raw_affiliation_strings":["Department of Information Technology, Babasaheb Bhimrao Ambedkar University, Lucknow, India"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology, Babasaheb Bhimrao Ambedkar University, Lucknow, India","institution_ids":["https://openalex.org/I143247161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101780405","display_name":"Akash Sharma","orcid":"https://orcid.org/0000-0002-9079-3205"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]},{"id":"https://openalex.org/I4210153536","display_name":"National Institute of Plant Genome Research","ror":"https://ror.org/04zw11527","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210153536"]},{"id":"https://openalex.org/I3141573830","display_name":"Department of Biotechnology","ror":"https://ror.org/03tjsyq23","country_code":"IN","type":"funder","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akash Sharma","raw_affiliation_strings":["National Institute of Plant Genome Research, New Delhi, India","Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"National Institute of Plant Genome Research, New Delhi, India","institution_ids":["https://openalex.org/I4210153536"]},{"raw_affiliation_string":"Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India","institution_ids":["https://openalex.org/I59475050","https://openalex.org/I3141573830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025861351","display_name":"Mansoor Ali Syed","orcid":"https://orcid.org/0000-0003-2697-7832"},"institutions":[{"id":"https://openalex.org/I3141573830","display_name":"Department of Biotechnology","ror":"https://ror.org/03tjsyq23","country_code":"IN","type":"funder","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mansoor Ali Syed","raw_affiliation_strings":["Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Translational Research Lab, Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India","institution_ids":["https://openalex.org/I59475050","https://openalex.org/I3141573830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5001747787"],"corresponding_institution_ids":["https://openalex.org/I59475050"],"apc_list":null,"apc_paid":null,"fwci":0.4143,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59772402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"19","issue":"2","first_page":"843","last_page":"853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.7567604780197144},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7246516942977905},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7101942896842957},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5171486735343933},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5164094567298889},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.43944379687309265},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34494730830192566},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2096690535545349}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7567604780197144},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7246516942977905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7101942896842957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5171486735343933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5164094567298889},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.43944379687309265},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34494730830192566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2096690535545349}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2020.3016781","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.3016781","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32795971","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32795971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3104720178","display_name":null,"funder_award_id":"ID:EEQ/2016/000509","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W130589596","https://openalex.org/W196117123","https://openalex.org/W614012683","https://openalex.org/W1116598203","https://openalex.org/W1468622774","https://openalex.org/W1644749979","https://openalex.org/W1648301895","https://openalex.org/W1963564133","https://openalex.org/W1970546734","https://openalex.org/W1979821113","https://openalex.org/W1981674621","https://openalex.org/W1995402091","https://openalex.org/W2000307707","https://openalex.org/W2005399537","https://openalex.org/W2011374571","https://openalex.org/W2016681407","https://openalex.org/W2017408113","https://openalex.org/W2021305441","https://openalex.org/W2034616499","https://openalex.org/W2036887984","https://openalex.org/W2040847667","https://openalex.org/W2053510513","https://openalex.org/W2060486418","https://openalex.org/W2062553086","https://openalex.org/W2063559185","https://openalex.org/W2065400501","https://openalex.org/W2071668037","https://openalex.org/W2078147093","https://openalex.org/W2090682255","https://openalex.org/W2105381419","https://openalex.org/W2114843025","https://openalex.org/W2116445963","https://openalex.org/W2123250471","https://openalex.org/W2123329045","https://openalex.org/W2126664691","https://openalex.org/W2133298831","https://openalex.org/W2135810600","https://openalex.org/W2136850043","https://openalex.org/W2137046528","https://openalex.org/W2138793275","https://openalex.org/W2140897859","https://openalex.org/W2149441684","https://openalex.org/W2163062452","https://openalex.org/W2163486683","https://openalex.org/W2168223461","https://openalex.org/W2175370850","https://openalex.org/W2236101211","https://openalex.org/W2239989859","https://openalex.org/W2267547839","https://openalex.org/W2288753073","https://openalex.org/W2341128841","https://openalex.org/W2381624004","https://openalex.org/W2398274554","https://openalex.org/W2512436367","https://openalex.org/W2529051581","https://openalex.org/W2559466477","https://openalex.org/W2571825089","https://openalex.org/W2590032828","https://openalex.org/W2730507713","https://openalex.org/W2738014443","https://openalex.org/W2749299468","https://openalex.org/W2767914218","https://openalex.org/W2767965002","https://openalex.org/W2773911587","https://openalex.org/W2788763260","https://openalex.org/W2790260771","https://openalex.org/W2803016979","https://openalex.org/W2803198632","https://openalex.org/W2808293799","https://openalex.org/W2885299775","https://openalex.org/W2889646458","https://openalex.org/W2898568606","https://openalex.org/W2899500262","https://openalex.org/W2900569176","https://openalex.org/W2913156703","https://openalex.org/W2915433652","https://openalex.org/W2944545583","https://openalex.org/W2953390364","https://openalex.org/W4254277121","https://openalex.org/W6709861506"],"related_works":["https://openalex.org/W2897335796","https://openalex.org/W4366998568","https://openalex.org/W2566199450","https://openalex.org/W1840972770","https://openalex.org/W3003904768","https://openalex.org/W2022048096","https://openalex.org/W2021619487","https://openalex.org/W2801036742","https://openalex.org/W4200527012","https://openalex.org/W2042559265"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)is":[2],"a":[3,11,45,57,115],"common":[4],"type":[5],"of":[6,29,31,39,41,48,59,68,84,109,136,141,179],"liver":[7],"cancer":[8],"and":[9,18,66,113,132,147,159,170,190],"has":[10],"high":[12],"mortality":[13],"world-widely.":[14],"The":[15],"diagnosis,":[16],"prognoses,":[17],"therapeutics":[19],"are":[20,89],"very":[21],"poor":[22],"due":[23],"to":[24,80],"the":[25,32,36,53,82,105,137,175,182,187],"unclear":[26],"molecular":[27,37],"mechanism":[28,38],"progression":[30,40,178],"disease.":[33],"To":[34],"unveil":[35],"HCC,":[42],"we":[43,103],"extract":[44],"large":[46],"sample":[47,94],"mRNA":[49],"expression":[50],"levels":[51],"from":[52,73],"GEO":[54],"database":[55],"where":[56],"total":[58],"167":[60],"samples":[61,71],"were":[62,72,122,149,163],"used":[63],"for":[64,118],"study,":[65],"out":[67],"them,":[69],"115":[70],"HCC":[74,93],"tumor":[75],"tissue.":[76],"This":[77],"study":[78],"aims":[79],"investigate":[81],"module":[83,108],"differentially":[85],"expressed":[86],"genes":[87,112,125,162],"(DEGs)which":[88],"co-expressed":[90,111],"only":[91,123,143],"in":[92,98,152,166],"data":[95],"but":[96],"not":[97],"normal":[99],"tissue":[100],"samples.":[101],"Thereafter,":[102],"identified":[104],"highly":[106],"significant":[107,110],"formed":[114],"PPI":[116,138],"network":[117],"these":[119,160],"genes.":[120,196],"There":[121],"six":[124,142],"(namely,":[126],"MSH3,":[127,144],"DMC1,":[128,145],"ALPP,":[129],"IL10,":[130],"ZNF223,":[131],"HSD17B7)obtained":[133],"after":[134],"analysis":[135,158],"network.":[139],"Out":[140],"HSD17B7,":[146],"IL10":[148],"found":[150],"enriched":[151],"GO":[153],"Term":[154],"&":[155,177],"Pathway":[156],"enrichment":[157],"candidate":[161],"mainly":[164],"involved":[165],"cellular":[167],"process,":[168],"metabolic":[169],"catalytic":[171],"activity,":[172],"which":[173],"promote":[174],"development":[176],"HCC.":[180],"Lastly,":[181],"composite":[183],"3-node":[184],"FFL":[185],"reveals":[186],"driver":[188],"miRNAs":[189],"TFs":[191],"associated":[192],"with":[193],"our":[194],"key":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}