{"id":"https://openalex.org/W3039529593","doi":"https://doi.org/10.1109/tcbb.2020.3005813","title":"An Improved Topology Prediction of Alpha-Helical Transmembrane Protein Based on Deep Multi-Scale Convolutional Neural Network","display_name":"An Improved Topology Prediction of Alpha-Helical Transmembrane Protein Based on Deep Multi-Scale Convolutional Neural Network","publication_year":2020,"publication_date":"2020-06-29","ids":{"openalex":"https://openalex.org/W3039529593","doi":"https://doi.org/10.1109/tcbb.2020.3005813","mag":"3039529593","pmid":"https://pubmed.ncbi.nlm.nih.gov/32750879"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2020.3005813","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.3005813","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/9702518/09128042.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/8857/9702518/09128042.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074638105","display_name":"Yuning Yang","orcid":"https://orcid.org/0000-0003-4556-139X"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuning Yang","raw_affiliation_strings":["Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0003-4556-139X","affiliations":[{"raw_affiliation_string":"Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791533","display_name":"Jiawen Yu","orcid":"https://orcid.org/0009-0004-9050-8103"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawen Yu","raw_affiliation_strings":["Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhe Liu","orcid":"https://orcid.org/0000-0002-9970-4029"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Liu","raw_affiliation_strings":["Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-9970-4029","affiliations":[{"raw_affiliation_string":"Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442261","display_name":"Xi Wang","orcid":"https://orcid.org/0000-0002-5218-2761"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Wang","raw_affiliation_strings":["Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452702","display_name":"Han Wang","orcid":"https://orcid.org/0000-0002-4302-1886"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Wang","raw_affiliation_strings":["Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-4302-1886","affiliations":[{"raw_affiliation_string":"Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038788906","display_name":"Zhiqiang Ma","orcid":"https://orcid.org/0000-0002-1922-6283"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Ma","raw_affiliation_strings":["Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Science and Technology, Northeast Normal University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082428303","display_name":"Dong Xu","orcid":"https://orcid.org/0000-0002-4809-0514"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Xu","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science and Bond Life Sciences Center, University of Missouri, Columbia, MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-4809-0514","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science and Bond Life Sciences Center, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3335,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57097282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"19","issue":"1","first_page":"295","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6706927418708801},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6607949137687683},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.635193943977356},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5970419645309448},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5964400172233582},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5419924259185791},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.538959264755249},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.4886036515235901},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.47302886843681335},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.45325830578804016},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4203539490699768},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3377372622489929},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.33185648918151855},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16490405797958374},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0982782244682312},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08960282802581787}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6706927418708801},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6607949137687683},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.635193943977356},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5970419645309448},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5964400172233582},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5419924259185791},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.538959264755249},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.4886036515235901},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.47302886843681335},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.45325830578804016},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4203539490699768},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3377372622489929},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.33185648918151855},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16490405797958374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0982782244682312},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08960282802581787},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2020.3005813","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.3005813","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/9702518/09128042.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32750879","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32750879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/tcbb.2020.3005813","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.3005813","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/9702518/09128042.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1653923516","display_name":null,"funder_award_id":"20180414006GH","funder_id":"https://openalex.org/F4320322174","funder_display_name":"People's Government of Jilin Province"},{"id":"https://openalex.org/G2309553337","display_name":null,"funder_award_id":"20170520058JH","funder_id":"https://openalex.org/F4320335953","funder_display_name":"Jilin Scientific and Technological Development Program"},{"id":"https://openalex.org/G2755366194","display_name":null,"funder_award_id":"20170520058JH","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G3254547431","display_name":null,"funder_award_id":"61802057","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G3379815116","display_name":null,"funder_award_id":"JJKH20191309KJ","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4055583730","display_name":null,"funder_award_id":"JJKH20191309KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"},{"id":"https://openalex.org/G4055916390","display_name":null,"funder_award_id":"JJKH20190290KJ","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4102039166","display_name":null,"funder_award_id":"61802057","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G442978556","display_name":null,"funder_award_id":"81671328","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4560768781","display_name":null,"funder_award_id":"81671328","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5225922884","display_name":null,"funder_award_id":"2412019FZ052","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G562891027","display_name":null,"funder_award_id":"2412019FZ048","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G6176752420","display_name":null,"funder_award_id":"20180520028JH","funder_id":"https://openalex.org/F4320322174","funder_display_name":"People's Government of Jilin Province"},{"id":"https://openalex.org/G754032093","display_name":null,"funder_award_id":"20180520028JH","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8099088507","display_name":null,"funder_award_id":"20180414006GH","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8376828015","display_name":null,"funder_award_id":"No. 2412019FZ052, 2412019FZ048","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8598606543","display_name":null,"funder_award_id":"20180520028JH","funder_id":"https://openalex.org/F4320335953","funder_display_name":"Jilin Scientific and Technological Development Program"},{"id":"https://openalex.org/G8811091804","display_name":null,"funder_award_id":"No. 20180414006GH, 20180520028JH, 20170520058JH","funder_id":"https://openalex.org/F4320335953","funder_display_name":"Jilin Scientific and Technological Development Program"},{"id":"https://openalex.org/G8951103179","display_name":null,"funder_award_id":"JJKH20190290KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"},{"id":"https://openalex.org/G961829735","display_name":null,"funder_award_id":"20180414006GH","funder_id":"https://openalex.org/F4320335953","funder_display_name":"Jilin Scientific and Technological Development Program"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320326270","display_name":"Education Department of Jilin Province","ror":"https://ror.org/05782e512"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320335953","display_name":"Jilin Scientific and Technological Development Program","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3039529593.pdf","grobid_xml":"https://content.openalex.org/works/W3039529593.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1515959604","https://openalex.org/W1525523977","https://openalex.org/W1665214252","https://openalex.org/W1951403192","https://openalex.org/W1968682237","https://openalex.org/W1971147414","https://openalex.org/W2019187626","https://openalex.org/W2026907061","https://openalex.org/W2052953199","https://openalex.org/W2056825408","https://openalex.org/W2059971420","https://openalex.org/W2072470496","https://openalex.org/W2074266029","https://openalex.org/W2089606003","https://openalex.org/W2092247420","https://openalex.org/W2097606916","https://openalex.org/W2097870001","https://openalex.org/W2101466114","https://openalex.org/W2110425545","https://openalex.org/W2120684043","https://openalex.org/W2130479394","https://openalex.org/W2133312664","https://openalex.org/W2145336405","https://openalex.org/W2149407349","https://openalex.org/W2151156268","https://openalex.org/W2152748513","https://openalex.org/W2152770371","https://openalex.org/W2164025376","https://openalex.org/W2190900687","https://openalex.org/W2315928616","https://openalex.org/W2397505103","https://openalex.org/W2433743436","https://openalex.org/W2517405041","https://openalex.org/W2554697011","https://openalex.org/W2559588458","https://openalex.org/W2734926260","https://openalex.org/W2747811776","https://openalex.org/W2769887238","https://openalex.org/W2791790018","https://openalex.org/W2891893703","https://openalex.org/W2896636431","https://openalex.org/W2900694973","https://openalex.org/W2900891475","https://openalex.org/W2919115771","https://openalex.org/W2923490814","https://openalex.org/W2971498163","https://openalex.org/W6637242042","https://openalex.org/W6891788290"],"related_works":["https://openalex.org/W4312417841","https://openalex.org/W4321369474","https://openalex.org/W2731899572","https://openalex.org/W3133861977","https://openalex.org/W4200173597","https://openalex.org/W3116150086","https://openalex.org/W2999805992","https://openalex.org/W4380075502","https://openalex.org/W4291897433","https://openalex.org/W4223943233"],"abstract_inverted_index":{"Alpha-helical":[0],"proteins":[1],"(":[2],"\u03b1TMPs)":[3],"are":[4,14,56],"essential":[5],"in":[6,170],"various":[7,31],"biological":[8],"processes.":[9],"Despite":[10],"their":[11],"tertiary":[12],"structures":[13,47],"crucial":[15],"for":[16,65,140],"revealing":[17],"complex":[18],"functions,":[19],"experimental":[20],"structure":[21],"determination":[22],"remains":[23],"challenging":[24],"and":[25,46,100,122,130,136,166,185],"costly.":[26],"In":[27,75],"the":[28,41,44,50,105,111,115,137,146,160,163,167,174,181,188],"past":[29],"decades,":[30],"sequence-based":[32],"topology":[33,82],"prediction":[34,83,183],"methods":[35,157],"have":[36],"been":[37],"developed":[38],"to":[39,96,109,159],"bridge":[40],"gap":[42],"between":[43],"sequences":[45],"by":[48],"characterizing":[49],"structural":[51],"features,":[52],"but":[53],"significant":[54],"improvements":[55],"still":[57],"required.":[58],"Deep":[59],"learning":[60,69],"brings":[61],"a":[62,118],"great":[63],"opportunity":[64],"its":[66],"powerful":[67],"representation":[68],"capability":[70],"from":[71],"limited":[72],"original":[73,112],"data.":[74],"this":[76],"work,":[77],"we":[78,151],"improved":[79],"our":[80,149,178],"\u03b1TMP":[81,142],"method":[84,179,192],"DMCTOP":[85,127,153],"using":[86],"deep":[87,93],"learning,":[88],"which":[89],"composed":[90],"of":[91,114,148],"two":[92],"convolutional":[94],"blocks":[95],"simultaneously":[97],"extract":[98],"local":[99],"global":[101],"contextual":[102],"features.":[103],"Consequently,":[104],"inputs":[106],"were":[107],"simplified":[108],"reflect":[110],"features":[113],"sequence,":[116,162],"including":[117],"protein":[119],"sequence":[120],"feature":[121],"an":[123,141],"evolutionary":[124],"conservation":[125],"feature.":[126],"can":[128],"efficiently":[129],"accurately":[131],"identify":[132],"all":[133,187],"topological":[134],"types":[135],"N-terminal":[138],"orientation":[139],"sequence.":[143],"To":[144],"validate":[145],"effectiveness":[147],"method,":[150],"benchmarked":[152],"against":[154],"13":[155],"peer":[156],"according":[158],"whole":[161],"transmembrane":[164],"segment":[165],"traditional":[168],"criterion":[169],"testing":[171],"experiments.":[172],"All":[173],"results":[175],"reveal":[176],"that":[177],"achieved":[180],"highest":[182],"accuracy":[184],"outperformed":[186],"previous":[189],"methods.":[190],"The":[191],"is":[193],"available":[194],"at":[195],"https://icdtools.nenu.edu.cn/dmctop.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}