{"id":"https://openalex.org/W3030278067","doi":"https://doi.org/10.1109/tcbb.2020.2997326","title":"SelfE: Gene Selection via Self-Expression for Single-Cell Data","display_name":"SelfE: Gene Selection via Self-Expression for Single-Cell Data","publication_year":2020,"publication_date":"2020-05-25","ids":{"openalex":"https://openalex.org/W3030278067","doi":"https://doi.org/10.1109/tcbb.2020.2997326","mag":"3030278067","pmid":"https://pubmed.ncbi.nlm.nih.gov/32750851"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2020.2997326","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.2997326","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052409778","display_name":"Priyadarshini Rai","orcid":"https://orcid.org/0000-0002-5684-3993"},"institutions":[{"id":"https://openalex.org/I119939252","display_name":"Indraprastha Institute of Information Technology Delhi","ror":"https://ror.org/03vfp4g33","country_code":"IN","type":"education","lineage":["https://openalex.org/I119939252"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Priyadarshini Rai","raw_affiliation_strings":["Center for Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Center for Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India","institution_ids":["https://openalex.org/I119939252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061015791","display_name":"Debarka Sengupta","orcid":"https://orcid.org/0000-0002-6353-5411"},"institutions":[{"id":"https://openalex.org/I119939252","display_name":"Indraprastha Institute of Information Technology Delhi","ror":"https://ror.org/03vfp4g33","country_code":"IN","type":"education","lineage":["https://openalex.org/I119939252"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debarka Sengupta","raw_affiliation_strings":["Department of Computer Science and Engineering, Center for Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Center for Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India","institution_ids":["https://openalex.org/I119939252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020310463","display_name":"Angshul Majumdar","orcid":"https://orcid.org/0000-0002-1065-3000"},"institutions":[{"id":"https://openalex.org/I119939252","display_name":"Indraprastha Institute of Information Technology Delhi","ror":"https://ror.org/03vfp4g33","country_code":"IN","type":"education","lineage":["https://openalex.org/I119939252"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Angshul Majumdar","raw_affiliation_strings":["Department of Electronics Engineering, Indraprastha Institute of Information Technology, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Department of Electronics Engineering, Indraprastha Institute of Information Technology, New Delhi, India","institution_ids":["https://openalex.org/I119939252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052409778"],"corresponding_institution_ids":["https://openalex.org/I119939252"],"apc_list":null,"apc_paid":null,"fwci":0.0829,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43178824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"19","issue":"1","first_page":"624","last_page":"632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5735069513320923},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5653596520423889},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.5535359382629395},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47084495425224304},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.44461917877197266},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.44166478514671326},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.37759828567504883},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.32246077060699463},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2951114773750305},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2682563066482544}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5735069513320923},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5653596520423889},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.5535359382629395},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47084495425224304},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.44461917877197266},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.44166478514671326},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.37759828567504883},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32246077060699463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2951114773750305},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2682563066482544}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2020.2997326","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.2997326","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32750851","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32750851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G5197773155","display_name":null,"funder_award_id":"DST/INSPIRE/04/2015/003068","funder_id":"https://openalex.org/F4320320020","funder_display_name":"Inspire Foundation"}],"funders":[{"id":"https://openalex.org/F4320320020","display_name":"Inspire Foundation","ror":"https://ror.org/019s18q02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1552434751","https://openalex.org/W1974774078","https://openalex.org/W1981641790","https://openalex.org/W2006533296","https://openalex.org/W2017337590","https://openalex.org/W2030017878","https://openalex.org/W2032518018","https://openalex.org/W2033072655","https://openalex.org/W2060300932","https://openalex.org/W2119387367","https://openalex.org/W2131358897","https://openalex.org/W2152692691","https://openalex.org/W2332292689","https://openalex.org/W2337440967","https://openalex.org/W2473258837","https://openalex.org/W2598326928","https://openalex.org/W2600453489","https://openalex.org/W2783644856","https://openalex.org/W2794891507","https://openalex.org/W2803292849","https://openalex.org/W2900387735","https://openalex.org/W2949272108","https://openalex.org/W2950548777","https://openalex.org/W2951506174","https://openalex.org/W4251163770","https://openalex.org/W6636914306","https://openalex.org/W6703681734"],"related_works":["https://openalex.org/W1975632186","https://openalex.org/W3027745756","https://openalex.org/W3205213561","https://openalex.org/W2531880140","https://openalex.org/W2126145365","https://openalex.org/W2036609560","https://openalex.org/W346861917","https://openalex.org/W3024018414","https://openalex.org/W385273440","https://openalex.org/W2373052636"],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1],"sequencing":[2],"has":[3,86],"been":[4,87,110,131],"proved":[5],"to":[6,21,33,112],"be":[7,113],"advantageous":[8],"in":[9,13,17,51,167],"discerning":[10],"molecular":[11],"heterogeneity":[12],"seemingly":[14],"similar":[15],"cells":[16],"a":[18,27,58,64,71,148],"tissue.":[19],"Due":[20],"the":[22,36,52,94,142,168,174],"paucity":[23],"of":[24,30,74,81,118,158],"starting":[25],"RNA,":[26],"large":[28,72],"fraction":[29],"transcripts":[31],"fail":[32],"amplify":[34],"during":[35],"polymerase":[37],"chain":[38],"reaction":[39],"cycle.":[40],"This":[41,77],"gets":[42],"compounded":[43],"by":[44],"trivial":[45],"biological":[46],"noise":[47],"such":[48,100],"as":[49,101,165],"variability":[50],"cell":[53],"cycle":[54],"specific":[55],"genes.":[56],"As":[57],"result":[59],"expression":[60,83,182],"matrix":[61],"obtained":[62],"from":[63],"single-cell":[65,82,181],"study":[66],"is":[67],"highly":[68],"sparse":[69],"with":[70,173],"number":[73],"missing":[75],"values.":[76],"hinders":[78],"downstream":[79],"analysis":[80,95,104,108,120],"data.":[84,169],"It":[85],"observed":[88,132,166],"that":[89,153,161],"feature":[90,135,159,177],"engineering":[91],"significantly":[92],"improves":[93],"outcomes.":[96],"Feature":[97],"extraction":[98],"methods":[99,179],"principal":[102],"component":[103],"and":[105],"zero-inflated":[106],"factor":[107],"have":[109,130],"shown":[111],"useful":[114],"for":[115,133,141,180],"subsequent":[116],"steps":[117],"data":[119,183],"including":[121],"clustering.":[122],"However,":[123],"too":[124],"little":[125],"or":[126],"no":[127],"visible":[128],"efforts":[129],"developing":[134],"selection":[136,178],"techniques,":[137],"which":[138],"offer":[139],"transparency":[140],"analyst's":[143],"consumption.":[144],"We":[145,170],"propose":[146],"SelfE,":[147],"novel":[149],"l<sub>2,0</sub>":[150],"-minimization":[151],"algorithm":[152],"determines":[154],"an":[155],"optimal":[156],"subset":[157],"vectors":[160],"preserves":[162],"sub-space":[163],"structures":[164],"compared":[171],"SelfE":[172],"commonly":[175],"used":[176],"analysis.":[184]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}