{"id":"https://openalex.org/W3019296765","doi":"https://doi.org/10.1109/tcbb.2020.2988024","title":"SNP Data Science for Classification of Bipolar Disorder I and Bipolar Disorder II","display_name":"SNP Data Science for Classification of Bipolar Disorder I and Bipolar Disorder II","publication_year":2020,"publication_date":"2020-04-20","ids":{"openalex":"https://openalex.org/W3019296765","doi":"https://doi.org/10.1109/tcbb.2020.2988024","mag":"3019296765","pmid":"https://pubmed.ncbi.nlm.nih.gov/32324560"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2020.2988024","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.2988024","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021866378","display_name":"Chia\u2010Yen Lee","orcid":"https://orcid.org/0000-0002-2928-3337"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chia-Yen Lee","raw_affiliation_strings":["Institute of Manufacturing Information and Systems, National Cheng Kung University, Tainan City, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Manufacturing Information and Systems, National Cheng Kung University, Tainan City, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112466961","display_name":"Jun-Hua Zeng","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jun-Hua Zeng","raw_affiliation_strings":["Institute of Manufacturing Information and Systems, National Cheng Kung University, Tainan City, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Manufacturing Information and Systems, National Cheng Kung University, Tainan City, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022724113","display_name":"Sheng-Yu Lee","orcid":"https://orcid.org/0000-0001-7796-9643"},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sheng-Yu Lee","raw_affiliation_strings":["Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109887906","display_name":"Ru\u2010Band Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ru-Band Lu","raw_affiliation_strings":["Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011953626","display_name":"Po\u2010Hsiu Kuo","orcid":"https://orcid.org/0000-0003-0365-3587"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Hsiu Kuo","raw_affiliation_strings":["Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021866378"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":null,"apc_paid":null,"fwci":1.203,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77581379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"18","issue":"6","first_page":"2862","last_page":"2869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.7570902109146118},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"Bipolar disorder","score":0.7210949659347534},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.7001955509185791},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.37428849935531616},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3381290137767792},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30623236298561096},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.2991611957550049},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2941429018974304},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18308374285697937},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.16174283623695374},{"id":"https://openalex.org/keywords/mood","display_name":"Mood","score":0.07751905918121338}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7570902109146118},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.7210949659347534},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.7001955509185791},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37428849935531616},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3381290137767792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30623236298561096},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2991611957550049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2941429018974304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18308374285697937},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16174283623695374},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.07751905918121338}],"mesh":[{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2020.2988024","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2020.2988024","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32324560","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32324560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1408307952","display_name":null,"funder_award_id":"MOST104-2622-B-006-006-CC2","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4376865021","display_name":null,"funder_award_id":"MOST103-2622-B-006-006-CC2","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1918686881","https://openalex.org/W1965396811","https://openalex.org/W1965594878","https://openalex.org/W1969299167","https://openalex.org/W1979999703","https://openalex.org/W1992868687","https://openalex.org/W1993588417","https://openalex.org/W2002772021","https://openalex.org/W2015867362","https://openalex.org/W2019690893","https://openalex.org/W2022242033","https://openalex.org/W2028260332","https://openalex.org/W2033539655","https://openalex.org/W2046434400","https://openalex.org/W2051616601","https://openalex.org/W2055188488","https://openalex.org/W2071128065","https://openalex.org/W2072090917","https://openalex.org/W2091374137","https://openalex.org/W2101250437","https://openalex.org/W2115718427","https://openalex.org/W2120702973","https://openalex.org/W2122189635","https://openalex.org/W2123427204","https://openalex.org/W2135046866","https://openalex.org/W2135106788","https://openalex.org/W2135667614","https://openalex.org/W2151014102","https://openalex.org/W2153032620","https://openalex.org/W2160598114","https://openalex.org/W2161633633","https://openalex.org/W2315295323","https://openalex.org/W2343469482","https://openalex.org/W2546848075","https://openalex.org/W2558077163","https://openalex.org/W2887361798","https://openalex.org/W2980625886","https://openalex.org/W2991501395"],"related_works":["https://openalex.org/W2164855536","https://openalex.org/W1997352593","https://openalex.org/W2143489661","https://openalex.org/W2070581548","https://openalex.org/W4281711902","https://openalex.org/W3206555169","https://openalex.org/W3016573916","https://openalex.org/W3157359833","https://openalex.org/W3024317680","https://openalex.org/W1511048503"],"abstract_inverted_index":{"Bipolar":[0],"disorder":[1,6],"I":[2],"(BD-I)":[3],"and":[4,12,54,56,71,146,153,174,185],"bipolar":[5],"II":[7],"(BD-II)":[8],"have":[9],"specific":[10],"characteristics":[11],"clear":[13],"diagnostic":[14,62,67],"criteria,":[15],"but":[16],"quite":[17],"different":[18],"treatment":[19],"guidelines.":[20],"In":[21],"clinical":[22],"practice,":[23],"BD-II":[24],"is":[25,123],"commonly":[26],"mistaken":[27],"as":[28],"a":[29,58,124,150],"mild":[30],"form":[31],"of":[32,52,60,74,103,107,120,127,133,190],"BD-I.":[33],"This":[34,139],"study":[35,140,179],"uses":[36,142],"data":[37],"science":[38],"technique":[39],"to":[40,64,148],"identify":[41,154],"the":[42,50,66,81,92,99,110,117,188],"important":[43],"Single":[44],"Nucleotide":[45],"Polymorphisms":[46],"(SNPs)":[47],"significantly":[48],"affecting":[49],"classifications":[51],"BD-I":[53],"BD-II,":[55],"develops":[57],"set":[59],"complementary":[61],"classifiers":[63],"enhance":[65],"process.":[68],"Screening":[69],"assessments":[70],"SNP":[72],"genotypes":[73],"316":[75],"Han":[76],"Chinese":[77],"were":[78],"performed":[79],"with":[80],"Affymetrix":[82],"Axiom":[83],"Genome-Wide":[84],"TWB":[85],"Array":[86],"Plate.":[87],"The":[88,130,178],"results":[89],"show":[90],"that":[91],"classifier":[93,111],"constructed":[94,112],"by":[95,113,136],"23":[96],"SNPs":[97,115,183],"reached":[98,116],"area":[100],"under":[101],"curve":[102],"ROC":[104],"(AUC)":[105],"level":[106,119],"0.939,":[108],"while":[109],"42":[114],"AUC":[118],"0.9574,":[121],"which":[122],"mere":[125],"addition":[126],"1.84":[128],"percent.":[129,138],"accuracy":[131],"rate":[132],"classification":[134],"increased":[135],"3.46":[137],"also":[141,186],"Gene":[143],"Ontology":[144],"(GO)":[145],"Pathway":[147],"conduct":[149],"functional":[151],"analysis":[152],"significant":[155],"items,":[156],"including":[157],"calcium":[158],"ion":[159],"binding,":[160],"GABA-A":[161],"receptor":[162],"activity,":[163],"Rap1":[164],"signaling":[165,170,176],"pathway,":[166],"ECM":[167],"proteoglycans,":[168],"IL12-mediated":[169],"events,":[171],"Nicotine":[172],"addiction),":[173],"PI3K-Akt":[175],"pathway.":[177],"can":[180],"address":[181],"time-consuming":[182],"identification":[184],"quantify":[187],"effect":[189],"SNP-SNP":[191],"interactions.":[192]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}