{"id":"https://openalex.org/W2979945966","doi":"https://doi.org/10.1109/tcbb.2019.2945761","title":"EPGA-SC : A Framework for<i>de novo</i>Assembly of Single-Cell Sequencing Reads","display_name":"EPGA-SC : A Framework for<i>de novo</i>Assembly of Single-Cell Sequencing Reads","publication_year":2019,"publication_date":"2019-10-07","ids":{"openalex":"https://openalex.org/W2979945966","doi":"https://doi.org/10.1109/tcbb.2019.2945761","mag":"2979945966","pmid":"https://pubmed.ncbi.nlm.nih.gov/31603794"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2019.2945761","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2019.2945761","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088826157","display_name":"Xingyu Liao","orcid":"https://orcid.org/0000-0002-0061-1317"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyu Liao","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-0061-1317","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719013","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-0188-1394"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-0188-1394","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422484","display_name":"Junwei Luo","orcid":"https://orcid.org/0000-0001-6841-9893"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junwei Luo","raw_affiliation_strings":["Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-6841-9893","affiliations":[{"raw_affiliation_string":"Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022432765","display_name":"You Zou","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"You Zou","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091157395","display_name":"Fang\u2010Xiang Wu","orcid":"https://orcid.org/0000-0002-4593-9332"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fang-Xiang Wu","raw_affiliation_strings":["Department of Mechanical Engineering and Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4593-9332","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering and Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101465265","display_name":"Yi Pan","orcid":"https://orcid.org/0000-0002-2766-3096"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Pan","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2766-3096","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100683466","display_name":"Feng Luo","orcid":"https://orcid.org/0000-0002-4813-2403"},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Luo","raw_affiliation_strings":["School of Computing, Clemson University, Clemson, SC, USA"],"raw_orcid":"https://orcid.org/0000-0002-4813-2403","affiliations":[{"raw_affiliation_string":"School of Computing, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100438360","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0003-1516-0480"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, P.R. China"],"raw_orcid":"https://orcid.org/0000-0003-1516-0480","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, P.R. China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1657,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52052724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"18","issue":"4","first_page":"1492","last_page":"1503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/contig","display_name":"Contig","score":0.9470735788345337},{"id":"https://openalex.org/keywords/sequence-assembly","display_name":"Sequence assembly","score":0.689806342124939},{"id":"https://openalex.org/keywords/hybrid-genome-assembly","display_name":"Hybrid genome assembly","score":0.655728816986084},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5842480063438416},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.5811252593994141},{"id":"https://openalex.org/keywords/single-cell-sequencing","display_name":"Single cell sequencing","score":0.5365481376647949},{"id":"https://openalex.org/keywords/deep-sequencing","display_name":"Deep sequencing","score":0.5224142074584961},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.499265193939209},{"id":"https://openalex.org/keywords/nanopore-sequencing","display_name":"Nanopore sequencing","score":0.415740430355072},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.36634552478790283},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3621378540992737},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3199996054172516},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22983896732330322},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.19087788462638855},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.11577406525611877},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10550490021705627}],"concepts":[{"id":"https://openalex.org/C59582021","wikidata":"https://www.wikidata.org/wiki/Q1128751","display_name":"Contig","level":4,"score":0.9470735788345337},{"id":"https://openalex.org/C18949551","wikidata":"https://www.wikidata.org/wiki/Q740578","display_name":"Sequence assembly","level":5,"score":0.689806342124939},{"id":"https://openalex.org/C113425843","wikidata":"https://www.wikidata.org/wiki/Q5953213","display_name":"Hybrid genome assembly","level":5,"score":0.655728816986084},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5842480063438416},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.5811252593994141},{"id":"https://openalex.org/C174749747","wikidata":"https://www.wikidata.org/wiki/Q15917269","display_name":"Single cell sequencing","level":5,"score":0.5365481376647949},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.5224142074584961},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.499265193939209},{"id":"https://openalex.org/C126513998","wikidata":"https://www.wikidata.org/wiki/Q8973627","display_name":"Nanopore sequencing","level":4,"score":0.415740430355072},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.36634552478790283},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3621378540992737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3199996054172516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22983896732330322},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.19087788462638855},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.11577406525611877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10550490021705627},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2019.2945761","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2019.2945761","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31603794","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31603794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.5199999809265137}],"awards":[{"id":"https://openalex.org/G1187543282","display_name":null,"funder_award_id":"61772557","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1729077721","display_name":null,"funder_award_id":"61732009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4066238608","display_name":null,"funder_award_id":"B18059","funder_id":"https://openalex.org/F4320327912","funder_display_name":"Higher Education Discipline Innovation Project"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327912","display_name":"Higher Education Discipline Innovation Project","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W33133400","https://openalex.org/W1966822396","https://openalex.org/W2037444377","https://openalex.org/W2050557699","https://openalex.org/W2057253402","https://openalex.org/W2061680337","https://openalex.org/W2075013491","https://openalex.org/W2086814185","https://openalex.org/W2096128575","https://openalex.org/W2107282968","https://openalex.org/W2107772251","https://openalex.org/W2113287691","https://openalex.org/W2113606293","https://openalex.org/W2117131162","https://openalex.org/W2119745866","https://openalex.org/W2120902911","https://openalex.org/W2121530737","https://openalex.org/W2121911035","https://openalex.org/W2129744420","https://openalex.org/W2129933858","https://openalex.org/W2131813051","https://openalex.org/W2133956160","https://openalex.org/W2136879569","https://openalex.org/W2141920662","https://openalex.org/W2151017710","https://openalex.org/W2157539385","https://openalex.org/W2160265768","https://openalex.org/W2160969485","https://openalex.org/W2161546116","https://openalex.org/W2167142762","https://openalex.org/W2180318265","https://openalex.org/W2211504288","https://openalex.org/W2330617919","https://openalex.org/W2520464109","https://openalex.org/W2529108608","https://openalex.org/W2610924493","https://openalex.org/W2782397389","https://openalex.org/W2799490241","https://openalex.org/W2886623299","https://openalex.org/W2890720538","https://openalex.org/W2897603144","https://openalex.org/W6601366811"],"related_works":["https://openalex.org/W3167837387","https://openalex.org/W3124129973","https://openalex.org/W3090794301","https://openalex.org/W3121387483","https://openalex.org/W2951181326","https://openalex.org/W625729589","https://openalex.org/W4281387755","https://openalex.org/W4226342948","https://openalex.org/W2137509018","https://openalex.org/W2128684264"],"abstract_inverted_index":{"Assembling":[0],"genomes":[1],"from":[2,148],"single-cell":[3,9,12,39,71,108],"sequencing":[4,30,72,86,88,109,165],"data":[5,40],"is":[6],"essential":[7],"for":[8,38,66,175],"studies.":[10],"However,":[11,93],"assemblies":[13,152,197],"are":[14,125],"challenging":[15],"due":[16],"to":[17,51,80,103,131,160],"(i)":[18,128],"the":[19,26,82,94,133,149,162],"highly":[20],"non-uniform":[21],"read":[22],"coverage":[23],"and":[24,32,90,97,167,170,179,213],"(ii)":[25,138],"elevated":[27],"levels":[28],"of":[29,48,70,123,135,142,164,207],"errors":[31,178],"chimeric":[33,177],"reads.":[34,73],"Although":[35],"several":[36],"assemblers":[37],"have":[41],"been":[42],"proposed":[43],"in":[44,107,202,205],"recent":[45],"years,":[46],"most":[47,199,203],"them":[49],"fail":[50],"construct":[52],"correct":[53],"long":[54],"contigs.":[55,181],"In":[56,111],"this":[57,112],"study,":[58,113],"we":[59,114],"present":[60],"a":[61],"new":[62],"framework":[63],"called":[64],"EPGA-SC":[65,116,124,184,193],"de":[67],"novo":[68],"assembly":[69],"The":[74,120,188],"EPGA":[75,102],"assembler":[76,156],"has":[77],"designed":[78,115],"strategies":[79],"solve":[81],"problems":[83],"caused":[84],"by":[85,154],"errors,":[87],"biases,":[89],"repetitive":[91,168],"regions.":[92],"extremely":[95],"unbalanced":[96],"richer":[98],"error":[99],"types":[100],"prevent":[101],"achieve":[104],"high":[105,143,150],"performance":[106],"data.":[110],"based":[117],"on":[118],"EPGA.":[119],"main":[121],"innovations":[122],"as":[126,158],"follows:":[127],"classifying":[129],"reads":[130,146],"reduce":[132],"proportion":[134],"false":[136],"reads;":[137],"using":[139],"multiple":[140],"sets":[141],"precision":[144,151],"paired-end":[145],"generated":[147],"produced":[153],"other":[155],"such":[157],"SPAdes":[159],"overcome":[161],"impact":[163],"biases":[166],"regions;":[169],"(iii)":[171],"developing":[172],"novel":[173],"algorithms":[174],"removing":[176],"extending":[180],"We":[182],"test":[183],"with":[185],"seven":[186],"datasets.":[187],"experimental":[189],"results":[190],"show":[191],"that":[192],"can":[194],"generate":[195],"better":[196],"than":[198],"current":[200],"tools":[201],"time":[204],"term":[206],"MAX":[208],"contig,":[209],"N50,":[210],"NG50,":[211],"NA50,":[212],"NGA50.":[214]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2019-10-18T00:00:00"}