{"id":"https://openalex.org/W2914482044","doi":"https://doi.org/10.1109/tcbb.2019.2897301","title":"Novel Regularization Method for Biomarker Selection and Cancer Classification","display_name":"Novel Regularization Method for Biomarker Selection and Cancer Classification","publication_year":2019,"publication_date":"2019-02-05","ids":{"openalex":"https://openalex.org/W2914482044","doi":"https://doi.org/10.1109/tcbb.2019.2897301","mag":"2914482044","pmid":"https://pubmed.ncbi.nlm.nih.gov/30716046"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2019.2897301","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2019.2897301","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100394460","display_name":"Xiaoying Liu","orcid":"https://orcid.org/0000-0002-9359-1457"},"institutions":[{"id":"https://openalex.org/I32820368","display_name":"Guangdong Polytechnic of Science and Technology","ror":"https://ror.org/01wq2p249","country_code":"CN","type":"education","lineage":["https://openalex.org/I32820368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Ying Liu","raw_affiliation_strings":["Computer Engineering Technical College, Guangdong Polytechnic of Science and Technology, Zhuhai, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-9359-1457","affiliations":[{"raw_affiliation_string":"Computer Engineering Technical College, Guangdong Polytechnic of Science and Technology, Zhuhai, Guangdong, China","institution_ids":["https://openalex.org/I32820368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062545526","display_name":"Sai Wang","orcid":"https://orcid.org/0000-0001-6378-5042"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Sai Wang","raw_affiliation_strings":["Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau"],"raw_orcid":"https://orcid.org/0000-0001-6378-5042","affiliations":[{"raw_affiliation_string":"Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112517279","display_name":"Hai Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Hai Zhang","raw_affiliation_strings":["Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau"],"raw_orcid":"https://orcid.org/0000-0003-1715-4332","affiliations":[{"raw_affiliation_string":"Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323532","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0003-1715-4332"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085127108","display_name":"Ziyi Yang","orcid":"https://orcid.org/0000-0002-3550-9283"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Zi-Yi Yang","raw_affiliation_strings":["Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau"],"raw_orcid":"https://orcid.org/0000-0002-3550-9283","affiliations":[{"raw_affiliation_string":"Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083841358","display_name":"Yong Liang","orcid":"https://orcid.org/0000-0002-2858-2810"},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]},{"id":"https://openalex.org/I4210135053","display_name":"Quality Research","ror":"https://ror.org/03v0zfc19","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210135053"]}],"countries":["MO","US"],"is_corresponding":false,"raw_author_name":"Yong Liang","raw_affiliation_strings":["State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau"],"raw_orcid":"https://orcid.org/0000-0002-2858-2810","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Information Technology, Macau University of Science and Technology, Taipa, Macau","institution_ids":["https://openalex.org/I111950717","https://openalex.org/I4210135053"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8286,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.71261868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"4","first_page":"1329","last_page":"1340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10500","display_name":"Sparse and Compressive Sensing Techniques","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9786999821662903,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.8203726410865784},{"id":"https://openalex.org/keywords/penalty-method","display_name":"Penalty method","score":0.6843737959861755},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5871899127960205},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5839099884033203},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4194177985191345},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.39055097103118896},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3776310086250305},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3471648395061493},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.33902621269226074},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.32895731925964355},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3236144781112671}],"concepts":[{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.8203726410865784},{"id":"https://openalex.org/C6180225","wikidata":"https://www.wikidata.org/wiki/Q3411771","display_name":"Penalty method","level":2,"score":0.6843737959861755},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5871899127960205},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5839099884033203},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4194177985191345},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.39055097103118896},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3776310086250305},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3471648395061493},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.33902621269226074},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32895731925964355},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3236144781112671},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2019.2897301","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2019.2897301","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30716046","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30716046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1528580419","https://openalex.org/W1672796142","https://openalex.org/W1769772704","https://openalex.org/W1964675052","https://openalex.org/W1965125844","https://openalex.org/W1980500788","https://openalex.org/W1994709204","https://openalex.org/W1996583386","https://openalex.org/W2000771269","https://openalex.org/W2011961482","https://openalex.org/W2024311320","https://openalex.org/W2026706435","https://openalex.org/W2034454344","https://openalex.org/W2041891835","https://openalex.org/W2053691226","https://openalex.org/W2056201402","https://openalex.org/W2057682568","https://openalex.org/W2063978378","https://openalex.org/W2064208261","https://openalex.org/W2069620150","https://openalex.org/W2071480068","https://openalex.org/W2074682976","https://openalex.org/W2075490785","https://openalex.org/W2086943873","https://openalex.org/W2099641086","https://openalex.org/W2102062980","https://openalex.org/W2104902148","https://openalex.org/W2106161928","https://openalex.org/W2114843025","https://openalex.org/W2118488518","https://openalex.org/W2122825543","https://openalex.org/W2128873464","https://openalex.org/W2129208356","https://openalex.org/W2129560785","https://openalex.org/W2131315497","https://openalex.org/W2135046866","https://openalex.org/W2138019504","https://openalex.org/W2141554253","https://openalex.org/W2148487094","https://openalex.org/W2159400887","https://openalex.org/W2166956514","https://openalex.org/W2343420905","https://openalex.org/W2346848267","https://openalex.org/W2579282444","https://openalex.org/W2899829877","https://openalex.org/W2913088541","https://openalex.org/W3098306969","https://openalex.org/W3105120000","https://openalex.org/W4322574962","https://openalex.org/W6637753837","https://openalex.org/W6675301529","https://openalex.org/W6684416548","https://openalex.org/W6758510119"],"related_works":["https://openalex.org/W2018662469","https://openalex.org/W2062802260","https://openalex.org/W1977335770","https://openalex.org/W2175677697","https://openalex.org/W3180934676","https://openalex.org/W2766314973","https://openalex.org/W3134574304","https://openalex.org/W2358930476","https://openalex.org/W2017292650","https://openalex.org/W2109185638"],"abstract_inverted_index":{"penalty":[0,7,53,81,99],"to":[1,14,36,71],"evaluate":[2,15],"the":[3,16,34,58,73,76,96,104],"grouping":[4],"effect":[5],"and":[6,64,69,114],"with":[8,27,66],"a":[9,24,38,47,88],"fixed":[10],"value":[11],"of":[12,60,75,111],"q":[13,70],"variable":[17],"sparsity,":[18],"respectively.":[19],"These":[20],"methods":[21,107],"typically":[22],"produce":[23],"good":[25],"performance":[26],"high":[28],"efficiency,":[29],"but":[30],"they":[31],"often":[32],"require":[33],"data":[35],"satisfy":[37],"certain":[39],"probability":[40],"distribution.":[41],"In":[42],"this":[43],"paper,":[44],"we":[45],"propose":[46],"novel":[48],"complex":[49],"harmonic":[50],"regularization":[51,106],"(CHR)":[52],"function,":[54],"which":[55],"can":[56,83],"approximate":[57],"combination":[59],"[Formula:":[61],"see":[62],"text]":[63],"regularizations":[65],"adjustable":[67],"p":[68],"select":[72],"groups":[74,110],"relevant":[77,112],"variables.":[78],"The":[79],"CHR":[80,98],"function":[82,100],"be":[84],"effectively":[85],"solved":[86],"by":[87],"direct":[89],"path":[90],"seeking":[91],"algorithm.":[92],"We":[93],"demonstrate":[94],"that":[95],"proposed":[97],"performs":[101],"better":[102],"than":[103],"state-of-the-art":[105],"in":[108],"selecting":[109],"variables":[113],"classification.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
