{"id":"https://openalex.org/W2908485946","doi":"https://doi.org/10.1109/tcbb.2018.2889978","title":"United Neighborhood Closeness Centrality and Orthology for Predicting Essential Proteins","display_name":"United Neighborhood Closeness Centrality and Orthology for Predicting Essential Proteins","publication_year":2018,"publication_date":"2018-12-27","ids":{"openalex":"https://openalex.org/W2908485946","doi":"https://doi.org/10.1109/tcbb.2018.2889978","mag":"2908485946","pmid":"https://pubmed.ncbi.nlm.nih.gov/30596582"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2889978","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2889978","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Gaoshi Li","orcid":"https://orcid.org/0000-0002-0188-1394"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I29739308","display_name":"Guangxi Normal University","ror":"https://ror.org/02frt9q65","country_code":"CN","type":"education","lineage":["https://openalex.org/I29739308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaoshi Li","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China","Guangxi Key Lab of Multi-source Information Mining and Security, Guangxi Normal University, Guilin, China"],"raw_orcid":"https://orcid.org/0000-0002-0188-1394","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Guangxi Key Lab of Multi-source Information Mining and Security, Guangxi Normal University, Guilin, China","institution_ids":["https://openalex.org/I29739308"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Li","orcid":"https://orcid.org/0000-0003-0178-1876"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-0178-1876","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438360","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0003-1516-0480"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-1516-0480","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079316675","display_name":"Yaohang Li","orcid":"https://orcid.org/0000-0003-0178-1876"},"institutions":[{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaohang Li","raw_affiliation_strings":["Department of Computer Science, Old Dominion University, Norfolk, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Old Dominion University, Norfolk, VA, USA","institution_ids":["https://openalex.org/I81365321"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101465265","display_name":"Yi Pan","orcid":"https://orcid.org/0000-0002-2766-3096"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Pan","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, GA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2766-3096","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3894,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.90126145,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"17","issue":"4","first_page":"1451","last_page":"1458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.9529953598976135},{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.9039493799209595},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6358601450920105},{"id":"https://openalex.org/keywords/closeness","display_name":"Closeness","score":0.587495744228363},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4606497287750244},{"id":"https://openalex.org/keywords/network-theory","display_name":"Network theory","score":0.45174548029899597},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4356020987033844},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.408650279045105},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39430665969848633},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34642383456230164},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20966842770576477},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2094871997833252},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.09011584520339966}],"concepts":[{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.9529953598976135},{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.9039493799209595},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6358601450920105},{"id":"https://openalex.org/C2779545769","wikidata":"https://www.wikidata.org/wiki/Q5135364","display_name":"Closeness","level":2,"score":0.587495744228363},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4606497287750244},{"id":"https://openalex.org/C11804174","wikidata":"https://www.wikidata.org/wiki/Q1192971","display_name":"Network theory","level":2,"score":0.45174548029899597},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4356020987033844},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.408650279045105},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39430665969848633},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34642383456230164},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20966842770576477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2094871997833252},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.09011584520339966},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2018.2889978","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2889978","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30596582","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30596582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1527238211","display_name":null,"funder_award_id":"2018WK4001","funder_id":"https://openalex.org/F4320321471","funder_display_name":"Hunan Provincial Science and Technology Department"},{"id":"https://openalex.org/G3328780670","display_name":null,"funder_award_id":"61728211","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4043378463","display_name":null,"funder_award_id":"61832019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4066238608","display_name":null,"funder_award_id":"B18059","funder_id":"https://openalex.org/F4320327912","funder_display_name":"Higher Education Discipline Innovation Project"},{"id":"https://openalex.org/G6109475432","display_name":null,"funder_award_id":"2017GXNSFAA198191","funder_id":"https://openalex.org/F4320322768","funder_display_name":"Natural Science Foundation of Guangxi Province"},{"id":"https://openalex.org/G8210156615","display_name":null,"funder_award_id":"61622213","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321471","display_name":"Hunan Provincial Science and Technology Department","ror":"https://ror.org/04qgr7x96"},{"id":"https://openalex.org/F4320322768","display_name":"Natural Science Foundation of Guangxi Province","ror":null},{"id":"https://openalex.org/F4320327912","display_name":"Higher Education Discipline Innovation Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W828529927","https://openalex.org/W1503938960","https://openalex.org/W1595498733","https://openalex.org/W1714524773","https://openalex.org/W1973564330","https://openalex.org/W1973758399","https://openalex.org/W1975191997","https://openalex.org/W1986310535","https://openalex.org/W1988496202","https://openalex.org/W1998152384","https://openalex.org/W1999808266","https://openalex.org/W2003516452","https://openalex.org/W2005740247","https://openalex.org/W2007245700","https://openalex.org/W2007921075","https://openalex.org/W2016608827","https://openalex.org/W2017975254","https://openalex.org/W2021149413","https://openalex.org/W2021723654","https://openalex.org/W2025971310","https://openalex.org/W2029158589","https://openalex.org/W2030226083","https://openalex.org/W2031798035","https://openalex.org/W2035020365","https://openalex.org/W2043764521","https://openalex.org/W2047998870","https://openalex.org/W2054564621","https://openalex.org/W2060816398","https://openalex.org/W2063749475","https://openalex.org/W2074443723","https://openalex.org/W2077386490","https://openalex.org/W2082202339","https://openalex.org/W2082565035","https://openalex.org/W2087194317","https://openalex.org/W2088590769","https://openalex.org/W2089125183","https://openalex.org/W2090422756","https://openalex.org/W2095867585","https://openalex.org/W2101725042","https://openalex.org/W2105089945","https://openalex.org/W2110852002","https://openalex.org/W2113553645","https://openalex.org/W2115550821","https://openalex.org/W2116447934","https://openalex.org/W2118830783","https://openalex.org/W2119114096","https://openalex.org/W2125580930","https://openalex.org/W2126520729","https://openalex.org/W2128784723","https://openalex.org/W2132582966","https://openalex.org/W2136749660","https://openalex.org/W2140462113","https://openalex.org/W2142437744","https://openalex.org/W2144393227","https://openalex.org/W2146447390","https://openalex.org/W2159595936","https://openalex.org/W2162891889","https://openalex.org/W2170401728","https://openalex.org/W2201354711","https://openalex.org/W2324728706","https://openalex.org/W2326727950","https://openalex.org/W2340802671","https://openalex.org/W2512143001","https://openalex.org/W2513497485","https://openalex.org/W2586452838","https://openalex.org/W2750770743","https://openalex.org/W2772934464","https://openalex.org/W2779222065","https://openalex.org/W2792330169","https://openalex.org/W2885618056","https://openalex.org/W2891614933","https://openalex.org/W2912724961","https://openalex.org/W4211208250"],"related_works":["https://openalex.org/W2046736422","https://openalex.org/W2611574733","https://openalex.org/W2947501077","https://openalex.org/W3174053386","https://openalex.org/W2735213133","https://openalex.org/W4286481244","https://openalex.org/W2169225831","https://openalex.org/W1968382581","https://openalex.org/W4287647061","https://openalex.org/W4385357749"],"abstract_inverted_index":{"Identifying":[0],"essential":[1,23,105,130,184],"proteins":[2,24,131,185],"plays":[3],"an":[4],"important":[5],"role":[6],"in":[7,133,136],"disease":[8],"study,":[9,126],"drug":[10],"design,":[11],"and":[12,38,76,178,181,205,207,213,219],"understanding":[13],"the":[14,27,81,238],"minimal":[15],"requirement":[16],"for":[17,22],"cellular":[18],"life.":[19],"Computational":[20],"methods":[21,32,87,112,198,210],"discovery":[25],"overcome":[26],"disadvantages":[28],"of":[29,43,84,121],"biological":[30],"experimental":[31],"that":[33,96,129,223],"are":[34,48],"often":[35,49,141],"time-consuming,":[36],"expensive,":[37],"inefficient.":[39],"The":[40],"topological":[41],"features":[42],"protein-protein":[44],"interaction":[45],"(PPI)":[46],"networks":[47],"used":[50],"to":[51,91,118,175],"design":[52],"computational":[53],"prediction":[54,82,122],"methods,":[55],"such":[56,99],"as":[57,100],"Degree":[58],"Centrality":[59,62,65,68,71,74,78,159],"(DC),":[60],"Betweenness":[61],"(BC),":[63],"Closeness":[64,158],"(CC),":[66],"Subgraph":[67],"(SC),":[69],"Eigenvector":[70],"(EC),":[72],"Information":[73],"(IC),":[75],"Neighborhood":[77,157],"(NC).":[79],"However,":[80],"accuracies":[83],"these":[85],"individual":[86],"still":[88],"have":[89,109],"space":[90],"be":[92],"improved.":[93],"Studies":[94],"show":[95,222],"additional":[97],"information,":[98],"orthologous":[101],"relations,":[102],"helps":[103],"discover":[104],"proteins.":[106],"Many":[107],"researchers":[108],"proposed":[110],"different":[111],"by":[113],"combining":[114],"multiple":[115],"information":[116,180],"sources":[117],"gain":[119],"improvement":[120],"accuracy.":[123],"In":[124],"this":[125,147],"we":[127,149,162],"find":[128],"appear":[132],"triangular":[134],"structure":[135],"PPI":[137],"network":[138],"significantly":[139],"more":[140],"than":[142,237],"nonessential":[143],"ones.":[144],"Based":[145],"on":[146,217],"phenomenon,":[148],"propose":[150],"a":[151,164,182,229],"novel":[152,183],"pure":[153],"centrality":[154,197],"measure,":[155],"so-called":[156],"(NCC).":[160],"Accordingly,":[161],"develop":[163],"new":[165],"combination":[166],"model,":[167,172],"Extended":[168],"Pareto":[169],"Optimality":[170],"Consensus":[171],"named":[173],"EPOC,":[174],"fuse":[176],"NCC":[177],"Orthology":[179],"identification":[186],"method,":[187,231],"NCCO,":[188],"is":[189],"fully":[190],"proposed.":[191],"Compared":[192],"with":[193],"seven":[194],"existing":[195],"classic":[196],"(DC,":[199],"BC,":[200],"IC,":[201],"CC,":[202],"SC,":[203],"EC,":[204],"NC)":[206],"three":[208],"consensus":[209,230],"(PeC,":[211],"ION,":[212],"CSC),":[214],"our":[215],"results":[216],"S.cerevisiae":[218],"E.coli":[220],"datasets":[221],"NCCO":[224],"has":[225],"clear":[226],"advantages.":[227],"As":[228],"EPOC":[232],"also":[233],"yields":[234],"better":[235],"performance":[236],"random":[239],"walk":[240],"model.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
