{"id":"https://openalex.org/W2905554201","doi":"https://doi.org/10.1109/tcbb.2018.2885757","title":"Understanding Protein Networks Using Vester's Sensitivity Model","display_name":"Understanding Protein Networks Using Vester's Sensitivity Model","publication_year":2018,"publication_date":"2018-12-11","ids":{"openalex":"https://openalex.org/W2905554201","doi":"https://doi.org/10.1109/tcbb.2018.2885757","mag":"2905554201","pmid":"https://pubmed.ncbi.nlm.nih.gov/30530336"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2885757","doi":"https://doi.org/10.1109/tcbb.2018.2885757","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2885757","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074883507","display_name":"Liana Amaya Moreno","orcid":"https://orcid.org/0000-0002-3331-3295","observed_orcids":["https://orcid.org/0000-0002-3331-3295"]},"institutions":[{"id":"https://openalex.org/I190134885","display_name":"Helmut Schmidt University","ror":"https://ror.org/04e8jbs38","country_code":"DE","type":"education","lineage":["https://openalex.org/I190134885"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Liana Amaya Moreno","raw_affiliation_strings":["Department of Mechanical Engineering, Helmut Schmidt University, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3331-3295","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Helmut Schmidt University, Hamburg, Germany","institution_ids":["https://openalex.org/I190134885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032504360","display_name":"Maryam Omidi","orcid":"https://orcid.org/0000-0003-2357-785X","observed_orcids":["https://orcid.org/0000-0003-2357-785X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maryam Omidi","raw_affiliation_strings":["Institute of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070560460","display_name":"Marcus Wurlitzer","orcid":"https://orcid.org/0000-0002-1911-4572","observed_orcids":["https://orcid.org/0000-0002-1911-4572"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Wurlitzer","raw_affiliation_strings":["Institute of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054675390","display_name":"B\u00e9reng\u00e8re Luthringer-Feyerabend","orcid":"https://orcid.org/0000-0002-8248-6715","observed_orcids":["https://orcid.org/0000-0002-8248-6715"]},"institutions":[{"id":"https://openalex.org/I4210139239","display_name":"Helmholtz-Zentrum Hereon","ror":"https://ror.org/03qjp1d79","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210139239"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B\u00e9reng\u00e8re Luthringer","raw_affiliation_strings":["Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Geesthacht, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8248-6715","affiliations":[{"raw_affiliation_string":"Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Geesthacht, Germany","institution_ids":["https://openalex.org/I4210139239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023203755","display_name":"Heike Helmholz","orcid":"https://orcid.org/0000-0001-6457-3607","observed_orcids":["https://orcid.org/0000-0001-6457-3607"]},"institutions":[{"id":"https://openalex.org/I4210139239","display_name":"Helmholtz-Zentrum Hereon","ror":"https://ror.org/03qjp1d79","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210139239"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heike Helmholz","raw_affiliation_strings":["Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Geesthacht, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6457-3607","affiliations":[{"raw_affiliation_string":"Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Geesthacht, Germany","institution_ids":["https://openalex.org/I4210139239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037776901","display_name":"Hartmut Schl\u00fcter","orcid":"https://orcid.org/0000-0002-9358-7036","observed_orcids":["https://orcid.org/0000-0002-9358-7036"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Schl\u00fcter","raw_affiliation_strings":["Institute of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046752653","display_name":"Regine Willumeit\u2010R\u00f6mer","orcid":"https://orcid.org/0000-0002-6004-6946","observed_orcids":["https://orcid.org/0000-0002-6004-6946"]},"institutions":[{"id":"https://openalex.org/I4210139239","display_name":"Helmholtz-Zentrum Hereon","ror":"https://ror.org/03qjp1d79","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210139239"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Regine Willumeit-R\u00f6mer","raw_affiliation_strings":["Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Geesthacht, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Geesthacht, Germany","institution_ids":["https://openalex.org/I4210139239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018583360","display_name":"Armin R. F\u00fcgenschuh","orcid":"https://orcid.org/0000-0003-3637-4066","observed_orcids":["https://orcid.org/0000-0003-3637-4066"]},"institutions":[{"id":"https://openalex.org/I51783024","display_name":"Brandenburg University of Technology Cottbus-Senftenberg","ror":"https://ror.org/02wxx3e24","country_code":"DE","type":"education","lineage":["https://openalex.org/I51783024"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Armin F\u00fcgenschuh","raw_affiliation_strings":["Institute of Mathematics, Brandenburg University of Technology Cottbus-Senftenberg, Cottbus, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3637-4066","affiliations":[{"raw_affiliation_string":"Institute of Mathematics, Brandenburg University of Technology Cottbus-Senftenberg, Cottbus, Germany","institution_ids":["https://openalex.org/I51783024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":0.0787,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.40776854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"4","first_page":"1440","last_page":"1450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7599999904632568},{"id":"https://openalex.org/keywords/magnesium-based-biomaterials","display_name":"magnesium-based biomaterials","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.7039999961853027},{"id":"https://openalex.org/keywords/bioactive-biomaterials","display_name":"bioactive biomaterials","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6645147800445557},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.55434250831604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4976063072681427},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41951465606689453},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41672688722610474},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.41622740030288696},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4160812199115753},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.41222697496414185},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3480392098426819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2534850835800171},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25037437677383423},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07966718077659607},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2018.2885757","doi":"https://doi.org/10.1109/tcbb.2018.2885757","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2885757","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30530336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30530336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W90330482","https://openalex.org/W1188527999","https://openalex.org/W1508254430","https://openalex.org/W1559547793","https://openalex.org/W1600572826","https://openalex.org/W1967557807","https://openalex.org/W1979765627","https://openalex.org/W1989930884","https://openalex.org/W1994680578","https://openalex.org/W2008107402","https://openalex.org/W2011142112","https://openalex.org/W2016787034","https://openalex.org/W2020012456","https://openalex.org/W2023641728","https://openalex.org/W2057156441","https://openalex.org/W2058221907","https://openalex.org/W2076747302","https://openalex.org/W2081349045","https://openalex.org/W2084320547","https://openalex.org/W2095335313","https://openalex.org/W2097368158","https://openalex.org/W2103224920","https://openalex.org/W2104155917","https://openalex.org/W2109632198","https://openalex.org/W2113305236","https://openalex.org/W2122342005","https://openalex.org/W2132864654","https://openalex.org/W2170776626","https://openalex.org/W2177968687","https://openalex.org/W2215626906","https://openalex.org/W2328003959","https://openalex.org/W2463195069","https://openalex.org/W2600371874","https://openalex.org/W4247173844","https://openalex.org/W7011302687","https://openalex.org/W7021090643"],"related_works":["https://openalex.org/W1797702204","https://openalex.org/W4376112453","https://openalex.org/W4376112202","https://openalex.org/W4224737743","https://openalex.org/W2485516716","https://openalex.org/W2464515224","https://openalex.org/W4224326768","https://openalex.org/W4376112403","https://openalex.org/W1499732058","https://openalex.org/W4376112235"],"abstract_inverted_index":{"Magnesium-based":[0],"biomaterials":[1,8],"belong":[2],"to":[3,89,130,144,196],"the":[4,26,41,49,76,91,131,153,169],"third":[5],"generation":[6],"of":[7,43,48,64,69,155,172],"that":[9],"are":[10,87],"also":[11],"bioactive.":[12],"These":[13],"smart":[14],"materials":[15],"combine":[16],"bioactivity":[17],"and":[18,20,111,141],"biodegradability,":[19],"elicit":[21],"specific":[22],"cellular":[23,191],"responses":[24],"at":[25],"molecular":[27,77],"level.":[28],"In":[29,148],"fact,":[30],"osteoinductive":[31],"properties":[32],"have":[33],"been":[34],"observed":[35],"in":[36,40,61,79,189],"mesenchymal":[37,106],"stem":[38,107],"cells":[39,108],"presence":[42],"Magnesium.":[44],"The":[45,67],"mechanistic":[46],"understanding":[47],"physiological":[50],"effects":[51],"however,":[52],"remains":[53],"a":[54,62],"difficult":[55],"task":[56],"as":[57,159],"Mg":[58,113],"is":[59],"involved":[60,188],"multitude":[63],"biological":[65],"reactions.":[66],"study":[68],"protein":[70],"interactions":[71],"may":[72],"shed":[73],"light":[74],"on":[75,176,182],"processes":[78],"Mg-stimulated":[80],"cells,":[81],"therefore,":[82],"suitable":[83],"data":[84,94,162],"mining":[85,163],"tools":[86],"required":[88],"analyze":[90],"large":[92],"amount":[93],"generated":[95],"via":[96],"proteomics.":[97],"Protein":[98,165],"compositions":[99],"over":[100],"time":[101],"between":[102],"two":[103],"conditions":[104],"(human":[105],"cultured":[109],"with":[110],"without":[112,179],"degradation":[114,175],"products)":[115],"were":[116,133,193],"analyzed":[117],"using":[118],"Vester's":[119,156],"Sensitivity":[120,157],"Model.":[121],"Proteins":[122],"whose":[123],"dynamics":[124],"significantly":[125],"change":[126],"from":[127],"one":[128],"setup":[129],"other":[132],"classified":[134],"into":[135],"four":[136],"categories:":[137],"passive,":[138],"active,":[139],"critical,":[140],"buffering":[142],"according":[143],"their":[145],"regulatory":[146],"activity.":[147],"this":[149],"work,":[150],"we":[151],"demonstrated":[152],"use":[154],"Model":[158],"an":[160],"appropriate":[161],"tool.":[164],"network":[166],"analyses":[167],"highlighted":[168],"primary":[170],"role":[171],"Mg-based":[173],"implant":[174],"cell":[177,183],"metabolism":[178],"deleterious":[180],"effect":[181],"viability.":[184],"Furthermore,":[185],"key":[186],"proteins":[187],"calcium-dependant":[190],"activities":[192],"emphasized":[194],"leading":[195],"further":[197],"studies.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}