{"id":"https://openalex.org/W2901613208","doi":"https://doi.org/10.1109/tcbb.2018.2882423","title":"An Efficient Ensemble Learning Approach for Predicting Protein-Protein Interactions by Integrating Protein Primary Sequence and Evolutionary Information","display_name":"An Efficient Ensemble Learning Approach for Predicting Protein-Protein Interactions by Integrating Protein Primary Sequence and Evolutionary Information","publication_year":2018,"publication_date":"2018-11-20","ids":{"openalex":"https://openalex.org/W2901613208","doi":"https://doi.org/10.1109/tcbb.2018.2882423","mag":"2901613208","pmid":"https://pubmed.ncbi.nlm.nih.gov/30475726"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2882423","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2882423","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696"},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu-Hong You","raw_affiliation_strings":["College of Electronics and Information Engineering, Xijing University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0003-1266-2696","affiliations":[{"raw_affiliation_string":"College of Electronics and Information Engineering, Xijing University, Xi'an, China","institution_ids":["https://openalex.org/I4210162994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101817107","display_name":"Wenzhun Huang","orcid":"https://orcid.org/0000-0003-4964-7211"},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Zhun Huang","raw_affiliation_strings":["College of Electronics and Information Engineering, Xijing University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Electronics and Information Engineering, Xijing University, Xi'an, China","institution_ids":["https://openalex.org/I4210162994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071771834","display_name":"Shanwen Zhang","orcid":"https://orcid.org/0000-0002-4534-5358"},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanwen Zhang","raw_affiliation_strings":["College of Electronics and Information Engineering, Xijing University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Electronics and Information Engineering, Xijing University, Xi'an, China","institution_ids":["https://openalex.org/I4210162994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017713277","display_name":"Yu\u2010An Huang","orcid":"https://orcid.org/0000-0002-5346-2394"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yu-An Huang","raw_affiliation_strings":["Department of Computing, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047290329","display_name":"Chang-Qing Yu","orcid":"https://orcid.org/0000-0003-4712-8784"},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Qing Yu","raw_affiliation_strings":["College of Electronics and Information Engineering, Xijing University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Electronics and Information Engineering, Xijing University, Xi'an, China","institution_ids":["https://openalex.org/I4210162994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100379665","display_name":"Liping Li","orcid":"https://orcid.org/0000-0002-2994-6583"},"institutions":[{"id":"https://openalex.org/I4210162994","display_name":"Xijing University","ror":"https://ror.org/05xsjkb63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210162994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Ping Li","raw_affiliation_strings":["College of Electronics and Information Engineering, Xijing University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Electronics and Information Engineering, Xijing University, Xi'an, China","institution_ids":["https://openalex.org/I4210162994"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.483,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.82747201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"809","last_page":"817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.709846019744873},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5131426453590393},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.4928865432739258},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.47161534428596497},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4390585720539093},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.4305644631385803},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39173221588134766},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.119545578956604},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.09912687540054321}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.709846019744873},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5131426453590393},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.4928865432739258},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.47161534428596497},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4390585720539093},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.4305644631385803},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39173221588134766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.119545578956604},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.09912687540054321},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098406","descriptor_name":"Ensemble Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098406","descriptor_name":"Ensemble Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098406","descriptor_name":"Ensemble Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098406","descriptor_name":"Ensemble Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2018.2882423","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2882423","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30475726","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30475726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6600000262260437,"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8"}],"awards":[{"id":"https://openalex.org/G3158980518","display_name":"\u57fa\u4e8e\u6c28\u57fa\u9178\u5e8f\u5217\u53ca\u836f\u7269\u5316\u5408\u7269\u5206\u5b50\u6307\u7eb9\u7684\u836f\u7269\uff0d\u9776\u6807\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u7814\u7a76","funder_award_id":"61572506","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1518822923","https://openalex.org/W1804250401","https://openalex.org/W1966916670","https://openalex.org/W1982267716","https://openalex.org/W1992991025","https://openalex.org/W1999586982","https://openalex.org/W2007618103","https://openalex.org/W2008543104","https://openalex.org/W2027922120","https://openalex.org/W2031614119","https://openalex.org/W2032408510","https://openalex.org/W2039473152","https://openalex.org/W2052034930","https://openalex.org/W2053186076","https://openalex.org/W2065176792","https://openalex.org/W2065304353","https://openalex.org/W2074553321","https://openalex.org/W2090123586","https://openalex.org/W2094397139","https://openalex.org/W2118886215","https://openalex.org/W2120386856","https://openalex.org/W2122863289","https://openalex.org/W2125874614","https://openalex.org/W2127616922","https://openalex.org/W2129812935","https://openalex.org/W2132582966","https://openalex.org/W2136305715","https://openalex.org/W2137009853","https://openalex.org/W2145955247","https://openalex.org/W2150248355","https://openalex.org/W2150452800","https://openalex.org/W2152705149","https://openalex.org/W2155004936","https://openalex.org/W2161701113","https://openalex.org/W2161710599","https://openalex.org/W2167869241","https://openalex.org/W2168638409","https://openalex.org/W2170682402","https://openalex.org/W2213532196","https://openalex.org/W2294639133","https://openalex.org/W2315196278","https://openalex.org/W2340589369","https://openalex.org/W2344144945","https://openalex.org/W2345181615","https://openalex.org/W2396940995","https://openalex.org/W2529594328","https://openalex.org/W2616561032","https://openalex.org/W2620425337"],"related_works":["https://openalex.org/W2378211422","https://openalex.org/W2745001401","https://openalex.org/W4321353415","https://openalex.org/W2130974462","https://openalex.org/W2028665553","https://openalex.org/W2086519370","https://openalex.org/W972276598","https://openalex.org/W2087343574","https://openalex.org/W4246352526","https://openalex.org/W2121910908"],"abstract_inverted_index":{"Protein-protein":[0],"interactions":[1],"(PPIs)":[2],"perform":[3],"a":[4,9,37,64,78,87,191],"very":[5],"important":[6],"function":[7],"in":[8,168],"number":[10,39],"of":[11,24,40,123,185],"cellular":[12],"processes,":[13],"including":[14,31],"signal":[15],"transduction,":[16],"post-translational":[17],"modifications,":[18],"apoptosis,":[19],"and":[20,54,69,95,111,151],"cell":[21],"growth.":[22],"Deregulation":[23],"PPIs":[25,47,84],"will":[26],"lead":[27],"to":[28,45,67,82,129],"many":[29],"diseases,":[30],"pernicious":[32],"anemia":[33],"or":[34],"cancers.":[35],"Although":[36],"large":[38],"high-throughput":[41],"techniques":[42],"are":[43,50,142],"designed":[44],"generate":[46],"data,":[48],"they":[49],"generally":[51],"expensive,":[52],"inefficient,":[53],"labor-intensive.":[55],"Hence,":[56],"there":[57],"is":[58,105,127],"an":[59,179],"urgent":[60],"need":[61],"for":[62,182,195],"developing":[63],"computational":[65,183],"method":[66,81,104,157,177,194],"accurately":[68],"rapidly":[70],"detect":[71,83],"PPIs.":[72],"In":[73],"this":[74,169],"article,":[75],"we":[76],"proposed":[77,103,156,176],"highly":[79],"efficient":[80],"by":[85],"integrating":[86],"new":[88],"protein":[89],"sequence":[90],"sub-stitution":[91],"matrix":[92],"feature":[93],"representation":[94,99],"ensemble":[96],"weighted":[97],"sparse":[98],"model":[100],"classifier.":[101],"The":[102],"demonstrated":[106],"on":[107],"Saccharomyces":[108],"cerevisiae":[109],"dataset":[110],"achieved":[112],"99.26":[113],"percent":[114,119],"prediction":[115],"accuracy":[116,134],"with":[117,144],"98.53":[118],"sensitivity":[120],"at":[121],"precision":[122],"100":[124],"percent,":[125],"which":[126,188],"shown":[128],"have":[130],"much":[131],"higher":[132],"predictive":[133],"than":[135,164],"the":[136,145],"state-of-the-art":[137],"methods.":[138],"Extensive":[139],"contrast":[140],"experiments":[141],"performed":[143],"benchmark":[146],"data":[147],"set":[148],"from":[149],"Human":[150],"Helicobacter":[152],"pylori":[153],"that":[154,174],"our":[155,175],"can":[158,189],"achieve":[159],"outstanding":[160],"better":[161],"success":[162],"rates":[163],"other":[165],"existing":[166],"approaches":[167],"problem.":[170],"Experiment":[171],"results":[172],"illustrate":[173],"presents":[178],"economical":[180],"approach":[181],"building":[184],"PPI":[186],"networks,":[187],"be":[190],"helpful":[192],"supplementary":[193],"future":[196],"proteomics":[197],"researches.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}