{"id":"https://openalex.org/W2900352840","doi":"https://doi.org/10.1109/tcbb.2018.2879673","title":"Introducing Heuristic Information Into Ant Colony Optimization Algorithm for Identifying Epistasis","display_name":"Introducing Heuristic Information Into Ant Colony Optimization Algorithm for Identifying Epistasis","publication_year":2018,"publication_date":"2018-11-05","ids":{"openalex":"https://openalex.org/W2900352840","doi":"https://doi.org/10.1109/tcbb.2018.2879673","mag":"2900352840","pmid":"https://pubmed.ncbi.nlm.nih.gov/30403637"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2879673","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2879673","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066144774","display_name":"Yingxia Sun","orcid":"https://orcid.org/0000-0003-3040-6899"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingxia Sun","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Rizhao, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103055165","display_name":"Xuan Wang","orcid":"https://orcid.org/0000-0003-2587-070X"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Wang","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Rizhao, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007539735","display_name":"Junliang Shang","orcid":"https://orcid.org/0000-0002-8488-2228"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junliang Shang","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Rizhao, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073144090","display_name":"Jin\u2010Xing Liu","orcid":"https://orcid.org/0000-0001-6104-2149"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Xing Liu","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Rizhao, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Hou Zheng","raw_affiliation_strings":["School of Software Engineering, Qufu Normal University, Rizhao, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058768577","display_name":"Xiujuan Lei","orcid":"https://orcid.org/0000-0002-9901-1732"},"institutions":[{"id":"https://openalex.org/I94310126","display_name":"Shanxi Normal University","ror":"https://ror.org/03zd3ta61","country_code":"CN","type":"education","lineage":["https://openalex.org/I94310126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiujuan Lei","raw_affiliation_strings":["School of Computer Science, Shannxi Normal University, Xi&#x2018;an, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Shannxi Normal University, Xi&#x2018;an, China","institution_ids":["https://openalex.org/I94310126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5066144774"],"corresponding_institution_ids":["https://openalex.org/I202126657"],"apc_list":null,"apc_paid":null,"fwci":1.6288,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.87940416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"17","issue":"4","first_page":"1253","last_page":"1261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10100","display_name":"Metaheuristic Optimization Algorithms Research","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10100","display_name":"Metaheuristic Optimization Algorithms Research","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9466999769210815,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9398000240325928,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.7787982225418091},{"id":"https://openalex.org/keywords/heuristic","display_name":"Heuristic","score":0.6441217064857483},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5949987769126892},{"id":"https://openalex.org/keywords/ant-colony-optimization-algorithms","display_name":"Ant colony optimization algorithms","score":0.5354106426239014},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4434194266796112},{"id":"https://openalex.org/keywords/fitness-function","display_name":"Fitness function","score":0.44046008586883545},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4050384759902954},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.40294286608695984},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20103240013122559},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.19600555300712585},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16397041082382202},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14760532975196838}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.7787982225418091},{"id":"https://openalex.org/C173801870","wikidata":"https://www.wikidata.org/wiki/Q201413","display_name":"Heuristic","level":2,"score":0.6441217064857483},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5949987769126892},{"id":"https://openalex.org/C40128228","wikidata":"https://www.wikidata.org/wiki/Q460851","display_name":"Ant colony optimization algorithms","level":2,"score":0.5354106426239014},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4434194266796112},{"id":"https://openalex.org/C176066374","wikidata":"https://www.wikidata.org/wiki/Q629118","display_name":"Fitness function","level":3,"score":0.44046008586883545},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4050384759902954},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.40294286608695984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20103240013122559},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.19600555300712585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16397041082382202},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14760532975196838}],"mesh":[{"descriptor_ui":"D000067508","descriptor_name":"Computer Heuristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000067508","descriptor_name":"Computer Heuristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000067508","descriptor_name":"Computer Heuristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2018.2879673","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2879673","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30403637","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30403637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G276912340","display_name":null,"funder_award_id":"61701279","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G317929691","display_name":null,"funder_award_id":"ZR2018MA019","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G3943136785","display_name":null,"funder_award_id":"61702299","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G467915402","display_name":null,"funder_award_id":"ZR2017PF006","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G5860415692","display_name":null,"funder_award_id":"61572284","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6524972921","display_name":null,"funder_award_id":"61502272","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W996251949","https://openalex.org/W1481655810","https://openalex.org/W1542966809","https://openalex.org/W1543229093","https://openalex.org/W1822695366","https://openalex.org/W1965539518","https://openalex.org/W1974510435","https://openalex.org/W1978500715","https://openalex.org/W1983675274","https://openalex.org/W1997744129","https://openalex.org/W2015523078","https://openalex.org/W2016389876","https://openalex.org/W2016393220","https://openalex.org/W2041170649","https://openalex.org/W2046918131","https://openalex.org/W2054717882","https://openalex.org/W2058514166","https://openalex.org/W2067523962","https://openalex.org/W2075059455","https://openalex.org/W2076011171","https://openalex.org/W2085800019","https://openalex.org/W2088100205","https://openalex.org/W2091518215","https://openalex.org/W2096128091","https://openalex.org/W2101350555","https://openalex.org/W2108352360","https://openalex.org/W2113784410","https://openalex.org/W2120423544","https://openalex.org/W2122210511","https://openalex.org/W2123202052","https://openalex.org/W2129961269","https://openalex.org/W2132004093","https://openalex.org/W2134874218","https://openalex.org/W2152905639","https://openalex.org/W2154053567","https://openalex.org/W2155781289","https://openalex.org/W2158620919","https://openalex.org/W2170990329","https://openalex.org/W2284964826","https://openalex.org/W2307163007","https://openalex.org/W2408073259","https://openalex.org/W2527140341","https://openalex.org/W2531971686","https://openalex.org/W2617467681","https://openalex.org/W2727539851","https://openalex.org/W2756150292","https://openalex.org/W3151658902","https://openalex.org/W6644780752"],"related_works":["https://openalex.org/W1547817677","https://openalex.org/W2615678788","https://openalex.org/W2023460495","https://openalex.org/W2109954095","https://openalex.org/W1967902778","https://openalex.org/W1981509636","https://openalex.org/W3139253026","https://openalex.org/W2157308673","https://openalex.org/W2099041096","https://openalex.org/W2077945311"],"abstract_inverted_index":{"Epistasis":[0],"learning,":[1],"which":[2,82,107,159],"is":[3,40,65,100,108,151,212],"aimed":[4],"at":[5],"detecting":[6,44],"associations":[7,137],"between":[8,138],"multiple":[9],"Single":[10],"Nucleotide":[11],"Polymorphisms":[12],"(SNPs)":[13],"and":[14,90,127,141,180,182,190,199],"complex":[15,37],"diseases,":[16,38],"has":[17,29],"gained":[18],"increasing":[19],"attention":[20],"in":[21,43,214],"genome":[22],"wide":[23],"association":[24],"studies.":[25],"Although":[26],"much":[27],"work":[28],"been":[30],"done":[31],"on":[32,72,194],"mapping":[33],"the":[34,49,56,73,79,84,115,128,136,142],"SNPs":[35],"underlying":[36],"there":[39],"still":[41],"difficulty":[42],"epistatic":[45,69],"interactions":[46,70],"due":[47],"to":[48,54,67,113,133,153],"lack":[50],"of":[51,81,169,204],"heuristic":[52,86,97],"information":[53,98,126],"expedite":[55],"search":[57,116],"process.":[58],"In":[59],"this":[60],"study,":[61],"a":[62,91,145,161,200],"method":[63],"EACO":[64,103,211],"proposed":[66],"detect":[68],"based":[71,176],"ant":[74],"colony":[75],"optimization":[76],"(ACO)":[77],"algorithm,":[78],"highlights":[80],"are":[83,131,192],"introduced":[85,101],"information,":[87],"fitness":[88,123],"function,":[89],"candidate":[92,148],"solutions":[93,149,158],"filtration":[94,150],"strategy.":[95],"The":[96],"multi-SURF*":[99],"into":[102,110],"for":[104,147,165],"identifying":[105,215],"epistasis,":[106],"incorporated":[109],"ant-decision":[111],"rules":[112],"guide":[114],"with":[117],"linear":[118],"time.":[119],"Two":[120],"functionally":[121],"complementary":[122],"functions,":[124],"mutual":[125],"Gini":[129],"index,":[130],"combined":[132],"effectively":[134],"evaluate":[135],"SNP":[139],"combinations":[140],"phenotype.":[143],"Furthermore,":[144],"strategy":[146],"provided":[152],"adaptively":[154],"retain":[155],"all":[156],"optimal":[157],"yields":[160],"more":[162],"accurate":[163],"way":[164],"epistasis":[166],"searching.":[167],"Experiments":[168],"EACO,":[170],"as":[171,173],"well":[172],"three":[174],"ACO":[175],"methods":[177,186],"(AntEpiSeeker,":[178],"MACOED,":[179],"epiACO)":[181],"four":[183],"commonly":[184],"used":[185],"(BOOST,":[187],"SNPRuler,":[188],"TEAM,":[189],"epiMODE)":[191],"performed":[193],"both":[195],"simulation":[196],"data":[197,202],"sets":[198],"real":[201],"set":[203],"age-related":[205],"macular":[206],"degeneration.":[207],"Results":[208],"indicate":[209],"that":[210],"promising":[213],"epistasis.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
