{"id":"https://openalex.org/W2895055893","doi":"https://doi.org/10.1109/tcbb.2018.2873299","title":"miRTRS: A Recommendation Algorithm for Predicting miRNA Targets","display_name":"miRTRS: A Recommendation Algorithm for Predicting miRNA Targets","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2895055893","doi":"https://doi.org/10.1109/tcbb.2018.2873299","mag":"2895055893","pmid":"https://pubmed.ncbi.nlm.nih.gov/30281478"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2873299","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2873299","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101822814","display_name":"Hui Jiang","orcid":"https://orcid.org/0000-0003-2604-3386"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Jiang","raw_affiliation_strings":["School of Computer Science and Technology, University of South China, Hengyang, China","School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-2604-3386","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, University of South China, Hengyang, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438360","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0003-1516-0480"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-1516-0480","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719013","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-0188-1394"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-0188-1394","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041285376","display_name":"Wei Lan","orcid":"https://orcid.org/0000-0001-5839-7504"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lan","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-5839-7504","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091157395","display_name":"Fang\u2010Xiang Wu","orcid":"https://orcid.org/0000-0002-4593-9332"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fang-Xiang Wu","raw_affiliation_strings":["Department of Mechanical Engineering, Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4593-9332","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101465265","display_name":"Yi Pan","orcid":"https://orcid.org/0000-0002-2766-3096"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Pan","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, USA"],"raw_orcid":"https://orcid.org/0000-0002-2766-3096","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, USA","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8802,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.69308969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"3","first_page":"1032","last_page":"1041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6666693091392517},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.561751127243042},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5556911826133728},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4962075352668762},{"id":"https://openalex.org/keywords/gene-prediction","display_name":"Gene prediction","score":0.4843486547470093},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43466705083847046},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41308242082595825},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.396994024515152},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3846006393432617},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.383973091840744},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3480130434036255},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21885031461715698},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10264098644256592},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.07464832067489624}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6666693091392517},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.561751127243042},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5556911826133728},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4962075352668762},{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.4843486547470093},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43466705083847046},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41308242082595825},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.396994024515152},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3846006393432617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.383973091840744},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3480130434036255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21885031461715698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10264098644256592},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.07464832067489624},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2018.2873299","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2873299","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30281478","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30281478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1729077721","display_name":null,"funder_award_id":"61732009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G358564744","display_name":null,"funder_award_id":"61420106009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4066238608","display_name":null,"funder_award_id":"B18059","funder_id":"https://openalex.org/F4320327912","funder_display_name":"Higher Education Discipline Innovation Project"},{"id":"https://openalex.org/G8210156615","display_name":null,"funder_award_id":"61622213","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327912","display_name":"Higher Education Discipline Innovation Project","ror":null},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1582076997","https://openalex.org/W1890374229","https://openalex.org/W1966241066","https://openalex.org/W2001508508","https://openalex.org/W2002995168","https://openalex.org/W2016106370","https://openalex.org/W2028071319","https://openalex.org/W2028962637","https://openalex.org/W2040851473","https://openalex.org/W2050869737","https://openalex.org/W2053611784","https://openalex.org/W2053835153","https://openalex.org/W2063328956","https://openalex.org/W2074231493","https://openalex.org/W2075995228","https://openalex.org/W2077327925","https://openalex.org/W2083155754","https://openalex.org/W2083381199","https://openalex.org/W2087064593","https://openalex.org/W2094253263","https://openalex.org/W2099888774","https://openalex.org/W2101117089","https://openalex.org/W2107180520","https://openalex.org/W2111094216","https://openalex.org/W2120456037","https://openalex.org/W2129931962","https://openalex.org/W2130388134","https://openalex.org/W2130674065","https://openalex.org/W2133658633","https://openalex.org/W2144896290","https://openalex.org/W2154718035","https://openalex.org/W2162674813","https://openalex.org/W2163199119","https://openalex.org/W2174734928","https://openalex.org/W2333207005","https://openalex.org/W2337379458","https://openalex.org/W2344280239","https://openalex.org/W2463737032","https://openalex.org/W2771019114","https://openalex.org/W2790385355","https://openalex.org/W2801501532","https://openalex.org/W4237011200","https://openalex.org/W6666042806"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2050308539","https://openalex.org/W3151405604","https://openalex.org/W2565797512","https://openalex.org/W4241694095","https://openalex.org/W2330252996","https://openalex.org/W2793648706","https://openalex.org/W3043187607"],"abstract_inverted_index":{"microRNAs":[0],"(miRNAs)":[1],"are":[2],"small":[3],"and":[4,14,36,122,162],"important":[5,28],"non-coding":[6],"RNAs":[7],"that":[8,150],"regulate":[9],"gene":[10,98],"expression":[11],"in":[12,30,158],"transcriptional":[13],"post-transcriptional":[15],"level":[16],"by":[17,42],"combining":[18],"with":[19,84,97,135],"their":[20],"targets":[21,25,41,69,78,93],"(genes).":[22],"Predicting":[23],"miRNA":[24,40,54,68,83,85,96,142],"is":[26,34],"an":[27,80],"problem":[29],"biological":[31,44],"research.":[32],"It":[33],"expensive":[35],"time-consuming":[37],"to":[38,52,104,113,125],"identify":[39],"using":[43],"experiments.":[45],"Many":[46],"computational":[47],"methods":[48,140,157],"have":[49,148],"been":[50],"proposed":[51],"predict":[53,77],"targets.":[55],"In":[56],"this":[57],"study,":[58],"we":[59],"develop":[60],"a":[61,72,95],"novel":[62],"method,":[63],"named":[64],"miRTRS,":[65],"for":[66,79,94,141],"predicting":[67],"based":[70],"on":[71],"recommendation":[73],"algorithm.":[74],"miRTRS":[75,109,134,153],"can":[76],"isolated":[81,91],"(new)":[82,92],"sequence":[86,99],"similarity,":[87],"as":[88,90],"well":[89],"similarity.":[100],"Furthermore,":[101],"when":[102],"compared":[103,133],"supervised":[105],"machine":[106],"learning":[107],"methods,":[108],"does":[110],"not":[111],"need":[112],"select":[114],"negative":[115],"samples.":[116],"We":[117,132],"use":[118],"10-fold":[119],"cross":[120],"validation":[121],"independent":[123],"datasets":[124],"evaluate":[126],"the":[127],"performance":[128],"of":[129,160],"our":[130,151],"method.":[131],"two":[136],"most":[137],"recently":[138],"published":[139],"target":[143],"prediction.":[144],"The":[145],"experimental":[146],"results":[147],"shown":[149],"method":[152],"outperforms":[154],"competing":[155],"prediction":[156],"terms":[159],"AUC":[161],"other":[163],"evaluation":[164],"metrics.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}