{"id":"https://openalex.org/W2436161947","doi":"https://doi.org/10.1109/tcbb.2018.2865420","title":"Incorporating Prior Knowledge about Genetic Variants into the Analysis of Genetic Association Data: An Empirical Bayes Approach","display_name":"Incorporating Prior Knowledge about Genetic Variants into the Analysis of Genetic Association Data: An Empirical Bayes Approach","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2436161947","doi":"https://doi.org/10.1109/tcbb.2018.2865420","mag":"2436161947","pmid":"https://pubmed.ncbi.nlm.nih.gov/30113898"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2865420","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2865420","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ruor.uottawa.ca/bitstreams/12a60d16-95bd-408c-94c6-57f1a443711e/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035259652","display_name":"Ali Karimnezhad","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ali Karimnezhad","raw_affiliation_strings":["Department of Biochemistry, Microbiology, and Immunology, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5340-1858","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology, and Immunology, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I2800722420","https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038684006","display_name":"David R. Bickel","orcid":"https://orcid.org/0000-0002-9623-3946"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David R. Bickel","raw_affiliation_strings":["Department of Biochemistry, Microbiology and Immunology, Department of Mathematics and Statistics, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9623-3946","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology and Immunology, Department of Mathematics and Statistics, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2073,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80444158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"17","issue":"2","first_page":"635","last_page":"646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.7326736450195312},{"id":"https://openalex.org/keywords/genetic-data","display_name":"Genetic data","score":0.49072325229644775},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.45517873764038086},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.45210760831832886},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4384850859642029},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40942832827568054},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34786438941955566},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.3174029290676117},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3111925721168518},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29682719707489014},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27919816970825195},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.22396177053451538},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.1885230541229248},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.11663040518760681},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.09954845905303955},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08679080009460449},{"id":"https://openalex.org/keywords/sociology","display_name":"Sociology","score":0.07390573620796204},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.06434577703475952}],"concepts":[{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.7326736450195312},{"id":"https://openalex.org/C2993807623","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genetic data","level":3,"score":0.49072325229644775},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.45517873764038086},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.45210760831832886},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4384850859642029},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40942832827568054},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34786438941955566},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.3174029290676117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3111925721168518},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29682719707489014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27919816970825195},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22396177053451538},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1885230541229248},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.11663040518760681},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.09954845905303955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08679080009460449},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.07390573620796204},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.06434577703475952},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tcbb.2018.2865420","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2865420","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30113898","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30113898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null},{"id":"pmh:oai:ruor.uottawa.ca:10393/34889","is_oa":true,"landing_page_url":"http://hdl.handle.net/10393/34889","pdf_url":"https://ruor.uottawa.ca/bitstreams/12a60d16-95bd-408c-94c6-57f1a443711e/download","source":{"id":"https://openalex.org/S4306400902","display_name":"uO Research (University of Ottawa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I153718931","host_organization_name":"University of Ottawa","host_organization_lineage":["https://openalex.org/I153718931"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Working Paper"},{"id":"pmh:oai:ruor.uottawa.ca:10393/39656","is_oa":false,"landing_page_url":"http://hdl.handle.net/10393/39656","pdf_url":null,"source":{"id":"https://openalex.org/S4306400902","display_name":"uO Research (University of Ottawa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I153718931","host_organization_name":"University of Ottawa","host_organization_lineage":["https://openalex.org/I153718931"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:ruor.uottawa.ca:10393/34889","is_oa":true,"landing_page_url":"http://hdl.handle.net/10393/34889","pdf_url":"https://ruor.uottawa.ca/bitstreams/12a60d16-95bd-408c-94c6-57f1a443711e/download","source":{"id":"https://openalex.org/S4306400902","display_name":"uO Research (University of Ottawa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I153718931","host_organization_name":"University of Ottawa","host_organization_lineage":["https://openalex.org/I153718931"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Working Paper"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6039697126","display_name":null,"funder_award_id":"123508","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8152603014","display_name":null,"funder_award_id":"RGPIN/356018-2009","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8987205718","display_name":"The genetics of weight, BMI, adiposity and obesity","funder_award_id":"076113","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2436161947.pdf"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1071598686","https://openalex.org/W1510659740","https://openalex.org/W1647270943","https://openalex.org/W1824047490","https://openalex.org/W1974746273","https://openalex.org/W1978747252","https://openalex.org/W1984068087","https://openalex.org/W1988520084","https://openalex.org/W2006145698","https://openalex.org/W2024728905","https://openalex.org/W2029892338","https://openalex.org/W2044908960","https://openalex.org/W2062303134","https://openalex.org/W2064193840","https://openalex.org/W2066874799","https://openalex.org/W2067316154","https://openalex.org/W2070009349","https://openalex.org/W2074089196","https://openalex.org/W2077011849","https://openalex.org/W2091841926","https://openalex.org/W2104976021","https://openalex.org/W2105381419","https://openalex.org/W2110065044","https://openalex.org/W2123748412","https://openalex.org/W2125905177","https://openalex.org/W2127921920","https://openalex.org/W2130530904","https://openalex.org/W2134783591","https://openalex.org/W2136091734","https://openalex.org/W2152325859","https://openalex.org/W2156553312","https://openalex.org/W2160697532","https://openalex.org/W2211238881","https://openalex.org/W2277687562","https://openalex.org/W2280297542","https://openalex.org/W2284771836","https://openalex.org/W2582743722","https://openalex.org/W2755962885","https://openalex.org/W2765740840","https://openalex.org/W2784050935","https://openalex.org/W2974222084","https://openalex.org/W3100378224","https://openalex.org/W3100932958","https://openalex.org/W3104206536","https://openalex.org/W3106286070","https://openalex.org/W4399503634","https://openalex.org/W4399570335","https://openalex.org/W6694607985","https://openalex.org/W6869483761","https://openalex.org/W6869854095","https://openalex.org/W6987114680","https://openalex.org/W7019071580"],"related_works":["https://openalex.org/W2352440174","https://openalex.org/W4309440960","https://openalex.org/W2062168445","https://openalex.org/W2348940229","https://openalex.org/W2363046693","https://openalex.org/W2389491697","https://openalex.org/W4301044699","https://openalex.org/W2602215520","https://openalex.org/W2407942904","https://openalex.org/W2185747393"],"abstract_inverted_index":{"In":[0],"a":[1,9,18,35,82,98,133,138,193],"genome-wide":[2],"association":[3],"study":[4],"(GWAS),":[5],"the":[6,42,59,70,78,84,87,91,105,109,147,164,180,186,204],"probability":[7],"that":[8,97,114,130,146,160],"single":[10],"nucleotide":[11],"polymorphism":[12],"(SNP)":[13],"is":[14,20,32,55,102,116],"not":[15,117],"associated":[16,103],"with":[17,104],"disease":[19],"its":[21],"local":[22],"false":[23],"discovery":[24],"rate":[25],"(LFDR).":[26],"The":[27,154],"LFDR":[28,43,174],"for":[29,172],"each":[30],"SNP":[31,47,101],"relative":[33,57,68],"to":[34,58,69,151,189],"reference":[36,61,72,93,111,135,140],"class":[37,62,73,94,112,136,166,182],"of":[38,44,63,74,86,195],"SNPs.":[39],"For":[40],"example,":[41],"an":[45],"exonic":[46,65,100],"can":[48],"vary":[49],"widely":[50],"depending":[51,162,177],"on":[52,90,163,179,209],"whether":[53],"it":[54,115,168],"considered":[56],"separate":[60,110,139,165],"other":[64],"SNPs":[66,76,171],"or":[67,119],"combined":[71,92,134,181],"all":[75],"in":[77],"data":[79,88,191],"set.":[80],"As":[81],"result,":[83],"analysis":[85],"based":[89],"might":[95],"indicate":[96,145],"specific":[99],"disease,":[106],"while":[107],"using":[108],"indicates":[113],"associated,":[118],"vice":[120],"versa.":[121],"To":[122],"address":[123],"that,":[124],"we":[125],"introduce":[126],"empirical":[127],"Bayes":[128],"methods":[129,149,188,206],"simultaneously":[131],"consider":[132],"and":[137,176,198,212],"class.":[141],"Our":[142],"simulation":[143],"studies":[144],"proposed":[148,205],"lead":[150],"improved":[152],"performance.":[153],"new":[155,187],"maximum":[156],"entropy":[157],"method":[158],"achieves":[159],"by":[161],"when":[167],"has":[169],"enough":[170],"reliable":[173],"estimation":[175],"solely":[178],"otherwise.":[183],"We":[184],"used":[185],"analyze":[190],"from":[192],"GWAS":[194],"2,000":[196],"cases":[197],"3,000":[199],"controls.":[200],"R":[201],"functions":[202],"implementing":[203],"are":[207],"available":[208],"CRAN":[210],"<https://cran.r-project.org/web/packages/LFDREmpiricalBayes>":[211],"Shiny":[213],"<https://empiricalbayes.shinyapps.io/lfdrempiricalbayesapp>.":[214]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}