{"id":"https://openalex.org/W2948726969","doi":"https://doi.org/10.1109/tcbb.2018.2864129","title":"Identifying lncRNA and mRNA Co-Expression Modules from Matched Expression Data in Ovarian Cancer","display_name":"Identifying lncRNA and mRNA Co-Expression Modules from Matched Expression Data in Ovarian Cancer","publication_year":2018,"publication_date":"2018-08-07","ids":{"openalex":"https://openalex.org/W2948726969","doi":"https://doi.org/10.1109/tcbb.2018.2864129","mag":"2948726969","pmid":"https://pubmed.ncbi.nlm.nih.gov/30106686"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2864129","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2864129","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086050506","display_name":"Qiu Xiao","orcid":"https://orcid.org/0000-0002-4726-7154"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu Xiao","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China","College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-4726-7154","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026469278","display_name":"Jiawei Luo","orcid":"https://orcid.org/0000-0003-2385-8272"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Luo","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China"],"raw_orcid":"https://orcid.org/0000-0003-2385-8272","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101756728","display_name":"Cheng Liang","orcid":"https://orcid.org/0000-0003-3832-0969"},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Liang","raw_affiliation_strings":["College of Information Science and Engineering, Shandong Normal University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393102","display_name":"Guanghui Li","orcid":"https://orcid.org/0000-0001-6531-1166"},"institutions":[{"id":"https://openalex.org/I13985625","display_name":"East China Jiaotong University","ror":"https://ror.org/05x2f1m38","country_code":"CN","type":"education","lineage":["https://openalex.org/I13985625"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanghui Li","raw_affiliation_strings":["School of Information Engineering, East China Jiaotong University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0001-6531-1166","affiliations":[{"raw_affiliation_string":"School of Information Engineering, East China Jiaotong University, Nanchang, China","institution_ids":["https://openalex.org/I13985625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079611154","display_name":"Jie Cai","orcid":"https://orcid.org/0000-0002-6561-5626"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Cai","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019845646","display_name":"Pingjian Ding","orcid":"https://orcid.org/0000-0002-2613-2496"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingjian Ding","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028850241","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0003-3740-9144"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China"],"raw_orcid":"https://orcid.org/0000-0003-3740-9144","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6584,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82766585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"2","first_page":"623","last_page":"634"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9742000102996826,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6536229848861694},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5368338823318481},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.527543306350708},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5058302879333496},{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.5000083446502686},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.46174484491348267},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.43963199853897095},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4126584529876709},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3330635130405426},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2119268774986267}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6536229848861694},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5368338823318481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.527543306350708},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5058302879333496},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.5000083446502686},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.46174484491348267},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.43963199853897095},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4126584529876709},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3330635130405426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2119268774986267},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2018.2864129","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2864129","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30106686","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30106686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2889707724","display_name":"\u57fa\u4e8e\u65b0\u4e00\u4ee3\u6d4b\u5e8f\u6570\u636e\u7684\u590d\u6742\u75be\u75c5\u7279\u5f02\u5171\u8c03\u63a7\u7f51\u7edc\u6784\u5efa\u53ca\u5206\u6790\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61572180","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6878829392","display_name":null,"funder_award_id":"ZR2016FB10","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G952884748","display_name":null,"funder_award_id":"61602283","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W1966143946","https://openalex.org/W1966498224","https://openalex.org/W1968580628","https://openalex.org/W1970741980","https://openalex.org/W1985205042","https://openalex.org/W1999746344","https://openalex.org/W2006556963","https://openalex.org/W2010040849","https://openalex.org/W2010355969","https://openalex.org/W2029343251","https://openalex.org/W2036178129","https://openalex.org/W2038667694","https://openalex.org/W2039030056","https://openalex.org/W2046387002","https://openalex.org/W2065762479","https://openalex.org/W2096529831","https://openalex.org/W2105116456","https://openalex.org/W2109761160","https://openalex.org/W2110957978","https://openalex.org/W2113868616","https://openalex.org/W2118718620","https://openalex.org/W2128983843","https://openalex.org/W2130410032","https://openalex.org/W2130687298","https://openalex.org/W2135029798","https://openalex.org/W2136787567","https://openalex.org/W2143693563","https://openalex.org/W2144359569","https://openalex.org/W2151196686","https://openalex.org/W2162547088","https://openalex.org/W2163485494","https://openalex.org/W2165685007","https://openalex.org/W2166251028","https://openalex.org/W2175378767","https://openalex.org/W2254019636","https://openalex.org/W2256102335","https://openalex.org/W2259477902","https://openalex.org/W2335029242","https://openalex.org/W2409062259","https://openalex.org/W2415355903","https://openalex.org/W2515619833","https://openalex.org/W2520864906","https://openalex.org/W2521476646","https://openalex.org/W2531962290","https://openalex.org/W2537679995","https://openalex.org/W2557489574","https://openalex.org/W2565218155","https://openalex.org/W2568548418","https://openalex.org/W2574217686","https://openalex.org/W2586707555","https://openalex.org/W2589372111","https://openalex.org/W2590492570","https://openalex.org/W2610367707","https://openalex.org/W2621020647","https://openalex.org/W2750900465","https://openalex.org/W3143596294","https://openalex.org/W6677759377","https://openalex.org/W6680012447"],"related_works":["https://openalex.org/W2297768894","https://openalex.org/W2378076731","https://openalex.org/W3109014690","https://openalex.org/W2122405502","https://openalex.org/W2114254072","https://openalex.org/W2127721729","https://openalex.org/W2884798239","https://openalex.org/W1531253727","https://openalex.org/W2366669483","https://openalex.org/W2333635112"],"abstract_inverted_index":{"Long":[0],"non-coding":[1],"RNAs":[2],"(lncRNAs)":[3],"have":[4,22],"been":[5,23],"shown":[6],"to":[7,84,141,153,161],"be":[8],"involved":[9],"in":[10,18,25],"multiple":[11],"biological":[12],"processes":[13],"and":[14,41,70,94,119,130,166,191],"play":[15],"critical":[16],"roles":[17],"tumorigenesis.":[19],"Numerous":[20],"lncRNAs":[21,33,190],"discovered":[24],"diverse":[26],"species,":[27],"but":[28],"the":[29,52,57,67,91,100,131,138,143,147,167,172,187],"functions":[30],"of":[31,54,60,73,189,194],"most":[32],"still":[34],"remain":[35],"unclear.":[36],"Meanwhile,":[37],"their":[38],"expression":[39,96],"patterns":[40],"regulation":[42],"mechanisms":[43],"are":[44,135,150],"also":[45],"far":[46],"from":[47],"being":[48],"fully":[49],"understood.":[50],"With":[51],"advances":[53],"high-throughput":[55],"technologies,":[56],"increasing":[58],"availability":[59],"genomic":[61],"data":[62],"creates":[63],"opportunities":[64],"for":[65],"deciphering":[66],"molecular":[68,192],"mechanism":[69,193],"underlying":[71],"pathogenesis":[72],"human":[74,162,195],"diseases.":[75,196],"Here,":[76],"we":[77],"develop":[78],"an":[79,105],"integrative":[80],"framework":[81],"called":[82],"JONMF":[83,160],"identify":[85],"lncRNA-mRNA":[86,127],"co-expression":[87,128,180],"modules":[88],"based":[89],"on":[90],"sample-matched":[92],"lncRNA":[93],"mRNA":[95],"profiles.":[97],"We":[98,158],"formulate":[99],"module":[101,144],"detection":[102],"task":[103],"as":[104,137],"optimization":[106],"problem":[107],"with":[108],"joint":[109],"orthogonal":[110],"non-negative":[111],"matrix":[112],"factorization":[113],"that":[114,171],"could":[115],"effectively":[116,176],"prevent":[117],"multicollinearity":[118],"produce":[120],"a":[121],"good":[122],"modularity":[123],"interpretation.":[124],"The":[125],"constructed":[126],"network":[129,134],"gene-gene":[132],"interaction":[133],"used":[136],"network-regularized":[139],"constraints":[140,149],"improve":[142],"accuracy,":[145],"while":[146],"sparsity":[148],"simultaneously":[151],"utilized":[152],"achieve":[154],"modular":[155],"sparse":[156],"solutions.":[157],"applied":[159],"ovarian":[163],"cancer":[164],"dataset":[165],"experiment":[168],"results":[169],"demonstrate":[170],"proposed":[173],"method":[174],"can":[175],"discover":[177],"biologically":[178],"functional":[179],"modules,":[181],"which":[182],"may":[183],"provide":[184],"insights":[185],"into":[186],"function":[188]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}