{"id":"https://openalex.org/W2801938236","doi":"https://doi.org/10.1109/tcbb.2018.2828810","title":"A Multi-Laplacian Prior and Augmented Lagrangian Approach to the Exploratory Analysis of Time-Varying Gene and Transcriptional Regulatory Networks for Gene Microarray Data","display_name":"A Multi-Laplacian Prior and Augmented Lagrangian Approach to the Exploratory Analysis of Time-Varying Gene and Transcriptional Regulatory Networks for Gene Microarray Data","publication_year":2018,"publication_date":"2018-04-20","ids":{"openalex":"https://openalex.org/W2801938236","doi":"https://doi.org/10.1109/tcbb.2018.2828810","mag":"2801938236","pmid":"https://pubmed.ncbi.nlm.nih.gov/29993914"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2018.2828810","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2828810","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100425719","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0003-1641-7831"},"institutions":[{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0003-1641-7831","affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I4210145292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101830959","display_name":"H. C. Wu","orcid":"https://orcid.org/0000-0002-4555-3675"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ho-Chun Wu","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0002-4555-3675","affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087004357","display_name":"C. H. Ho","orcid":"https://orcid.org/0000-0003-1951-8005"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Cheuk-Hei Ho","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0003-1951-8005","affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057049452","display_name":"S. C. Chan","orcid":"https://orcid.org/0000-0001-7212-4182"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Shing-Chow Chan","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0001-7212-4182","affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6597,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66316437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"6","first_page":"1816","last_page":"1829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6645934581756592},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5988298654556274},{"id":"https://openalex.org/keywords/augmented-lagrangian-method","display_name":"Augmented Lagrangian method","score":0.5658999681472778},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5264920592308044},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47997164726257324},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.46832042932510376},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4343542158603668},{"id":"https://openalex.org/keywords/lagrangian","display_name":"Lagrangian","score":0.4151248335838318},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32500821352005005},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2447601556777954},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20996519923210144},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.12516626715660095},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.09857183694839478}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6645934581756592},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5988298654556274},{"id":"https://openalex.org/C150452318","wikidata":"https://www.wikidata.org/wiki/Q4820432","display_name":"Augmented Lagrangian method","level":2,"score":0.5658999681472778},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5264920592308044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47997164726257324},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.46832042932510376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4343542158603668},{"id":"https://openalex.org/C53469067","wikidata":"https://www.wikidata.org/wiki/Q505735","display_name":"Lagrangian","level":2,"score":0.4151248335838318},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32500821352005005},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2447601556777954},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20996519923210144},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.12516626715660095},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.09857183694839478}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2018.2828810","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2018.2828810","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29993914","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29993914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W59516454","https://openalex.org/W180478659","https://openalex.org/W1205638266","https://openalex.org/W1502501036","https://openalex.org/W1534340623","https://openalex.org/W1677575702","https://openalex.org/W1905165690","https://openalex.org/W1921666167","https://openalex.org/W1963522244","https://openalex.org/W1989652873","https://openalex.org/W1999894343","https://openalex.org/W2000359198","https://openalex.org/W2004401280","https://openalex.org/W2009001778","https://openalex.org/W2013444425","https://openalex.org/W2017613731","https://openalex.org/W2023348596","https://openalex.org/W2031842395","https://openalex.org/W2032909213","https://openalex.org/W2050666122","https://openalex.org/W2054286320","https://openalex.org/W2056575133","https://openalex.org/W2062029454","https://openalex.org/W2063325205","https://openalex.org/W2076372398","https://openalex.org/W2077723503","https://openalex.org/W2077941487","https://openalex.org/W2080498142","https://openalex.org/W2081980086","https://openalex.org/W2103453943","https://openalex.org/W2106474670","https://openalex.org/W2106927126","https://openalex.org/W2110328538","https://openalex.org/W2115108153","https://openalex.org/W2119933870","https://openalex.org/W2131706188","https://openalex.org/W2133102806","https://openalex.org/W2135215848","https://openalex.org/W2138049103","https://openalex.org/W2138150506","https://openalex.org/W2139199642","https://openalex.org/W2142170851","https://openalex.org/W2143076232","https://openalex.org/W2146614932","https://openalex.org/W2160533336","https://openalex.org/W2161511352","https://openalex.org/W2161922735","https://openalex.org/W2163480486","https://openalex.org/W2169141721","https://openalex.org/W2484345041","https://openalex.org/W2964113774","https://openalex.org/W3098625064","https://openalex.org/W3123317843","https://openalex.org/W4235178178","https://openalex.org/W4242577767","https://openalex.org/W4253875976","https://openalex.org/W6640131802","https://openalex.org/W6722377780"],"related_works":["https://openalex.org/W2315802443","https://openalex.org/W2796636403","https://openalex.org/W2767923834","https://openalex.org/W2364565895","https://openalex.org/W2015700328","https://openalex.org/W2767847608","https://openalex.org/W2376104286","https://openalex.org/W2082353735","https://openalex.org/W2911678823","https://openalex.org/W2152648570"],"abstract_inverted_index":{"This":[0],"paper":[1],"proposes":[2],"a":[3,30,54,101,183],"novel":[4],"multi-Laplacian":[5,43],"prior":[6,44],"(MLP)":[7],"and":[8,17,36,45,94,105,111,137,170],"augmented":[9],"Lagrangian":[10],"method":[11,39,133,179],"(ALM)":[12],"approach":[13],"for":[14,40,60,187],"gene":[15,25,55,66,114,171],"interactions":[16],"putative":[18,61,188],"transcription":[19],"factors":[20],"(TFs)":[21],"identification":[22,63,190],"from":[23,85],"time-course":[24,113],"microarray":[26,115,172],"data.":[27,173],"It":[28,174],"employs":[29],"non-linear":[31],"time-varying":[32],"auto-regressive":[33],"(N-TVAR)":[34],"model":[35],"the":[37,42,46,75,78,86,92,121,124,131,152,177],"Maximum-A-Posteriori-Probability":[38],"incorporating":[41],"continuity":[47],"constraint.":[48],"The":[49],"MLP":[50],"allows":[51,77],"connections":[52],"to/from":[53],"to":[56,82,119,159],"be":[57,83,97,160],"better":[58,135],"preserved":[59],"TF":[62,189],"in":[64],"non-stationarity":[65],"regulatory":[67],"network":[68],"as":[69,182],"compared":[70],"with":[71,163,191],"conventional$L_1$-based":[72],"penalties.":[73],"Moreover,":[74,148],"ALM":[76],"resultant":[79],"non-smooth$L_1$-based":[80],"penalties":[81],"decoupled":[84],"remaining":[87],"smooth":[88,106],"terms,":[89],"so":[90],"that":[91,130,176],"former":[93],"latter":[95],"can":[96],"efficiently":[98],"solved":[99],"using":[100,145],"low-complexity":[102],"proximity":[103],"operator":[104],"optimization":[107],"technique,":[108],"respectively.":[109],"Synthetic":[110],"real":[112],"datasets":[116],"are":[117],"tested":[118],"evaluate":[120],"performance":[122],"of":[123,154],"proposed":[125,132,178],"method.":[126],"Experimental":[127],"results":[128],"show":[129],"gives":[134],"accuracy":[136],"higher":[138],"computational":[139],"speed":[140],"than":[141],"our":[142],"previous":[143],"work":[144],"smoothed":[146],"approximation.":[147],"its":[149],"performance,":[150],"without":[151],"use":[153],"ChIP-chip":[155,169],"data,":[156],"is":[157],"found":[158],"highly":[161],"comparable":[162],"other":[164],"state-of-the-art":[165],"methods":[166],"integrating":[167],"both":[168],"suggests":[175],"may":[180],"serve":[181],"useful":[184],"exploratory":[185],"tool":[186],"reduced":[192],"experimental":[193],"cost.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}