{"id":"https://openalex.org/W2772123710","doi":"https://doi.org/10.1109/tcbb.2017.2779512","title":"The Robust Classification Model Based on Combinatorial Features","display_name":"The Robust Classification Model Based on Combinatorial Features","publication_year":2017,"publication_date":"2017-12-04","ids":{"openalex":"https://openalex.org/W2772123710","doi":"https://doi.org/10.1109/tcbb.2017.2779512","mag":"2772123710","pmid":"https://pubmed.ncbi.nlm.nih.gov/29990202"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2017.2779512","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2779512","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058966302","display_name":"Xiaohui Lin","orcid":"https://orcid.org/0000-0002-7358-6706"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohui Lin","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050969681","display_name":"Xin Huang","orcid":"https://orcid.org/0000-0002-0953-7985"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Huang","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013283299","display_name":"Lina Zhou","orcid":"https://orcid.org/0000-0003-1973-5667"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I180585399","display_name":"Dalian Institute of Chemical Physics","ror":"https://ror.org/00prkya54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I180585399","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Zhou","raw_affiliation_strings":["Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I180585399","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015696755","display_name":"Weijie Ren","orcid":"https://orcid.org/0000-0002-2711-8813"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijie Ren","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091022545","display_name":"Jun Zeng","orcid":"https://orcid.org/0000-0003-2103-4536"},"institutions":[{"id":"https://openalex.org/I180585399","display_name":"Dalian Institute of Chemical Physics","ror":"https://ror.org/00prkya54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I180585399","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zeng","raw_affiliation_strings":["Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I180585399","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100584714","display_name":"Weihong Yao","orcid":"https://orcid.org/0009-0002-3145-3494"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihong Yao","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100680478","display_name":"Xingyuan Wang","orcid":"https://orcid.org/0009-0009-5011-0666"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyuan Wang","raw_affiliation_strings":["School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Dalian University of Technology, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I27357992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5058966302"],"corresponding_institution_ids":["https://openalex.org/I27357992"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.14182569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"16","issue":"2","first_page":"650","last_page":"657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10824","display_name":"Image Retrieval and Classification Techniques","score":0.9732000231742859,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12535","display_name":"Machine Learning and Data Classification","score":0.960099995136261,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45478713512420654},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4314758777618408},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34887951612472534},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.344786137342453}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45478713512420654},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4314758777618408},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34887951612472534},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.344786137342453}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2017.2779512","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2779512","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29990202","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29990202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G2582337214","display_name":null,"funder_award_id":"21375011","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1520812622","https://openalex.org/W1530699444","https://openalex.org/W1544233162","https://openalex.org/W1544937424","https://openalex.org/W1727290854","https://openalex.org/W1770869992","https://openalex.org/W1836115926","https://openalex.org/W1892363833","https://openalex.org/W1942658485","https://openalex.org/W1948109450","https://openalex.org/W1978654172","https://openalex.org/W1979323152","https://openalex.org/W2007615926","https://openalex.org/W2018737582","https://openalex.org/W2036369755","https://openalex.org/W2037982056","https://openalex.org/W2039095343","https://openalex.org/W2039767429","https://openalex.org/W2046307973","https://openalex.org/W2047031939","https://openalex.org/W2049705880","https://openalex.org/W2058031917","https://openalex.org/W2062533676","https://openalex.org/W2064208261","https://openalex.org/W2072369801","https://openalex.org/W2087684630","https://openalex.org/W2088851040","https://openalex.org/W2089920864","https://openalex.org/W2091634599","https://openalex.org/W2109363337","https://openalex.org/W2115358726","https://openalex.org/W2116875780","https://openalex.org/W2119588499","https://openalex.org/W2122825543","https://openalex.org/W2125655246","https://openalex.org/W2126815340","https://openalex.org/W2128985829","https://openalex.org/W2132400238","https://openalex.org/W2135046866","https://openalex.org/W2136863166","https://openalex.org/W2147246240","https://openalex.org/W2150459098","https://openalex.org/W2159400887","https://openalex.org/W2159585030","https://openalex.org/W2171064835","https://openalex.org/W2171528238","https://openalex.org/W2252382131","https://openalex.org/W2259531529","https://openalex.org/W2508622936","https://openalex.org/W2558166060","https://openalex.org/W2574045722","https://openalex.org/W2578900543","https://openalex.org/W2605802858","https://openalex.org/W2611104316","https://openalex.org/W2911964244","https://openalex.org/W4243195610"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W3046775127","https://openalex.org/W3107602296","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W2033914206","https://openalex.org/W4283697347"],"abstract_inverted_index":{"Analyzing":[0],"the":[1,5,13,44,64,70,76,81,101,163,169,187,198],"disease":[2,14],"data":[3],"from":[4],"view":[6],"of":[7,104,119,134,162,172,193],"combinatorial":[8,77],"features":[9,78,194],"may":[10],"better":[11,170,196],"characterize":[12],"phenotype.":[15],"In":[16,167],"this":[17],"study,":[18],"a":[19,29,55],"novel":[20],"method":[21],"is":[22],"proposed":[23],"to":[24,74,126,160,178],"construct":[25],"feature":[26,36,45,67,72],"combinations":[27,181,188],"and":[28,61,79,94,99,137,145,149,155,180],"classification":[30,82],"model":[31],"(CFC-CM)":[32],"by":[33,183,190],"mining":[34],"key":[35],"relationships.":[37],"CFC-CM":[38,105,123,173],"iteratively":[39],"tests":[40],"for":[41,115],"differences":[42],"in":[43,69,140,176],"relationship":[46],"between":[47,142,150],"different":[48],"groups.":[49],"To":[50],"do":[51],"this,":[52],"it":[53,130],"uses":[54],"modified":[56],"$k$k-top-scoring":[57],"pair":[58],"(M-$k$k-TSP)":[59],"algorithm":[60],"then":[62],"selects":[63],"most":[65],"discriminative":[66],"pairs":[68],"current":[71],"set":[73],"infer":[75],"build":[80],"model.":[83],"Compared":[84],"with":[85],"support":[86],"vector":[87],"machines,":[88],"random":[89],"forests,":[90],"least":[91],"absolute":[92],"shrinkage":[93],"selection":[95],"operator,":[96],"elastic":[97],"net,":[98],"M-$k$k-TSP,":[100],"superior":[102,159],"performance":[103],"on":[106],"nine":[107],"public":[108],"gene":[109],"expression":[110],"datasets":[111],"validates":[112],"its":[113],"potential":[114],"more":[116],"precise":[117],"identification":[118],"complex":[120,199],"diseases.":[121,200],"Subsequently,":[122],"was":[124],"applied":[125],"two":[127,185],"metabolomics":[128],"datasets,":[129],"obtained":[131],"accuracy":[132],"rates":[133],"$88.73\\pm":[135],"2.06\\%$88.73\u00b12.06%":[136],"$79.11\\pm":[138],"2.70\\%$79.11\u00b12.70%":[139],"distinguishing":[141],"hepatocellular":[143],"carcinoma":[144],"hepatic":[146],"cirrhosis":[147],"groups":[148],"acute":[151],"kidney":[152],"injury":[153],"(AKI)":[154],"non-AKI":[156],"samples,":[157],"results":[158,171],"those":[161],"other":[164],"five":[165],"methods.":[166],"summary,":[168],"show":[174],"that":[175],"contrast":[177],"molecules":[179],"constituted":[182],"just":[184],"features,":[186],"inferred":[189],"appropriate":[191],"number":[192],"could":[195],"identify":[197]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}