{"id":"https://openalex.org/W2740884958","doi":"https://doi.org/10.1109/tcbb.2017.2733529","title":"Continuous Petri Nets and microRNA Analysis in Melanoma","display_name":"Continuous Petri Nets and microRNA Analysis in Melanoma","publication_year":2017,"publication_date":"2017-07-31","ids":{"openalex":"https://openalex.org/W2740884958","doi":"https://doi.org/10.1109/tcbb.2017.2733529","mag":"2740884958","pmid":"https://pubmed.ncbi.nlm.nih.gov/28767374"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2017.2733529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2733529","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004880055","display_name":"Giulia Russo","orcid":"https://orcid.org/0000-0001-6616-7856"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Russo","raw_affiliation_strings":["Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003874484","display_name":"Marzio Pennisi","orcid":"https://orcid.org/0000-0003-0231-7653"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzio Pennisi","raw_affiliation_strings":["Department of Mathematics and Computer Science, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001741371","display_name":"Roberta Boscarino","orcid":null},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Boscarino","raw_affiliation_strings":["Department of Drug Sciences, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["Department of Drug Sciences, University of Catania, Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1668-3320","affiliations":[{"raw_affiliation_string":"Department of Drug Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39063666"],"apc_list":null,"apc_paid":null,"fwci":1.0137,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.74944911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"5","first_page":"1492","last_page":"1499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.6791795492172241},{"id":"https://openalex.org/keywords/melanoma","display_name":"Melanoma","score":0.6751068830490112},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6491160988807678},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.559849202632904},{"id":"https://openalex.org/keywords/protein-kinase-b","display_name":"Protein kinase B","score":0.5429763793945312},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49119850993156433},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4897165596485138},{"id":"https://openalex.org/keywords/neuroblastoma-ras-viral-oncogene-homolog","display_name":"Neuroblastoma RAS viral oncogene homolog","score":0.48015540838241577},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4799342751502991},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.41377323865890503},{"id":"https://openalex.org/keywords/petri-net","display_name":"Petri net","score":0.4121553301811218},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3545430898666382},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.34961578249931335},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3431280255317688},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32668161392211914},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.212875634431839},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20840665698051453},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16805395483970642},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.15063875913619995},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09590566158294678}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6791795492172241},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6751068830490112},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6491160988807678},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.559849202632904},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5429763793945312},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49119850993156433},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4897165596485138},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.48015540838241577},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4799342751502991},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41377323865890503},{"id":"https://openalex.org/C38677869","wikidata":"https://www.wikidata.org/wiki/Q724168","display_name":"Petri net","level":2,"score":0.4121553301811218},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3545430898666382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34961578249931335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3431280255317688},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32668161392211914},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.212875634431839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20840665698051453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16805395483970642},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15063875913619995},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09590566158294678},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2017.2733529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2733529","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28767374","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28767374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322690","display_name":"Universit\u00e0 di Catania","ror":"https://ror.org/03a64bh57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1577110168","https://openalex.org/W1757407923","https://openalex.org/W2007618103","https://openalex.org/W2011812596","https://openalex.org/W2035816919","https://openalex.org/W2043623672","https://openalex.org/W2059186652","https://openalex.org/W2062327977","https://openalex.org/W2087846936","https://openalex.org/W2090448257","https://openalex.org/W2094397139","https://openalex.org/W2106247749","https://openalex.org/W2110622353","https://openalex.org/W2117209457","https://openalex.org/W2118037724","https://openalex.org/W2124911220","https://openalex.org/W2127616922","https://openalex.org/W2133552211","https://openalex.org/W2134142320","https://openalex.org/W2142237411","https://openalex.org/W2149748804","https://openalex.org/W2158565065","https://openalex.org/W2161926944","https://openalex.org/W2174117436","https://openalex.org/W2294639133","https://openalex.org/W2317505839","https://openalex.org/W2347065665","https://openalex.org/W2414712109","https://openalex.org/W2430050289","https://openalex.org/W2438477168","https://openalex.org/W2469418432","https://openalex.org/W2510930007","https://openalex.org/W2585589460","https://openalex.org/W2589215837","https://openalex.org/W2611450565","https://openalex.org/W4232836483","https://openalex.org/W6720211761","https://openalex.org/W6980870245"],"related_works":["https://openalex.org/W1968041503","https://openalex.org/W2164992866","https://openalex.org/W3129743340","https://openalex.org/W2613470058","https://openalex.org/W2035816919","https://openalex.org/W2890752806","https://openalex.org/W2767735945","https://openalex.org/W2024936926","https://openalex.org/W2261929084","https://openalex.org/W2064116264"],"abstract_inverted_index":{"Personalized":[0],"target":[1],"therapies":[2],"represent":[3],"one":[4],"of":[5,39,127,132,175,194],"the":[6,12,37,151,159,188,192],"possible":[7],"treatment":[8,18],"strategies":[9],"to":[10,50,70,100,190],"fight":[11],"ongoing":[13],"battle":[14],"against":[15],"cancer.":[16],"New":[17],"interventions":[19],"are":[20],"still":[21],"needed":[22],"for":[23],"an":[24],"effective":[25,61],"and":[26,35,96,107,140],"successful":[27],"cancer":[28,171],"therapy.":[29],"In":[30,178],"this":[31,75],"scenario,":[32],"we":[33,77],"simulated":[34],"analyzed":[36],"dynamics":[38],"BRAF":[40,46],"V600E":[41],"melanoma":[42,91,170],"patients":[43],"treated":[44],"with":[45,166],"inhibitors":[47],"in":[48,62,90,98,113,169],"order":[49,99],"find":[51],"potentially":[52],"interesting":[53],"targets":[54],"that":[55,66,84,119,161],"may":[56,67,186],"make":[57],"standard":[58],"treatments":[59],"more":[60],"particularly":[63],"aggressive":[64],"tumors":[65],"not":[68],"respond":[69],"selective":[71],"inhibitor":[72],"drugs.":[73],"To":[74],"aim,":[76],"developed":[78],"a":[79],"continuous":[80],"Petri":[81],"Net":[82],"model":[83,116],"simulates":[85],"fundamental":[86],"signalling":[87],"cascades":[88,106],"involved":[89,112],"development,":[92],"such":[93],"as":[94],"MAPK":[95,134],"PI3K/AKT,":[97],"deeply":[101],"analyze":[102],"these":[103],"complex":[104],"kinase":[105],"predict":[108],"new":[109],"crucial":[110],"nodes":[111],"melanomagenesis.":[114],"The":[115],"pointed":[117],"out":[118,149],"some":[120],"microRNAs,":[121],"like":[122],"hsa-mir-132,":[123],"downregulates":[124],"expression":[125],"levels":[126],"p120RasGAP:":[128],"under":[129],"high":[130],"concentrations":[131],"p120RasGAP,":[133],"pathway":[135],"activation":[136],"is":[137,163],"significantly":[138,164],"decreased":[139],"consequently":[141],"also":[142],"PI3K/PDK1/AKT":[143],"activation.":[144],"Furthermore,":[145],"our":[146],"analysis":[147],"carried":[148],"through":[150,182],"Genomic":[152],"Data":[153,156],"Commons":[154],"(GDC)":[155],"Portal":[157],"shows":[158],"evidence":[160],"hsa-mir-132":[162],"associated":[165],"clinical":[167],"outcome":[168],"genomic":[172],"data":[173],"sets":[174],"BRAF-mutated":[176],"patients.":[177],"conclusion,":[179],"targeting":[180],"miRNAs":[181],"antisense":[183],"oligonucleotides":[184],"technology":[185],"suggest":[187],"way":[189],"enhance":[191],"action":[193],"BRAF-inhibitors.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}