{"id":"https://openalex.org/W2613994501","doi":"https://doi.org/10.1109/tcbb.2017.2701824","title":"Essential Protein Detection by Random Walk on Weighted Protein-Protein Interaction Networks","display_name":"Essential Protein Detection by Random Walk on Weighted Protein-Protein Interaction Networks","publication_year":2017,"publication_date":"2017-05-12","ids":{"openalex":"https://openalex.org/W2613994501","doi":"https://doi.org/10.1109/tcbb.2017.2701824","mag":"2613994501","pmid":"https://pubmed.ncbi.nlm.nih.gov/28504946"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2017.2701824","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2701824","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037135234","display_name":"Bin Xu","orcid":"https://orcid.org/0000-0001-7695-9515"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Xu","raw_affiliation_strings":["Department of Computer Science and Technology, Tongji University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086316879","display_name":"Jihong Guan","orcid":"https://orcid.org/0000-0003-2313-7635"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihong Guan","raw_affiliation_strings":["Department of Computer Science and Technology, Tongji University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057663550","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0002-1031-9491"},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Department of Computer Science and Technology, Nanchang University, Nanchang, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110854275","display_name":"Zewei Wang","orcid":"https://orcid.org/0009-0002-0378-1474"},"institutions":[{"id":"https://openalex.org/I3132425485","display_name":"Shanghai American School","ror":"https://ror.org/03xzda142","country_code":"CN","type":"education","lineage":["https://openalex.org/I3132425485"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zewei Wang","raw_affiliation_strings":["Shanghai Southwest Model Middle School, 67 Huicheng Vallige-1, Baise Road, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Southwest Model Middle School, 67 Huicheng Vallige-1, Baise Road, Shanghai, China","institution_ids":["https://openalex.org/I3132425485"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5037135234"],"corresponding_institution_ids":["https://openalex.org/I116953780"],"apc_list":null,"apc_paid":null,"fwci":1.595,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83200406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"16","issue":"2","first_page":"377","last_page":"387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.6884416341781616},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6408599615097046},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.6080161929130554},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.5520232915878296},{"id":"https://openalex.org/keywords/enhanced-data-rates-for-gsm-evolution","display_name":"Enhanced Data Rates for GSM Evolution","score":0.5508407354354858},{"id":"https://openalex.org/keywords/clustering-coefficient","display_name":"Clustering coefficient","score":0.5278332829475403},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5077808499336243},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.4986093044281006},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.49107837677001953},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4828087091445923},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.4697839319705963},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4671803116798401},{"id":"https://openalex.org/keywords/random-walk","display_name":"Random walk","score":0.46178704500198364},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.4342365860939026},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.42617887258529663},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.38007697463035583},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3109356462955475},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2521206736564636},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24825572967529297},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24707332253456116},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19131454825401306},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11920881271362305},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.11483287811279297}],"concepts":[{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.6884416341781616},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6408599615097046},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.6080161929130554},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.5520232915878296},{"id":"https://openalex.org/C162307627","wikidata":"https://www.wikidata.org/wiki/Q204833","display_name":"Enhanced Data Rates for GSM Evolution","level":2,"score":0.5508407354354858},{"id":"https://openalex.org/C22047676","wikidata":"https://www.wikidata.org/wiki/Q898680","display_name":"Clustering coefficient","level":3,"score":0.5278332829475403},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5077808499336243},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.4986093044281006},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.49107837677001953},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4828087091445923},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.4697839319705963},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4671803116798401},{"id":"https://openalex.org/C121194460","wikidata":"https://www.wikidata.org/wiki/Q856741","display_name":"Random walk","level":2,"score":0.46178704500198364},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4342365860939026},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.42617887258529663},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.38007697463035583},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3109356462955475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2521206736564636},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24825572967529297},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24707332253456116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19131454825401306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11920881271362305},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.11483287811279297},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2017.2701824","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2701824","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28504946","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28504946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8737677124","display_name":null,"funder_award_id":"61373036","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322449","display_name":"Tongji University","ror":"https://ror.org/03rc6as71"},{"id":"https://openalex.org/F4320327516","display_name":"Program of Shanghai Subject Chief Scientist","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1503938960","https://openalex.org/W1524141331","https://openalex.org/W1571220527","https://openalex.org/W1630454103","https://openalex.org/W1647729745","https://openalex.org/W1854214752","https://openalex.org/W1973758399","https://openalex.org/W1986310535","https://openalex.org/W1996612368","https://openalex.org/W1999808266","https://openalex.org/W2005740247","https://openalex.org/W2007245700","https://openalex.org/W2017975254","https://openalex.org/W2025971310","https://openalex.org/W2036799174","https://openalex.org/W2038492783","https://openalex.org/W2053906518","https://openalex.org/W2059747206","https://openalex.org/W2060816398","https://openalex.org/W2062776683","https://openalex.org/W2084619201","https://openalex.org/W2087194317","https://openalex.org/W2089125183","https://openalex.org/W2091579499","https://openalex.org/W2094433034","https://openalex.org/W2099651125","https://openalex.org/W2100628741","https://openalex.org/W2103017472","https://openalex.org/W2105089945","https://openalex.org/W2113140044","https://openalex.org/W2113553645","https://openalex.org/W2113654464","https://openalex.org/W2115550821","https://openalex.org/W2119114096","https://openalex.org/W2119359534","https://openalex.org/W2121507105","https://openalex.org/W2124354935","https://openalex.org/W2124540200","https://openalex.org/W2130687290","https://openalex.org/W2130790725","https://openalex.org/W2132582966","https://openalex.org/W2133654213","https://openalex.org/W2133826858","https://openalex.org/W2137464714","https://openalex.org/W2142437744","https://openalex.org/W2154600255","https://openalex.org/W2155019453","https://openalex.org/W2159595936","https://openalex.org/W2162891889","https://openalex.org/W2167869241","https://openalex.org/W6636975626","https://openalex.org/W6639055396"],"related_works":["https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2769306272","https://openalex.org/W376580281","https://openalex.org/W3203526752"],"abstract_inverted_index":{"Essential":[0],"proteins":[1,14,82],"are":[2,130],"critical":[3],"to":[4,110,152,192],"the":[5,19,66,78,88,112,121,167,200,212,231],"development":[6],"and":[7,29,147,185,222,228,230],"survival":[8],"of":[9,12,22,68,81,90,114,123,128,161,169,172,182],"cells.":[10],"Identification":[11],"essential":[13,36,69,115],"is":[15,150,164,189],"helpful":[16],"for":[17,30],"understanding":[18],"minimal":[20],"set":[21],"required":[23],"genes":[24],"in":[25,83,108,156],"a":[26,101],"living":[27],"cell":[28],"designing":[31],"new":[32],"drugs.":[33],"To":[34,118],"detect":[35],"proteins,":[37],"various":[38,134],"computational":[39],"methods":[40,226],"have":[41],"been":[42],"proposed":[43,151],"based":[44,225],"on":[45,77,94,199],"protein-protein":[46],"interaction":[47,52,144],"(PPI)":[48],"networks.":[49,158],"However,":[50],"protein":[51,70,92,116,187,194],"data":[53,232],"obtained":[54],"by":[55,132,166],"high-throughput":[56],"experiments":[57],"usually":[58],"contain":[59],"high":[60],"false":[61],"positives,":[62],"which":[63],"negatively":[64],"impacts":[65],"accuracy":[67,113],"detection.":[71,117],"Moreover,":[72],"most":[73,208,213],"existing":[74,209],"studies":[75],"focused":[76],"local":[79],"information":[80],"PPI":[84,124,157,202],"networks,":[85],"while":[86],"ignoring":[87],"influence":[89],"indirect":[91,186],"interactions":[93,129],"essentiality.":[95],"In":[96],"this":[97],"paper,":[98],"we":[99],"propose":[100],"novel":[102],"method,":[103,179],"called":[104],"Essentiality":[105],"Ranking":[106],"(EssRank":[107],"short),":[109],"boost":[111],"deal":[119],"with":[120],"inaccuracy":[122],"data,":[125],"confidence":[126,145],"scores":[127,146],"evaluated":[131,165],"integrating":[133,233],"biological":[135],"information.":[136],"Weighted":[137],"edge":[138,154],"clustering":[139],"coefficient":[140],"(WECC),":[141],"considering":[142],"both":[143,183],"network":[148,203],"topology,":[149],"calculate":[153,193],"weights":[155],"The":[159],"weight":[160],"each":[162],"node":[163],"sum":[168],"WECC":[170],"values":[171],"its":[173],"linking":[174],"edges.":[175],"A":[176],"random":[177],"walk":[178],"making":[180],"use":[181],"direct":[184],"interactions,":[188],"then":[190],"employed":[191],"essentiality":[195],"iteratively.":[196],"Experimental":[197],"results":[198],"yeast":[201],"show":[204],"that":[205],"EssRank":[206],"outperforms":[207],"methods,":[210],"including":[211],"commonly-used":[214],"centrality":[215],"measures":[216],"(SC,":[217],"DC,":[218],"BC,":[219],"CC,":[220],"IC,":[221],"EC),":[223],"topology":[224],"(DMNC":[227],"NC)":[229],"method":[234],"IEW.":[235]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}