{"id":"https://openalex.org/W2570408261","doi":"https://doi.org/10.1109/tcbb.2017.2649529","title":"PSPEL: In Silico Prediction of Self-Interacting Proteins from Amino Acids Sequences Using Ensemble Learning","display_name":"PSPEL: In Silico Prediction of Self-Interacting Proteins from Amino Acids Sequences Using Ensemble Learning","publication_year":2017,"publication_date":"2017-01-10","ids":{"openalex":"https://openalex.org/W2570408261","doi":"https://doi.org/10.1109/tcbb.2017.2649529","mag":"2570408261","pmid":"https://pubmed.ncbi.nlm.nih.gov/28092572"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2017.2649529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2649529","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100393871","display_name":"Jianqiang Li","orcid":"https://orcid.org/0000-0002-2208-962X"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Qiang Li","raw_affiliation_strings":["College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696"},"institutions":[{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu-Hong You","raw_affiliation_strings":["Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, Urumqi, China"],"affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, Urumqi, China","institution_ids":["https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375265","display_name":"Xiao Li","orcid":"https://orcid.org/0000-0001-9702-4153"},"institutions":[{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Li","raw_affiliation_strings":["Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, Urumqi, China"],"affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, Urumqi, China","institution_ids":["https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100633973","display_name":"Zhong Ming","orcid":"https://orcid.org/0000-0001-9310-3460"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong Ming","raw_affiliation_strings":["College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100371773","display_name":"Xing Chen","orcid":"https://orcid.org/0000-0001-9297-7174"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Chen","raw_affiliation_strings":["School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100393871"],"corresponding_institution_ids":["https://openalex.org/I180726961"],"apc_list":null,"apc_paid":null,"fwci":4.5724,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95754966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"14","issue":"5","first_page":"1165","last_page":"1172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8303745985031128},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.6730600595474243},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.602080762386322},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5894855856895447},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5736786127090454},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5117652416229248},{"id":"https://openalex.org/keywords/ensemble-learning","display_name":"Ensemble learning","score":0.4564928412437439},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.42322778701782227},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.42018646001815796},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36896687746047974},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3275412321090698},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19617903232574463},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08103790879249573}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8303745985031128},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.6730600595474243},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.602080762386322},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5894855856895447},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5736786127090454},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5117652416229248},{"id":"https://openalex.org/C45942800","wikidata":"https://www.wikidata.org/wiki/Q245652","display_name":"Ensemble learning","level":2,"score":0.4564928412437439},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.42322778701782227},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.42018646001815796},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36896687746047974},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3275412321090698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19617903232574463},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08103790879249573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2017.2649529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2649529","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28092572","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28092572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3158980518","display_name":null,"funder_award_id":"61572506","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4639603687","display_name":null,"funder_award_id":"2014A030313555","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5693537545","display_name":null,"funder_award_id":"61572330","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6610236737","display_name":null,"funder_award_id":"61373086","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1543773936","https://openalex.org/W1963824809","https://openalex.org/W1984580598","https://openalex.org/W1985919127","https://openalex.org/W1990212480","https://openalex.org/W1991669728","https://openalex.org/W2003516452","https://openalex.org/W2006124679","https://openalex.org/W2012415146","https://openalex.org/W2013488317","https://openalex.org/W2028928739","https://openalex.org/W2029008895","https://openalex.org/W2032408510","https://openalex.org/W2033855745","https://openalex.org/W2035405269","https://openalex.org/W2037036397","https://openalex.org/W2043764521","https://openalex.org/W2047606947","https://openalex.org/W2050721857","https://openalex.org/W2052034930","https://openalex.org/W2052685738","https://openalex.org/W2075337064","https://openalex.org/W2079035862","https://openalex.org/W2084619201","https://openalex.org/W2087322782","https://openalex.org/W2102268440","https://openalex.org/W2104315543","https://openalex.org/W2113019448","https://openalex.org/W2128781438","https://openalex.org/W2130378394","https://openalex.org/W2130687290","https://openalex.org/W2136602355","https://openalex.org/W2143720865","https://openalex.org/W2149310258","https://openalex.org/W2153635508","https://openalex.org/W2155004936","https://openalex.org/W2162392441","https://openalex.org/W2164071427","https://openalex.org/W2170682402","https://openalex.org/W2294639133","https://openalex.org/W2295745415","https://openalex.org/W2340013129","https://openalex.org/W2739999456","https://openalex.org/W2915975108","https://openalex.org/W6650995103"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2003194288","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867"],"abstract_inverted_index":{"Self":[0],"interacting":[1],"proteins":[2],"(SIPs)":[3],"play":[4],"an":[5,114],"important":[6,27],"role":[7],"in":[8,29,71,96],"various":[9],"aspects":[10],"of":[11,17,24,37,104,141],"the":[12,18,25,119,134,157,164],"structural":[13],"and":[14,52,61,78,121,129,143,160],"functional":[15],"organization":[16],"cell.":[19],"Detecting":[20],"SIPs":[21,38,76,131],"is":[22,66,87,101],"one":[23],"most":[26],"issues":[28],"current":[30],"molecular":[31],"biology.":[32],"Although":[33],"a":[34,67,83,151,172],"large":[35],"number":[36],"data":[39,132],"has":[40],"been":[41],"generated":[42],"by":[43],"experimental":[44],"methods,":[45],"wet":[46],"laboratory":[47],"approaches":[48],"are":[49,111],"both":[50],"time-consuming":[51],"costly.":[53],"In":[54,80],"addition,":[55],"they":[56],"yield":[57],"high":[58,139],"false":[59],"negative":[60],"positive":[62],"rates.":[63],"Thus,":[64],"there":[65],"great":[68],"need":[69],"for":[70],"silico":[72],"methods":[73],"to":[74,89,113,117,170,176],"predict":[75,90,177],"accurately":[77],"efficiently.":[79],"this":[81],"study,":[82],"new":[84],"sequence-based":[85],"method":[86,136,148,166],"proposed":[88,135,165],"SIPs.":[91,178],"The":[92],"evolutionary":[93],"information":[94],"contained":[95],"Position-Specific":[97],"Scoring":[98],"Matrix":[99],"(PSSM)":[100],"extracted":[102],"from":[103],"protein":[105],"with":[106,156],"known":[107],"sequence.":[108],"Then,":[109],"features":[110],"fed":[112],"ensemble":[115],"classifier":[116,159],"distinguish":[118],"self-interacting":[120],"non-self-interacting":[122],"proteins.":[123],"When":[124],"performed":[125],"on":[126],"Saccharomyces":[127],"cerevisiae":[128],"Human":[130],"sets,":[133],"can":[137,167],"achieve":[138],"accuracies":[140],"86.86":[142],"91.30":[144],"percent,":[145],"respectively.":[146],"Our":[147],"also":[149],"shows":[150],"good":[152],"performance":[153],"when":[154],"compared":[155],"SVM":[158],"previous":[161],"methods.":[162],"Consequently,":[163],"be":[168,171],"considered":[169],"novel":[173],"promising":[174],"tool":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
