{"id":"https://openalex.org/W2557373494","doi":"https://doi.org/10.1109/tcbb.2016.2633267","title":"Introducing a Stable Bootstrap Validation Framework for Reliable Genomic Signature Extraction","display_name":"Introducing a Stable Bootstrap Validation Framework for Reliable Genomic Signature Extraction","publication_year":2016,"publication_date":"2016-11-29","ids":{"openalex":"https://openalex.org/W2557373494","doi":"https://doi.org/10.1109/tcbb.2016.2633267","mag":"2557373494","pmid":"https://pubmed.ncbi.nlm.nih.gov/27913357"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2016.2633267","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2016.2633267","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080925773","display_name":"Nikolaos\u2010Kosmas Chlis","orcid":"https://orcid.org/0000-0002-6712-8346"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolaos-Kosmas Chlis","raw_affiliation_strings":["Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6712-8346","affiliations":[{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086247449","display_name":"Ekaterini S. Bei","orcid":null},"institutions":[{"id":"https://openalex.org/I55741626","display_name":"Technical University of Crete","ror":"https://ror.org/03f8bz564","country_code":"GR","type":"education","lineage":["https://openalex.org/I55741626"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ekaterini S. Bei","raw_affiliation_strings":["School of Electrical and Computer Engineering, Technical University of Crete, Chania, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Technical University of Crete, Chania, Greece","institution_ids":["https://openalex.org/I55741626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031391584","display_name":"Michalis Zervakis","orcid":"https://orcid.org/0000-0002-0705-631X"},"institutions":[{"id":"https://openalex.org/I55741626","display_name":"Technical University of Crete","ror":"https://ror.org/03f8bz564","country_code":"GR","type":"education","lineage":["https://openalex.org/I55741626"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michalis Zervakis","raw_affiliation_strings":["School of Electrical and Computer Engineering, Technical University of Crete, Chania, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Technical University of Crete, Chania, Greece","institution_ids":["https://openalex.org/I55741626"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9619,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.77501968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"181","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5372682809829712},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.48512184619903564},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4828120172023773},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.47946488857269287},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.45655056834220886},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4370518624782562},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.4300903081893921},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.41880184412002563},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30676448345184326},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2823098301887512},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2670697867870331},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1995522379875183},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.18241342902183533}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5372682809829712},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.48512184619903564},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4828120172023773},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.47946488857269287},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.45655056834220886},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4370518624782562},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4300903081893921},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.41880184412002563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30676448345184326},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2823098301887512},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2670697867870331},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1995522379875183},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.18241342902183533},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tcbb.2016.2633267","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2016.2633267","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27913357","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27913357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:50573","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50573","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM Trans. Comput. Biol. Bioinform. 15, 181-190 (2016)","raw_type":null},{"id":"pmh:oai:push-zb.helmholtz-munich.de:50573","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50573","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM Trans. Comput. Biol. Bioinform. 15, 181-190 (2016)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323220","display_name":"Alexander S. Onassis Public Benefit Foundation","ror":"https://ror.org/017nq0d63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1484870202","https://openalex.org/W1572741096","https://openalex.org/W1663973292","https://openalex.org/W1680392829","https://openalex.org/W1749911542","https://openalex.org/W1945425306","https://openalex.org/W1965474078","https://openalex.org/W1966703382","https://openalex.org/W1974211482","https://openalex.org/W1978797722","https://openalex.org/W1979348232","https://openalex.org/W1980574509","https://openalex.org/W1982191152","https://openalex.org/W1985489555","https://openalex.org/W1995951336","https://openalex.org/W1999842873","https://openalex.org/W2018486347","https://openalex.org/W2022397091","https://openalex.org/W2024367581","https://openalex.org/W2032909675","https://openalex.org/W2036483402","https://openalex.org/W2039032007","https://openalex.org/W2040447199","https://openalex.org/W2044527070","https://openalex.org/W2045412692","https://openalex.org/W2072417257","https://openalex.org/W2095763381","https://openalex.org/W2096856875","https://openalex.org/W2101536220","https://openalex.org/W2103017472","https://openalex.org/W2104107436","https://openalex.org/W2111758831","https://openalex.org/W2118069309","https://openalex.org/W2121541039","https://openalex.org/W2130410032","https://openalex.org/W2141009231","https://openalex.org/W2143426320","https://openalex.org/W2146739527","https://openalex.org/W2151990594","https://openalex.org/W2153032620","https://openalex.org/W2156672587","https://openalex.org/W2157132621","https://openalex.org/W2157795344","https://openalex.org/W2162162988","https://openalex.org/W2165432359","https://openalex.org/W2167105148","https://openalex.org/W2172025063","https://openalex.org/W2214074259","https://openalex.org/W2295197472","https://openalex.org/W2316437103","https://openalex.org/W2329541771","https://openalex.org/W2594639291","https://openalex.org/W2942228371","https://openalex.org/W4285719527","https://openalex.org/W4294107304","https://openalex.org/W4294216483","https://openalex.org/W4301253858","https://openalex.org/W6634379142","https://openalex.org/W6637386731"],"related_works":["https://openalex.org/W1603736412","https://openalex.org/W2898732673","https://openalex.org/W4304185162","https://openalex.org/W2410053581","https://openalex.org/W2061685118","https://openalex.org/W3006282800","https://openalex.org/W2383658677","https://openalex.org/W2462100143","https://openalex.org/W2038894244","https://openalex.org/W2096467860"],"abstract_inverted_index":{"The":[0,117,178],"application":[1],"of":[2,9,15,27,31,77,86,95,107,112,122,135,157,164,171,180,186],"machine":[3],"learning":[4],"methods":[5,58,141],"for":[6,13,104],"the":[7,25,51,78,84,93,105,125,136,154,158,162,165,172,184],"identification":[8],"candidate":[10,113],"genes":[11,32,114],"responsible":[12],"phenotypes":[14],"interest,":[16],"such":[17,96],"as":[18,129],"cancer,":[19],"is":[20,115,133,175],"a":[21,46,101,130],"major":[22],"challenge":[23],"in":[24,49,150,189],"field":[26],"bioinformatics.":[28],"These":[29],"lists":[30,72,111],"are":[33,148],"often":[34],"called":[35],"genomic":[36,61,190],"signatures":[37,62,166],"and":[38,55,89,109,128,139],"their":[39,193],"linkage":[40],"to":[41,68,152],"phenotype":[42],"associations":[43],"may":[44],"form":[45],"significant":[47],"step":[48,127],"discovering":[50],"causation":[52],"between":[53],"genotypes":[54],"phenotypes.":[56],"Traditional":[57],"that":[59],"produce":[60],"from":[63],"DNA":[64],"Microarray":[65],"data":[66],"tend":[67],"extract":[69],"significantly":[70],"different":[71,145],"under":[73],"relatively":[74],"small":[75],"variations":[76],"training":[79],"data.":[80],"That":[81],"instability":[82],"hinders":[83],"validity":[85],"research":[87],"findings":[88],"raises":[90],"skepticism":[91],"about":[92],"reliability":[94],"methods.":[97],"In":[98],"this":[99,181],"study,":[100],"complete":[102],"framework":[103],"extraction":[106],"stable":[108],"reliable":[110],"presented.":[116],"proposed":[118,173],"methodology":[119],"enforces":[120],"stability":[121,187],"results":[123,179],"at":[124],"validation":[126],"result,":[131],"it":[132],"independent":[134,169],"feature":[137],"selection":[138],"classification":[140],"used.":[142],"Furthermore,":[143],"two":[144],"statistical":[146,155],"tests":[147],"performed":[149],"order":[151],"assess":[153],"significance":[156],"observed":[159],"results.":[160],"Moreover,":[161],"consistency":[163],"extracted":[167],"by":[168],"executions":[170],"method":[174],"also":[176],"evaluated.":[177],"study":[182],"highlight":[183],"importance":[185],"issues":[188],"signatures,":[191],"beyond":[192],"prediction":[194],"capabilities.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2025-10-10T00:00:00"}
