{"id":"https://openalex.org/W2345065869","doi":"https://doi.org/10.1109/tcbb.2016.2515608","title":"Identifying Disease Associated miRNAs Based on Protein Domains","display_name":"Identifying Disease Associated miRNAs Based on Protein Domains","publication_year":2016,"publication_date":"2016-01-25","ids":{"openalex":"https://openalex.org/W2345065869","doi":"https://doi.org/10.1109/tcbb.2016.2515608","mag":"2345065869","pmid":"https://pubmed.ncbi.nlm.nih.gov/26829801"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2016.2515608","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2016.2515608","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086370741","display_name":"Guimin Qin","orcid":"https://orcid.org/0000-0001-8272-9599"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gui-Min Qin","raw_affiliation_strings":["School of Electronics and Information Engineering, Tongji University","School of Software, Xidian University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronics and Information Engineering, Tongji University","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"School of Software, Xidian University, Xi'an, China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068852522","display_name":"Ruiyi Li","orcid":"https://orcid.org/0000-0002-6414-4834"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui-Yi Li","raw_affiliation_strings":["School of Computer Science and Technology, Xidian University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xidian University, Xi'an, China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049435754","display_name":"Xing\u2010Ming Zhao","orcid":"https://orcid.org/0000-0002-4531-3970"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing-Ming Zhao","raw_affiliation_strings":["School of Electronics and Information Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronics and Information Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6567,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.69577016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"13","issue":"6","first_page":"1027","last_page":"1035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8320764303207397},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7200088500976562},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.7169485688209534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.59868985414505},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5669169425964355},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4728674590587616},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.377693772315979},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29455652832984924},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12715089321136475}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8320764303207397},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7200088500976562},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7169485688209534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.59868985414505},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5669169425964355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4728674590587616},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.377693772315979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29455652832984924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12715089321136475},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2016.2515608","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2016.2515608","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26829801","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26829801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2670986457","display_name":"\u52a8\u6001\u751f\u7269\u5206\u5b50\u7f51\u7edc\u6f14\u5316\u6a21\u5f0f\u6316\u6398\u7b97\u6cd5\u7814\u7a76","funder_award_id":"61100157","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3146641191","display_name":null,"funder_award_id":"JB141001","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4048704190","display_name":null,"funder_award_id":"2013M540386","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G5369175185","display_name":"\u57fa\u4e8e\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u7684\u75be\u75c5\u57fa\u56e0\u9884\u6d4b\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61572363","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5737903045","display_name":null,"funder_award_id":"91130032","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6773893820","display_name":null,"funder_award_id":"BDZ011401","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8179239958","display_name":null,"funder_award_id":"91530321","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1648301895","https://openalex.org/W1667789979","https://openalex.org/W1722231891","https://openalex.org/W1853773810","https://openalex.org/W1967087625","https://openalex.org/W1972703850","https://openalex.org/W1979712855","https://openalex.org/W1980250100","https://openalex.org/W1986512768","https://openalex.org/W1997921822","https://openalex.org/W1999313030","https://openalex.org/W1999684691","https://openalex.org/W2004306748","https://openalex.org/W2004720468","https://openalex.org/W2014946489","https://openalex.org/W2016106370","https://openalex.org/W2022732522","https://openalex.org/W2026570544","https://openalex.org/W2027762384","https://openalex.org/W2038122249","https://openalex.org/W2040022355","https://openalex.org/W2047967134","https://openalex.org/W2049344510","https://openalex.org/W2061743943","https://openalex.org/W2067207699","https://openalex.org/W2073038311","https://openalex.org/W2075470736","https://openalex.org/W2079150475","https://openalex.org/W2082197744","https://openalex.org/W2082422923","https://openalex.org/W2090076432","https://openalex.org/W2098318517","https://openalex.org/W2098905329","https://openalex.org/W2105136962","https://openalex.org/W2110881853","https://openalex.org/W2119687825","https://openalex.org/W2122211092","https://openalex.org/W2123696077","https://openalex.org/W2124499207","https://openalex.org/W2126249571","https://openalex.org/W2128768066","https://openalex.org/W2129158737","https://openalex.org/W2130775057","https://openalex.org/W2138150502","https://openalex.org/W2139776980","https://openalex.org/W2141885858","https://openalex.org/W2151519667","https://openalex.org/W2158135353","https://openalex.org/W2404054178","https://openalex.org/W4320301318","https://openalex.org/W6713303503","https://openalex.org/W6850060383"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W3151405604","https://openalex.org/W2565797512","https://openalex.org/W2050308539","https://openalex.org/W2793648706","https://openalex.org/W2019096591","https://openalex.org/W3032012916","https://openalex.org/W2057742104","https://openalex.org/W4283692078","https://openalex.org/W2025542119"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,20],"a":[3,77],"class":[4],"of":[5,29,34,93],"small":[6],"endogenous":[7],"non-coding":[8],"genes,":[9],"acting":[10],"as":[11],"regulators":[12],"in":[13,26,68],"the":[14,18,32,41,45,58,88],"post-transcriptional":[15],"processes.":[16,71],"Recently,":[17],"miRNAs":[19,37,59,84,109],"found":[21],"to":[22,56,61,64,80],"be":[23],"widely":[24],"involved":[25],"different":[27],"types":[28],"diseases.":[30],"Therefore,":[31],"identification":[33],"disease":[35,46,82,107],"associated":[36,83],"can":[38,104],"help":[39],"understand":[40],"mechanisms":[42],"that":[43,101],"underlie":[44],"and":[47,90],"identify":[48,57,81,106],"new":[49,78],"biomarkers.":[50],"However,":[51],"it":[52],"is":[53],"not":[54],"easy":[55],"related":[60,108],"diseases":[62],"due":[63],"its":[65],"extensive":[66],"involvements":[67],"various":[69],"biological":[70],"In":[72],"this":[73],"work,":[74],"we":[75],"present":[76],"approach":[79],"based":[85],"on":[86,97],"domains,":[87],"functional":[89],"structural":[91],"blocks":[92],"proteins.":[94],"The":[95],"results":[96],"real":[98],"datasets":[99],"demonstrate":[100],"our":[102],"method":[103],"effectively":[105],"with":[110],"high":[111],"precision.":[112]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}