{"id":"https://openalex.org/W2527550857","doi":"https://doi.org/10.1109/tcbb.2015.2465951","title":"Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia","display_name":"Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia","publication_year":2015,"publication_date":"2015-08-20","ids":{"openalex":"https://openalex.org/W2527550857","doi":"https://doi.org/10.1109/tcbb.2015.2465951","mag":"2527550857","pmid":"https://pubmed.ncbi.nlm.nih.gov/29610105"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2015.2465951","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2465951","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5918696","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115603699","display_name":"Lijun Zhang","orcid":"https://orcid.org/0000-0003-4974-2745"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijun Zhang","raw_affiliation_strings":["Institute for Personalized Medicine, Pennsylvania State University-College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Personalized Medicine, Pennsylvania State University-College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027188615","display_name":"Ming Wang","orcid":"https://orcid.org/0000-0002-9977-7041"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Wang","raw_affiliation_strings":["Public Health Sciences, Pennsylvania State University-College of Medicine, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences, Pennsylvania State University-College of Medicine, Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074154229","display_name":"Nicholas W. Sterling","orcid":"https://orcid.org/0000-0001-6240-0892"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas W. Sterling","raw_affiliation_strings":["Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348739","display_name":"Eunyoung Lee","orcid":"https://orcid.org/0000-0002-9440-9119"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eun-Young Lee","raw_affiliation_strings":["Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048576265","display_name":"Paul J. Eslinger","orcid":"https://orcid.org/0000-0002-6032-7801"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Eslinger","raw_affiliation_strings":["Departments of Neurology, Public Health Sciences, and Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, Public Health Sciences, and Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008908282","display_name":"Daymond Wagner","orcid":"https://orcid.org/0000-0001-9346-8515"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daymond Wagner","raw_affiliation_strings":["Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031819552","display_name":"Guangwei Du","orcid":"https://orcid.org/0000-0002-8267-0301"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangwei Du","raw_affiliation_strings":["Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024470069","display_name":"Mechelle M. Lewis","orcid":"https://orcid.org/0000-0002-1375-689X"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mechelle M. Lewis","raw_affiliation_strings":["Departments of Neurology, Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112216962","display_name":"Young K. Truong","orcid":"https://orcid.org/0009-0003-8679-2917"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Truong","raw_affiliation_strings":["Department of Biostatistics, University of North Carolina at Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of North Carolina at Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078867051","display_name":"F. DuBois Bowman","orcid":"https://orcid.org/0000-0002-3204-6535"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. DuBois Bowman","raw_affiliation_strings":["Department of Biostatistics, Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013155941","display_name":"Xuemei Huang","orcid":"https://orcid.org/0000-0003-3583-5502"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuemei Huang","raw_affiliation_strings":["Departments of Neurology, Pharmacology, Radiology, Neurosurgery, and Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, Pharmacology, Radiology, Neurosurgery, and Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6833,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.84510726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"15","issue":"2","first_page":"570","last_page":"580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/precuneus","display_name":"Precuneus","score":0.6591693162918091},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5892665386199951},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.5307343602180481},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.5139476656913757},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5116713047027588},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.5084902048110962},{"id":"https://openalex.org/keywords/cuneus","display_name":"Cuneus","score":0.5002255439758301},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"Basal ganglia","score":0.4783617854118347},{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.46972692012786865},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"Cognitive decline","score":0.45914244651794434},{"id":"https://openalex.org/keywords/cognitive-flexibility","display_name":"Cognitive flexibility","score":0.4446045756340027},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.43418997526168823},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3040390610694885},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26934587955474854},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.17280521988868713},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.13503199815750122}],"concepts":[{"id":"https://openalex.org/C2781441883","wikidata":"https://www.wikidata.org/wiki/Q1632835","display_name":"Precuneus","level":3,"score":0.6591693162918091},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5892665386199951},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5307343602180481},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5139476656913757},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5116713047027588},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5084902048110962},{"id":"https://openalex.org/C2780608534","wikidata":"https://www.wikidata.org/wiki/Q961620","display_name":"Cuneus","level":4,"score":0.5002255439758301},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.4783617854118347},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.46972692012786865},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.45914244651794434},{"id":"https://openalex.org/C66102695","wikidata":"https://www.wikidata.org/wiki/Q5141208","display_name":"Cognitive flexibility","level":3,"score":0.4446045756340027},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.43418997526168823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3040390610694885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26934587955474854},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17280521988868713},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.13503199815750122}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tcbb.2015.2465951","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2465951","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043","2998-4165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29610105","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29610105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:5372548","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5918696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5918696","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5918696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM Trans Comput Biol Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5918696","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5918696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM Trans Comput Biol Bioinform","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G2077350215","display_name":"Analytic Methods for Determining Multimodal Biomarkers for Parkinson's Disease","funder_award_id":"5u18ns082143-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3088804958","display_name":null,"funder_award_id":"C06 RR 016499","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G424215407","display_name":null,"funder_award_id":"M01-RR-010732","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4647889088","display_name":null,"funder_award_id":"U18 NS082143","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G497840552","display_name":null,"funder_award_id":"R01\u2010NS060722","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5325823329","display_name":"Multimodal MRI markers of nigrostriatal pathology in Parkinson's disease","funder_award_id":"4u01ns082151-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6090465210","display_name":"Structural MRI marker(s) of Parkinson's Disease's Progression","funder_award_id":"5r01ns060722-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G713621388","display_name":null,"funder_award_id":"UL 1 TR002014","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G893008047","display_name":null,"funder_award_id":"U01NS082151","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G92513505","display_name":null,"funder_award_id":"TL1TR002016","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1532756434","https://openalex.org/W1805914682","https://openalex.org/W1923227680","https://openalex.org/W1967337284","https://openalex.org/W1969534031","https://openalex.org/W1970534639","https://openalex.org/W1970798317","https://openalex.org/W1972038286","https://openalex.org/W1983075581","https://openalex.org/W1990435051","https://openalex.org/W1994802648","https://openalex.org/W2001285351","https://openalex.org/W2001469430","https://openalex.org/W2008147706","https://openalex.org/W2008935325","https://openalex.org/W2015936929","https://openalex.org/W2026772921","https://openalex.org/W2030629933","https://openalex.org/W2035079822","https://openalex.org/W2044940345","https://openalex.org/W2045892248","https://openalex.org/W2048207814","https://openalex.org/W2050379871","https://openalex.org/W2055097813","https://openalex.org/W2059110291","https://openalex.org/W2059431752","https://openalex.org/W2064963539","https://openalex.org/W2064996887","https://openalex.org/W2069010777","https://openalex.org/W2073449985","https://openalex.org/W2080584577","https://openalex.org/W2081694037","https://openalex.org/W2094730477","https://openalex.org/W2094973111","https://openalex.org/W2100845822","https://openalex.org/W2101135654","https://openalex.org/W2102198125","https://openalex.org/W2103232186","https://openalex.org/W2103934527","https://openalex.org/W2105086806","https://openalex.org/W2110208125","https://openalex.org/W2111613011","https://openalex.org/W2114613490","https://openalex.org/W2121369614","https://openalex.org/W2121956378","https://openalex.org/W2122941602","https://openalex.org/W2123886317","https://openalex.org/W2125418292","https://openalex.org/W2125463914","https://openalex.org/W2128443648","https://openalex.org/W2130793535","https://openalex.org/W2131881760","https://openalex.org/W2138266733","https://openalex.org/W2143893263","https://openalex.org/W2145729305","https://openalex.org/W2151721316","https://openalex.org/W2156102858","https://openalex.org/W2157270343","https://openalex.org/W2157848968","https://openalex.org/W2164417323","https://openalex.org/W2166609052","https://openalex.org/W2169005503"],"related_works":["https://openalex.org/W1989161677","https://openalex.org/W3112264872","https://openalex.org/W4234096678","https://openalex.org/W2046250855","https://openalex.org/W2905212241","https://openalex.org/W2574348594","https://openalex.org/W3093867320","https://openalex.org/W2063180731","https://openalex.org/W4283164400","https://openalex.org/W2981495241"],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1],"(PD)":[2],"is":[3],"a":[4,114],"progressive":[5],"neurodegenerative":[6],"disorder":[7],"characterized":[8],"clinically":[9],"by":[10,21],"motor":[11],"dysfunction":[12],"(bradykinesia,":[13],"rigidity,":[14],"tremor,":[15],"and":[16,19,60,76,88,97,105,134,161,165,172,187,190,195,217],"postural":[17],"instability),":[18],"pathologically":[20],"the":[22,28,32,145,184,227],"loss":[23],"of":[24,31],"dopaminergic":[25],"neurons":[26],"in":[27,45,48,58,72,144,159,183,208],"substantia":[29],"nigra":[30],"basal":[33],"ganglia.":[34],"Growing":[35],"literature":[36],"supports":[37],"that":[38],"cognitive":[39,65,81,90,135,206],"deficits":[40],"may":[41,61],"also":[42,181],"be":[43,62],"present":[44],"PD,":[46],"even":[47],"non-demented":[49,73,95],"patients.":[50],"Gray":[51],"matter":[52],"(GM)":[53],"atrophy":[54],"has":[55],"been":[56],"reported":[57],"PD":[59,74,96,146,151,201],"related":[63],"to":[64,80,149,167],"decline.":[66],"This":[67],"study":[68],"investigated":[69],"cortical":[70,156,229],"thickness":[71,108],"subjects":[75,100,152],"elucidated":[77],"its":[78],"relationship":[79],"impairment":[82],"using":[83,113],"high-resolution":[84],"T1-weighted":[85],"brain":[86,125,132],"MRI":[87],"comprehensive":[89],"function":[91],"scores":[92],"from":[93],"71":[94],"48":[98],"control":[99],"matched":[101],"for":[102,122],"age,":[103],"gender,":[104],"education.":[106],"Cortical":[107,178],"was":[109,180],"compared":[110],"between":[111,124],"groups":[112],"flexible":[115],"hierarchical":[116],"multivariate":[117],"Bayesian":[118],"model,":[119],"which":[120,139,223],"accounts":[121],"correlations":[123],"regions.":[126],"Correlation":[127],"analyses":[128],"were":[129,224],"performed":[130],"among":[131],"areas":[133,164,174],"domains":[136],"as":[137],"well,":[138],"showed":[140,203],"significant":[141,154],"group":[142],"differences":[143],"population.":[147],"Compared":[148],"Controls,":[150],"demonstrated":[153],"age-adjusted":[155],"thinning":[157,179,230],"predominantly":[158],"inferior":[160],"superior":[162,168,170],"parietal":[163],"extended":[166],"frontal,":[169,194],"temporal,":[171],"precuneus":[173],"(posterior":[175,198],"probability":[176,199],">0.9).":[177,200],"found":[182],"left":[185],"precentral":[186],"lateral":[188],"occipital,":[189],"right":[191],"postcentral,":[192],"middle":[193],"fusiform":[196],"regions":[197,231],"patients":[202],"significantly":[204],"reduced":[205],"performance":[207],"executive":[209],"function,":[210],"including":[211],"set":[212],"shifting":[213],"(p":[214,220,232],"=":[215,221],"0.005)":[216],"spontaneous":[218],"flexibility":[219],"0.02),":[222],"associated":[225],"with":[226],"above":[228],"<":[233],"0.05).":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}