{"id":"https://openalex.org/W2193527393","doi":"https://doi.org/10.1109/tcbb.2015.2430352","title":"LGH: A Fast and Accurate Algorithm for Single Individual Haplotyping Based on a Two-Locus Linkage Graph","display_name":"LGH: A Fast and Accurate Algorithm for Single Individual Haplotyping Based on a Two-Locus Linkage Graph","publication_year":2015,"publication_date":"2015-05-06","ids":{"openalex":"https://openalex.org/W2193527393","doi":"https://doi.org/10.1109/tcbb.2015.2430352","mag":"2193527393","pmid":"https://pubmed.ncbi.nlm.nih.gov/26671798"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2015.2430352","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2430352","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101644878","display_name":"Minzhu Xie","orcid":"https://orcid.org/0000-0002-8962-093X"},"institutions":[{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN","SG"],"is_corresponding":true,"raw_author_name":"Minzhu Xie","raw_affiliation_strings":["College of Physics and Information Science, Hunan Normal University, Changsha, China","School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore"],"affiliations":[{"raw_affiliation_string":"College of Physics and Information Science, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]},{"raw_affiliation_string":"School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438360","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0003-1516-0480"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100363021","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0001-5754-5835"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore"],"affiliations":[{"raw_affiliation_string":"School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101644878"],"corresponding_institution_ids":["https://openalex.org/I172675005","https://openalex.org/I173759888","https://openalex.org/I3130607311"],"apc_list":null,"apc_paid":null,"fwci":1.9139,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.8721556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"6","first_page":"1255","last_page":"1266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.6215775012969971},{"id":"https://openalex.org/keywords/vertex","display_name":"Vertex (graph theory)","score":0.583622395992279},{"id":"https://openalex.org/keywords/iterated-function","display_name":"Iterated function","score":0.5555786490440369},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49584922194480896},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.48039963841438293},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.46315091848373413},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.46004819869995117},{"id":"https://openalex.org/keywords/locus","display_name":"Locus (genetics)","score":0.4562661647796631},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.40453478693962097},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23595458269119263},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21869021654129028},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16341400146484375}],"concepts":[{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.6215775012969971},{"id":"https://openalex.org/C80899671","wikidata":"https://www.wikidata.org/wiki/Q1304193","display_name":"Vertex (graph theory)","level":3,"score":0.583622395992279},{"id":"https://openalex.org/C140479938","wikidata":"https://www.wikidata.org/wiki/Q5254619","display_name":"Iterated function","level":2,"score":0.5555786490440369},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49584922194480896},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.48039963841438293},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.46315091848373413},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.46004819869995117},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4562661647796631},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.40453478693962097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23595458269119263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21869021654129028},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16341400146484375},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tcbb.2015.2430352","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2430352","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26671798","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26671798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7131201080","display_name":null,"funder_award_id":"61370172","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8223640893","display_name":null,"funder_award_id":"61232001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8844864148","display_name":null,"funder_award_id":"MOE2012-T2-1-055","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"}],"funders":[{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1579697098","https://openalex.org/W1866835760","https://openalex.org/W1907324449","https://openalex.org/W1965464420","https://openalex.org/W1970199171","https://openalex.org/W1985809830","https://openalex.org/W1990461755","https://openalex.org/W2009441527","https://openalex.org/W2032033112","https://openalex.org/W2036815225","https://openalex.org/W2048818637","https://openalex.org/W2057114447","https://openalex.org/W2061585606","https://openalex.org/W2065714474","https://openalex.org/W2067513312","https://openalex.org/W2067677152","https://openalex.org/W2094813938","https://openalex.org/W2096791516","https://openalex.org/W2104708336","https://openalex.org/W2108153759","https://openalex.org/W2110772696","https://openalex.org/W2117400776","https://openalex.org/W2120126913","https://openalex.org/W2122767081","https://openalex.org/W2129326667","https://openalex.org/W2142642738","https://openalex.org/W2153200875","https://openalex.org/W2160609250","https://openalex.org/W2164971951","https://openalex.org/W2170307781","https://openalex.org/W2171536018","https://openalex.org/W2171777347","https://openalex.org/W2885727518","https://openalex.org/W2914081640","https://openalex.org/W6639095687"],"related_works":["https://openalex.org/W3146762847","https://openalex.org/W2398263405","https://openalex.org/W2166354960","https://openalex.org/W2056886854","https://openalex.org/W2025446304","https://openalex.org/W2131321814","https://openalex.org/W1888102361","https://openalex.org/W2171251480","https://openalex.org/W4237549798","https://openalex.org/W2151690061"],"abstract_inverted_index":{"Phased":[0],"haplotype":[1,166],"information":[2,54],"is":[3,115,146,184],"crucial":[4],"in":[5],"our":[6,182],"complete":[7],"understanding":[8],"of":[9,20,28,32,42,55,72,86,88,113],"differences":[10],"between":[11],"individuals":[12],"at":[13],"the":[14,30,53,66,73,83,143,149,170],"genetic":[15],"level.":[16],"Given":[17],"a":[18,25,40,45,60,79,93,140,165],"collection":[19],"DNA":[21,57],"fragments":[22,58],"sequenced":[23],"from":[24],"homologous":[26],"pair":[27,41,167],"chromosomes,":[29],"problem":[31,68],"single":[33,141,194],"individual":[34,195],"haplotyping":[35],"(SIH)":[36],"aims":[37],"to":[38,77],"reconstruct":[39],"haplotypes":[43],"using":[44],"computer":[46],"algorithm.":[47,98],"In":[48,75],"this":[49],"paper,":[50],"we":[51,91],"encode":[52],"aligned":[56],"into":[59,139],"two-locus":[61],"linkage":[62,152],"graph":[63,153],"and":[64,95,128,177,187],"approach":[65],"SIH":[67],"by":[69,105],"vertex":[70,80,171],"labeling":[71,81,112],"graph.":[74],"order":[76],"find":[78],"with":[82,101,121],"minimum":[84],"sum":[85],"weights":[87,130],"incompatible":[89],"edges,":[90],"develop":[92],"fast":[94],"accurate":[96,186],"heuristic":[97],"It":[99],"starts":[100],"detecting":[102],"error-tolerant":[103,137,155],"components":[104,156],"an":[106],"adapted":[107],"breadth-first":[108],"search.":[109],"A":[110],"proper":[111],"vertices":[114],"then":[116],"identified":[117],"for":[118,193],"each":[119,136],"component,":[120],"which":[122],"sequencing":[123],"errors":[124],"are":[125,131,157],"further":[126],"corrected":[127],"edge":[129],"adjusted":[132],"accordingly.":[133],"After":[134],"contracting":[135],"component":[138],"vertex,":[142],"above":[144],"procedure":[145],"iterated":[147],"on":[148,169,175],"resulting":[150],"condensed":[151],"until":[154],"no":[158],"longer":[159],"detected.":[160],"The":[161],"algorithm":[162,183],"finally":[163],"outputs":[164],"based":[168],"labeling.":[172],"Extensive":[173],"experiments":[174],"simulated":[176],"real":[178],"data":[179],"show":[180],"that":[181],"more":[185],"faster":[188],"than":[189],"five":[190],"existing":[191],"algorithms":[192],"haplotyping.":[196]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}