{"id":"https://openalex.org/W2096004942","doi":"https://doi.org/10.1109/tcbb.2015.2415815","title":"An Independent Filter for Gene Set Testing Based on Spectral Enrichment","display_name":"An Independent Filter for Gene Set Testing Based on Spectral Enrichment","publication_year":2015,"publication_date":"2015-03-23","ids":{"openalex":"https://openalex.org/W2096004942","doi":"https://doi.org/10.1109/tcbb.2015.2415815","mag":"2096004942","pmid":"https://pubmed.ncbi.nlm.nih.gov/26451820"},"language":"en","primary_location":{"id":"doi:10.1109/tcbb.2015.2415815","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2415815","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/7293246/07065232.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ieeexplore.ieee.org/ielx7/8857/7293246/07065232.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080933903","display_name":"H. Robert Frost","orcid":"https://orcid.org/0000-0002-6794-9945"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Robert Frost","raw_affiliation_strings":["Institute for Quantitative Biomedical Sciences, Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and the Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Quantitative Biomedical Sciences, Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and the Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363804","display_name":"Zhigang Li","orcid":"https://orcid.org/0000-0002-6224-1833"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhigang Li","raw_affiliation_strings":["Institute for Quantitative Biomedical Sciences, Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and the Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Quantitative Biomedical Sciences, Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and the Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039782389","display_name":"Folkert W. Asselbergs","orcid":"https://orcid.org/0000-0002-1692-8669"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210105827","display_name":"Netherlands Heart Institute","ror":"https://ror.org/01mh6b283","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210105827"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Folkert W. Asselbergs","raw_affiliation_strings":["Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute and the Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute and the Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210105827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason H. Moore","raw_affiliation_strings":["Institute for Quantitative Biomedical Sciences, Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and the Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Quantitative Biomedical Sciences, Section of Biostatistics and Epidemiology, Department of Community and Family Medicine and the Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5508,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66390594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"5","first_page":"1076","last_page":"1086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/test-statistic","display_name":"Test statistic","score":0.5942673087120056},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.58978670835495},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5812636017799377},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.5606863498687744},{"id":"https://openalex.org/keywords/filter","display_name":"Filter (signal processing)","score":0.5531811714172363},{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.5428916811943054},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47721272706985474},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.473512202501297},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4619465470314026},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4418044686317444},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.42964017391204834},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3880297541618347},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38186115026474},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38117504119873047},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3637400269508362},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3073819875717163},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28794848918914795}],"concepts":[{"id":"https://openalex.org/C169857963","wikidata":"https://www.wikidata.org/wiki/Q1461038","display_name":"Test statistic","level":3,"score":0.5942673087120056},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.58978670835495},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5812636017799377},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.5606863498687744},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.5531811714172363},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.5428916811943054},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47721272706985474},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.473512202501297},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4619465470314026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4418044686317444},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.42964017391204834},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3880297541618347},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38186115026474},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38117504119873047},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3637400269508362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3073819875717163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28794848918914795},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1109/tcbb.2015.2415815","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2415815","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/7293246/07065232.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26451820","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26451820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics","raw_type":null},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1484070","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1484070/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS , 12 (5) pp. 1076-1086. (2015)","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4666312","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4666312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM Trans Comput Biol Bioinform","raw_type":"Text"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/333184","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/333184","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM, 12(5), 1076. Institute of Electrical and Electronics Engineers Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/333184","is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/333184","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM, 12(5), 1076","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1109/tcbb.2015.2415815","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcbb.2015.2415815","pdf_url":"https://ieeexplore.ieee.org/ielx7/8857/7293246/07065232.pdf","source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1534238430","display_name":null,"funder_award_id":"R01 GM103506","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2612212953","display_name":null,"funder_award_id":"R01 LM010098","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G3364216530","display_name":null,"funder_award_id":"R01 LM011360","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G3889800190","display_name":null,"funder_award_id":"R01 EY022300","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5465968542","display_name":null,"funder_award_id":"P20 GM103506","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5668804095","display_name":null,"funder_award_id":"P20 GM103534","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G582462499","display_name":null,"funder_award_id":"R01 LM009012","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6345136743","display_name":null,"funder_award_id":"LM011360","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6483986534","display_name":null,"funder_award_id":"R01 GM103534","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6608586327","display_name":null,"funder_award_id":"GM103506","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6682602594","display_name":null,"funder_award_id":"LM010098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7965638068","display_name":null,"funder_award_id":"GM103534","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8919309667","display_name":null,"funder_award_id":"EY022300","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096004942.pdf","grobid_xml":"https://content.openalex.org/works/W2096004942.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W100168059","https://openalex.org/W1236321187","https://openalex.org/W1520752838","https://openalex.org/W1587447328","https://openalex.org/W1953958325","https://openalex.org/W1965214246","https://openalex.org/W1968228833","https://openalex.org/W1975451889","https://openalex.org/W1977556410","https://openalex.org/W1983463159","https://openalex.org/W1997642891","https://openalex.org/W1997840761","https://openalex.org/W1999119052","https://openalex.org/W2004475371","https://openalex.org/W2010457001","https://openalex.org/W2020859582","https://openalex.org/W2025855398","https://openalex.org/W2027895157","https://openalex.org/W2058358568","https://openalex.org/W2071949631","https://openalex.org/W2095712218","https://openalex.org/W2096108882","https://openalex.org/W2100980426","https://openalex.org/W2107038434","https://openalex.org/W2110065044","https://openalex.org/W2112220625","https://openalex.org/W2113345760","https://openalex.org/W2118249480","https://openalex.org/W2118258530","https://openalex.org/W2124704116","https://openalex.org/W2130021595","https://openalex.org/W2130410032","https://openalex.org/W2138255346","https://openalex.org/W2141545183","https://openalex.org/W2142796008","https://openalex.org/W2144766641","https://openalex.org/W2144907278","https://openalex.org/W2149060280","https://openalex.org/W2150392051","https://openalex.org/W2159482845","https://openalex.org/W2164279703","https://openalex.org/W2317381522","https://openalex.org/W2799002609","https://openalex.org/W3099211645","https://openalex.org/W4234895322","https://openalex.org/W4243185644","https://openalex.org/W4246697467","https://openalex.org/W4294216483","https://openalex.org/W6785123139"],"related_works":["https://openalex.org/W3003558595","https://openalex.org/W2113330311","https://openalex.org/W154531455","https://openalex.org/W4249473446","https://openalex.org/W2620592310","https://openalex.org/W2030905385","https://openalex.org/W2259063491","https://openalex.org/W3142061843","https://openalex.org/W4255580322","https://openalex.org/W1995992573"],"abstract_inverted_index":{"Gene":[0],"set":[1,46,74,81,92,97,119,144,197],"testing":[2,19,49,198],"has":[3],"become":[4],"an":[5],"indispensable":[6],"tool":[7],"for":[8,18,87],"the":[9,34,40,65,107,110,114,121,129,132,148,154,156,166,180,189],"analysis":[10],"of":[11,36,90,113,131,141,158],"high-dimensional":[12],"genomic":[13,25,61],"data.":[14],"An":[15],"important":[16],"motivation":[17],"gene":[20,45,57,73,80,91,96,118,143,160,177,185,196],"sets,":[21],"rather":[22],"than":[23],"individual":[24],"variables,":[26],"is":[27,50,139,162],"to":[28,67,95,188],"improve":[29],"statistical":[30,68,111],"power":[31,69],"by":[32,71],"reducing":[33],"number":[35],"tested":[37],"hypotheses.":[38],"Given":[39],"dramatic":[41],"growth":[42],"in":[43,193],"common":[44],"collections,":[47,75],"however,":[48],"often":[51],"performed":[52],"with":[53],"nearly":[54],"as":[55,59,103],"many":[56],"sets":[58,161,186],"underlying":[60],"variables.":[62],"To":[63],"address":[64],"challenge":[66],"posed":[70],"large":[72],"we":[76],"have":[77],"developed":[78],"spectral":[79],"filtering":[82,89],"(SGSF),":[83],"a":[84,104],"novel":[85],"technique":[86],"independent":[88,140],"collections":[93],"prior":[94],"testing.":[98],"The":[99],"SGSF":[100,181],"method":[101],"uses":[102],"filter":[105,137],"statistic":[106,138],"p-value":[108],"measuring":[109],"significance":[112,130],"association":[115],"between":[116],"each":[117],"and":[120,175],"sample":[122],"principal":[123],"components":[124],"(PCs),":[125],"taking":[126],"into":[127],"account":[128],"associated":[133],"eigenvalues.":[134],"Because":[135],"this":[136],"standard":[142],"test":[145],"statistics":[146],"under":[147,153],"null":[149],"hypothesis":[150],"but":[151],"dependent":[152],"alternative,":[155],"proportion":[157],"enriched":[159],"increased":[163,195],"without":[164],"impacting":[165],"type":[167],"I":[168],"error":[169],"rate.":[170],"As":[171],"shown":[172],"using":[173],"simulated":[174],"real":[176],"expression":[178],"data,":[179],"algorithm":[182],"accurately":[183],"filters":[184],"unrelated":[187],"experimental":[190],"outcome":[191],"resulting":[192],"significantly":[194],"power.":[199]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-19T07:52:34.831488","created_date":"2025-10-10T00:00:00"}
